Microbial influence on liver regeneration: understanding gut microbiota and hepatic recovery post partial hepatectomy

作     者：Satya Priya Sharma Ki Tae Suk 

作者机构：Institute for Liver and Digestive DiseasesCollege of MedicineHallym UniversityChuncheonKorea 

出 版 物：《Hepatobiliary Surgery and Nutrition》 (肝胆外科与营养（英文）)

年 卷 期：2024年第13卷第2期

页      面：314-316页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by the Hallym University Research Fund,the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,Science and Technology(No.NRF-2020R1A6A1A03043026) the Korea Institute for Advancement of Technology(No.P0020622) 

主　　题：Liver regeneration dysbiosis metabolites short-chain fatty acids(SCFAs) lipid biosynthesis 

摘      要：The liver is a unique solid organ with a regenerative capacity that is an important factor in the outcome of partial hepatectomy(PHx)performed to treat life-threating liver diseases(1-3).Multiple intrahepatic and extrahepatic signaling pathways synergistically regulate liver regeneration to restore typical liver functionality and thereby promote maximal life expectancy(2,4).Among the extrahepatic factors,gut metabolites are pivotal signaling molecules that affect the regulation of liver regeneration(5,6).Interestingly,dysbiosis of the gut microbiota due to disease or treatment strategies can influence liver regeneration negatively and delay recovery(7-9).In this empirical study,Yin et al.