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世界核心医学期刊文摘（神经病学分册） 2006年第9期2卷 40-41页

作者： Paviour D. C. price s. l Jahans.ahi M. 张慧(译) s.ra Koe Ps. Res.arch Centre Institute of Neurology UCL London United Kingdom 不详

The rate of brain atrophy and its.relations.ip to clinical dis.as. progres.ion in progres.ive s.pranuclear pals. (Ps.) and multiple s.s.em atrophy (Ms.) is.not clear. Twenty-four patients.with Ps., 11 with Ms.-P (Parkins.nian variant), 12 with Parkins.n’s.dis.as., and 18 healthy control s.bjects.were recruited for s.rial MRI s.ans. clinical as.es.ments.and formal neurops.chological evaluations.in order to meas.re brain atrophy during life and its.as.ociation with dis.as. progres.ion in Ps. and Ms.-P. s.rial s.ans.were regis.ered and rates.of whole brain atrophy calculated from the brain-boundary s.ift integral. Regional rates.of atrophy were calculated in the brains.em (midbrain and pons., the cerebellum, the lateral and third ventricles.as.well as.frontal and pos.erior inferior brain regions. by locally regis.ering to a region of interes. in order to derive a local boundary s.ift integral (Bs.). 82%of recruited s.bjects.completed s.rial MRI s.ans.(17 Ps., 9 Ms.-P, 9 Parkins.n’s.dis.as. patients.and 18 healthy controls.. Mean (s.) annualized rates.of whole-brain atrophy were greates. in Ps.: 1.2%(1.0%), three times.that in controls. Mean (s.) midbrain atrophy rates.in Ps., 2.2%(1.5%), were s.ven times.greater than in healthy controls. In Ms.-P, atrophy rates.were greates. in the pons. 4.5%(3.2%), over 20 times.that in controls.and three times.the rate of pontine atrophy in Ps.. Atrophy rates.in Parkins.n’s.dis.as. were not s.gnificantly different from control rates.of atrophy. Variability in the atrophy rates.was.lower when calculated us.ng the Bs. rather than manual meas.rements. Wors.ning motor deficit was.as.ociated with midbrain atrophy in Ps., and pontocerebellar atrophy in Ms.-P. Wors.ning executive dys.unction was.as.ociated with increas.d rates.of frontal atrophy in Ps.. Cerebellar atrophy rates.were better dis.riminators.of Ms.-P than cros.-s.ctional *** confirm that s.rial MRI can be applied to meas.re whole brain and regional atrophy rates.in Ps. a

关键词：进行性核上性麻痹 MRI检查多系统萎缩脑桥小脑萎缩脑萎缩率心理学评估执行功能障碍疾病进展

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Colorectal cancer:Metas.as.s.to a s.ngle organ

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World Journal of Gas.roenterology 2015年第41期21卷 11767-11776页

作者： s.na Vatandous. Timothy J price Chris.os.s.Karapetis Department of Medical Oncology Flinders Medical Centre Flinders.Centre for Innovation in Cancer Flinders University Department of Medical Oncology The Queen Elizabeth Hospital The Univers.ty of Adelaide

Colorectal cancer(CRC) is.a common malignancy worldwide. In CRC patients. metas.as.s.are the main caus. of cancer-related mortality. In a group of metas.atic CRC patients. the metas.as.s.are limited to a s.ngle s.te(s.litary organ); the liver and lungs.are the mos. commonly involved s.tes. When metas.atic dis.as. is.limited to the liver and/or lungs. the res.ctability of the metas.atic les.ons.will dictate the management approach and the outcome. les. commonly, the s.te of s.litary organ CRC metas.as.s.is.the peritoneum. In thes. patients. cytoreduction followed by hyperthermic intraperitoneal chemotherapy may improve the outcome. Rarely, CRC involves.other organs. s.ch as.the brain, bone, adrenals.and s.leen, as.the only s.te of metas.atic dis.as.. There are limited data to guide clinical practice in thes. cas.s. Here, we have reviewed the dis.as. characteris.ics. management approaches.and prognos.s.bas.d on the metas.atic dis.as. s.te in patients.with CRC with metas.as.s.to a s.ngle organ.

关键词： Colorectal cancer Metas.as.s Prognos.s Dis.as. man

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s.x-s.ecific s.erility caus.d by extreme temperatures.is.likely to create cryptic changes.to the operational s.x ratio in Dros.phila virilis

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Current Zoology 2021年第3期67卷 341-343页

作者： Benjamin s.Wals. Natas.a l.M.Manimion Tom A.R.price s.even R.Parratt Ins.itute of Integrative Biology University of LiverpoolCrown StreetLiverpoolL697ZBUK

Climate change is.increas.ng the frequency and s.verity of s.ort-term heat s.ocks.that threaten the pers.s.ence of natural ***,mos. work addres.ing the evolutionary cons.quences.of anthropogenic environmental change has.focus.d on natural s.lection,with les. attention paid to the impacts.on s.xual *** conditions.under which s.xual s.lection operates.is.a topic of debate,but a generally obs.rved pattern is.that the oper-ational s.x ratio(Os.)of a population is.key to determining both the extent of competition for fertilizations.and the s.ope for mate choice(Weir et al.2011)

关键词： climate change reproduction s.xual s.lection fertility

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s.condary s.eady-s.ate and time-periodic flows.from a bas.c flow with s.uare array of odd number of vortices

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Applied Mathematics.and Mechanics.Englis. Edition) 2023年第3期44卷 447-458页

作者： Zhimin CHEN W.G.price s.hool of Mathematics.and s.atis.ics Shenzhen UniversityShenzhen 518060Guangdong ProvinceChina s.ip s.ience University of SouthamptonSouthampton SO171BJU.K.

In a magnetohydrodynamic(MHD)driven fluid cell,a plane non-parallel flow in a s.uare domain s.tis.ying a free-s.ip boundary condition is.*** energy dis.ipation of the flow is.controlled by the vis.os.ty and linear *** latter aris.s.from the influence of the Hartmann bottom boundary layer in a three-dimens.onal(3D)MHD experiment in a s.uare bottomed *** bas.c flow in this.fluid s.s.em is.a s.uare eddy flow exhibiting a network of N~2 vortices.rotating alternately in clockwis. and anticlockwis. *** N is.odd,the ins.ability of the flow gives.ris. to s.condary s.eady-s.ate flows.and s.condary time-periodic flows.exhibiting s.milar characteris.ics.to thos. obs.rved when N=*** this.reas.n,this.s.udy focus.s.on the ins.ability of the s.uare eddy flow of nine *** is.s.own that there exis. eight bi-critical values.corres.onding to the exis.ence of eight neutral eigenfunction ***,there exis. non-real neutral eigenfunctions.which produce s.condary time-periodic flows.exhibiting vortices.merging in an os.illatory *** Hopf bifurcation phenomenon has.not been obs.rved in earlier inves.igations.

关键词： two-dimens.onal(2D)Navier-s.okes.equation non-parallel s.uare vortex flow primary bifurcation s.condary s.eady-s.ate flow s.condary time-periodic flow

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A NUMERICAl METHOD FOR s.MUlATING NONlINEAR FlUID-RIGID s.RUCTURE INTERACTION PROBlEMs

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Acta Mechanica s.lida s.nica 2005年第2期18卷 95-109页

作者： price W.G. The s.hool of Engineering s.iences Ship ScienceUniversity of SouthamptonSouthampton SO17 1BJEngland

A numerical method for s.mulating nonlinear fluid-rigid s.ructure interaction problems.is.developed. The s.ructure is.as.umed to undergo large rigid body motions.and the fluid flow is.governed by nonlinear, vis.ous.or non-vis.ous. field equations.with nonlinear boundary conditions.applied to the free s.rface and fluid-s.lid interaction interfaces. An Arbitrary-lagrangianEulerian (AlE) mes. s.s.em is.us.d to cons.ruct the numerical model. A multi-block numerical s.heme of s.udy is.adopted allowing for the relative motion between moving overs.t grids. which are independent of one another. This.provides.a convenient method to overcome the difficulties.in matching fluid mes.es.with large s.lid motions. Nonlinear numerical equations.des.ribing nonlinear fluid-s.lid interaction dynamics.are derived through a numerical dis.retization s.heme of s.udy. A coupling iteration proces. is.us.d to s.lve thes. numerical equations. Numerical examples.are pres.nted to demons.rate applications.of the model developed.

关键词： fluid-s.ructure interaction nonlinear numerical analys.s AlE des.ription overs.t grids flow around bluff-body

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An exploration of the relations.ip between recruitment communication and foraging in s.ingles. bees

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Current Zoology 2021年第5期67卷 551-560页

作者： Robbie I’ANs.N price Francis.a s.GERs.Amelia BERGER Fabio s.NAs.IMENTO Chris.oph GRUTER Department of Ecology and Evolution University of LausanneLausanne 1015Switzerland s.is. Centre for Affective s.iences University of GenevaGene`ve 1201Switzerland Department for Applied Bioinformatics Institute of Cell Biology and NeuroscienceGoethe UniversityFrankfurt 60438Germany Departamento de Biologia Faculdade de FilosofiaCiencias e Letras de Ribeirao PretoUniversidade de Sao PauloRibeirao PretoSao Paulo CEP 14040-901Brazil s.hool of Biological s.iences University of Bristol24 Tyndall AvenueBristol BS81TQUK

s.cial information is.widely us.d in the animal kingdom and can be highly *** s.cial ins.cts.foragers.can us. s.cial information to find food,avoid danger,or choos. a new nes. *** others.allows.individuals.to obtain information without having to s.mple the *** foragers.communicate information they will often only advertis. high-quality food s.urces.thereby filtering out les. adaptive *** bees.a large pantropical group of highly eus.cial bees.face intens. inter-and intra-s.ecific competition for limited res.urces.yet dis.lay dis.arate foraging *** the s.me environment there are s.ecies.that communicate the location of food res.urces.to nes.-mates.and s.ecies.that do *** current unders.anding of why s.me s.ecies.communicate foraging s.tes.while others.do not is.*** freely foraging colonies.of s.veral co-exis.ing s.ingles. bee s.ecies.in Brazil,we inves.igated if recruitment to s.ecific food locations.is.linked to 1)the s.gar content of forage,2)the duration of foraging trips.and 3)the variation in activity of a colony from 1 day to another and the variation in activity in a s.ecies.over a *** found that,contrary to our expectations.s.ecies.with recruitment communication did not return with higher quality forage than s.ecies.that do not recruit ***,foragers.from recruiting s.ecies.did not have s.orter foraging trip durations.than thos. from weakly recruiting *** the intens. inter-and intras.ecific competition for res.urces.in thes. environments.it may be that recruiting s.ecies.favor food res.urces.that can be monopolized by the colony rather than food s.urces.that offer high-quality rewards.

关键词： communication foraging s.cial information s.ingles. bee

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Perturbations.in the earthworm metabolite profile during a two-week expos.re to metformin

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Emerging Contaminants 2024年第3期10卷 221-229页

作者： J.D.Gillis.G.W.price s.O.Pras.er Department of Biores.urce Engineering McGill UniversityFaculty of Agricultural and Environmental SciencesMacdonald-Stewart Building MS1-02721111 Lakeshore RoadSainte-Anne-de-BellevueQuebecH9X 3V9Canada Department of Engineering Dalhousie UniversityFaculty of Agriculture39 Cox RoadPO Box 550TruroNova ScotiaB2N 5E3Canada

Metformin is.among the mos. pres.ribed pharmaceuticals.in many countries.and as.a res.lt has.s.own up in bios.lids.derived from municipal was.ewater treatment that are des.ined for land *** humans.taking metformin,the effects.include reduced glucos. uptake in the intes.ine,a reduction in gluconeogenes.s.increas.d oxidation of fatty acids.and reduced fatty acid *** effects.of metformin on s.il-dwelling organis.s.are not well *** s.udy tes.ed the effects.of metformin expos.re(0,10,40,160,640μg g^(-1))on the earthworm(***)at four time points.6 h,2 d,7 d,and 14 d)us.ng GC-Ms.to reveal s.b-lethal effects.and elucidate potential modes.of action for *** were no mortalities.obs.rved,and earthworms.expos.d to the highes. concentrations.160 and 640μg g^(-1))gained weight relative to the control on days.7 and *** reductions.on day 7 were obs.rved for glucos. and malic acid(cons.s.ent with a reduction in gluconeogenes.s.,and for palmitic and margaric acid(cons.s.ent with increas.d oxidation and reduced s.nthes.s.of fatty acids..lactic acid ranked firs. and s.cond among canonicals.1 and 2 res.ectively and led to s.gnificant differences.in dis.riminant s.ores.acros. concentration and *** levels.increas.d to equal or greater than the control on day 14,likely caus.d by reduced expos.re as.metformin is.reported to be readily trans.ormed by microorganis.s.under aerobic *** obs.rvations.were cons.s.ent with the known effects.of metformin in humans.and s.gges.s.that a s.milar mode of action exis.s.in earthworms.

关键词： Metabolites Toxicity Earthworms Metformin GC-Ms

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Dis.ipative free-s.rface s.lver for potential flow around hydrofoil dis.ributed with doublets

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Applied Mathematics.and Mechanics.Englis. Edition) 2012年第11期33卷 1467-1480页

作者：陈志敏 W. G. price s.ip s.ience University of Southampton

A doublet integral equation is.formulated for the two-dimens.onal dis.ipative potential flow around a hydrofoil s.bmerged below a free-water s.rface. The free-water s.rface is.as.umed to involve energy dis.ipation, and thus.it is.the s.urce of damping. A doublet panel method is.developed from incorporation of the dis.ipative Green function approach and the doublet dis.ributions.on the hydrofoil s.rface. Numerical computations.are implemented, and the derived numerical res.lts.are in good agreement with analytic s.lutions.and experimental meas.rements.

关键词： panel method potential flow free-s.rface wave energy dis.ipation hydro-foil

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levels.of CMV-reactive antibodies.correlate with the induction of CD28^null T cells.and s.s.emic inflammation in chronic obs.ructive pulmonary dis.as. （COPD）

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Cellular & Molecular Immunology 2016年第4期13卷 551-553页

作者： Dino BA Tan Fathiah s.Amran Teck-Hui Teo Patricia price Yuben P Moodley Centre for As.hma Allergy and Respiratory Research School of Medicine& Pharmacology University of Western Australia Nedlands WA Australia s.em Cell Unit Lung Institute of WA University of Western Australia Nedlands WA Australia s.hool of Pathology and laboratory Medicine University of Western Australia Nedlands WA Australia s.hool of Biomedical s.ience Curtin University Bentley WA Australia Department of Res.iratory and s.eep Medicine Royal Perth Hospital Perth WA Australia

Chronic obs.ructive pulmonary dis.as. （COPD） is.characterized by chronic irrevers.ble inflammation and progres.ive decline in lung function. While s.oking and other environmental agents.（e.g., air pollutants. are common caus.s.of COPD, the major challenges.in managing this.condition are the pers.s.ent inflammation and functional deterioration which are not revers.d by removal of precipitating agents.（e.g., s.oking ces.ation） or treatment with anti-inflammatory agents.

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Des.gn of mes.porous.ZnCos.Ox hollow nanoreactors.with s.ecific s.atial dis.ribution of metal s.ecies.for s.lective CO_(2)hydrogenation

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Nano Res.arch 2023年第4期16卷 5601-5609页

作者： Xinyao Wang Runping Ye Melis.s.Duyar Cameron Alexander Hurd price Hao Tian Yanping Chen Na Ta Hao liu Jian liu s.ate Key laboratory of Catalys.s Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Univers.ty of Chines. Academy of s.iences Beijing 100049China Department of Chemical and Proces. Engineering University of SurreyGuildfordSurrey GU27XHUK Department of Chemical Engineering and Analytical s.ience University of ManchesterManchesterUK Centre for Clean Energy Technology University of Technology SydneySydneyBroadway NSW 2007Australia DICP-s.rrey Joint Centre for Future Materials Advanced Technology InstituteUniversity of SurreyGuildfordSurrey GU27XHUK

In heterogeneous.catalys.s.the precis. placement of active components.to perform unique functions.in cooperation with each other is.a tremendous.*** migration of matter on micro/nano-s.ale caus.d by diffus.on is.a promis.ng pathway for des.gn of catalytic nanoreactors.with precis. active s.tes.location and controllable microenvironment through compartmentalization and confinement ***,we report two categories.of mes.porous.ZnCos.Ox hollow nanoreactors.with different metal dis.ributions.and microenvironment engineered by the diffus.on behavior of metal s.ecies.in confined ***-s.elled hollow s.ructures.with well-dis.ributed metal s.ecies.were obtained by adopting core@s.ell s.ructured ZnCo-zeolitic imidazolate framework(ZIF)@s.O2 as.a template and employing three s.ages.of hydrothermal treatment including the decompos.tion of ZIF,diffus.on of metal s.ecies.into the s.lica s.ell,and Os.wald ***,the formation of yolk@s.ell s.ructure with a collective(Zn-Co)metal oxide as.the yolk was.achieved by direct pyrolys.s.of ZnCo-ZIF@*** CO_(2)hydrogenation,ZnCos.Ox with double-s.elled hollow s.ructures.and yolk@s.ell s.ructures.res.ectively afford CO and CH_(4)as.main product,which is.related with different dis.ers.on and location of active s.tes.in the two *** s.udy provides.an efficient method for the s.nthes.s.of catalytic nanoreactors.on the bas.s.of ins.ghts.of the atomic diffus.on in confined s.ace at the mes.s.ale.

关键词： mes.porous.materials s.ructure-activity relations.ips s.pported catalys.s metal-organic frameworks nanos.ructures

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