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Probing the degradation of pharmaceuticals in urine using MFC and studying their removal efficiency by UPLC-MS/MS

Journal of Pharmaceutical Analysis 2021年第3期11卷 320-329页

作者： priya sharma Devendra Kumar Srikanth Mutnuri Applied Environmental Biotechnology Laboratory Birla Institute of Technology&Science(BITS)Pilani403726ZuarinagarIndia Central Sophisticated Instrumentation Facility Birla Institute of Technology&Science(BITS)Pilani403726ZuarinagarIndia Department of Pharmaceutical Sciences College of PharmacyUniversity of Nebraska Medical CenterOmahaNE68198-602USA

Nutrient recovery from source-separated human urine has attracted interest as it is rich in nitrogen and phosphorus that can be utilized as ***,urine also contains pharmaceuticals,steroid hormones,*** their removal is crucial as they have detrimental effects on the environment and human *** current study focuses on investigating the degradation of pharmaceuticals using a double-chamber microbial fuel cell(MFC).Urine was spiked with four pharmaceuticals(trimethoprim,lamivudine,levofloxacin,and estrone)at a concentration of 2 mg/*** MFC was operated for 7 months in batch mode with this spiked urine as *** degradation efficiency of the MFC was studied,for which a selective liquid chromatography-tandem mass-spectrometric method was developed for the quantitation of compounds used in the spiking experiments and was validated with a lower limit of quantification of 0.39 ng/*** maximum removal rate achieved was 96%±2%.The degradation mechanism involved processes like sorption and anoxic *** voltage curve obtained showed that the presence of pharmaceuticals had an initial negative impact on power generation along with increased organic content;however,after the reactor acclimatization,increased power output was achieved with maximum organics removal at 30 h of retention *** work opens a new perspective for the anoxic biodegradation of pharmaceuticals and can be useful in future bioremediation studies.

关键词： Pharmaceuticals Urine MFC Biodegradation Liquid chromatography mass spectroscopy

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Microbial influence on liver regeneration: understanding gut microbiota and hepatic recovery post partial hepatectomy

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Hepatobiliary Surgery and Nutrition 2024年第2期13卷 314-316页

作者： Satya priya sharma Ki Tae Suk Institute for Liver and Digestive Diseases College of MedicineHallym UniversityChuncheonKorea

The liver is a unique solid organ with a regenerative capacity that is an important factor in the outcome of partial hepatectomy(PHx)performed to treat life-threating liver diseases(1-3).Multiple intrahepatic and extrahepatic signaling pathways synergistically regulate liver regeneration to restore typical liver functionality and thereby promote maximal life expectancy(2,4).Among the extrahepatic factors,gut metabolites are pivotal signaling molecules that affect the regulation of liver regeneration(5,6).Interestingly,dysbiosis of the gut microbiota due to disease or treatment strategies can influence liver regeneration negatively and delay recovery(7-9).In this empirical study,Yin et al.

关键词： Liver regeneration dysbiosis metabolites short-chain fatty acids(SCFAs) lipid biosynthesis

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Significance of gut microbiota in alcoholic and non-alcoholic fatty liver diseases

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World Journal of Gastroenterology 2021年第37期27卷 6161-6179页

作者： Satya priya sharma Ki Tae Suk Dong Joon Kim Institute for Liver and Digestive Diseases Hallym University College of MedicineChuncheon 24252South Korea

Liver-gut communication is vital in fatty liver diseases,and gut microbes are the key regulators in maintaining liver *** alcohol abuse and persistent overnutrition create dysbiosis in gut ecology,which can contribute to fatty liver *** this review,we discuss the gut microbial compositional changes that occur in alcoholic and nonalcoholic fatty liver diseases and how this gut microbial dysbiosis and its metabolic products are involved in fatty liver disease *** also summarize the new approaches related to gut microbes that might help in the diagnosis and treatment of fatty liver disease.

关键词： Fatty liver disease Alcoholic fatty liver disease Non-alcoholic fatty liver disease Gut microbiome Dysbiosis

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Comparative Finite Element Analysis of Jaipur Foot and Polyurethane Foot

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Engineering（科研） 2013年第10期5卷 518-521页

作者： priya sharma Shubhda sharma S. Vidhya M. K. Mathur Centre for Biomedical Research VIT University Vellore Tamilnadu Jaipur India

FEA is amongst best methods that help users to solve complex problems. There are fixed number of nodes in each ele-ment of the model that define the element boundaries to which boundary condition and loads can be applied. The geo-metry of the structure, the load applications, stress and displacement gradients can be approximated in a accurate man-ner, if the mesh is finer. The problem with the foot was unusual cracks in JP Foot and early breakage of PU Foot due to crack propagation[1]. To solve this problem we modelled the foot using SolidWorks and performed FEA Analysis for single leg below knee amputee patients. After analysis, it has been concluded that JP Foot as compared to PU Foot has more stress bearing capacity but has less displacement threshold due to its material properties[2]. This work will lead to optimization of both the feet thus enhancing the durability of foot.

关键词： Load Applications Crack Propagation Durability Solid Works Stress Displacement

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Salt Tolerance Mechanisms and Approaches:Future Scope of Halotolerant Genes and Rice Landraces

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Rice science 2020年第5期27卷 368-383页

作者： Tarun Bhatt Aditi sharma Sanjeev Puri Anu priya Minhas Department of Biotechnology University Institute of Engineering and TechnologySector-25Panjab UniversityChandigarh 160014India

All rice plant developmental stages are severely affected by soil salinity. Salinity-induced ionic and osmotic stresses affect stomata closure and gaseous exchange, and reduce transpiration and the rate of carbon assimilation, and hence decrease plant yield. Understanding the response of rice plants toward salinity stress at the genetic level and developing salt-tolerant varieties are the vital mandates for its effective management. This review described the present status of salt-tolerance achieved in rice by various mechanisms including the ion homeostasis(Na^+/H^+, OsNHX antiporters), compatible organic solutes(glycine betaine and proline), antioxidative genes(OsECS, OsVTE1, OsAPX and OsMSRA4.1), salt responsive regulatory elements(transcription factors, cis-acting elements and miRNAs) and genes ecoding protein kinases(MAPKs, SAPKs and STRKs). Further, the future perspective of developing salt-tolerant varieties lies in exploring halotolerant gene homologs from rice varieties, especially the landraces. Genetic diversity among rice landraces can serve as a valuable resource for future studies toward variety improvement through breeding and genome editing. Further, identification, multiplication, preservation and utilization of biodiversity among landraces are the urgent buffers to be saved as a heritage for future generations to come.

关键词： rice soil salinity ion homeostasis halotolerant landrace

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An Optimized Fuzzy Based Ant Colony Algorithm for 5G-MANET

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Computers, Materials & Continua 2022年第1期70卷 1069-1087页

作者： R.Nithya K.Amudha A.Syed Musthafa Dilip Kumar sharma Edwin Hernan Ramirez-Asis priya Velayutham V.Subramaniyaswamy Sudhakar Sengan Department of Computer Science and Engineering Vivekananda College of Engineering for WomenTiruchengode637205Tamil NaduIndia Department of Electronics and Communication Engineering Kongunadu College of Engineering and TechnologyThottiam621215Tamil NaduIndia Department of Information Technology M.Kumarasamy College of EngineeringKarur639113Tamil NaduIndia Department of Mathematics Jaypee University of Engineering and TechnologyGuna473226M.P.India Business and Tourism Faculty Universidad Nacional Santiago Antunez De MayoloHuarazPeru Department of Computer Science and Engineering Paavai Engineering CollegeNamakkal637018Tamil NaduIndia School of Computing SASTRA Deemed UniversityThanjavur613401Tamil NaduIndia Department of Computer Science and Engineering PSN College of Engineering and TechnologyTirunelveli627152Tamil NaduIndia

The 5G demonstrations in a business has a significant role in today’s fast-moving *** in 5G,drives a wireless system intended at an enormously high data rate,lower energy,low latency,and *** this reason,routing protocols of MANET have the possibility of being fundamentally flexible,high performance,and *** 5G communication aims to afford higher data rates and significantly low Over-The-Air *** through supplementary ACO routing processes,a security-aware,fuzzy improved ant colony routing optimization protocol is proposed in *** goal is to develop aMANET routing protocol that could provide a stable packet transmission ratio,less overhead connectivity,and low end-to-end latency in shared standard scenarios and attack *** demonstrates effective results with hybrid architecture and proved to be effective than other state-of-the-art routing protocols of MANETs,like AODV,its routing organization implemented through Optimized Fuzzy based ACO Algorithm for ***-wavelengths are required to perform a significant role in *** research proposed to test the efficiency of MANET consisting of only mmWave User *** reduced packet transmission loss of UEs withmmWave,meaning well-transmitted SNR leads directly to a better packet delivery *** verify results,simulation using the NS-3 simulator mmWave module is used.

关键词： 5G attacks D2D communications MANET mmWave security

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Photocatalytic Degradation of Azure A Using N-Doped Zinc Oxide

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Journal of Textile Science and Technology 2015年第3期1卷 118-126页

作者： priya Rathore Rakshit Ameta Sanyogita sharma Department of Chemistry PAHER University Udaipur India

Photocatalysis has been predicted as a promising technology for waste water treatment. N-doped zinc oxide has been used as an effective catalyst for carrying out number of chemical reactions, but limited work has been reported on use of N-doped ZnO as photocatalyst. In the present work, the photocatalytic degradation of Azure A was carried out in the presence of N-doped zinc oxide and the progress of the reaction was observed spectrophotometrically. The morphologies and structures of the as-synthesized nanomaterials were investigated by using FT-IR and DRS techniques. On the basis of observations, a tentative mechanism has been proposed for the photocatalytic degradation of dye.

关键词： Azure A Nanoparticles N-Doped Zinc Oxide Photocatalysis

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Aneurysmal bone cyst of the maxilla rare presentation with radiological and pathological correlation

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Plastic and Aesthetic Research 2015年第1期2卷 73-75页

作者： Bharat Bhushan sharma priya Ramchandran Sandeep sharma Shweta sharma Department of Radio Diagnosis PGIMER and Dr.RML HospitalNew Delhi 110001India Intensive Care Unit and Anesthesiology Heartlands HospitalB912AFBriminghamUK Pain Management and Anesthesiology SGT Medical College Gurgaon 122505HaryanaIndia ENT and Head and Neck Surgery PGIMER and Dr.RML HospitalNew Delhi 110001India

The incidence of aneurysmal bone cyst in the maxillofacial region is rare and may remain undiagnosed for a long period prior to becoming *** may cause associated issues secondary to compression by extending to the surrounding vital anatomical *** aggressive course can lead to bony destruction with intracranial *** present a case of a 23-year-old man who presented with bilateral exorbitism with nasal obstruction.

关键词： Aggressive course aneurysmal bone cyst bone destruction intracranial extension

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Reliability Measures for Tele-Communication System with Redundant Transferring Machine by Using Algebraic Method

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American Journal of Operations Research 2016年第5期6卷 371-377页

作者： Pawan Kumar sharma Ganesh Kumar Thakur Bandana priya Department of Applied Science Krishna Engineering College Mohan Nagar India Department of Applied Science G. L. Bajaj Institute of Technology & Management Greater Noida India

There are so many existing methods to obtain system reliability like re-generating point function technique, supplementary variables technique etc., but all these techniques are full of complicated calculations. Keeping above these facts in mind, the authors in this paper have evaluated some reliability parameters for tele-communication system by using Boolean functions technique and algebraic method. Reliability of considered tele-communication system has been evaluated by considering the fact that failures follow arbitrary time distribution. In particular, the reliability expression has also been calculated for Exponential and Weibull distributions. Further, an important reliability parameter namely M.T.T.F. (mean time to failure) has also been calculated. A numerical example with graphical illustrations has been appended at the end to highlight the important results and practical utility of the model.

关键词： Boolean Function Technique Algebra of Logics Weibull Distribution Exponential Distribution

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基于质量源于设计理念研究不同地区余甘子的关键性状

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Digital Chinese Medicine 2023年第3期6卷 272-284页

作者： Grishm Rohilla priya Masand Pooja Dhama Anurag Sunil Gupta Alok sharma Department of Pharmacognosy ISF College of PharmacyMogaPunjab 142001India Department of Pharmaceutical Technology Meerut Institute of Engineering&TechnologyMeerutUttar Pradesh 250005India School of Pharmacy Mangalayatan UniversityAligarhUttar Pradesh 202146India

目的探讨质量源于设计(QbD)工具在评估印度5个不同地区余甘子地理变异中的应用。方法在本实验中,采用简化四次模型的Box-Behnken设计,运行105次,结合使用Design Expert软件进行随机响应面映射。本研究使用了三种不同的浸提方法(索氏浸... 详细信息

目的探讨质量源于设计(QbD)工具在评估印度5个不同地区余甘子地理变异中的应用。方法在本实验中,采用简化四次模型的Box-Behnken设计,运行105次,结合使用Design Expert软件进行随机响应面映射。本研究使用了三种不同的浸提方法(索氏浸提、浸渍浸提和超声浸提)以及三种溶剂[蒸馏水、甲醇和水-甲醇混合物(50:50 v/v)]。采用气相色谱-质谱法(GC-MS)测定并分析余甘子的抗氧化活性、总黄酮含量(TFC)和总酚含量(TPC),以鉴定其主要成分。结果QbD叠加图显示余甘子的提取值不低于30%w/w,2,2-二苯基-1-三硝基苯肼(DPPH)不低于60%mcg/mL(微克每毫升),TFC不低于75 mg QE/g(毫克槲皮素当量每克干原料),TPC不低于80 mg GAE/g(毫克没食子酸当量每克干原料)。此外,(GC-MS)数据证实了余甘子的生物活性存在变异。结论本研究模型能较好的描述浸提值、DPPH、TFC和TPC的变化。QbD方法可能倾向于在浸提过程中优先考虑彻底性,最终提高浸提产品的质量。

关键词：余甘子质量源于设计气相色谱-质谱法浸提参数生物活性

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