检索结果-南通市图书馆

small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi Pradeepkiran priyanka Rawat Arubala P.Reddy Erika Orlov PHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of Pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of Public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAP-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

Linear and nonlinear elastic analysis of closely spaced strip foundations using Pasternak model

在线全文

学校读者我要写书评

暂无评论

Frontiers of structural and Civil Engineering 2017年第2期11卷 228-243页

作者： priyanka GHOsH s. RAJEsH J. sAI CHAND Department of Civil Engineering Indian Institute of Technology Kanpur Kanpur 208016 India

In this study, an attempt is made to determine the interaction effect of two closely spaced strip footings using Pasternak model. The study considers small strain problem and has been performed using linear as well as nonlinear elastic analysis to determine the interaction effect of two nearby strip footings. The hyperbolic stress-strain relationship has been considered for the nonlinear elastic analysis. The linear elastic analysis has been carried out by deriving the equations for the interference effect of the footings in the framework of Pasternak model equation; whereas, the nonlinear elastic analysis has been performed using the finite difference method to solve the second order nonlinear differential equation evolved from Pasternak model with proper boundary conditions. Results obtained from the linear and the nonlinear elastic analysis are presented in terms of non-dimensional interaction factors by varying different parameters like width of the foundation, load on the foundation and the depth of the rigid base. Results are suitably compared with the existing values in the literature.

关键词： bearing capacity linear and non-linear elasticity foundation interaction effect numerical modeling Pastemak model

Bianchi Type-Ⅱ Inflationary Models with stiff Matter and Decaying Cosmological Term

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 2014年第7期31卷 27-31页

作者： shri Ram, priyanka Department of Mathematical sciences Indian Institute of Technology Banaras Hindu University Varanasi 221 005 India

We deal with Einstein＇s field equations with a time-decaying cosmological term of the forms （i） ∧=β（a/a）＋ α/a62 and （ii）∧ = α/a^2, where a is the average scale factor of the universe, α and β are constants for a spatially homogeneous and anisotropic LRs Bianchi type-Ⅱ spacetime. Exact solutions of the field equations for stiff matter are obtained by applying a special law of variation for the Hubble parameter. Anisotropic cosmological models are presented with a constant negative deceleration parameter which corresponds to the accelerated phase of the present universe. The cosmological constant A is obtained as a decreasing function of time that is approaching a small positive value at the present epoch, which is corroborated by the consequences from recent supernovae Ia observations. The physical and kinematical behaviors of the models are also discussed.

关键词： Anisotropy

seismic analysis of nailed vertical excavation using pseudo-dynamic approach

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2016年第4期15卷 621-631页

作者： Piyush sarangi priyanka Ghosh Department of Civil Engineering Indian Institute of Technology

An attempt has been made to study the behavior of nailed vertical excavations in medium dense to dense cohesionless soil under seismic conditions using a pseudo-dynamic approach. The effect of several parameters such as angle of internal friction of soil （φ）, horizontal （kh） and vertical （kv） earthquake acceleration coefficients, amplification factor （fa）, length of nails （L）, angle of nail inclination （a） and vertical spacing of nails （s） on the stability of nailed vertical excavations has been explored. The limit equilibrium method along with a planar failure surface is used to derive the formulation involved with the pseudo-dynamic approach, considering axial pullout of the installed nails. A comparison of the pseudo-static and pseudo-dynamic approaches has been established in order to explore the effectiveness of the pseudo-dynamic approach over pseudo-static analysis, since most of the seismic stability studies on nailed vertical excavations are based on the latter. The results are expressed in terms of the global factor of safety （FOs）. seismic stability, i.e., the FOs of nailed vertical excavations is found to decrease with increase in the horizontal and vertical earthquake forces. The present values of FOs are compared with those available in the literature.

关键词： earthquake factor of safety pseudo-dynamic approach soil nailing vertical excavation

simultaneous enantioseparation and simulation studies of atenolol,metoprolol and propranolol on Chiralpak^■IG column using supercritical fluid chromatography

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2021年第6期11卷 746-756页

作者： Pranav A.Pandya priyanka A.shah Pranav s.shrivastav Department of Chemistry School of SciencesGujarat UniversityAhmedabad380009India

Enantioseparation of threeβ-blockers,i.e.,atenolol,metoprolol and propranolol,was studied on amylose tris(3-chloro-5-methylphenylcarbamate)immobilized chiral stationary phase using supercritical fluid chromatography(sFC).The effect of organic modifiers(methanol,isopropanol and their mixture),column temperature and back pressure on chiral separation ofβ-blockers was *** chromatographic separation with respect to resolution,retention,and analysis time was achieved using a mixture of CO_(2) and 0.1%isopropyl amine in isopropanol:methanol(50:50,V/V),in 75:25(V/V)*** the optimized conditions,the resolution factors(Rs)and separation factors(a)were greater than3.0 and 1.5,***,with increase in temperature(25-45℃)and pressure(100-150 bars)there was corresponding decrease in retention factors(k),a and ***,a reverse trend(a and Rs)was observed for atenolol with increase in *** thermodynamic data from van’t Hoff plots revealed that the enantioseparation was enthalpy driven for metoprolol and propranolol while entropy driven for *** understand the mechanism of chiral recognition and the elution behavior of the enantiomers,molecular docking studies were *** binding energies obtained from simulation studies were in good agreement with the elution order found experimentally and also with the free energy *** method was validated in the concentration range of 0.5-10μg/m L for all the *** limit of detection and limit of quantitation ranged from 0.126 to 0.137μg/m L and 0.376-0.414μg/m L,*** method was used successfully to analyze these drugs in pharmaceutical preparations.

关键词： Enantioseparation supercritical fluid chromatography β-blockers Chiralpak^(■)IG column Molecular docking Binding energy

Effect of Medical Qigong Therapy on Distress,Fatigue,and Quality of Life in Head and Neck Cancer Patients Undergoing Intensity-Modulated Radiation Therapy:A single Arm Clinical Trial

在线全文

学校读者我要写书评

暂无评论

World Journal of Traditional Chinese Medicine 2021年第4期7卷 427-435页

作者： priyanka s.sagaonkar Renu Pattanshetty Department of Oncology Physiotherapy KLE Academy of Higher Education and Research Institute of PhysiotherapyBelagaviKarnatakaIndia

Background:Cancer of Head and Neck(HNC)is the 2 nd common cancer in India leading to around 8%of the global cancer ***-modulated radiation therapy(IMRT)is advanced method minimizing exposure of radiation to adjacent normal structures but is associated with higher fatigue indirectly elevating distress *** Qigong(MQ),a meditative mind therapy has numerous health *** purpose of the current study was to investigate effect of MQ therapy on distress,fatigue,and quality of life in HNC patients undergoing *** and Methods:This experimental study was conducted on 16 Hospitalized HNC subjects undergoing IMRT aged 18–65 *** the subjects performed Qigong Walk Cycle for 5 weekdays for 4 weeks from initiation of *** of Brief Fatigue Inventory(BFI),6 min walk distance(6 MWD),Functional Assessment of Cancer Therapy-Head and Neck(FACT-HN)were documented at the baseline and at end of 4 th week and ***:IBM sPss statistics version 23.0;Indian version of Windows was used for statistical *** 16 HNC subjects majorly rural residents(62.5%)of mean age group 47.68±10.25 years with tobacco chewing as prevalent habit(94%)with maximum cases recorded in stage III of the *** pre and post test score comparison of serum cortisol,BFI and 6 MWD found high statistical significance with P=0.001 while that of the total and all components of FACT HN was found to be significant with P≤***:MQ therapy was effective in managing the levels of distress and fatigue thereby improving quality of life of all HNC subjects.

关键词： Distress fatigue head and neck cancer intensity-modulated radiation therapy medical qigong quality of life serum cortisol tobacco chewing

The network of cytokines,receptors and transcription factors governing the development of dendritic cell subsets

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2011年第8期2卷 620-630页

作者： priyanka sathe Li Wu Walter and Eliza Hall Institute 1G Royal ParadeParkvilleVictoria 3050Australia Department of Medical Biology University of MelbourneAustralia Tsinghua University school of Medicine Beijing 100084China

The pathways leading to the development of different dendritic cell(DC)subsets have long been *** recent years,a number of precursors on the route to DC development,both under steady state and inflammatory conditions,have been described,and the nature of these pathways is becoming *** addition,the development of various knockout mouse models and an in vitro system modelling DC development have revealed the role of numerous cytokines and transcription factors that influence DC ***,we review recent findings on the factors important in DC development in the context of the developmental pathways that have been described.

关键词： dendritic cell cytokines receptors transcription factors

Miniaturized antenna design for communication establishment of peer-to-peer communication in the oil pipelines

在线全文

学校读者我要写书评

暂无评论

Petroleum Research 2021年第3期6卷 291-302页

作者： E.B.priyanka s.Thangavel T.Kalavathidevi Department of Automobile Engineering Kongu Engineering CollegeErode638060India Department of Mechatronics Engineering Kongu Engineering CollegeErode638060India Department of Electronics and Instrumentation Engineering Kongu Engineering CollegeErode638060India

In the oil pipeline world,wireless automation plays an important role through integrated electronic technology in antenna design for robust *** technology gets evaluated by its power consumption and compactness to afford a better solution to real-world problems with better sophistication to adopt a modernized wireless *** that,the IoT(Internet of Things)technology plays a predominant role by combining with Artificial Intelligence to optimize and revolute the characterization of data *** the data communication is initiated,the main contributor to the transmission is the miniaturized antenna holding different types in its structure and *** acquires the required radio spectrum channel with the advanced multi coding modulating technique by utilizing token ring mesh topology for the data transfer with acquired data *** chapter describes the design and fabrication of a miniaturized antenna using MEMs technology(Micro-Electro-Mechanical system)and its different types using INTELLIsUITE software to get suited for better communication in oil *** on the application,it also enumerates the choices of micro or nanoantennas with its specification upholding data adopting techniques with modulation schemes to support IoT applications.

关键词： Antenna MEMs Channel width Optimization Oil pipelines and IoT

Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases

在线全文

学校读者我要写书评

暂无评论

signal Transduction and Targeted Therapy 2023年第12期8卷 5686-5726页

作者： priyanka Dey Talukdar Urmi Chatterji Cancer Research Laboratory Department of ZoologyUniversity of Calcutta35 Ballygunge Circular RoadKolkata 700019 West BengalIndia

specific cell states in metazoans are established by the symphony of gene expression programs that necessitate intricate synergic interactions between transcription factors and the *** of these regulatory molecules is associated with cell state transitions,which in turn is accountable for diverse maladies,including developmental disorders,metabolic disorders,and most significantly,cancer.A decade back most transcription factors,the key enablers of disease development,were historically viewed as‘undruggable’;however,in the intervening years,a wealth of literature validated that they can be targeted indirectly through transcriptional co-activators,their confederates in various physiological and molecular *** co-activators,along with transcription factors,have the ability to initiate and modulate transcription of diverse genes necessary for normal physiological functions,whereby,deregulation of such interactions may foster tissue-specific disease ***,it is essential to analyze how these co-activators modulate specific multilateral processes in coordination with other *** proposed review attempts to elaborate an in-depth account of the transcription co-activators,their involvement in transcription regulation,and context-specific contributions to pathophysiological *** review also addresses an issue that has not been dealt with in a comprehensive manner and hopes to direct attention towards future research that will encompass patient-friendly therapeutic strategies,where drugs targeting co-activators will have enhanced benefits and reduced side *** insights into currently available therapeutic interventions and the associated constraints will eventually reveal multitudes of advanced therapeutic targets aiming for disease amelioration and good patient prognosis.

关键词： therapeutic eventually potential