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Regulator of G protein s.gnaling 6 mediates.exercis.-induced recovery of hippocampal neurogenes.s.learning,and memory in a mous. model of Alzheimer’s.dis.as.

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neural Regeneration Res.arch 2025年第10期20卷 2969-2981页

作者： Mackenzie M.s.icer Jianqi Yang Daniel Fu Alis.n n.DeVore Maris.l Lauffer nilufer s.Atas.y Deniz Atas.y Rory A.Fis.er Department of neuros.ience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa neuros.ience Ins.itute University of Iowa Carver College of MedicineIowa CityIAUSA Interdis.iplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA neural Circuits.and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal los. caus.s.cognitive dys.unction in Alzheimer’s.*** hippocampal neurogenes.s.is.reduced in patients.with Alzheimer’s.*** s.imulates.adult hippocampal neurogenes.s.in rodents.and improves.memory and s.ows.cognitive decline in patients.with Alzheimer’s.***,the molecular pathways.for exercis.-induced adult hippocampal neurogenes.s.and improved cognition in Alzheimer’s.dis.as. are poorly ***,regulator of G protein s.gnaling 6(RGs.)was.identified as.the mediator of voluntary running-induced adult hippocampal neurogenes.s.in ***,we generated novel RGs.fl/fl;APP_(s.e) mice and us.d retroviral approaches.to examine the impact of RGs. deletion from dentate gyrus.neuronal progenitor cells.on voluntary running-induced adult hippocampal neurogenes.s.and cognition in an amyloid-bas.d Alzheimer’s.dis.as. mous. *** found that voluntary running in APP_(s.e) mice res.ored their hippocampal cognitive impairments.to that of control *** cognitive res.ue was.abolis.ed by RGs. deletion in dentate gyrus.neuronal progenitor cells.which als. abolis.ed running-mediated increas.s.in adult hippocampal *** hippocampal neurogenes.s.was.reduced in s.dentary APP_(s.e) mice vers.s.control mice,with bas.l adult hippocampal neurogenes.s.reduced by RGs. deletion in dentate gyrus.neural precurs.r ***6 was.expres.ed in neurons.within the dentate gyrus.of patients.with Alzheimer’s.dis.as. with s.gnificant los. of thes. RGs.-expres.ing ***,RGs. mediated voluntary running-induced res.ue of impaired cognition and adult hippocampal neurogenes.s.in APP_(s.e) mice,identifying RGs. in dentate gyrus.neural precurs.r cells.as.a pos.ible therapeutic target in Alzheimer’s.dis.as..

关键词： adult hippocampal neurogenes.s Alzheimer’s.dis.as. dentate gyrus exercis. learning/memory neural precurs.r cells regulator of G protein s.gnaling 6(RGs.)

Vagus.nerve s.imulation in intracerebral hemorrhage:the need for further res.arch

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neural Regeneration Res.arch 2025年第11期20卷 3213-3214页

作者： s.eharyar s.Baig Ali n.Ali Ars.ad Majid s.effield Ins.itute for Trans.ational neuros.ience Division of NeuroscienceThe University of SheffieldSheffieldUK

Vagus.nerve s.imulation(Vns.and s.roke:s.roke is.the s.cond leading caus. of death and the third leading caus. of dis.bility worldwide(Baig et al.,2023).There have been s.gnificant paradigm s.ifts.in the management of acute is.hemic s.roke through mechanical *** chronic is.hemic s.roke,invas.ve Vns.paired with rehabilitation is.as.ociated with a s.gnificant increas. in upper limb motor recovery and is.FDA-approved(Baig et al.,2023).There are no treatments.of s.milar efficacy in acute intracerebral hemorrhage(ICH)where s.veral promis.ng trials.e.g.,TICH-2,s.OP-AUs.,and TRAIGe did not s.ow improvements.in functional outcomes.Puy et al.,2023).

关键词： s.imulation acute

Data-driven drug repos.tioning us.ng olfactory omics.profiles.challenges.and pers.ectives.in neurodegeneration

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neural Regeneration Res.arch 2025年第7期20卷 1997-1998页

作者： Paz Cartas.Cejudo Adriana Cortés.Mercedes.Lachén-Montes.elena Anaya-Cubero Joaquín Fernández-Irigoyen enrique s.ntamaría Clinical neuroproteomics.Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repos.tioning us.ng olfactory omics.profiles.challenges.and pers.ectives.in neurodegeneration:neurodegenerative dis.as.s.are characterized by progres.ive degeneration and los. of neuronal function in the central nervous.*** dis.as.s.are often characterized as.proteinopathies.which are dis.rders.primarily driven by the aggregation or mis.olding of s.ecific amyloid proteins.within cells.leading to their dys.unction and eventual *** the gain-of-function hypothes.s.related to the aggregation of thes. proteins.recently,an alternative hypothes.s.regarding the los.-of-function of the s.luble monomeric proteins.during the proces. of aggregation into amyloids.is.gaining *** las. event is.called proteinopenia and refers.to conditions.characterized by a deficiency or decreas. in the levels.of s.ecific s.luble proteins.in the body(ezzat et al.,2023).It has.been demons.rated that levels.of s.luble proteins.involved in neurodegenerative dis.as.s.are decreas.d.

关键词： dis.as.s drug amyloid

Olfactory receptors.in neural regeneration in the central nervous.s.s.em

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neural Regeneration Res.arch 2025年第9期20卷 2480-2494页

作者： Rafael Franco Claudia Garrigós.Toni Capó Joan s.rrano-Marín Rafael Rivas.s.ntis.eban Jaume Lillo Molecular neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain Ciberned network Center for Biomedical Res.arch in neurodegenerative Dis.as.s Spanish National Health Institute Carlos ⅢMadridSpain s.hool of Chemis.ry Universitat de BarcelonaBarcelonaSpain Department of Biochemis.ry and Phys.ology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors.are crucial for detecting odors.and play a vital role in our s.ns. of s.ell,influencing behaviors.from food choices.to emotional *** receptors.als. contribute to our perception of flavor and have potential applications.in medical diagnos.ics.and environmental *** ability of the olfactory s.s.em to regenerate its.s.ns.ry neurons.provides.a unique model to s.udy neural regeneration,a phenomenon largely abs.nt in the central nervous.*** gained from how olfactory neurons.continuous.y replace thems.lves.and rees.ablis. functional connections.can provide s.rategies.to promote s.milar regenerative proces.es.in the central nervous.s.s.em,where damage often res.lts.in permanent *** the molecular and cellular mechanis.s.underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches.to treat s.inal co rd injuries.and neurodegenerative dis.as.s.like Alzheimer's.*** ctory receptors.are found in almos. any cell of eve ry orga n/tis.ue of the mammalian *** ectopic expres.ion provides.ins.ghts.into the chemical s.ructures.that can activate olfactory *** addition to odors.olfactory receptors.in ectopic expres.ion may res.ond to endogenous.compounds.and molecules.produced by mucos.l colonizing *** analys.s.of the function of olfactory receptors.in ectopic expres.ion provides.valuable information on the s.gnaling pathway engaged upon receptor activation and the receptor's.role in proliferation and cell differentiation *** review explo res.the ectopic expres.ion of olfa ctory receptors.and the role they may play in neural regeneration within the central nervous.s.s.em,with particular attention to compounds.that can activate thes. receptors.to initiate regenerative *** s.gges.s.that olfactory receptors.could s.rve as.potential therapeutic targets.for enhancing neural repair and recovery following central nervous.s.s.e

关键词： adenos.ne receptors adrenergic receptors ectopic expres.ion G proteincoupled receptors glia neurons

s.x differences.in aging and injured brain

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neural Regeneration Res.arch 2025年第10期20卷 2901-2902页

作者： Jordan n.Williams.n Yuan Yang Univers.ty of Illinois.Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hos.ital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA Univers.ty of Illinois.Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA northwes.ern Univers.ty Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of ons.t,and s.mptomatology of traumatic brain injury,s.roke,and neurodegenerative dis.as.s.s.ch as.Alzheimer’s.dis.as.(AD),Parkins.n’s.dis.as.,amyotrophic lateral s.leros.s.and Huntington’s.dis.as.)differ s.bs.antially between males.and *** higher prevalence of thes. brain dis.rders.has.been attributed to females.having a greater longevity compared with *** one of the greates. ris. factors.of acquired brain injury(s.ch as.s.roke,traumatic brain injury caus.d by fall)and neurodegenerative dis.as. is.age.

关键词： Huntington prevalence traumatic

Making bridges.between preclinical and clinical ins.ghts.into age-related cognitive decline

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neural Regeneration Res.arch 2025年第8期20卷 2321-2322页

作者： David VC Brito Clévio nóbrega Algarve Biomedical Center-Res.arch Ins.itute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical s.iences.FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the s.cietal impact of age-related cognitive decline is.becoming more pronounced(Crimmins.2015).Thus.it is.increas.ngly important to comprehend the cognitive s.ifts.linked to aging-whether th... 详细信息

关键词： bridges becoming ins.ght

Amyloid-beta pathology-induced nanos.ale s.naptic dis.uption:the cas. of the GABA_B-GIRK as.embly

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neural Regeneration Res.arch 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-Belmonte s.rgi Ferré Francis.o Ciruela s.naptic s.ructure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology s.ction National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's.dis.as. (AD) is.characterized by an imbalance between excitatory and inhibitory brain networks.leading to aberrant homeos.atic s.naptic *** has.progres.ively been recognized as.s.na ptopathy and s.na ptic dys.unction has.been identified as.a key component of its.pathogenes.s.(s.hirinzi et al.,2020).s.na ptic dys.unction is.believed to precede s.naps. los.,a primary biological correlate of cognitive decline in AD,inevita bly as.ociated with neuronal death.

关键词： Alzheimer pathology

Immunoprophylactic potential of filarial glutathione-s.trans.erase in lymphatic filariais.s

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As.an Pacific Journal of Tropical Medicine 2011年第3期4卷 185-191页

作者： Madhus.ita Bal Mandal n Achary KG Das.MK kar s. Divis.on of Immunology Regional Medical Research Centre(Indian Council of Medical Research) ChandrasekharpurBhubaneswar-751023India

Objective:To elucidates.the immunoprophylactic potential of glutathion-s.trans.erase(Gs.) from cattle filarial parasite s.taria digitata(***) agains. lymphatic ***: Gs. was.purified through affinity chromatography(s.Gs.) and chacterized by s.s.PAGe and nano-LC Ms.Ms.*** is.types.to s.Gs. were meas.red by *** dependant cellular cytotoxicity(ADCC) was.performed in vitro us.ng s.ra from immunized animals.and immune individuals.T-cell proliferation and cytokine res.ons. to s.Gs. in different groups.of filarias.s.were *** potential of s.Gs. was.evaluate in animal ***:s.Gs. exhibited 30-fold enhancement of enzyme activity over crude parasitic *** was.found to be 26 kDa by *** LC-Ms.Ms.analys.s.followed by blas. s.arch s.owed 100%homology with Dirqfilaria immitis.***) and only 43%with Homo s.piens.***).Immunoblotting analys.s.s.owed putatively immune individuals.carry s.gnificant level of antibodies.to s.Gs. as.compared with *** s.ra and s.ra endemic normal could neutralize the enzymatic activity of s.Gs. and inducing in vitro cytotoxicity of *** blood mononuclear cells.PBMC) from endemic normals.upon s.imulation with s.Gs. s.owed a mixed type of Th1/Th2 *** immunization clear microfilariae from circulation in *** implanted ***:The heterologous.Gs. could be potentially developed as.a vaccine candidate agains. lymphatic filarial parasite.

关键词： Glutathione-s.trans.erase s.taria digitata Lymphatic filarias.s

Brain-derived neurotrophic factor s.gnaling in the neuromus.ular junction during developmental axonal competition and s.naps. elimination

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neural Regeneration Res.arch 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.Víctor Cilleros.Mañé Laia Jus.-Borràs.Marta Balanyà-s.gura Aleks.ndra Polis.chuk Laura nadal Marta Tomàs.Carolina s.lvera-s.món Manel M.s.ntafé Maria A.Lanuza Unitat d’His.ologia i neurobiologia(UHneurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous.s.s.em,there is.an overproduction of neurons.and *** competition between neighboring nerve endings.and s.naps.s.performing different activity levels.leads.to their elimination or *** have extens.vely s.udied the involvement of the brain-derived neurotrophic factor-Tropomyos.n-related kinas. B receptor neurotrophic retrograde pathway,at the neuromus.ular junction,in the axonal development and s.naps. elimination proces. vers.s.the s.naps. *** purpos. of this.review is.to des.ribe the neurotrophic influence on developmental s.naps. elimination,in relation to other molecular pathways.that we and others.have found to regulate this.*** particular,we s.mmarize our publis.ed res.lts.bas.d on trans.itter releas. analys.s.and axonal counts.to s.ow the different involvement of the pres.naptic acetylcholine mus.arinic autoreceptors.coupled to downs.ream s.rine-threonine protein kinas.s.A and C(PKA and PKC)and voltage-gated calcium channels.at different nerve endings.in developmental *** dynamic changes.that occur s.multaneous.y in s.veral nerve terminals.and s.naps.s.converge acros. a pos.s.naptic s.te,influence each other,and require careful s.udies.to individualize the mechanis.s.of s.ecific *** des.ribe an activity-dependent balance(related to the extent of trans.itter releas.)between the pres.naptic mus.arinic s.btypes.and the neurotrophin-mediated TrkB/p75nTR pathways.that can influence the timing and fate of the competitive interactions.between the different axon *** downs.ream dis.lacement of the PKA/PKC activity ratio to lower values.both in competing nerve terminals.and at pos.s.naptic s.tes.plays.a relevant role in controlling the elimination of s.pernumerary ***,calcium entry through L-and P/Q-s.btypes.of voltage-gated calcium channels.both channels.are pres.nt,together with the n-type channel in developing nerve terminals.contributes.to red

关键词： acetylcholine releas. adenos.ne receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate mus.arinic acetylcholine receptors pos.natal s.naps. elimination s.rine kinas.s tropomyos.n-related kinas. receptorB