Levels of CMV-reactive antibodies correlate with the induction of CD28^null T cells and systemic inflammation in chronic obstructive pulmonary disease （COPD）

作     者：Dino BA Tan Fathiah S Amran Teck-Hui Teo Patricia Price Yuben P Moodley 

作者机构：Centre for Asthma Allergy and Respiratory Research School of Medicine& Pharmacology University of Western Australia Nedlands WA Australia Stem Cell Unit Lung Institute of WA University of Western Australia Nedlands WA Australia School of Pathology and Laboratory Medicine University of Western Australia Nedlands WA Australia School of Biomedical Science Curtin University Bentley WA Australia Department of Respiratory and Sleep Medicine Royal Perth Hospital Perth WA Australia 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2016年第13卷第4期

页      面：551-553页

核心收录：

学科分类：0710[理学-生物学] 083002[工学-环境工程] 071010[理学-生物化学与分子生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 0903[农学-农业资源与环境] 0713[理学-生态学] 

基　　金：supported by an Ada Bartholomew Grant from The University of Western Australia a MRF Young Investigator Grant from Royal Perth Hospital 

摘      要：Chronic obstructive pulmonary disease （COPD） is characterized by chronic irreversible inflammation and progressive decline in lung function. While smoking and other environmental agents （e.g., air pollutants） are common causes of COPD, the major challenges in managing this condition are the persistent inflammation and functional deterioration which are not reversed by removal of precipitating agents （e.g., smoking cessation） or treatment with anti-inflammatory agents.