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Nasal metastases from renal cell carcinoma are associated with Memorial Sloan-Kettering Cancer Center poor-prognosis classification

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Chinese Journal of Cancer 2011年第2期30卷 144-148页

作者： Caroline Victoria Choong Tiffany tang Wen Yee Chay Christopher Goh Miah Hiang Tay Nor Azhari Mohd Zam puay hoon tan Min-Han tan Department of Medical Oncology National Cancer Centre Singapore Singapore 169610 Republic of Singapore Department of Otolaryngology Singapore General Hospital Singapore Singapore 169608 Republic of Singapore Department of Urology Singapore General Hospital Singapore Singapore 169608 Republic of Singapore Department of Pathology Singapore General Hospital Singapore Singapore 169608 Republic of Singapore.

Unusual sites of metastases are recognized in patients with renal cell carcinoma (RCC). However, the prognostic implications of these sites are not well understood. We used the Memorial Sloan-Kettering Cancer Center (MSKCC) risk classification for metastatic RCC to evaluate 912 consecutive patients with RCC managed at the Singapore General Hospital between 1990 and 2009. Among these patients, 301 had metastases either at diagnosis or during the course of illness. Nasal metastases, all arising from clear cell RCC, were identified histologically in 4 patients (1.3% of those with metastasis). All 4 patients were classified as MSKCC poor prognosis by current risk criteria. Nasal metastases were significantly associated with lung and bone metastases. The frequency of nasal metastases in patients with metastatic RCC is about 1%, occurring predominantly in patients with clear cell RCC. Nasal metastases are associated with poor prognosis as estimated by the MSKCC risk classification, with attendant implications for selection of targeted therapy, and are usually associated with multi-organ dissemination, including concurrent lung and bone involvement.

关键词：风险分类肾细胞癌症预后鼻医院管理 CC标准治疗方案

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A rare case of isolated castrate resistant bilateral testicular metastases in advanced prostate cancer

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Asian Journal of Urology 2018年第2期5卷 127-130页

作者： Jiarui Su Edwin Jonathan Aslim Hakan Aydin puay hoon tan Henry Sun Sien Ho Department of Urology Singapore General HospitalSingapore Department of Anatomical Pathology Singapore General HospitalSingapore Division of Pathology Singapore General HospitalSingapore

Testicular metastasis is rare with the prostate being the most common site of primary *** report a case of a 72-year-old man with castration-resistant prostate cancer(CRPC)and known metastases to bone and lymph nodes,who developed bilateral painful swollen testes 3 years after the initial diagnosis of prostate *** had first presented with lower urinary tract symptoms(LUTS)with suspicious findings on digital rectal examination of the prostate,and an elevated serum prostate specific antigen(PSA)level of 129 ng/*** prostate biopsy revealed Gleason 4þ5 *** staging showed locally advanced prostate cancer with extensive metastases to bone and pelvic and retroperitoneal lymph *** was given hormonal therapy for over 2 years until progression to *** months later he developed painful bilateral testicular swellings,and serum markers for testicular germ cell cancer were *** orchiectomy was performed,showing metastatic prostate cancer(Gleason 4þ5)on *** month postoperatively his PSA level dropped to 0.1 ng/mL from a presurgery level of 6.24 ng/mL.

关键词： Castration-resistant prostate cancer Metastases Testicular tumor Orchiectomy

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Mucinous nonneoplastic cyst of the pancreas: A truly novel pathological entity?

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World Journal of Gastroenterology 2005年第13期11卷 2045-2047页

作者： Brian K.P.Goh Yu-Meng tan puay-hoon tan London L.P.J.Ooi Department of Surgery Department of Pathology

Recently, a novel and distinct pancreatic cystic tumor termed 'mucinous nonneoplastic' cyst was described in the *** report our experience with a 71-year-old female with a cystic tumor in the body of the pancreas demonstrating features suggestive of this diagnosis. We also review the literature regarding this 'novel' pathological entity and discuss critically its existence and its differential diagnoses.

关键词：病理学非肿瘤性囊肿胰腺囊肿病例报告

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Multiparametric MRI reporting using Prostate Imaging Reporting and Data System version 2.0 (PI-RADSv2) retains clinical efficacy in a predominantly post-biopsy patient population

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Asian Journal of Urology 2019年第3期6卷 256-263页

作者： Edwin Jonathan Aslim Yan Mee Law puay hoon tan John Carson Allen Jr Lionel Tim-Ee Cheng Viswanath Anand Chidambaram Li Yan Khor Benjamin Yongcheng tan Ernest Wencong Eu Christopher Wai Sam Cheng John Shyi Peng Yuen Henry Sun Sien Ho Lui Shiong Lee Department of Urology Singapore General HospitalSingapore Department of Diagnostic Radiology Singapore General HospitalSingapore Division of Pathology Singapore General HospitalSingapore Centre of Quantitative Medicine DUKE-NUS Medical SchoolSingapore Department of Anatomical Pathology Singapore General HospitalSingapore

Objective:To evaluate the efficacy of multiparametric magnetic resonance imaging(mp-MRI)using Prostate Imaging Reporting and Data System version 2.0(PI-RADSv2)definitions in detecting organ-confined prostate ***:All patients who underwent radical prostatectomy between January 1,2014 and December 30,2014 were *** underwent mp-MRI within 180 days before *** with prior pelvic irradiation or androgen deprivation therapy were *** embedded,whole-mount histopathology was centrally reviewed and correlated with imaging for tumour location,Gleason score(GS)and ***:There were 39 patients included,of which 35(90%)had mp-MRI done post-biopsy.A total of 93 cancer foci were identified on whole-mount pathology,of which mp-MRI detected 63(68%).Of those detected by mp-MRI,14 were PI-RADS 3(n=6 for GS 6,n=8 for GS 7,no GS≥8)and 49 were PI-RADS 4e5(nZ7 for GS 6,nZ33 for GS 7,and nZ9 for GS≥8).There were 30(32%)cancer foci missed by mp-MRI(n=15 for GS 6,n=13 for GS 7 and n=2 for GS≥8).A lesion classified as PI-RADS 4e5 predicted a higher grade cancer on pathology as compared to PI-RADS 3(for GS 7 lesions,odds ratio[OR]=3.53,95%CI:0.93e13.45,p=0.064).The mp-MRI size detection limit was 20 mm2 and 100 mm2 for 50%and 75%probability of cancer,*** associating with radiological and pathologic stage,the weighted Kappa value was 0.69(p<0.0001).The sensitivity and positive predictive values for this study were 68%(95%CI:57%e77%)and 78%(95%CI:67%e86%),***:In this predominantly post-biopsy cohort,mp-MRI using PI-RADSv2 reporting has a reasonably high diagnostic accuracy in detecting clinically significant prostate cancer.

关键词： Gleason score Histopathology Magnetic resonance imaging Prostatectomy Prostatic cancer

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