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Appropriateness of Amikacin Dose Prescription, Monitoring and Safety during Hospitalization as an Impact of Clinical Pharmacologist Intervention, in the Israeli Regional Hospital

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Journal of Biosciences and Medicines 2024年第3期12卷 337-354页

作者： renata Shihmanter Olga Lazar Lidia Arcavi Clinical Pharmacology Unit Kaplan Medical Center Rehovot and Hebrew University Hadassah Medical School Jerusalem Israel Department of Medicine Kaplan Medical Center Rehovot and Hebrew University Hadassah Medical School Jerusalem Israel

Background: Use of inappropriate amikacin dose is one of the most important factors in inducing toxicity, prolonged hospitalization as well as in increasing patient’s mortality. Objective: The aims of this study are the analysis of amikacin dose, serum level and the examination of the effectiveness of the clinical pharmacologist (CP) therapeutic drug monitoring (TDM) intervention to guarantee the safety of amikacin use. Methods: This is a one-year retrospective observational chart review study, which evaluates amikacin dose, serum drug level, development of adverse effects in patients on amikacin with or without CP TDM consultation. Results: Amikacin was prescribed for 393 complex patients, with median age 83. Amikacin group (AG) included 140 (32%) courses with CP consultation (AG1) and 292 (68%) courses without CP consultation (AG2). The distribution of most study characteristics in both groups was similar including amikacin dose (9-10 mg/kg/day), renal failure (14%) and mortality (12%). Acceptance for CP consultation was in 46% of amikacin courses and dose changes were done in 63% after CP intervention. Prolonged antibiotic course (4.6 ± 1.5 vs 3.8 ± 1.6 days, p < 0.0001) and the patient’s hemodynamic instability (15% vs 7%, p = 0.01) were more frequent in the AG1 compared to the AG2. There was a strong association between CP consultation and prolonged hospitalization (p = 0.005), while no association between it and amikacin adverse effects, renal failure or mortality. Conclusions: There was no trend to reducing amikacin toxicity, days of hospitaliza tion or mortality in patients with CP consultation. CP TDM intervention was more in the management of complicated clinical situations. However, it is necessary to optimize it.

关键词： Amikacin Therapeutic Drug Monitoring Appropriate Clinical Pharmacologist Safety Adverse Effects

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PNAS:科学家发现新的精子运动调节器

现代生物医学进展 2017年第27期17卷 I0001-I0002页

作者： Castaneda, Julio M. Hua, Rong Miyata, Haruhiko Oji, Asami Guo, Yueshuai Cheng, Yiwei Zhou, Tao Guo, Xuejiang Cui, Yiqiang Shen, Bin Wang, Zibin Hu, Zhibin Zhou, Zuomin Sha, Jiahao prunskaite-hyyrylainen, renata Yu, Zhifeng Ramirez-Solis, Ramiro Ikawa, Masahito Matzuk, Martin M. Liu, Mingxi Baylor Coll Med Dept Pathol & Immunol Houston TX 77030 USA Osaka Univ Res Inst Microbial Dis Suita Osaka 5650871 Japan Nanjing Med Univ State Key Lab Reprod Med Nanjing 210029 Jiangsu Peoples R China Nanjing Med Univ Dept Histol & Embryol Nanjing 210029 Jiangsu Peoples R China Osaka Univ Grad Sch Pharmaceut Sci Suita Osaka 5650871 Japan Nanjing Med Univ Anim Core Facil Nanjing 210029 Jiangsu Peoples R China Baylor Coll Med Ctr Reprod Med Houston TX 77030 USA Univ Oulu Fac Biochem & Mol Med FI-90014 Oulu Finland Baylor Coll Med Ctr Drug Discovery Houston TX 77030 USA Wellcome Trust Sanger Inst Hinxton CB10 1SA England Univ Tokyo Inst Med Sci Minato Ku Tokyo 1088639 Japan Baylor Coll Med Dept Mol & Cellular Biol Houston TX 77030 USA Baylor Coll Med Dept Mol & Human Genet Houston TX 77030 USA Baylor Coll Med Dept Pharmacol Houston TX 77030 USA

南京医科大学生殖医学国家重点实验室、基础医学院组织胚胎学系刘明兮课题组与贝勒医学院MartinM．Matzuk课题组、大阪大学MasahitoIkawa课题组等共同解析了一个精子运动调节基因TCTE1，结果发表于《美国科学院院刊》（PNAs）。

关键词：精子运动调节器科学家国家重点实验室组织胚胎学课题组生殖医学医科大学

Mesenchymal stem cells in ischemic tissue regeneration

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World Journal of Stem Cells 2023年第2期15卷 16-30页

作者： renata Szydlak Medical Biochemistry Faculty of Medicine Jagiellonian UniversityMedical College Kraków 31-034 Poland

Diseases caused by ischemia are one of the leading causes of death in the world.Current therapies for treating acute myocardial infarction,ischemic stroke,and critical limb ischemia do not complete recovery.Regenerative therapies opens new therapeutic strategy in the treatment of ischemic disorders.Mesenchymal stem cells(MSCs)are the most promising option in the field of cell-based therapies,due to their secretory and immunomodulatory abilities,that contribute to ease inflammation and promote the regeneration of damaged tissues.This review presents the current knowledge of the mechanisms of action of MSCs and their therapeutic effects in the treatment of ischemic diseases,described on the basis of data from in vitro experiments and preclinical animal studies,and also summarize the effects of using these cells in clinical trial settings.Since the obtained therapeutic benefits are not always satisfactory,approaches aimed at enhancing the effect of MSCs in regenerative therapies are presented at the end.

关键词： Ischemia Mesenchymal stem cells Regenerative medicine Stem cell therapy Clinical applications

Evidence-Based Complementary and Alternative Medicine Effects of Capybara Oil on Cardiac Remodeling of C57bl/6 Mice

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Journal of Biosciences and Medicines 2024年第5期12卷 213-232页

作者： Rafael M. Almeida Wagner D. Giannetti Guilherme R. Silveira Carolina R. Castilho renata V. Lisboa Bianca T. Ciambarella Rodrigo N. Ferreira Jorge José de Carvalho Laboratory of Ultrastructure and Tissue Biology Institute of Biology State University of Rio de Janeiro Rio de Janeiro Brazil Higher Education Center of Valenç a Dom Andr&#233 Arcoverde Educational Foundation Valen&#231a Brazil

Cardiovascular diseases are the main cause of morbidity and mortality in the world, and obesity and the metabolic syndrome are risk factors for its development. One of the therapies to reduce cardiovascular risk is the use of polyunsaturated fatty acids. In Brazil, a source of such acid is the oil extracted from the fat of the capybara. The objective of this work is to study the effects of the capybara oil on lipid and glucose metabolism, as well as its effects on the adipose tissue and cardiac remodeling. We assessed the effects of capybara oil treatment on body mass, lipid and carbohydrate metabolism, systolic blood pressure, adipose tissue and cardiac remodeling, and performed an ultrastructural evaluation of the myocardium in C57Bl/6 mice treated with high-fat diet. Treatment with capybara oil reduced total cholesterol and triglyceride levels, systolic blood pressure, visceral and subcutaneous adipose tissue, and adipocyte diameter. In addition, cardiac remodeling was attenuated, preserving cardiomyocytes, increasing vascularization, reducing cardiomyocyte hypertrophy and the extracellular matrix, and preserving the morphological integrity of mitochondria. Capybara oil has several beneficial effects on the cardiovascular and metabolic system, and further studies are needed to better understand its role in the prevention or treatment of cardiovascular diseases.

关键词： Capybara Oil Cardiac Remodeling Polyunsaturated Fatty Acids Obesity Metabolic Syndrome

A new concept to forecast the process of suspended sediment accumulation in the bottom sediment of small reservoirs

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International Journal of Sediment Research 2023年第4期38卷 556-565页

作者： Maksymilian Cie?la renata Gruca-Rokosz Lilianna Bartoszek Department of Environmental and Chemistry Engineering Faculty of Civil and Environmental Engineering and Architecture Rzeszow University of Technology

The new concept presented for forecasting the rate of accumulation of suspended sediment in reservoir water in the bottom sediment allows reasonable estimates of the siltation process globally, regionally, or locally, to be obtained without the need for costly research. The method draws on three key parameters,i.e., the concentration of suspended sediments(SS), and its organic matter(OMSS) content, as well as the storage capacity(VR)(i.e., the water storage in the reservoir). All of these parameters easy to determine,with information on them, in fact, made widely available by most agencies managing reservoirs in different parts of the world. In practice, the proposed method can represent a missing link in the precise determination of a reservoirs rate of siltation(and hence, losses of storage capacity).

关键词： Sediment accumulation Suspended sediment Organic matter Storage reservoirs Siltation rates Water resources

Digital representation methods:The case of algorithmic design

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Frontiers of Architectural Research 2022年第3期11卷 527-541页

作者： renata Castelo-Branco Ines Caetano Antonio Leitao INESC-ID/Institute Superior Tecnico University of LisbonLisbonPortugal

Architectural representation encompasses the means used to describe architectural entities.This discipline has long been under constant change due to architects’everpresent desire for innovation.Algorithmic design(AD)is currently making its way into the plethora of representation methods that integrate the architect’s day-to-day work tools.However,it provides its fair share of controversy and hardship as it goes.This paper assesses whether AD is suitable as a representation method for architectural design by making a systematic analysis of this medium as a contemporary representation method.Specifically,we investigate(1)its birth and evolution as a means of representation,(2)the characteristics that make it simultaneously appealing and off-putting to the architectural community,(3)the influence of technological evolution and education on its proliferation,and(4)its capacity to represent design problems in comparison to the currently predominant means of digital architectural representation,that is,computer-aided drafting and building information modeling.

关键词： Representation methods Algorithmic design Computer-aided drafting Building information modeling

Neuromuscular,biomechanical,and energetic adjustments following repeated bouts of downhill running

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Journal of Sport and Health Science 2022年第3期11卷 319-329页

作者： Arash Khassetarash Gianluca Vernillo renata L.Krüger W.Brent Edwards Guillaume Y.Millet Human Performance Laboratory Faculty of KinesiologyUniversity of CalgaryCalgary T2N 1N4Canada Department of Biomedical Sciences for Health University of MilanMilan 20133Italy Inter-university Laboratory of Human Movement Biology UJM-Saint-EtienneUniversitéde LyonSaint-Etienne 42023France Institut Universitaire de France(IUF) Paris 75231France

Purpose This study used downhill running as a model to investigate the repeated bout effect(RBE)on neuromuscular performance,running biomechanics,and metabolic cost of running.Methods Ten healthy recreational male runners performed two 30-min bouts of downhill running(DR1 and DR2)at a-20%slope and 2.8 m/s 3 weeks apart.Neuromuscular fatigue,level running biomechanics during slow and fast running,and running economy parameters were recorded immediately before and after the downhill bouts,and at 24 h,48 h,72 h,96 h,and 168 h thereafter(i.e.,follow-up days).Results An RBE was confirmed by attenuated muscle soreness and serum creatine kinase rise after DR2 compared to DR1.An RBE was also observed in maximum voluntary contraction(MVC)force loss and voluntary activation where DR2 resulted in attenuated MVC force loss and voluntary activation immediately after the run and during follow-up days.The downhill running protocol significantly influenced level running biomechanics;an RBE was observed in which center of mass excursion and,therefore,lower-extremity compliance were greater during follow-up days after DR1 compared to DR2.The observed changes in level running biomechanics did not influence the energy cost of running.Conclusion This study demonstrated evidence of adaptation in neural drive as well as biomechanical changes with the RBE after DR.The higher neural drive resulted in attenuated MVC force loss after the second bout.It can be concluded that the RBE after downhill running manifests as changes to global and central fatigue parameters and running biomechanics without substantially altering the energy cost of running.

关键词： Cost of running Eccentric exercise Fatigue Muscle damage

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Dementia in military and veteran populations:a review of risk factors—traumatic brain injury,post-traumatic stress disorder,deployment,and sleep

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Military Medical Research 2022年第3期9卷 351-364页

作者： Zara Raza Syeda F.Hussain Suzanne Ftouni Gershon Spitz Nick Caplin Russell G.Foster renata S.M.Gomes Research and Innovation Blind Veterans UK12-14 Harcourt StreetLondonW1H 4HDUK BRAVO VICTOR Research12-14 Harcourt StreetLondonW1H 4HDUK Circadian Therapeutics OxfordOX11BYUK School of Psychological Sciences Monash University18 Innovation WalkClayton CampusWellington RoadMelbourneVIC3800Australia Sleep&Circadian Neuroscience Institute(SCNi) Nuffield Department of Clinical NeurosciencesSir William Dunn School of PathologyOxford Molecular Pathology InstituteUniversity of OxfordSouth Parks RoadOxfordOX13RFUK Northern Hub for Veterans and Military Families Research Department of NursingMidwifery and HealthFaculty of Health and Life SciencesNorthumbria UniversityNewcastleNE77XAUK

The military population face a unique set of risk factors that may increase the risk of being diagnosed with dementia.Traumatic brain injury(TBI)and post-traumatic stress disorder(PTSD)have a higher prevalence in this group in comparison to the civilian population.By delving into the individual relationships between TBI and dementia,and PTSD and dementia,we are able to better explore dementia in the military and veteran populations.While there are some inconsistencies in results,the TBI-dementia association has become more widely accepted.Moderate-tosevere TBI has been found to increase the risk of being diagnosed with Alzheimer’s disease.A correlation between PTSD and dementia has been established,however,whether or not it is a causal relationship remains unclear.Factors such as blast,combat and chemical exposure may occur during a deployment,along with TBI and/or PTSD diagnosis,and can impact the risk of dementia.However,there is a lack of literature exploring the direct effects of deployment on dementia risk.Sleep problems have been observed to occur in those following TBI,PTSD and deployment.Poor sleep has been associated with possible dementia risk.Although limited studies have focused on the link between sleep and dementia in military and veteran populations,sleep is a valuable factor to study due to its association and interconnection with other military/veteran factors.This review aims to inform of various risk factors to the cognitive health of military members and veterans:TBI,PTSD,deployment,and sleep.

关键词： Dementia Alzheimer’s disease Traumatic brain injury Post-traumatic stress disorder Military Veteran Deployment Sleep

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Biological, chemical and mechanical factors regulating migration and homing of mesenchymal stem cells

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World Journal of Stem Cells 2021年第6期13卷 619-631页

作者： renata Szydlak Department of Medical Biochemistry Faculty of MedicineJagiellonian University Medical CollegeKraków 31-034Poland

Mesenchymal stem cells(MSCs)are a population of primary and non-specialized cells,which can be isolated from various tissues.Currently,MSCs are key players in cellular therapy and regenerative medicine.However,the possibility of using MSCs in the treatment of many diseases needs to be preceded,though,by indepth analysis of their properties,especially by determining the mechanism of tissue homing as well as the mechanism,due to which cells contribute to tissue regeneration.This review is intended to present information on recent findings regarding the mechanism of recruitment and tissue homing by MSCs and discuss current hypotheses for how MSCs can reach target tissues.

关键词： Mesenchymal stem cell Cell migration Regenerative medicine Mesenchymal stem cell-based therapy