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Densitometric HPTLC analysis of 8-gingerol in Zingiber officinale extract and ginger-containing dietary supplements,teas and commercial creams

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Asian Pacific Journal of Tropical Biomedicine 2013年第8期3卷 634-638页

作者： prawez alam Department of Pharmacognosy College of PharmacySalman Bin AbdulAziz UniversityP.O. Box 173Al-Kharj 11942Kingdom of Saudi Arabia

Objective:To develop and validate a simple,accurate HPTLC method for the analysis of 8-gingerol and to determine the quantity of 8-gingerol inZingiber officinaleextract and gingercontaining dietary supplements,teas and commercial ***:The analysis was performed on 10×20 cm aluminium-backed plates coated with 0.2 mm layers of silica gel 60 F254(E-Merck,Germany)with n-hexane:ethyl acetate 60:40(v/v)as mobile *** TLC Scanner III was used for the UV densitometric scanning at ***:This system was found to give a compact spot of 8-gingerol at retention factor(Rf) value of(0.39依0.04)and linearity was found in the ranges 50-500 ng/spot(r2=0.9987).Limit of detection(12.76 ng/spot),limit of quantification(26.32 ng/spot),accuracy(less than 2%)and recovery(ranging from 98.22-99.20)were found ***:The HPTLC method developed for quantification of 8-gingerol was found to be simple,accurate,reproducible,sensitive and is applicable to the analysis of 8-gingerol in Zingiber officinaleextract and ginger-containing dietary supplements,teas and commercial creams.

关键词： 8-gingerol HPTLC ICH guidelines Zingiber officinale

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Quantitative estimation of hesperidin by HPTLC in different varieties of citrus peels

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Asian Pacific Journal of Tropical Biomedicine 2014年第4期4卷 262-266页

作者： prawez alam Aftab alam Khalid Anwer Saleh I Alqasoumi Department of Pharmacognosy College of PharmacySalman Bin Abdulaziz University Department of Pharmaceutics College of PharmacySalman Bin Abdulaziz University Department of Pharmacognosy College of PharmacyKing Saud University

Objective:To develop a simple,selective,sensitive and accurate high-performance thin layer chromatography(HPTLC)method to determine the quantity of hesperidin in different varieties of citrus ***:The method was carried out in aluminum-backed silica gel 60 F_(254)plates with ethyl acetate-methanol-water 15:3:2(%,v/v)as mobile ***:A compact band was obtained for hesperidin at R_f value of(0.40±0.04).The calibration plot was linear in the range of 100-800 ng/spot of hesperidin and the correlation coefficient of 0.9986was indicative of good linear dependence of peak area on *** of detection(8.87ng/spot),limit of quantification(23.21 ng/spot),accuracy(less than 2%)and recovery(ranging from98.55-99.38)were found ***:The method developed can be used for routine analysis of hesperidin in crude drug as well as in herbal and pharmaceutical dosage form containing citrus fruits as an ingredient.

关键词： HPTLC Citrus Hesperidin

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Theoretical and experimental study on lipophilicity and wound healing activity of ginger compounds

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Asian Pacific Journal of Tropical Biomedicine 2014年第4期4卷 329-333页

作者： Mohammed Afroz Bakht Mohammed F.Alajmi Perwez alam Aftab alam prawez alam Tariq Mohammed Aljarba Department of Pharmaceutical Chemistry College of PharmacySalman Bin AbdulAziz University Department of Pharmacognosy College of PharmacyKing Saud University Department of Pharmacognosy College of PharmacySalman Bin AbdulAziz University

Objective:To correlate the chromatographic and computational method to calculate lipophilicity of selected ginger compounds and to observe the effects of log P on wound ***:Mixtures of acetonitrile and water with acetonitrile content between 95%and 50%v/v in 5%increments were kept separately in 10 different chromatographic chambers,saturated with solvent for 2 *** were observed under UV light atλ=254 nm p-anisaldehyde used as a spraying reagent Theoretical calculation was done using the Alogps 2.1 online program at ***/lab/*** percentage wound contraction,five groups of animal(mice)(25-30 g)of either sex were *** were created on dorsal surface of animals using toothed forceps,scalpel and pointed *** wound areas were calculated using vernier *** making wound mice were orally administered 35 mg/kg 6-shogoal,6-gingerol,8-gingerol and 10-gingerol *** E as the control group received tap ***:The Iipophilicity values determined in thin layer chromatography were correlated with the theoretically calculated various log P by linear regression *** correlations were found between log P values calculated by software program and the experimental reversedphase thin-layer chromatography *** of wound healing property of ginger compounds is directly dependent on lipophilieity *** lipophilic compound has highest ***:Experimentally determined lipophilieity(R_(MO))values were correlated with log P determined by software's and found ***(R_(MO)is a useful parameter for the determination and prediction of biological activity of ginger compounds.

关键词： lipophilicity RP-TLC RMO Calculated partition coefficient Wound healing

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