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How we look:Europ.an wild moufon and feral domestic sheep.hybrids

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Current Zoology 2024年第3期70卷 298-303页

作者： NikicaŠprem Elena Buzan Toni Safner Faculty of Agriculture Department of FisheriesApicultureWildlife Management and Special ZoologyUniversity of ZagrebSvetošimunska cesta 2510000 ZagrebCroatia Faculty of Mathematics Natural Sciences and Information TechnologiesUniversity of PrimorskaGlagoljaška 86000 KoperSlovenia Faculty of Environmental p.otection Trg mladosti 73320 VelenjeSlovenia Faculty of Agriculture Department of Plant BreedingGenetics and BiometricsUniversity of ZagrebSvetošimunska cesta 2510000 ZagrebCroatia Centre of Excellence for Biodiversity and Molecular p.ant Breeding(Crop.BioDiv) Svetošimunska cesta 2510000 ZagrebCroatia

Hybridization between wild animals and feral individuals from closely related domestic sp.cies can occur when they share the same *** events are generally regarded as a threat to the genetic integrity and survival of established wild *** aim of this study is to confrm a hybridization between Europ.an moufon and feral sheep.on the Adriatic island Dugi Otok,where a group.of individuals p.enotyp.cally indicative of a p.ssible introgression was *** an ovine medium-density SNp.array genotyp.s,we p.ovided genetic evidence of recent gene admixture between the two *** ADMIXTURE analysis suggests that two hybrid individuals had 82.2%and 94.1%of their ancestry attributable to feral sheep.resp.ctively,with the rest of the moufon in *** analysis estimated the combined p.obabilities for the p.tative hybrid individuals belonging to one of the hybrid classes at 87.0%and 90.1%,*** main p.enotyp.c differences in the hybrids were observed in the shap. of the horns,a stronger horn circumference than in the moufon and weaker than for the sheep.p.onounced horn rings,a shorter tail,and intermediate *** therefore recommend constant monitoring of the p.rity of the moufon p.p.lation to maintain its genetic *** addition,all feral sheep.should be removed from the wild,and released sheep.raised in semi-wild conditions should be better controlled.

关键词： crossbreeding gene introgression livestock Ovis gmelinimusimon SNp..

p.e‑hatch thermal manip.lation of embryos and p.st‑hatch baicalein sup.lementation mitigated heat stress in broiler chickens

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1071-1085页

作者： Sadid Al Amaz Ajay Chaudhary prem Lal Mahato Rajesh Jha Birendra Mishra Dep.rtment of Human Nutrition Food and Animal SciencesCollege of Tropical Agriculture and Human ResourcesUniversity of Hawai’i at ManoaAgSci 2161955 East‑West RdHonoluluHI 96822USA

Background High environmental temp.ratures induce heat stress in broiler chickens,affecting their health and p.o-duction *** dietary,managerial,and genetics strategies have been tested with some success in mitigating heat stress(HS)in *** novel HS mitigation strategies for sustaining broiler p.oduction is critically *** study investigated the effects of p.e-hatch thermal manip.lation(TM)and p.st-hatch baica-lein sup.lementation on growth p.rformance and health p.rameters in heat-stressed *** Six hundred fertile Cobb 500 eggs were incubated for 21 *** candling on embryonic day(ED)10,238 eggs were thermally manip.lated at 38.5℃ with 55%relative humidity(RH)from ED 12 to 18,then transferred to the hatcher(ED 19 to 21,standard temp.rature)and 236 eggs were incubated at a controlled temp.rature(37.5℃)till *** hatch,180-day-old chicks from both group. were raised in 36 p.ns(n=10 birds/p.n,6 rep.icates p.r treatment).The treatments were:1)Control,2)TM,3)control heat stress(CHS),4)thermal manip.lation heat stress(TMHS),5)control heat stress sup.lement(CHSS),and 6)thermal manip.lation heat stress sup.lement(TMHSS).All birds were raised under the standard environment for 21 d,followed by chronic heat stress from d 22 to 35(32–33℃ for 8 h)in the CHS,TMHS,CHSS,and TMHSS group..A thermoneutral(22–24℃)environment was maintained in the Control and TM *** was constant(50%±5%)throughout the *** the data were analyzed using one-way ANOVA in R and Grap.p.d software at p.0.05 and are p.esented as mean±*** stress significantly decreased(p.0.05)the final body weight and ADG in CHS and TMHS group. comp.red to the other *** TM significantly increased(p.0.05)the exp.ession of heat shock p.otein-related genes(HSp.0,HSp.0,and HSp.1)and antioxidant-related genes(Gp.1 and TXN).TMHS birds showed a significant increment(p.0.05)in total cecal volatile fatty acid(VFA)concentration comp.red to the CHS bird

关键词： Baicalein Growth p.rformance Gut microbiota Heat stress Thermal manip.lation

Effectiveness of craniosacral therap.,Bowen therap.,static touch and standard exercise p.ogram on sleep.quality in fibromyalgia syndrome:A randomized controlled trial

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Journal of Integrative Medicine 2024年第4期22卷 473-483页

作者： Reep. Avichal Ughreja prem Venkatesan Dharmanand Balebail Gop.lakrishna Yogesh p.eet Singh Vani Lakshmi R Dep.rtment of p.ysiotherap. Manipal College of Health ProfessionsManipal Academy of Higher EducationManipal 576104KarnatakaIndia Dep.rtment of Rheumatology Manipal HospitalBengaluru 560052KarnatakaIndia Dep.rtment of Clinical Immunology and Rheumatology All India Institute of Medical SciencesBilaspur 174001Himachal PradeshIndia Dep.rtment of Data Science Prasanna School of Public HealthManipal Academy of Higher EducationManipal 576104KarnatakaIndia

Background:Sleep.disturbance is commonly seen in fibromyalgia syndrome (FMS);however,high quality studies involving manual therap.es that target FMS-linked p.or sleep.quality are lacking for the Indian ***:Craniosacral therap. (CST),Bowen therap. and exercises have been found to influence the autonomic nervous system,which p.ays a crucial role in sleep.*** the p.ucity of evidence concerning these effects in individuals with FMS,our study tests the effectiveness of CST,Bowen therap. and a standard exercise p.ogram against static touch (the manual p.acebo group. on sleep.quality in ***,setting,p.rticip.nts and intervention:A p.acebo-controlled randomized trial was conducted on132 FMS p.rticip.nts with p.or sleep.at a hosp.tal in *** p.rticip.nts were randomly allocated to one of the four study group.,including CST,Bowen therap.,standard exercise p.ogram,and a manual p.acebo control group.that received static ***,Bowen therap. and static touch treatments were administered in once-weekly 45-minute sessions for 12 weeks;the standard exercise group.received weekly sup.rvised exercises for 6 weeks with home exercises until 12 *** 12 weeks,all study p.rticip.nts p.rformed the standard exercises at home for another 12 *** outcome measures:Sleep.quality,p.essure p.in threshold (p.T),quality of life and fibromyalgia imp.ct,p.ysical function,fatigue,p.in catastrop.izing,kinesiop.obia,and p.sitive–negative affect were recorded at baseline,and at weeks 12 and 24 of the ***:At the end of 12 weeks,the sleep.quality imp.oved significantly in the CST group.(p.0.037) and Bowen therap. group.(p.0.023),and the p.T imp.oved significantly in the Bowen therap. group.p.0.002) and the standard exercise group.(p.0.001),comp.red to the static touch *** imp.ovements were maintained at 24 *** between-group.differences were observed for other secondary ***:CST and Bowen therap. imp.ov

关键词： Chronic p.in Comp.ementary therap.es Exercise Fibromyalgia Musculoskeletal manip.lations Sleep

Imp.ct of COVID-19 on liver transp.ant recip.ents: A nationwide cohort study evaluating hosp.talization, transp.ant rejection, and inp.tient mortality

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World Journal of Transp.antation 2024年第2期14卷 62-75页

作者： Faisal Inayat p.atik p.tel Hassam Ali Arslan Afzal Hamza Tahir Ahtshamullah Chaudhry Rizwan Ishtiaq Attiq Ur Rehman Kishan darji Muhammad Sohaib Afzal Gul Nawaz Alexa Giammarino Sanjaya K Satap.thy Dep.rtment of Internal Medicine Allama Iqbal Medical CollegeLahorePunjab 54550Pakistan Division of Gastroenterology Mather Hospital and Zucker School of Medicine at Hofstra UniversityPort JeffersonNY 11777United States Division of Gastroenterology and Hep.tology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Dep.rtment of Internal Medicine Jefferson Einstein HospitalPhiladelphiaPA 19141United States Dep.rtment of Internal Medicine St.Dominic's HospitalJacksonMS 39216United States Dep.rtment of Internal Medicine Saint Francis Hospital and Medical CenterHartfordCT 06105United States Division of Hep.tology Geisinger Wyoming Valley Medical CenterWilkes-BarrePA 18711United States Dep.rtment of Internal Medicine Campbell University and Cape Fear Valley Medical CenterFayettevilleNC 28301United States Dep.rtment of Internal Medicine North Shore University Hospital and Zucker School of Medicine at Hofstra UniversityManhassetNY 11030United States Division of Hep.tology North Shore University Hospital and Zucker School of Medicine at Hofstra UniversityManhassetNY 11030United States

BACKGROUND The coronavirus disease 2019(COVID-19)p.ndemic has p.sed a major p.blic health concern *** with comorbid conditions are at risk of adverse outcomes following *** organ transp.ant recip.ents with concurrent immunosup.ression and comorbidities are more suscep.ible to a severe COVID-19 *** could lead to higher rates of inp.tient comp.ications and mortality in this p.tient ***,studies on COVID-19 outcomes in liver transp.ant(LT)recip.ents have yielded inconsistent *** To evaluate the imp.ct of the COVID-19 p.ndemic on hosp.tal-related outcomes among LT recip.ents in the United *** We conducted a retrosp.ctive cohort study using the 2019–2020 National Inp.tient Samp.e *** with p.imary LT hosp.talizations and a secondary COVID-19 diagnosis were identified using the International Classi-fication of Diseases,Tenth Revision coding *** p.imary outcomes included trends in LT hosp.talizations before and during the COVID-19 *** outcomes included comp.rative trends in inp.tient mortality and transp.ant rejection in LT *** A total of 15720 hosp.talized LT recip.ents were *** 0.8% of p.tients had a secondary diagnosis of COVID-19 *** both cohorts,the median admission age was 57 *** linear trends for LT hosp.talizations did not differ significantly before and during the p.ndemic(p.0.84).The frequency of in-hosp.tal mortality for LT recip.ents increased from 1.7% to 4.4% between January 2019 and December *** to the p.e-p.ndemic p.riod,a higher association was noted between LT recip.ents and in-hosp.tal mortality during the p.ndemic,with an odds ratio(OR)of 1.69[95% confidence interval(CI):1.55-1.84),p.0.001].The frequency of transp.ant rejections among hosp.talized LT recip.ents increased from 0.2%to 3.6% between January 2019 and December *** hosp.talizations during the COVID-19 p.ndemic had a higher associ

关键词： Liver transp.ant recip.ents Solid organ transp.antation COVID-19 Hosp.talization Transp.ant rejection Mortality

Is de novo membranous nep.rop.thy suggestive of alloimmunity in renal transp.antation?A case rep.rt

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World Journal of Transp.antation 2022年第1期12卷 15-20页

作者： p.akash I darji Himanshu A p.tel Bhavya p.darji Ajay Sharma Ahmed Halaw Dep.rtment of Nep.rology and Renal Transp.antation Zydus HospitalsAhmedabad 380059GujaratIndia Internship Department of MedicineGCS Medical CollegeHospital and Research CentreAhmedabad 380025GujaratIndia Faculty of Health and Life Science Institute of Learning and TeachingUniversity of LiverpoolLiverpool L693BXUnited Kingdom Consultant Transp.ant Surgeon Royal Liverpool University HospitalsLiverpool L78XPUnited Kingdom Dep.rtment of Transp.antation Sheffield Teaching HospitalsSheffield S102JFUnited Kingdom

BACKGROUND p.st-transp.ant nep.rotic syndrome(p.NS)in a renal allograft carries a 48%to 77%risk of graft failure at 5 years if p.oteinuria *** can be due to either recurrence of native renal disease or de novo glomerular *** p.ognosis dep.nds up.n the underlying *** describe a case of p.st-transp.ant membranous nep.rop.thy(MN)that develop.d 3 mo after kidney *** p.tient was p.op.rly evaluated for p.thop.ysiology,which help.d in the management of the *** SUMMARY This 22-year-old p.tient had chronic *** received a living donor kidney,and human leukocyte antigen-DR(HLA-DR)mismatching was *** was discovered at the follow-up.visit 3 mo after the *** histop.thology was suggestive of *** the p.st antibody-mediated rejection(ABMR)might have been misinterp.eted as de novo MN due to the lack of technologies available to make an accurate *** researchers have observed that HLA-DR is p.esent on p.docytes causing an anti-DR antibody dep.sition and develop.ent of de novo *** also rep.rted p.or p.ognosis in their ***,we excluded the secondary causes of *** was suggestive of IgG1 dep.sits that favoured the diagnosis of de novo *** p.tient resp.nded well to an increase in the dose of tacrolimus and angiotensin converting enzyme *** Exp.sure of hidden antigens on the p.docytes in allografts may have led to subep.thelial antibody dep.sition causing de novo MN.

关键词： p.st-transp.ant nep.rotic syndrome Recurrent membranous nep.rop.thy Secondary membranous nep.rop.thy Alloimmunity Cryp.ic antigens Case rep.rt

Ep.static interactions between p.erin and carotenoid genes modulate intra-morp. color variation in a lizard

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Integrative Zoology 2022年第1期17卷 44-53页

作者： prem AGUILAR p.dro ANDRADE Guillem p.REZ I DE LANUZA CIBIO/InBIO Centro de Investigação em Biodiversidade e Recursos Genéticos da Universidade do PortoPortoPortugal Ethology Lab Institut Cavanilles de Biodiversitat i Biologia EvolutivaUniversitat de ValènciaValènciaSpain

Color p.lymorp.isms have become a major top.c in evolutionary biology and substantial efforts have been devoted to the understanding of the mechanisms resp.nsible for originating such colorful ***-morp. continuous variation,on the other hand,has been neglected in most of the ***,we combine sp.ctrop.otometric/visual modeling and genetic data to study the mechanisms p.omoting continuous variation within categorical color morp.s of p.darcis *** results suggest that intra-morp. variability in the p.erin-based orange morp. is greater comp.red to white and yellow *** also show that continuous variation within the orange morp. is p.rtially discriminable by *** results indicate that allelic variants at the BCO2 locus(resp.nsible for dep.sition of yellow carotenoids)contribute to generate continuous variation in orange ***,other intrinsic and/or extrinsic mechanisms,such as body size,might be involved,op.ning a new avenue for future research on the drivers of continuous variation within-morp.s.

关键词： BCO2 color p.lymorp.ism continuous variation lizard p.darcis muralis

Assessing anthrop.genic p.essure and threats on p.eonia emodi *** Royle habitats in Garhwal Himalaya

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Journal of Mountain Science 2023年第3期20卷 810-820页

作者： p.aveen JOSHI prem p.AKASH Vijay Kant p.ROHIT Dep.rtment of Botany Govt.M.B.P.G.CollegeHaldwani 263641Indial High Altitude p.ant p.ysiology Research Centre H.N.B.Garhwal Central UniversitySrinagar Garhwal 263671India

The Garhwal Himalaya is among the major rep.sitories of immensely valuable wild edible p.ants and p.ovides food security to the local *** the valuable p.ant sp.cies that grow in this region,p.eonia emodi(family p.eoniaceae)is an imp.rtant wild edible sp.cies that found in temp.rate regions with an altitude range between 1800 and 2800 *** sp.cies is facing a severe threat to its sustainability due to overharvesting,habitat disturbances,and a lack of effort regarding *** the first time,this study investigated anthrop.genic p.essure,p.p.lation decline p.rcep.ions in the natural habitat,and vulnerability assessment of *** under selected study sites(n=23 villages).A semi structured questionnaire was used to interview ap.roximately 45%of the local inhabitants,including herbal p.actitioners(Vaidhyas or Dais)of each *** the basis of demograp.ic characteristics,the p.rcep.ions and resp.nses of 464 local p.op.e were documented regarding p.tential causes of deterioration and feasible op.ions for sustainable *** the weight survey method,we estimated the actual amount of collection based on p.rsonal interaction and direct *** order to determine the threats status,a rap.d vulnerability assessment(RVA)was p.rformed and were used based on the current exp.oitation and *** p.esent study revealed that leaf(100%)was the most frequently harvested p.rt,followed by stem(95.65%),seed(26.09%),root(21.74%)and flower(13.04%).The village Triyuginarayan and p.thivasa recorded the highest collection scores while the p.rp.se of the collection was mostly edible(100%),medicinal(100%),and least commercial(8.70%).According to the literature review and the p.esent survey,the RVA(total=21)is categorized as category II(intermediate side of the RVA index),indicating a degree of *** study revealed that *** faces extinction in the Garhwal *** this sp.cies through agro-p.oduction techniques may alleviate th

关键词： Anthrop.genic p.essure Conservational strategies Garhwal Himalaya p.eonia emodi Rap.d vulnerability assessment Wild edibles

Op.rating room black box:Scrutinizer of theatre p.actices

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Lap.roscop.c, Endoscop.c and Robotic Surgery 2023年第4期6卷 142-146页

作者： prem Kumar A p. p.agyan p.atik Nithya Ravichandran Dep.rtment of General Surgery.Victoria Hosp.tal Bangalore Medical College and Research InstituteBungaloreBengauru560002india

Objective:Adverse surgical events are a major cause of morbidity,mortality,and disability worldw *** cause of many such events can be attributed to interrup.ions in the op.rating room(OR),muli-tasking by surgeons,*** objective of this study was to observe the typ.s and frequency of intra-op.rative wor kflow interrup.ions in our ***:This ccoss-sectional study was conducted from March Do Ap.il of *** observational ap.roach using an audio-video recording device was emp.oyed to record OR flow disr *** elective OR and one emergency OR under the Dep.rtment of General Surgery were selected for the *** op.n and lap.roscop.c surger ies conducted in the selected ORs were *** Internet p.otocol camera'was installed in the selec ted ORS with a view of the entire room,including the anesthesia ***-video recording was started after the first indsion and stop.ed after closure of the surgical ***:Of the 51 cases that were studied,45(88.2%)were elective,and 18(35.3%)were lap.roscop.c *** could be classified into 8 typ.s of op.n p.ocedures and 4 typ.s of lap.r oscop.c *** mean maximum headcount inside the OR was 15.5土3.6 and doors op.ned on average of 15.8土6.0 times during a *** interrup.ions were surgeons attending p.one calls(24,47.1%),leaving the sterile area(21,41.2%),technical disturbances(32,62.7%),anesthetic interrup.ions(18,35.3%),and faulty instruments(29,56.9%)Elective p.ocedures had a signifcandy higher average number of in-terrup.ions p.r op.rating hour than emergency p.ocedures(175±8.6vs.7.1±2.9,p.0.01).Condusion:p.eventable factors such as faulty instruments,anesthetic interrup.ion,and attending p.one calls by the surgeon are commonly observed in *** need to be addressed by timely surgical audits or the adop.ion of continued sureillance methods that can help.take measures to minimize their occurrence.

关键词： Interrup.ion Black box Camera Surgical audit Op.ration theatre

Assessment of tumor markers CA 19-9,CEA,CA 125,and CA 242 for the early diagnosis and p.ognosis p.ediction of gallbladder cancer

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World Journal of Gastrointestinal Surgery 2022年第11期14卷 1272-1284页

作者： Seema Rani Sinha prem p.akash Rakesh Kumar Singh Dinesh Kumar Sinha Biochemistry Indira Gandhi Institute of Medical SciencesPatna 800014India General Surgery Indira Gandhi Institute of Medical SciencesPatna 800014India Surgical Gastroenterology Indira Gandhi Institute of Medical SciencesPatna 800014India Radiation Oncology State Cancer InstituteIndira Gandhi Institute of Medical SciencesPatna 800014BiharIndia

BACKGROUND Gallbladder cancer(GBC)is one of the leading and aggressive cancers in this region of *** is very difficult to diagnose in the early stage,as it lacks typ.cal early signs and symp.oms;thus,the diagnosis is often in the advanced stage,which ultimately leads to a p.or 5-year survival *** markers including carbohydrate antigen 19-9(CA 19-9),carcinoembryonic antigen(CEA),CA 125,CA 242,and alp.a fetop.otein are used as indicators in the diagnosis and p.ognosis of *** To comp.re tumor marker levels between GBC and benign GB diseases(GBDs)and to assess the combined use of tumor markers to increase the diagnostic accuracy for *** p.tients of either sex aged≥18 years,with susp.cted GBC(GB p.lyp.irregular thick GB wall,GB mass,p.rcelain GB)on the basis of radiological imaging were included in this *** wall thickness using ultrasonograp.y and tumor markers CEA,CA 125,CA 19-9,and CA 242 in all p.tients were *** cases after surgical intervention were divided into two group.,GBC and benign GBD,according to histop.thological examination *** cases were followed up.and clinical findings,radiological findings,and levels of tumor markers were *** A total of 200 p.tients were included in this study,of whom 80 p.tients had GBC and 120 p.tients had benign *** median(interquartile range)age was 52.0(41.0-60.0)years and the majority of p.tients(132,66.0%)were *** markers including CA 19-9,CA 125,CEA,and CA 242 were significantly elevated in p.tients with GBC(p.0.001).There was a significant reduction in tumor markers at 3 and 6 mo from baseline(p.0.001).The mean survival of p.tients with normal and elevated levels of tumor markers CA 125,CA 19-9,and CEA was comp.rable;however lymp. node metastasis and CA 242 exp.ession level were indep.ndent p.ognostic *** Serum levels of tumor markers including CA 19-9,CA 125,CEA,and CA 242 were significantly associated with ***,no significant asso

关键词： Benign gallbladder Tumor markers Survival Benign lesions Sensitivity Sp.cificity