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Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease

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Genes & Diseases 2024年第1期11卷 67-71页

作者： Souvik Kar Andrea Perrelli Kiran Kumar bali Raffaella Mastrocola Arpita Kar bushra Khan Luis Gand Arnab nayak Christian Hartmann Wolfram SKunz Amir Samii Helmut bertalanffy Saverio Francesco Retta International Neuroscience Institute Rudolf-PichlmayrStrasse 4Hannover 30625Germany Department of Clinical and biological Sciences University of TorinoOrbassano(TO)10043Italy CCM Italia Research Network National Coordination Center at the Department of Clinical and Biological SciencesUniversity of TorinoOrbassano(TO)10043Italy Department of Experimental Pain Research Mannheim Center for Translational Neuroscience(MCTN)Medical Faculty MannheimHeidelberg UniversityMannheim 68167Germany Department of Kidney Liver and Metabolic DiseasesChildren’s HospitalHannover Medical SchoolHannover 30625Germany Ricarda-Huch-Street-10b Hannover 30880Germany Institute of Molecular and Cell Physiology Hannover Medical SchoolHannover 30625Germany Department of Neuropathology Institute of PathologyHannover Medical SchoolHannover 30625Germany Institute of Experimental Epileptology and Cognition Research and Department of Epileptology University Hospital BonnVenusberg-Campus 1Bonn 53127Germany epartment of Pharmacology and Physiology University of Rochester Medical CenterRochesterNY 14642USA

cerebrovascular disease of genetic origin characterized by abnormally dilated capillaries and a wide spectrum of symptoms,including headaches,seizures,neurological deficits,and intracerebral *** unpredictable clinical course and the current lack of therapies make the identification of prognostic and predictive biomarkers an imperative research challenge.1 Herein,we provide evidence that galectin-3(Gal-3),a major tissue and circulating biomarker of oxidative stress and inflammation,is significantly up-regulated both in CCM patients and ***,wholetranscriptome sequencing,qRT-PCR,and Western blotting studies demonstrated a significant up-regulation of Gal-3 expression levels both in surgical CCM specimens and in blood samples of CCM patients.

关键词： inflammation cerebral dilated

Phloroglucinol, a nutraceutical for IR-induced cardiac damage in diabetic rats

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Animal Models and Experimental Medicine 2019年第3期2卷 210-216页

作者： b.pranav nayak K.R.Ganesha Nathani Minaz Rema Razdan Sumanta Kumar Goswami Department of Pharmacology Al‐Ameen College of PharmacyBengaluruKarnatakaIndia Department of Pharmaceutical sciences Northeastern UniversityBostonMAUSA

background:Myocardial injury due to ischemia‐reperfusion(IR)is aggravated in diabetes which is associated with oxidative *** oxidative stress via use of antioxidants has been shown to be effective at minimizing myocardial cell death and improving cardiac *** aim of the present study was to evaluate the cardioprotective effect of phloroglucinol against myocardial reperfusion injury(MRI)in diabetic ***:Diabetes was induced in female rats with streptozotocin(50 mg/kg).The diabetic rats were orally treated with phloroglucinol(100 and 200 mg/kg daily for 28 days).After treatment the hearts were isolated and mounted on a Langendorff *** hearts were subjected to 15 minutes of IR to induce myocardial *** functions including heart rate(HR),resting and developed tension,and rate of change of contraction(+dP/dtmax)were *** injury biomarkers lactate dehydrogenase(LDH)and creatine kinase(CK‐Mb)were measured in the heart *** of the antioxidant enzymes reduced glutathione(GSH)and malondialdehyde(MDA)were *** and eosin(H&E)staining was also ***:After IR injury,a decrease in HR and+dP/dtmax in hearts from diabetic rat was seen compared to healthy rat hearts,which was reversed by phloroglucinol *** infarct size,measured by H&E staining,was increased in diabetic rats compared to healthy rats and an increase in the activity of LDH and CK‐Mb in the heart perfusate in diabetic rats was decreased by phloroglucinol *** increase in MDA levels and a decrease in levels of antioxidant enzymes were observed in diabetic rats,which was reversed with phloroglucinol ***:Phloroglucinol treatment has potential therapeutic promise in the treatment of MRI in diabetes.

关键词： Langendroff apparatus myocardial reperfusion injury phloroglucinol streptozotocin

Chemical reaction effect of an axisymmetric flow over radially stretched sheet

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Propulsion and Power Research 2019年第1期8卷 79-84页

作者： b.nayak S.R.Mishra G.Gopi Krishna Department of Mathematics Sikslia‘O’AnusandhanKhandagiriBhubaneswar 751030OdisaIndia Department of Mathematics Sri Venkateswara UniversityTirupatiIndia

A steady boundary layer flow over a porous flat plate has been considered in the present *** transfer analysis with first order chemical reaction is also considered instead of heat *** plate concentration is considered in the form of power law instead of taking *** goveming PDEs are transformed into ordinary differential equations using similarity transfomation and then these ODEs are solved by employing Runge-Kutta fourth order method associated with shooting technique.A parametric study of all involving parameters is obtained by the help of *** major findings are:(i)the concentration of the fluid in its boundary layer decrease with increase in heavier species,the reaction rate parameter and the power law exponent;(ji)the rate of mass transfer increases with an increase in reaction rafe parameter and power-law exponent.

关键词： Magnetohydrodynamic Mass transfer First order chemical reaction Runge-Kutta method Shooting technique

Synthesis and Characterization of bio-based Epoxy blends from Renewable Resource based Epoxidized Soybean Oil as Reactive Diluent

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Chinese Journal of Polymer Science 2015年第1期33卷 137-152页

作者： Sushanta K Sahoo Smita Mohanty Sanjay K nayak Laboratory for Advanced Research in Polymeric Materials (LARPM) Central Institute of Plastics Engineering & Technology (CIPET)B/25 CNI complex Patia Bhubaneswar 751024 Odisha India

A novel bioresin, epoxidized soybean oil was synthesized by in situ method and was characterized employing FTIR and NMR. The bioresin was blended with epoxy（DGEbA） at different ratios as reactive diluents for improved processibility and toughened nature. The composition with 20 wt% bioresin exhibited improved impact strength to the tune of 60% as compared to virgin epoxy. Fracture toughness parameters critical stress intensity factor（KIC） and critical strain energy release rate（GIC） were evaluated using single edge notch bending test and demonstrated superior enhancement in toughness. Dynamic mechanical, thermal, thermo mechanical and fracture morphological analyses have been studied for bio-based epoxy blends. Curing kinetics has been evaluated through DSC analysis to investigate the effect of bioresin on cross-linking reaction of neat epoxy with triethylenetetramine as curing agent.

关键词： bio-based epoxy Soybean oil Fracture toughness Curing kinetics TMA.

Least-Square Support Vector Machine and Wavelet Selection for Hearing Loss Identification

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Computer Modeling in Engineering & Sciences 2020年第10期125卷 299-313页

作者： Chaosheng Tang Deepak Ranjan nayak Shuihua Wang School of Computer Science and Technology Henan Polytechnic UniversityJiaozuo454000China Department of Computer Science and Engineering Malaviya National Institute of TechnologyJaipur302017India School of Mathematics and Actuarial Science University of LeicesterLeicesterLE17RHUK Department of Information Systems Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia

Hearing loss(HL)is a kind of common illness,which can significantly reduce the quality of *** example,HL often results in mishearing,misunderstanding,and communication ***,it is necessary to provide early diagnosis and timely treatment for *** study investigated the advantages and disadvantages of three classical machine learning methods:multilayer perceptron(MLP),support vector machine(SVM),and least-square support vector machine(LS-SVM)approach andmade a further optimization of the LS-SVM model via wavelet *** investigation illustrated that themultilayer perceptron is a shallowneural network,while the least square support vector machine uses hinge loss function and least-square ***,a wavelet selection method was proposed,and we found db4 can achieve the best *** experiments showed that the LS-SVM method can identify the hearing loss disease with an overall accuracy of three classes as 84.89±1.77,which is superior to SVM *** results show that the least-square support vector machine is effective in hearing loss identification.

关键词： Hearing loss wavelet entropy multilayer perceptron least square support vector machine

HERMAN RINGS WITH SMALL PERIODS AND OMITTED VALUES

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Acta Mathematica Scientia 2018年第6期38卷 1951-1965页

作者： Tarun Kumar CHAKRA Gorachand CHAKRAbORTY Tarakanta nayak School of basic Sciences Indian Institute of Technology Bhubaneswar Department of Mathematics Goverment General Degree College

All possible arrangements of cycles of three periodic as well as four periodicHerman rings of transcendental meromorphic functions having at least one omitted value aredetermined. It is shown that if p = 3 or 4, then the number of p-cycles of Herman rings isat most one. We have also proved a result about the non-existence of a 3-cycle and a 4-cycleof Herman rings simultaneously. Finally some examples of functions having no Herman ringare discussed.

关键词： omitted values Herman rings and transcendental meromorphic functions

Effect of Zn Concentration on Microstructural,Optical,and Hyperfine Properties of Nanocrystalline a-Fe_(2)O_(3)

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Acta Metallurgica Sinica(English Letters) 2014年第4期27卷 563-568页

作者： N.R.Panda D.Sahu b.S.Acharya P.nayak S.P.Pati D.Das School of basic Science Indian Institute of Technology BhubaneswarBhubaneswar 751013OdishaIndia School of Physics Sambalpur UniversitySambalpur 768019OdishaIndia School of Chemistry Sambalpur UniversitySambalpur 768019OdishaIndia C.V.Raman College of Engineering Bhubaneswar 752054OdishaIndia Department of Electronic Engineering Tohoku UniversitySendai 980-8579Japan UGC-DAE CSR Sector IIILB-8Bidhan NagarKolkata 700098India

Efforts have been made to prepare nanocomposites of a-Fe2O3-ZnO by wet chemical route with varying concentrations of the *** microstructural properties of the samples are investigated by powder X-ray diffractometry（PXRD） and Transmission electron *** concentration of Zn ions（up to 20 at%） leads to the formation of nanocomposites of a-Fe2O3 and *** of ZnFe2O4 phase is detected by the substitution of higher concentration of Zn2？（30 at%） in the *** average size of the nanoparticles remains in the range of 22–27 nm as obtained from XRD *** results obtained from electron microscopic studies are also close to these *** measurement shows the excitonic peak of ZnO around 390 nm which gets strengthened with Zn *** spectra show the metal–oxygen band below 700 *** temperature Mssbauer studies of the samples show the transition of iron oxide form antiferromagnetic state to paramagnetic state with increasing concentration of Zn2？.Sharp quenching of hyperfine field with Zn concentration is observed as the Hintvalue reduced to zero from 51 T.

关键词： Iron oxide ZnO Electron microscopy Mssbauer study

Assessment of ecosystem services of rice farms in eastern India

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Ecological Processes 2019年第1期8卷 435-450页

作者： A.K.nayak Md Shahid A.D.nayak b.Dhal K.C.Moharana b.Mondal R.Tripathi S.D.Mohapatra P.bhattacharyya N.N.Jambhulkar A.K.Shukla Nuala Fitton Pete Smith H.Pathak ICAR-National Rice Research Institute CuttackOdisha 753006India Indian Institute of Soil Sciences NabibaghBhopalMadhya PradeshIndia Institute of biological&Environmental Sciences University of Aberdeen23 St Machar DriveAberdeen AB243UUUK.

background:Rice is a major cereal crop and staple food of eastern India,and most farmers depend solely on rice for their *** farming provides both tangible and non-tangible benefits to ecosystems which need to be maintained and *** benefits are provided through ecosystem services(ES)that include both marketable and ***:In this study,the rice farms in eastern India were valued by quantifying the economic value of the services under conventional method of rice cultivation and the gap of ecosystem services value and farm income per unit area were assessed.A stratified random sampling technique was used in this study for selection of agro-climatic zones,districts,blocks,gram panchayat,and study units(households).Soil sampling was also performed for assessing the regulating services(biocontrol of pests,carbon flow,soil erosion,nitrogen fixation),provisioning services(food and by-products),and supporting services(soil fertility,hydrological flow,nutrient cycling,and soil formation).Results:The results indicated that the total economic value of ecosystem services ranged from US$1238 to 1688 ha−1 year−*** marketed(primary production)and non-marketed ecosystem services values ranged from 66–89 to 11–34%of the total,*** of some of the ecosystem services such as cultural services,biodiversity,and gas regulation,which may play a significant role in total ecosystem services,has not been made due to non-availability of data and appropriate methodology for rice *** values of parameters can explain the variability in ecosystem services among the agro-climatic zones in eastern *** of locations based on variability of ecosystem services helps in identifying intervention points for sustaining and improving ecosystem services,while permitting sustainable agro-ecological *** highest total economic gap between ES value and farm income was found in the north central plateau zone(US$

关键词： Ecosystem services Rice farming Economic gap Payment for ecosystem services(PES)

Measurement of(n,α)and(n,2n)reaction cross sections at a neutron energy of 14.92±0.02 MeV for potassium and copper with uncertainty propagation

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Chinese Physics C 2022年第1期46卷 110-117页

作者： A.Gandhi Aman Sharma Rebecca Pachuau1 Namrata Singh L.S.Danu S.V.Suryanarayana b.K.nayak A.Kumar Department of Physics Banaras Hindu UniversityVaranasi 221005India Nuclear Physics Division Bhabha Atomic Research CentreMumbai 400085India

Experimentally measured neutron activation cross sections are presented for the ^(65)Cu(n,0)^(62m)Cu,^(41) K(n,a)^(38C)l,and ^(65)Cu(n.2n)^(64)Cu reactions with detailed uncertainty *** neutron cross secions were measured at an incident energy of 14.92±0.02 MeV,and the neutrons were based on the(d,n)a fusion *** ^(27) Al(n,a)^(24)Na reaction was used as a reference reaction for the normalization of the neutron *** pre-calib-rated lead-shielded HPGe detector was used to detect the residues'γ-ray *** data from the measured cross sections are compared to the previously measured cross sections from the EXFOR database,theoretically calculated cross sections using the TALYS and EMPIRE codes,and evaluated nuclear data.

关键词： nuclear reactions (n,a)and(n,2n)reactions t(c/,n)a neutron source uncertainty propagation covariance analysis TALYS-1.9 and EMPIRE-3.2 code