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The Periaqueductal Gray and Its Extended Participation in Drug Addiction Phenomena

Neuroscience Bulletin 2021年第10期37卷 1493-1509页

作者： priscila vazquez-leon Abraham Miranda-Paez Jesus Chavez-Reyes Gonzalo Allende Paulino Barragan-Iglesias Bruno A.Marichal-Cancino Departamento de Fisiologia y Farmacologia Centro de Ciencias BasicasUniversidad Autonoma de AguascalientesCiudad Universitaria20131 AguascalientesAgs.Mexico Departamento de Fisiologia Escuela Nacional de Ciencias BiologicasInstituto Politecnico NacionalWilfrido Massieu esq.Manuel Stampa s/n Col.Nueva Industrial Vallejo07738 Gustavo A.MaderoMexico CityMexico

The periaqueductal gray(PAG)is a complex mesencephalic structure involved in the integration and execution of active and passive self-protective behaviors against imminent threats,such as immobility or flight from a *** activity is also associated with the integration of responses against physical discomfort(e.g.,anxiety,fear,pain,and disgust)which occurs prior an imminent attack,but also during withdrawal from drugs such as morphine and *** PAG sends and receives projections to and from other well-documented nuclei linked to the phenomenon of drug addiction including:(i)the ventral tegmental area;(ii)extended amygdala;(iii)medial prefrontal cortex;(iv)pontine nucleus;(v)bed nucleus of the stria terminalis;and(vi)*** models have suggested that the PAG contributes to the modulation of anxiety,fear,and nociception(all of which may produce physical discomfort)linked with chronic exposure to drugs of *** produced by the major pharmacological classes of drugs of abuse is mediated through actions that include participation of the *** support of this,there is evidence of functional,pharmacological,***/or genetic alterations in the PAG during the impulsive/compulsive intake or withdrawal from a *** to its small size,it is difficult to assess the anatomical participation of the PAG when using classical neuroimaging techniques,so its phys-iopathology in drug addiction has been underestimated and poorly *** this theoretical review,we discuss the involvement of the PAG in drug addiction mainly via its role as an integrator of responses to the physical discomfort associated with drug withdrawal.

关键词： Periaqueductal gray Reward circuit Antireward circuit Alcohol Caffeine Cannabis Opioids Stimulants

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A plant-pollinator system： How learning versus cost-benefit can induce periodic oscillations

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International Journal of Biomathematics 2018年第2期11卷 189-215页

作者： Virgilio vazquez Ignacio Barradas Instituto de Fisicay Matemdticas Universidad Tecnologica de la Mixteca Huajuapan de leon Oaxaca 69000 Mexico Centro de Investigacion en Matemdticas Apartado Postal 302 Guanajuato Guanajuato 36000 Mexico

In this paper, we propose a model describing the interaction between two species： a plant population that gets pollinated by an insect population. We assume the plant population is divided into two groups： the first group in mutualistic relationship with the insect and the second group attracting the insects while deceiving them and not delivering any reward. In addition, we assume that the insect population reduces the number of visits to the plants after several unsuccessful visits. We are interested in the conditions for the coexistence of both species, especially in the appearance of damped or sustained oscillations. We focus the analysis on the parameters that measure the balance among deceit, the benefit that the insect gets from the plant, and the learning by the pollinators. We are especially interested in analyzing the effect of learning by the insect population due to unsuccessfully visiting the deceiving plants.

关键词： Deceptive pollination mutualism learning oscillations Hopf bifurcation.

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Morphological control of cadmium sulfide nanostructures by electrophoretic deposition

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Particuology 2016年第1期14卷 73-77页

作者： Alejandro vazquez Thelma Serrano Boris Kharisov Idalia Gomez Universidad Autonoma de Nuevo leon UANL Facultad de Ciencias Quimicas Av. Universidad S/N San Nicolas de los Garza Nuevo Leon 66451 Mexico

Thin films and one-dimensional CdS nanostructures were formed by electrophoretic deposition of nanoparticles with morphological control, Particles less than 1Ohm in diameter were prepared by a microwave assisted synthesis using trisodium citrate as capping agent. The particles were character- ized by UV-Vis spectrophotometry, dynamic light scattering, and X-ray diffraction. Nanoparticles in the resulting aqueous dispersion were electrodeposited without any further treatment on aluminum plates. The nanostructures consisted of thin films with surface roughness being tuned with the applied voltage. One-dimensional nanostructures were formed by varying the applied voltage and by changing the molar ratio of the precursors in the nanocrystal synthesis. These results illustrate two different mechanisms of electrophoretic deposition that lead to the formation of different nanostructures,

关键词： Electrophoretic deposition Nanostructure Nanoparticle

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Volatile organic compound emission and biochemical properties of degraded Ultisols ameliorated by no tillage and liming

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Pedosphere 2020年第5期30卷 597-606页

作者： Laura GIAGNONI Cosimo TAITI Paloma leon Corrado COSTA Paolo MENESATTI Rafael ESPEJO Clara GOMEZ-PACCARD Chiquinquira HONTORIA Eduardo vazquez Marta BENITO Stefano MANCUSO Giancarlo RENELLA Department of Agriculture FoodEnvironment and Forestry(DAGRI)University of FlorenceP.le delle Cascine 18Florence 50144(Italy) Departamento de Production Agraria E.T.S.I.AgrondmicaAlimentaria y de BiosistemasUniversidad Politecnica de MadridAvda.Complutense s/nMadrid 28040(Spain) Consiglio per la Ricerca in Agricoltura e I'Analisi dell'Economia Agraria(CREA)-Unita di Ricerca per ilngegneria Agraria via della Pascolare 16Monterotondo ScaloRM 00015(Italy) Department of Soil Biogeochemistry and Soil Ecology University of BayreuthDr.Hans-Frisch-Strafie 1-3Bayreuth 95448(Germany) University of Padua Department of AgronomyFoodNatural ResourcesAnimals and Environment(DAFNAE)Viale dell'Universita 16Legnaro 35020(Italy)

TTie Ultisols in the Rana de Canamero area in Southwest Spain showed aluminum(Al)phytotoxicity,and the clearance of natural vegetation and decades of intensive conventional agriculture caused the deplation of soil organic matter(SOM).Therefore,we studied the long-term effects of no tillage and liming using sugar beet foam(SF)and red gypsum(RG),alone or in combination,on the restoration of Ultisols affected by acidification,Al phytotoxicity,and SOM *** measured the main soil chemical properties,soil microbial biomass,soil enzyme activities involved in carbon,nitrogen,phosphorus,and sulfur mineralization,and the emission of volatile organic compounds(VOCs).The results indicated that liming effectively neutralized the soil acidity in the long term and,in combination with no tillage,significantly increased soil microbial biomass and enzyme ***-three VOCs were detected using the proton transfer reaction-time of flight(PTR-ToF)technique,and both liming and tillage changed the VOC emission *** greatest difference in VOC emission pattern was observed between no-tilled un-amended soils and tilled lime-amended soils,suggesting the activation of different metabolic pathways within the microbial communities of soils under different *** in VOC emission patterns could be attributed to the decomposition of carbohydrates,which were also sustained by the higher enzyme activities in the lime-amended soils.

关键词： carbohydrate decomposition degraded soils long-term field trial soil acidity soil enzyme activities soil microbial biomass soil restoration

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Energy Efficiency in Smart Grid: A Prospective Study on Energy Management Systems

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Smart Grid and Renewable Energy 2015年第8期6卷 250-259页

作者： Hermes José Loschi Julio leon Yuzo Iano Ernesto Ruppert Filho Fabrizzio Daibert Conte Telmo Cardoso Lustosa priscila Oliveira Freitas Department of Communications Faculty of Electrical and Computer Engineering University of Campinas (UNICAMP) Campinas/SP Brazil

The term Smart Grid has become a term to represent the benefits of a smart and sophisticated electrical grid, which can meet various social expectations related to sustainability and energy efficiency. The Smart Grid promises to enable a better power management for energy utilities and consumers, to provide the ability to integrate the power grid, to support the development of micro grids, and to involve citizens in energy management with higher levels of responsibility. However, this context comes with potential pitfalls, such as vulnerabilities to cyber-security and privacy risks. In this article, a prospective study about energy management, and exploring critical issues of modeling of energy management systems in a context Smart. Grid is presented along with background of energy management systems. An analysis of the demand response condition is also presented. Finally, the advantages and disadvantages of the implementation of energy management systems, and a comparison with the Brazilian electricity system are discussed.

关键词： Smart Grid Management Cloud Computing Energy Efficiency

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Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family

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Cancer Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Redecillas Sergio Cuenca-Lopez Eduardo Andres-leon Laura Carmen Terron-Camero Blanca Cano-Gutierrez Jose Manuel Cozar Jose Antonio Lorente Fernando vazquez-Alonso Luis Javier Martinez-Gonzalez Maria Jesus Alvarez-Cubero GENYO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery Service.University Hospital Clínico San Cecilio GranadaGranadaSpain Urology Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear Editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC *** increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk ***,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(SNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.

关键词： cancer clinical cases

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Does Adult Intestinal Invagination Need Surgery? Report of a Case and Review of Literature

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International Journal of Clinical Medicine 2011年第4期2卷 456-458页

作者： Carlos leon-Espinoza Maria Gomez-Mateo Fernando Lopez-Mozos Roberto Marti-Obiol Juan Raga-vazquez Joaquin Ortega-Serrano 不详

Benign intestinal tumors are the most frequent cause of small bowel intussusception in adults. This report presents a case of a 67-year-old male with abdominal pain, leukocytosis and C-reactive protein elevation. After ultrasonography and double contrast CT-scan consistent with ileal intussusception patient underwent laparoscopy, which confirmed diagnose. Intestinal resection and anastomosis were performed via minilaparotomy. Further histological study showed a fibroid inflammatory polyp or Vanek’s tumor as intussusception’s lead point.

关键词： Invagination Intussusception Vanek

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Expressions of＂Conviviality＂ in Everyday Life From a Communal Praxis

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Psychology Research 2013年第2期3卷 95-103页

作者： Maria del Rocio Guzman Benavente, Maria de la Luz Ortiz vazquez, Laura Emestina Barrag/m Ledesma Maria Teresita Castillo leon Universidad Juarez del Estado de Durango Durango M6xico Universidad Aut6noma de Yucatan Yucatan Mexico

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Major Existing Classification Matrices and Future Directions for Internet of Things

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Advances in Internet of Things 2017年第4期7卷 112-120页

作者： Kedir Mamo Basher Juan-Ivan Nieto-Hipolito Maria De Los Angeles Cosio leon Mabel vazquez-Briseno Juan de Dios Sánchez López Raymundo Buenrostro Mariscal Facultad de Ingeniería Arquitectura y Dise&#241 o UABC Ensenada México

Classification method is a formula, logical description generalizing characteristics of objects of related area. Nowadays, billions of smart objects are immersed in the environment, sensing, interacting, and cooperating with each other to enable efficient services. When we think about IoT, classification is a major challenge particularly if our technology is international level applicable. So, this limitation needs clear and deep analysis of the existing classification matrixes and gives some future directions depending on the different researches in the area. The paper surveys the current state-of-art in the classification of IoT. First, we try to explain commonly existing classification matrixes;Second, cooperation of different methods defending on classification matrixes used. Then analyses challenges that IoT faced from classification angle and finally we give some direction for future IoT classification.

关键词： Internet of Things Classification of IoT IoT Overview Future of IoT Smart Objects

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Hypersensitivity to Aspirin as a Factor for Poor Control in Hereditary Angioedema

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Journal of Biosciences and Medicines 2017年第3期5卷 39-54页

作者： Carlos Alberto Garcia-Lopez Maria Eugenia Vargas-Camano Emmanuel Alcazar-Casarin Guillermo Quintana Mexiac Pablo leon Gomez Mario Alberto Ynga-Durand Benjamin Lopez-Velazquez Maria Isabel Castrejon-vazquez Servicio Inmunologia Clinica y Alergia Centro Medico Nacional“20 de Noviembre”ISSSTEMexico CityMexico Laboratorio de Inmunidad de Mucosas Seccion de Investigacion y PosgradoEscuela Superior de MedicinaInstituto Politecnico NacionalMexico CityMexico

Background: Hereditary angioedema (HAE) is a primary immunodeficiency disorder characterized by C1 complement inhibitor deficiency and unregulated activation of complement. Aspirin hypersensitivity is related to an increase in the amount of leukotrienes with eosinophil and mast cell activation and increased levels of glandular kallikrein with upregulated local conversion of bradykinin. Both conditions can be present in the same patient. Objectives: We present five patients with HAE;they were all being treated in similar ways according to the therapeuthic options available in our institute (danazol). However, three of them had recurrent episodes of angioedema;in these cases, it was identified aspirin hypersensitivity as a cause of poor disease control. A review of the literature is included. Case Presentation: We present the cases of four females and one male (age range 21 - 58 years) with type I HAE. Subjects were all ISSSTE beneficiaries (state workers) treated at the National Medical Center “20 de Noviembre”. Aspirin hypersensitivity was identified in three patients. Elimination of NSAIDs along with dietary elimination of high salicylate-containing foods improved control of angioedema crisis (severe and/ or recurrent episodes). Discussion: Aspirin hypersensitivity was identified as a factor for poor control in our patients with HAE. Such cases improved with dietary elimination of high salicylate-containing foods and avoidance of NSAIDs. Conclusions: This is the first report of patients with HAE and aspirin hypersensitivity as a cause of poor control. We recommend a deliberate search of these comorbidities, especially in cases of poor disease control. Further studies are needed to continue the investigation on this topic.

关键词： Hereditary Angioedema Immunodeficiency Complement Salicylates

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