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Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease

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Genes & Diseases 2024年第1期11卷 67-71页

作者： Souvik Kar Andrea Perrelli Kiran Kumar bali Raffaella Mastrocola Arpita Kar bushra Khan Luis Gand Arnab nayak Christian Hartmann Wolfram SKunz Amir Samii Helmut bertalanffy Saverio Francesco Retta International Neuroscience Institute Rudolf-PichlmayrStrasse 4Hannover 30625Germany Department of Clinical and biological Sciences University of TorinoOrbassano(TO)10043Italy CCM Italia Research Network National Coordination Center at the Department of Clinical and Biological SciencesUniversity of TorinoOrbassano(TO)10043Italy Department of Experimental Pain Research Mannheim Center for Translational Neuroscience(MCTN)Medical Faculty MannheimHeidelberg UniversityMannheim 68167Germany Department of Kidney Liver and Metabolic DiseasesChildren’s HospitalHannover Medical SchoolHannover 30625Germany Ricarda-Huch-Street-10b Hannover 30880Germany Institute of Molecular and Cell Physiology Hannover Medical SchoolHannover 30625Germany Department of Neuropathology Institute of PathologyHannover Medical SchoolHannover 30625Germany Institute of Experimental Epileptology and Cognition Research and Department of Epileptology University Hospital BonnVenusberg-Campus 1Bonn 53127Germany epartment of Pharmacology and Physiology University of Rochester Medical CenterRochesterNY 14642USA

cerebrovascular disease of genetic origin characterized by abnormally dilated capillaries and a wide spectrum of symptoms,including headaches,seizures,neurological deficits,and intracerebral *** unpredictable clinical course and the current lack of therapies make the identification of prognostic and predictive biomarkers an imperative research challenge.1 Herein,we provide evidence that galectin-3(Gal-3),a major tissue and circulating biomarker of oxidative stress and inflammation,is significantly up-regulated both in CCM patients and ***,wholetranscriptome sequencing,qRT-PCR,and Western blotting studies demonstrated a significant up-regulation of Gal-3 expression levels both in surgical CCM specimens and in blood samples of CCM patients.

关键词： inflammation cerebral dilated

Phloroglucinol, a nutraceutical for IR-induced cardiac damage in diabetic rats

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Animal Models and Experimental Medicine 2019年第3期2卷 210-216页

作者： b.pranav nayak K.R.Ganesha Nathani Minaz Rema Razdan Sumanta Kumar Goswami Department of Pharmacology Al‐Ameen College of PharmacyBengaluruKarnatakaIndia Department of Pharmaceutical sciences Northeastern UniversityBostonMAUSA

background:Myocardial injury due to ischemia‐reperfusion(IR)is aggravated in diabetes which is associated with oxidative *** oxidative stress via use of antioxidants has been shown to be effective at minimizing myocardial cell death and improving cardiac *** aim of the present study was to evaluate the cardioprotective effect of phloroglucinol against myocardial reperfusion injury(MRI)in diabetic ***:Diabetes was induced in female rats with streptozotocin(50 mg/kg).The diabetic rats were orally treated with phloroglucinol(100 and 200 mg/kg daily for 28 days).After treatment the hearts were isolated and mounted on a Langendorff *** hearts were subjected to 15 minutes of IR to induce myocardial *** functions including heart rate(HR),resting and developed tension,and rate of change of contraction(+dP/dtmax)were *** injury biomarkers lactate dehydrogenase(LDH)and creatine kinase(CK‐Mb)were measured in the heart *** of the antioxidant enzymes reduced glutathione(GSH)and malondialdehyde(MDA)were *** and eosin(H&E)staining was also ***:After IR injury,a decrease in HR and+dP/dtmax in hearts from diabetic rat was seen compared to healthy rat hearts,which was reversed by phloroglucinol *** infarct size,measured by H&E staining,was increased in diabetic rats compared to healthy rats and an increase in the activity of LDH and CK‐Mb in the heart perfusate in diabetic rats was decreased by phloroglucinol *** increase in MDA levels and a decrease in levels of antioxidant enzymes were observed in diabetic rats,which was reversed with phloroglucinol ***:Phloroglucinol treatment has potential therapeutic promise in the treatment of MRI in diabetes.

关键词： Langendroff apparatus myocardial reperfusion injury phloroglucinol streptozotocin

Systematic study of the(n,2n)reaction cross section for^(121)Sb and^(123)Sb isotopes

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Chinese Physics C 2022年第5期46卷 77-94页

作者： R.K.Singh N.L.Singh R.D.Chauhan Mayur Mehta S.V.Suryanarayana Rajnikant Makwana b.K.nayak H.Naik Tarak Nath Nag K.Katovsky Department of Physics Faculty of Sciencethe M.S.University of BarodaVadodara-390002INDIA Department of Physics Netaji Subhas University of TechnologyDwarkaNew Delhi-110078INDIA Institute for Plasma Research Gandhinagar-382428INDIA Nuclear Physics Division Bhabha Atomic Research CentreMumbaiINDIA Radiochemistry Division Bhabha Atomic Research CentreMumbaiINDIA Department of Electrical Power Engineering Brno University of TechnologyBrno-61600Czech Republic

The cross sections of the^(121)Sb(n,2n)^(120)Sb^(m) and ^(123)Sb(n,2n)^(122)Sb reactions were measured at 12.50,15.79 and 18.87 MeV neutron energies relative to the standard ^(27)Al(n,α)^(24)Na monitor reaction using neutron activation and offline γ-ray *** of the samples was performed at the bARC-TIFR Pelletron Linac Facility,Mumbai,*** quasi-monoenergetic neutrons were generated via the ^(7)Li(p,n)*** model calculations were performed by nuclear reaction codes TALYS(ver.1.9)and EMPIRE(ver.3.2.2)using various input parameters and nuclear level density *** cross sections of the ground and the isomeric state as well as the isomeric cross section ratio were studied theoretically from reaction threshold to 26 MeV *** effect of pre-equilibrium emission is also discussed in detail using different theoretical *** present measured cross sections were discussed and compared with the reported experimental data and evaluation data of the JEFF-3.3,ENDF/b-VIII.0,JENDL/AD-2017 and TENDL-2019 libraries.A detailed analysis of the uncertainties in the measured cross section data was performed using the covariance analysis ***,a systematic study of the(n,2n)reaction cross section for^(121)Sb and^(123)Sb isotopes was also performed within 14-15 MeV neutron energies using various systematic *** work helps to overcome discrepancies in Sb data and illustrate a better understanding of pre-equilibrium emission in the(n,2n)reaction channel.

关键词： antimony (n,2n)reaction cross section 7Li(p,n)reaction neutron source neutron activation and offlineγ-ray spectrometry systematic formulae covariance analysis TALYS(ver.1.9)and EMPIRE(ver.3.2.2)codes

Chemical reaction effect of an axisymmetric flow over radially stretched sheet

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Propulsion and Power Research 2019年第1期8卷 79-84页

作者： b.nayak S.R.Mishra G.Gopi Krishna Department of Mathematics Sikslia‘O’AnusandhanKhandagiriBhubaneswar 751030OdisaIndia Department of Mathematics Sri Venkateswara UniversityTirupatiIndia

A steady boundary layer flow over a porous flat plate has been considered in the present *** transfer analysis with first order chemical reaction is also considered instead of heat *** plate concentration is considered in the form of power law instead of taking *** goveming PDEs are transformed into ordinary differential equations using similarity transfomation and then these ODEs are solved by employing Runge-Kutta fourth order method associated with shooting technique.A parametric study of all involving parameters is obtained by the help of *** major findings are:(i)the concentration of the fluid in its boundary layer decrease with increase in heavier species,the reaction rate parameter and the power law exponent;(ji)the rate of mass transfer increases with an increase in reaction rafe parameter and power-law exponent.

关键词： Magnetohydrodynamic Mass transfer First order chemical reaction Runge-Kutta method Shooting technique

Synthesis and Characterization of bio-based Epoxy blends from Renewable Resource based Epoxidized Soybean Oil as Reactive Diluent

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Chinese Journal of Polymer Science 2015年第1期33卷 137-152页

作者： Sushanta K Sahoo Smita Mohanty Sanjay K nayak Laboratory for Advanced Research in Polymeric Materials (LARPM) Central Institute of Plastics Engineering & Technology (CIPET)B/25 CNI complex Patia Bhubaneswar 751024 Odisha India

A novel bioresin, epoxidized soybean oil was synthesized by in situ method and was characterized employing FTIR and NMR. The bioresin was blended with epoxy（DGEbA） at different ratios as reactive diluents for improved processibility and toughened nature. The composition with 20 wt% bioresin exhibited improved impact strength to the tune of 60% as compared to virgin epoxy. Fracture toughness parameters critical stress intensity factor（KIC） and critical strain energy release rate（GIC） were evaluated using single edge notch bending test and demonstrated superior enhancement in toughness. Dynamic mechanical, thermal, thermo mechanical and fracture morphological analyses have been studied for bio-based epoxy blends. Curing kinetics has been evaluated through DSC analysis to investigate the effect of bioresin on cross-linking reaction of neat epoxy with triethylenetetramine as curing agent.

关键词： bio-based epoxy Soybean oil Fracture toughness Curing kinetics TMA.

Least-Square Support Vector Machine and Wavelet Selection for Hearing Loss Identification

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Computer Modeling in Engineering & Sciences 2020年第10期125卷 299-313页

作者： Chaosheng Tang Deepak Ranjan nayak Shuihua Wang School of Computer Science and Technology Henan Polytechnic UniversityJiaozuo454000China Department of Computer Science and Engineering Malaviya National Institute of TechnologyJaipur302017India School of Mathematics and Actuarial Science University of LeicesterLeicesterLE17RHUK Department of Information Systems Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia

Hearing loss(HL)is a kind of common illness,which can significantly reduce the quality of *** example,HL often results in mishearing,misunderstanding,and communication ***,it is necessary to provide early diagnosis and timely treatment for *** study investigated the advantages and disadvantages of three classical machine learning methods:multilayer perceptron(MLP),support vector machine(SVM),and least-square support vector machine(LS-SVM)approach andmade a further optimization of the LS-SVM model via wavelet *** investigation illustrated that themultilayer perceptron is a shallowneural network,while the least square support vector machine uses hinge loss function and least-square ***,a wavelet selection method was proposed,and we found db4 can achieve the best *** experiments showed that the LS-SVM method can identify the hearing loss disease with an overall accuracy of three classes as 84.89±1.77,which is superior to SVM *** results show that the least-square support vector machine is effective in hearing loss identification.

关键词： Hearing loss wavelet entropy multilayer perceptron least square support vector machine

HERMAN RINGS WITH SMALL PERIODS AND OMITTED VALUES

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Acta Mathematica Scientia 2018年第6期38卷 1951-1965页

作者： Tarun Kumar CHAKRA Gorachand CHAKRAbORTY Tarakanta nayak School of basic Sciences Indian Institute of Technology Bhubaneswar Department of Mathematics Goverment General Degree College

All possible arrangements of cycles of three periodic as well as four periodicHerman rings of transcendental meromorphic functions having at least one omitted value aredetermined. It is shown that if p = 3 or 4, then the number of p-cycles of Herman rings isat most one. We have also proved a result about the non-existence of a 3-cycle and a 4-cycleof Herman rings simultaneously. Finally some examples of functions having no Herman ringare discussed.

关键词： omitted values Herman rings and transcendental meromorphic functions

In-silico and in-vitro evaluation of docetaxel and berberine as potential p53 modulating apoptotic inducers in oral squamous cell carcinoma

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Asian Pacific Journal of Tropical biomedicine 2022年第12期12卷 530-540页

作者： Smrutipragnya Samal Rajesh Kumar Meher Debasmita Dubey Showkat Ahmad Mir binata nayak Mahesh Chandra Sahu Pradeep Kumar Naik Goutam Rath Santosh Kumar Swain Department of Otorhinolaryngology and Head and Neck Surgery IMS and SUM HospitalSiksha‘O’Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar-751003OdishaIndia Centre of Excellence in Natural Products and Therapeutics Department of Biotechnology and BioinformaticsSambalpur UniversityJyotiviharBurlaSambalpurOdishaIndia Medical Research Laboratory IMS and SUM HospitalSiksha‘O’Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar-751003OdishaIndia School of Life Sciences Sambalpur UnivesityJyotiviharBurlaSambalpurOdishaIndia ICMR-Regional Medical Research Centre ChandrasekharpurBhubaneswar-751023India School of Pharmaceutical Sciences Siksha‘O’Anusandhan Deemed to be UniversityBhubaneswar-751030India

Objective:To investigate the interaction of p53 with docetaxel and berberine and their anticancer activities against oral squamous cell ***:The interaction between p53 with docetaxel and berberine was investigated and their mechanisms of action against oral squamous cell carcinoma were *** studies were performed to determine any toxic impact of the drugs on the vital organs of tested ***:In silico results revealed the molecular interaction of docetaxel and berberine with p53 and the molecules were found to be potential p53 *** and berberine inhibited the proliferation of cancer cells in a concentration-dependent *** cytometry analysis revealed that docetaxel and berberine at IC50 concentrations upregulated the expression of p53 in oral squamous cell carcinoma cells,thus triggering apoptotic cell *** addition,no toxicity was observed in the liver and kidney tissues of mice after docetaxel and berberine ***:Docetaxel and berberine significantly suppressed the proliferation of oral cancer cells by activating p53 expression and causing apoptotic cell *** compounds can be potential agents for the treatment of oral cancer,with little to no toxicity at the tissue level.

关键词： Docetaxel berberine PC-3 OVCAR-3 OSCC SCC-29b p53 Anticancer Apoptosis

Measurement of neutron capture cross section on^(71)Ga at 2.15 and 3.19 MeV and uncertainty propagation and covariance analysis

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Chinese Physics C 2023年第7期47卷 72-80页

作者： Rebecca Pachuau A.Gandhi Namrata Singh A.Kumar Mayur Mehta S.V.Suryanarayana L.S.Danu b.K.nayak b.Lalremruata Department of Physics Banaras Hindu UniversityVaranasi-221005India Institute for Plasma Research Gandhinagar-382428India Nuclear Physics Division Bhabha Atomic Research CentreMumbai-400085India Homi bhabha National Institute AnushaktinagarMumbai-400094India Department of Physics Mizoram UniversityTanhrilAizawl-796004India Horia Hulubei National Institute of Physics and Nuclear Engineering-IFIN-HH Bucharest077125Romania MCNS Manipal Academy of Higher EducationManipal 576104India

The cross section values of the^(71)Ga(n,γ)^(72)Ga reaction are measured,which are 9.14±0.81 mb and 5.74±0.50 mb at 2.15 and 3.19 MeV,*** detailed uncertainty propagation and covariance analysis are also ***^(7)Li(p,n)^(7)be reaction was used to generate the neutrons,and the neutron flux was normalized using the^(115)In(n,n′)^(115)In^(m)monitor *** measured cross section data are compared with the data available in the EXFOR database,the data obtained using nuclear reaction model codes EMPIRE-3.2 and TALYS-1.95,and also the evaluated nuclear data from ENDF/b-VIII.0 and JEFF-3.1/*** comparison shows that our result at 3.19 MeV is in good agreement with those of EMPIRE-3.2 and JEFF-3.1/*** there are no other measurements available at3.19 MeV,our data could not be compared with literature data at 3.19 MeV,but they are consistent with the cross section values available at 2.98±0.26 and 3.0±0.1 *** result at 2.15 MeV is slightly higher than the literature value available in EXFOR,evaluated value,and theoretically predicted result.

关键词： neutron capture cross section gallium uncertainty propagation and covariance analysis