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Particuology 2024年第7期90卷 189-198页

作者： Bina Gidwani Vishal Jain Veenu Joshi Ravindra kumar Pandey Shiv Shankar Shukla Amber Vyas Columbia Institute of Pharmacy Raipur(C.G.)India University Institute of Pharmacy Pt Ravishankar Shukla UniversityRaipur(C.G.)India Center for Basic Science and Research Pt Ravishankar Shukla UniversityRaipur(C.G.)India

Simvastatin, a BCS class II drug, is associated with poor aqueous solubility, first-pass metabolism and short half-life. In the present work, nanoparticles were prepared and evaluated. Optimization of formulation and process parameters was done through the use of independent and dependent variables. Preliminary studies were done to determine suitable range of the concentration of Eudragit polymer (10%–30%) and the ratio of drug to polymer (1:1 to 1:5) for the formation of nanoparticles by emulsification and a solvent evaporation technique. Results revealed that the mean size of nanoparticles was affected by stirring speed from 5000 RPM, 8000 RPM, and 12000 RPM. The results of increase in association efficiency and percent yield with increase in amount of drug from 100 mg, 150 mg, and 200 mg in selected range were observed. In-vitro release studies showed that two formulations possess highest initial burst and slow sustained drug release. There was 2.93-fold decrease in total cholesterol and 3.27-fold increases in triglyceride level during in-vivo study.

关键词： Simvastatin Eudragit RS 100 Nanoparticles Hyperlipidemia

Fertilization and Soil Ploughing Practices under Changing Physical Environment Lead to Soil Organic Carbon Dynamics under Conservation Agriculture in Rice-Wheat Cropping System: A Scoping Review

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Agricultural Sciences 2024年第1期15卷 82-113页

作者： Salwinder Singh Dhaliwal Arvind kumar Shukla Sanjib kumar Behera Sarwan kumar Dubey Agniva Mandal Mehakpreet Kaur Randhawa Sharanjit Kaur Brar Gagandeep Kaur Amardeep Singh Toor Sohan Singh Walia Priyadarshani Arun Khambalkar Department of Soil Science Punjab Agricultural University Ludhiana India Rajmata Vijayaraje Scindia Krishi Vishwa Vidyalaya Gwalior India Indian Institute of Soil Science (ISSS) Bhopal India Indian Council of Agricultural Research—Central Soil Salinity Research Institute (ICAR-CSSRI) Karnal India Department of Agricultural Chemistry and Soil Science Bidhan Chandra Krishi Viswavidyalaya Mohanpur India Department of Crop and Soil Sciences Washington State University Pullman USA School of Organic Farming Punjab Agricultural University Ludhiana India Department of Soil Science Rajmata Vijayaraje Sciendia Krishi Viswa Vidalaya Gwalior India

Ploughing and fertilization practices in rice-wheat system have deteriorated the soil carbon (C) pools. Conservation agriculture (CA) based management approaches have proven to enhance C sequestration and reverse the loss of soil-organic-carbon (SOC), which further enhances soil fertility. Different fractions of SOC pools react to the alterations in management practices and indicate changes in SOC dynamics as compared to total C in the soil. Higher SOC levels in soil have been observed in case of reduced/no-till (nt) practices than conventional tillage (CT). However, between CT and zero tillage/nt, total SOC stocks diminished with an increase in soil depth, which demonstrated that the benefits of SOC are more pronounced in the topsoil under nt. Soil aggregation provides physical protection to C associated with different-sized particles, thus, the improvement in soil aggregation through CA is an effective way to mitigate soil C loss. Along with less soil disturbance, residual management, suitable crop rotation, rational application of manures and fertilizers, and integrated nutrient management have been found to be effective in not only improving soil C stock but also enhancing the soil health and productivity. Thus, CA can be considered as a potential method in the build-up of SOC of soil in rice-wheat system.

关键词： Tillage Conservation Agriculture Soil Organic Carbon Carbon Fractions Rice-Wheat System Organic Amendments

Transition metal-based single-atom catalysts(TM-SACs);rising materials for electrochemical CO_(2) reduction

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Journal of Energy Chemistry 2022年第7期31卷 444-471,I0012页

作者： Bishnupad Mohanty Suddhasatwa Basu Bikash kumar Jena Materials Chemistry Department CSIR-Institute of Minerals and Materials TechnologyBhubaneswar 751013India Academy of Scientific&Innovative Research(AcSIR) Ghaziabad 201002India

The continuous increase of global atmospheric CO_(2) concentrations brutally damages our environment. A series of methods have been developed to convert CO_(2) to valuable fuels and value-added chemicals to maintain the equilibrium of carbon cycles. The electrochemical CO_(2) reduction reaction(CO_(2)RR) is one of the promising methods to produce fuels and chemicals, and it could offer sustainable paths to decrease carbon intensity and support renewable energy. Thus, significant research efforts and highly efficient catalysts are essential for converting CO_(2) into other valuable chemicals and fuels. Transition metal-based single atoms catalysts(TM-SACs) have recently received much attention and offer outstanding electrochemical applications with high activity and selectivity opportunities. By taking advantage of both heterogeneous and homogeneous catalysts, TM-SACs are the new rising star for electrochemical conversion of CO_(2) to the value-added product with high selectivity. In recent years, enormous research effort has been made to synthesize different TM-SACs with different M–Nxsites and study the electrochemical conversion of CO_(2) to CO. This review has discussed the development and characterization of different TMSACs with various catalytic sites, fundamental understanding of the electrochemical process in CO_(2) RR,intrinsic catalytic activity, and molecular strategics of SACs responsible for CO_(2)RR. Furthermore, we extensively review previous studies on 1 st-row transition metals TM-SACs(Ni, Co, Fe, Cu, Zn, Sn) and dual-atom catalysts(DACs) utilized for electrochemical CO_(2) conversions and highlight the opportunities and challenges.

关键词： CO_(2)RR Single-atom catalyst SACs Dual-atom catalyst DACs Transition metals Support catalysts

Potential of roots and shoots of Napier grass for arresting soil erosion and runoff of mollisols soils of Himalayas

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International Soil and Water Conservation Research 2023年第3期11卷 538-548页

作者： Sushma Tamta Akhilesh kumar Daniel Prakash Kushwaha Krishi Vigyan Kendra Khodawandpur848202BegusaraiBiharIndia Department of Soiland Water Conservation Engineering G.B.Pant University of Agriculture and TechnologyPantnagar263145India

In this study, a soil filled Hydraulic Tilting Flume (HTF) was used as a test plot under simulated rainfallconditions. This flume was flled with mollisols soils (sandy loam in texture) collected from tarai regionof Himalayas. The effects of root and shoot characteristics of Napier grass in terms of leaf area index (LAI),shoot length (SL), number of leaves (NL), number of tillers (nt), shoot biomass (SB), root density (RD),root length (RL), root biomass (RB), and total biomass (TB) were investigated on runoff and sedimentoutflow at 90, 120 and 150 days after planting (DAP). Four simulated rainfall intensities namely 4.0, 6.5,8.3 and 9.4 cm/h over three land slopes of 1, 2 and 3% were selected. Runoff samples collected fromwhole plant plot and only root plot were analyzed for runoff and sediment outflow. Findings revealedthat Napier grasses were very effective to reduce runoff and sediment outflow and its efficacy increasedwith the extended growth stages. The reduction in runoff and sediment outflow at 90, 120 and 150 DAPwas obtained as 56% and 85%, 68% and 90%, and 74% and 96%, respectively, as compared to bare plotconditions. It was observed that the comparative contribution of shoots in runoff rate reduction washigher than the roots. On the contrary, the root part of the plant showed more contribution in sedimentrate reduction as compared to the shoot part. Step wise regression was attempted for the selection ofeffective input parameters to establish authentic runoff and sediment outflow models. Power form ofmultiple non-linear regression (MNLR) showed very satisfactory results for predicting runoff and sedimentoutflow with coefficient of determination (R^(2)) as 97.4% and 99.0%, respectively, root mean squareerror (RMSE) as 38.8 cc/m^(2)/min and 0.126 g/m^(2)/min, respectively, and coefficient of efficiency (CE) as93.9% and 96.7%, respectively, during testing period.

关键词： Rootand shoot characteristics Runoff and sedimentreduction Simulated rainfall conditions Hydraulic tilting flume Step wise regression analysis

Bioresorbable magnesium-based alloys containing strontium doped nanohydroxyapatite promotes bone healing in critical sized bone defect in rat femur shaft

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Journal of Magnesium and Alloys 2023年第1期11卷 270-286页

作者： Shazia Shaikh Irfan Qayoom R.Sarvesha Ashok kumar Department of Biological Sciences and Bioengineering Indian Institute of Technology KanpurKanpur 208016India Centre for Environmental Science and Engineering Indian Institute of Technology KanpurKanpur 208016India Department of Materials Science and Engineering Indian Institute of Technology KanpurKanpur 208016India Center for Nanosciences Indian Institute of Technology KanpurKanpur 208016India The Mehta Family Centre for Engineering in Medicine Indian Institute of Technology KanpurKanpur 208016India

Magnesium-based biomaterials have been in extensive research for orthopedic applications for decades due to their optimal mechanical features and osteopromotive nature;nevertheless,rapid degradation restricts their clinical *** this study,pristine magnesium was purified(P-Mg)using a melt self-purification approach and reinforced using indigenously synthesized nanohydroxyapatite(HAP,0.6 wt.%)and strontium substituted nanohydroxyapatite(SrHAP,0.6 wt.%)using a low-cost stir assisted squeeze casting method to control their degradation *** electron back-scattered diffraction(EBSD)and X-ray diffraction(XRD)examinations,all casted materials were carefully evaluated for microstructure and phase *** characteristics,in vitro degradation,and in vitro biocompatibility with murine pre-osteoblasts were also tested on the fabricated *** in vivo examination of bone formation,osteointegration,and degradation rate,the magnesium-based alloys were fabricated as small cylindrical pins with a diameter of 2.7 mm and a height of 2 *** pins were implanted in a critical-sized defect in a rat femur shaft(2.7 mm diameter and 2 mm depth)for 8 weeks and evaluated by microCT and histological evaluation for bone growth and *** compared to P-Mg and P-MgHAP,micro-CT and histological analyses revealed that the P-MgSrHAP group had the highest bone formation towards the periphery of the implant and hence maximum *** the removed pins from the bone defect were analyzed using GIXRD,they displayed hydroxyapatite peaks that were consistent with *** P-Mg,P-MgHAP,and P-MgSrHAP 8 weeks after implantation,in vivo degradation rates derived from micro-CT were around 0.6 mm/year,0.5 mm/year,and 0.1 mm/year,***,P-MgSrHAP possesses the requisite degradation rate as well as sufficient mechanical and biological properties,indicating that it has the potential to be used in the development/fabrication of bi

关键词： Magnesium purification Reinforcement Degradation rate Nanocement Bone regeneration

Chaperone-assisted E3 ligase CHIP:A double agent in cancer

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Genes & Diseases 2022年第6期9卷 1521-1555页

作者： Sunny kumar Malini Basu Mrinal K.Ghosh Cancer Biology and Inflammatory Disorder Division Council of Scientific and Industrial Research-Indian Institute of Chemical Biology(CSIR-IICB)TRUE CampusCN-6SectoreVSalt LakeKolkata-700091&4Raja S.C.Mullick RoadJadavpurKolkata 700032India Department of Microbiology Dhruba Chand Halder CollegeDakshin BarasatSouth 24 ParaganasWest Bengal 743372India

The carboxy-terminus of Hsp70-interacting protein(CHIP)is a ubiquitin ligase and co-chaperone belonging to Ubox family that plays a crucial role in the maintenance of cellular homeostasis by switching the equilibrium of the folding-refolding mechanism towards the proteasomal or lysosomal degradation *** links molecular chaperones ***70,HSP70 and HSP90 with ubiquitin proteasome system(UPS),acting as a quality control *** contains charged domain in between N-terminal tetratricopeptide repeat(TPR)and C-terminal Ubox *** domain interacts with the aberrant client proteins via chaperones while Ubox domain facilitates the ubiquitin transfer to the client proteins for ***,CHIP is a classic molecule that executes ubiquitination for degradation of client ***,CHIP has been found to be indulged in cellular differentiation,proliferation,metastasis and ***,CHIP can play its dual role as a tumor suppressor as well as an oncogene in numerous malignancies,thus acting as a double ***,in this review,we have reported almost all substrates of CHIP established till date and classified them according to the hallmarks of *** addition,we discussed about its architectural alignment,tissue specific expression,sub-cellular localization,folding-refolding mechanisms of client proteins,E4 ligase activity,normal physiological roles,as well as involvement in various diseases and tumor ***,we aim to discuss its importance in HSP90 inhibitors mediated cancer ***,this report concludes that CHIP may be a promising and worthy drug target towards pharmaceutical industry for drug development.

关键词： Chaperones(HSC70/HSP70&HSP90) CHIP Oncogene Therapy Tumor suppressor Ubiquitin proteasome system(UPS)

Virome identification in wheat in the Czech Republic using small RNA deep sequencing

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Journal of Integrative Agriculture 2020年第7期19卷 1825-1833页

作者： Khushwant SINGH Jana JAROSOVA Jan FOUSEK CHEN Huan Jiban kumar KUNDU Plant Virus and Vector Interactions Group Division of Crop Protection and Plant HeatthCrop Research InstitutePrague 16106Czech Republic Zhejiang Tianke High-Technology Development Co. Ltd.Hangzhou 310012P.R.China

High-throughput deep-sequencing technology and bioinformatics analysis of the small RNA(sRNA)population isolated from plants allows universal virus detection and complete virome reconstruction for a given *** the present sRNA deep-sequencing analysis of virus-infected wheat samples in the Czech Republic,samples were firstly tested for barley yellow dwarf viruses(BYDVs),wheat streak mosaic virus(WSMV)and wheat dwarf virus(WDV)using ELISA,RT-PCR and *** sRNA sequencing of these samples yielded more than^60 million single-end 50-bp reads with high confidence for nine field samples of ***,16.5%of reads were virus-specific and 83.5%were mapped to the *** 21-nt reads(-7.7E+06 reads)were found than 24-nt(~6.20E+06 reads)or 22-nt(-4.30E+06 reads)*** novo assembly of the high-quality contigs revealed the presence of three earlier repoted viruses in the Czech Republic:BYDVs(31.48%),WSMV(24.23%)and WDV(2666%).We also showed the presence of cereal yellow dwarf virus(14.33%;two species CYDV-RPS and CYDV-RPV family Luteoviridae/Polerovirus)and wheat yellow dwarf virus(WYDV,3.30%;Luteoviridae).Phylogenetic analysis showed CYDV and WYDV grouped separately from ***,several recombination breakpoints were found among the groups of yellow dwarf viruses(BYDVs,CYDV,and WYDV).Using RNA deep sequencing,we confirmed the presence of the three known viruses(BYDVs,WSMV,and WDV)and the first record of two species of CYDV and WYDV in wheat in the Czech Republic.

关键词： NGS sRNA BYDVs CYDV WSMV WYDV WDV

Transplantation of engineered exosomes derived from bone marrow mesenchymal stromal cells ameliorate diabetic peripheral neuropathy under electrical stimulation

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Bioactive Materials 2021年第8期6卷 2231-2249页

作者： Anamika Singh Alok Raghav Parvaiz Ahmad Shiekh Ashok kumar Biomaterial and Tissue Engineering Group Department of Biological Sciences and BioengineeringIndian Institute of Technology KanpurKanpur208016UPIndia Centre for Nanosciences Indian Institute of Technology KanpurKanpur208016UPIndia Centre for Environmental Sciences and Engineering Indian Institute of Technology KanpurKanpur208016UPIndia

Diabetic peripheral neuropathy(DPN)is a long-term complication associated with nerve dysfunction and uncontrolled *** spite of new drug discoveries,development of effective therapy is much needed to cure ***,we have developed a combinatorial approach to provide biochemical and electrical cues,considered to be important for nerve *** derived from bone marrow mesenchymal stromal cells(BMSCs)were fused with polypyrrole nanoparticles(PpyNps)containing liposomes to deliver both the cues in a single delivery *** developed DPN rat model and injected intramuscularly the fused exosomal system to understand its long-term therapeutic *** found that the fused system along with electrical stimulation normalized the nerve conduction velocity(57.60±0.45 m/s)and compound muscle action potential(16.96±0.73 mV)similar to healthy control(58.53±1.10 m/s;18.19±1.45 mV).Gastrocnemius muscle morphology,muscle mass,and integrity were recovered after ***,we also observed paracrine effect of delivered exosomes in controlling hyperglycemia and loss in body weight and also showed attenuation of damage to the tissues such as the pancreas,kidney,and *** work provides a promising effective treatment and also contribute cutting edge therapeutic approach for the treatment of DPN.

关键词： Exosomes Bone marrow mesenchymal stromal cells Polypyrrole Diabetes mellitus Diabetic peripheral neuropathy

COVID-19 therapeutics:Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery

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Genes & Diseases 2023年第4期10卷 1402-1428页

作者： Sunny kumar Malini Basu Pratyasha Ghosh Uttam Pal Mrinal K.Ghosh Cancer Biology and Inflammatory Disorder Division Council of Scientific and Industrial Research-Indian Institute of Chemical Biology(CSIR-IICB)TRUE CampusCN-6SectoreVSalt LakeKolkata-700091&4Raja S.C.Mullick RoadJadavpurKolkata 700032India Department of Microbiology Dhruba Chand Halder CollegeDakshin BarasatWest Bengal 743372India Department of Economics Bethune CollegeUniversity of CalcuttaKolkata 700006India

Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)causes the compli-cated disease *** are continuously facing huge problems in the treatment of patients,as COVID-19-specific drugs are not available,hence the principle of drug repurpos-ing serves as a one-and-only ***,the repurposing of many drugs is underway;few of them are already approved by the regulatory bodies for their clinical use and most of them are in different phases of clinical *** in this review,our main aim is to discuss in detail the up-to-date information on the target-based pharmacological classification of repurposed drugs,the potential mechanism of actions,and the current clinical trial status of various drugs which are under repurposing since early *** last,we briefly proposed the probable phar-macological and therapeutic drug targets that may be preferred as a futuristic drug discovery approach in the development of effective medicines.

关键词： Clinical trials COVID-19 Drug discovery Pharmacology Repurposing of drugs SARS-CoV-2

Recent developments in self-powered smart chemical sensors for wearable electronics

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Nano Research 2021年第11期14卷 3669-3689页

作者： Aaryashree Surjit Sahoo Pravin Walke Saroj kumar Nayak Chandra Sekhar Rout Dattatray J.Late Shibaura Institute of Technology Koto-CityTokyo135-8548Japan School of Basic Sciences Indian Institute of Technology BhubaneswarJatniOdisha752050India National Centre for Nanosciences and Nanotechnology University of MumbaiMumbaiMaharashtra400098India Centre for Nano and Material Sciences Jain UniversityRamanagaramBangalore562112India Centre for Nanoscience&Nanotechnology Amity University MaharashtraMumbai-Pune ExpresswayBhatanPost—SomathnePanvelMaharashtra410206India

The next generation of electronics technology is purely going to be based on wearable sensing systems. Wearable electronic sensors that can operate in a continuous and sustainable manner without the need of an external power sources, are essential for portable and mobile electronic applications. In this review article, the recent progress and advantages of wearable self-powered smart chemical sensors systems for wearable electronics are presented. An overview of various modes of energy conversion and storage technologies for self-powered devices is provided. Self-powered chemical sensors (SPCS) systems with integrated energy units are then discussed, separated as solar cell-based SPCS, triboelectric nano-generators based SPCS, piezoelectric nano-generators based SPCS, energy storage device based SPCS, and thermal energy-based SPCS. Finally, the outlook on future prospects of wearable chemical sensors in self-powered sensing systems is addressed.

关键词： chemical sensors self-powered wearable electronics smart sensors