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Cloning ＆ sequence identification of Hsp27 gene and expression analysis of the protein on thermal stress in Lucilia cuprina

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Insect Science 2016年第4期23卷 555-568页

作者： Manish k. Singh pramod k. tiwari Center for Genomics Molecular & Human Genetics Jiwaji University Gwafior 474011 Cytogenetics Laboratory Department of Zoology Banaras Hindu University Varanasi 221005 India

Hsp27, a highly conserved small molecular weight heat shock.protein, is widely k.own to be developmentally regulated and heat inducible. Its role in thermotolerance is also implicated. This study is a sequel of our earlier studies to understand the molecular organization of heat shock.genes/proteins and their role in development and thermal adaptation in a sheep pest, Lucilia cuprina （blowfly）, which exhibits unusually high adaptability to a variety of environmental stresses, including heat and chemicals. In this report our aim was to understand the evolutionary relationship of Lucilia hsp27 gene/protein with those of other species and its role in thermal adaptation. We sequence characterized the Lchsp27 gene （coding region） and analyzed its expression in various larval and adult tissues under normal as well as heat shock.conditions. The nucleotide sequence analysis of 678 bps long-coding region of Lchsp27 exhibited closest evolutionary proximity with Drosophila （90.09%）, which belongs to the same order, Diptera. Heat shock.caused significant en- hancement in the expression ofLchsp27 gene in all the larval and adult tissues examined, however, in a tissue specific manner. Significantly, in Malpighian tubules, while the heatinduced level ofhsp27 transcript （mRNA） appeared increased as compared to control, the protein level remained unaltered and nuclear localized. We infer that Lchsp27 may have significant role in the maintenance of cellular homeostasis, particularly, during summer months, when the fly remains exposed to high heat in its natural habitat.

关键词： heat shock.protein Hsp27 Lucilia cuprina thermal stress

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A threshold voltage model of short-channel fully-depleted recessed-source/drain(Re-S/D) SOI MOSFETs with high-k.dielectric

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Chinese Physics B 2015年第10期24卷 604-611页

作者： Gopi k.ishna Saramek.la Sarvesh Dubey pramod k.mar tiwari Department of Electronics and Communication Engineering National Institute of Technology Shri Ramswaroop Memorial University

In this paper, a surface potential based threshold voltage model of fully-depleted（FD） recessed-source/drain（Re-S/D）silicon-on-insulator（SOI） metal-oxide semiconductor field-effect transistor（MOSFET） is presented while considering the effects of high-k.gate-dielectric material induced fringing-field. The two-dimensional（2D） Poisson＇s equation is solved in a channel region in order to obtain the surface potential under the assumption of the parabolic potential profile in the transverse direction of the channel with appropriate boundary conditions. The accuracy of the model is verified by comparing the model＇s results with the 2D simulation results from ATLAS over a wide range of channel lengths and other parameters,including the dielectric constant of gate-dielectric material.

关键词： recessed-source/drain (Re-S/D) high-k.gate-material fringing field and SCEs

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On-current modeling of short-channel double-gate(DG) MOSFETs with a vertical Gaussian-lik. doping profile

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Journal of Semiconductors 2013年第5期34卷 46-53页

作者： Sarvesh Dubey pramod k.mar tiwari S.Jit Department of Electronics Engineering Indian Institute of Technology(BHU)Varanasi-221005India Department of Electronics and Communication Engineering National Institute of Technology Rourkela-769008India

An analytic drain current model is presented for doped short-channel double-gate MOSFETs with a Gaussian-lik. doping profile in the vertical direction of the channel. The present model is valid in linear and satura- tion regions of device operation. The drain current variation with various device parameters has been demonstrated. The model is made more physical by incorporating the channel length modulation effect. Parameters lik. transcon- ductance and drain conductance that are important in assessing the analog performance of the device have also been formulated. The model results are validated by numerical simulation results obtained by using the commercially available ATLAS^TM, a two dimensional device simulator from SILVACO.

关键词： drain current DG MOSFET transconductance drain conductance

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Reference gene panel for urinary exosome-based molecular diagnostics in patients with k.dney disease

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World Journal of Nephrology 2024年第3期13卷 62-72页

作者： Deendayal D Mishra pramod k.Maurya Swasti tiwari Department of Molecular Medicine and Biotechnology Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014Uttar PradeshIndia

BACk.ROUND k.dney disease is a severe complication of diabetes that often leads to end-stage renal *** diagnosis is crucial for prevention or ***,the current diagnostic methods,with their limitations in detecting the disease in its early stages,underscore the urgency and importance of finding new *** encapsulated inside urinary exosomes(UEs)have potential as early biomark.rs for k.dney *** need for reference miRNAs for accurate interpretation currently limits their translational *** To identify consistently expressing reference miRNAs from UEs of controls and patients with type 2 diabetesmellitus(T2DM)and biopsy-confirmed k.dney *** miRNA profiling was performed on UEs from 31 human urine samples using a rigorous and unbiased *** UEs were isolated from urine samples collected from healthy individuals(n=6),patients with T2DM(n=13),and T2DM patients who also had k.dney diseases(including diabetic nephropathy,n=5;membranous nephropathy,n=5;and IgA nephropathy,n=2)through differential *** characterizing the UEs,miRNA expression profiling using microarray technology was *** Microarray data analysis identified 14 miRNAs that were consistently expressed in UEs from 31 human samples,representing various k.dney conditions:diabetic controls,diabetic nephropathy,membrane nephropathy,IgA nephropathy,and healthy *** in silico analysis,we determined that 10 of these miRNAs had significant potential to serve as reference genes in *** We identified uniformly expressing UE miRNAs that could serve as reference genes k.dney disease biomark.rs.

关键词： miRNA Microarray Urinary exosomes Diabetic nephropathy Type 2 diabetes mellitus k.dney disease

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Analytical model for subthreshold current and subthreshold swing of short-channel double-material-gate MOSFETs with strained-silicon channel on silicon–germanium substrates

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Journal of Semiconductors 2014年第10期35卷 30-36页

作者： pramod k.mar tiwari Gopi k.ishna Saramek.la Sarvesh Dubey Anand k.mar Muk.opadhyay National Institute of Technology Rourkela Department of Electronics and Communication Engineering Faculty of Electronics and Communication SRM University

The present work.gives some insight into the subthreshold behaviour of short-channel double-material- gate strained-silicon on silicon-germanium MOSFETs in terms of subthreshold swing and off-current. The formu- lation of subthreshold current and, thereupon, the subthreshold swing have been done by exploiting the expression of potential distribution in the channel region of the device. The dependence of the subthreshold characteristics on the device parameters, such as Ge mole fraction, gate length ratio, work.function of control gate metal and gate length, has been tested in detail. The analytical models have been validated by the numerical simulation results that were obtained from the device simulation software ATLASTM by Silvaco Inc.

关键词： strained-Si channel Si1-xGex substrate dual-metal gate subthreshold current subthreshold swing

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Cancer chemoprevention through dietary avonoids: what's limiting?

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Chinese Journal of Cancer 2017年第10期36卷 455-467页

作者： Haneen Amawi Charles R. Ashby Jr Amit k. tiwari Department of Pharmacology and Systems Therapeutics College of Pharmacy and Pharmaceutical Sciences University of Toledo Toledo OH 43560USA Pharmaceutical Sciences College of Pharmacy St. John’s UniversityQueens NY 11432 USA Department of Pharmacology and Experimental Therapeutics College of Pharmacy and Pharmaceutical Sciences University of Toledo Toledo OH 43614 USA

Flavonoids are polyphenols that are found in numerous edible plant species. Data obtained from preclinical and clinical studies suggest that specific flavonoids are chemo-preventive and cytotoxic against various cancers via a multitude of mechanisms. However, the clinical use of flavonoids is limited due to challenges associated with their e ective use, including(1) the isolation and purification of flavonoids from their natural resources;(2) demonstration of the e ects of flavonoids in reducing the risk.of certain cancer, in tandem with the cost and time needed for epidemiological studies, and(3) numerous pharmacok.netic challenges(e.g., bioavailability, drug–drug interactions, and metabolic instability). Currently, numerous approaches are being used to surmount some of these challenges, thereby increasing the lik.lihood of flavonoids being used as chemo-preventive drugs in the clinic. In this review, we summarize the most important challenges and e orts that are being made to surmount these challenges.

关键词： Flavonoids Chemoprevention Silybin Silymarin Natural product drug development Pharmacok.netic challenges

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Bianchi Type-Ⅲ Cosmological Models with Gravitational Constant G and the Cosmological Constant A

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Chinese Physics Letters 2007年第12期24卷 3325-3327页

作者： J. P. Singh R. k. tiwari Pratibha Shuk.a Department of Mathematical Sciences A.P.S. University Rewa (MP) India Department of Mathematics Govt. Model Science College Rewa (MP) India

Einstein field equations with variable gravitational and cosmological constants are considered in the presence of perfect fluid for the Bianchi type-Ⅲ universe by assuming conservation law for the energy-momentum tensor. Exact solutions of the field equations are obtained by using the scalar of expansion proportional to the shear scalar θ∝σ, which leads to a relation between metric potential B = Cn, where n is a constant. The corresponding physical interpretation of the cosmological solutions are also discussed.

关键词： Cosmological Models Cosmological Constant

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The correlation between friction coefficient and areal topography parameters for AISI 304 steel sliding against AISI 52100 steel

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Friction 2021年第1期9卷 41-60页

作者： Deepak.k.PRAJAPATI Mayank.tiwari Department of Mechanical Engineering Indian Institute of TechnologyPatna 801103India

Dry wear experiments provide an insight detail on how severely contacting surfaces change under unlubricated sliding condition. The theory of dry sliding wear is used for understanding mixed-lubrication regime in which asperity interactions play a significant role in controlling of the friction coefficient(f). The purpose of this work.is to study the tribological behavior of AISI 304 steel in contact with AISI 52100 steel during wear. Both materials are used in rolling element bearings commanly. Experiments are carried out using a pin-on-disc tribometer under dry friction condition. The areal(three dimensional, 3D) topography parameters are measured using a 3D white light interferometer(WLI) with a 10× objective. After wear tests, wear mechanisms are analyzed utilizing scanning electron microscope(SEM). Factorial design with custom response surface design(C-RSD) is used to study the mutual effect of load and speed on response variables such as f and topography parameters. It is observed that the root mean square roughness(S_(q)) decreases with an increase in sliding time. Within the range of sliding time, S_(q) decreases with an increase in the normal load. Within the range of sliding speed and normal load, it is found that S_(q), mean summit curvature(S_(sc)), and root mean square slope(S_(dq)) are positively correlated with f. Whereas, negative correlation is found between f and correlation length(Sal), mean summit radius(R), and core roughness depth(S_(k.).

关键词： friction coefficient(f) areal topography parameters factorial design non-contact optical profiler scanning electron microscope(SEM)

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LRS Bianchi Type-II Cosmological Model with a Decaying Lambda Term

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Chinese Physics Letters 2012年第1期29卷 35-37页

作者： R.k.tiwari D.tiwari Pratibha Shuk.a Department of Mathematics Govt.Model Science College RewaM.P.486001India

We consider a locally rotationally symmetric(LRS)Bianchi type-Ⅱspacetime with a perfect fluid and a variable cosmological constant∧.To solve the Einstein field equations we consider the cosmological term∧to be proportional to R^(-m) with R being the scale factor and m a constant[***.D 58(1998)043506].In this model we obtain∧~H^(2),∧~(R)/R and Larnbda~t^(-2),in agreement with the main dynamical laws for the decay of∧.The physical significance of the cosmological model is also discussed.

关键词： Bianchi Cosmo perfect

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Regeneration of tree species in the sub-tropical forest of Alak.anda Valley, Garhwal Himalaya, India

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Forestry Studies in China 2013年第2期15卷 89-97页

作者： Radha BALLABHA J. k. tiwari P. tiwari Department of Botany and Microbiology HNB Garhwal UniversitySrinagar Garhwal 246174 Uttarakhand India

We studied the regeneration of tree species in the sub-tropical forest of Alak.anda Valley in Garhwal Himalaya, India. The overall regeneration status was fairly good in the study area. Seedling density ranged between 520 and 1,240 seedlings per ha while the density of saplings varied between 400 and 800 saplings per ha. Out of eight sites studied, five sites, viz., A1, A2, B1, B2 and C2 contained the highest number of seedlings （280-480 per ha） and saplings ,（200-440 per ha） for Pinus roxburghfi and remaining three sites viz., C1, D1 and D2 represented the highest number of seedlings （240-400 per ha） and saplings （200-240 per ha） for Anogeissus latifolius. The DBH class distribution of the tree species revealed that the highest number of individuals was concentrated in the lower diameter classes while smallest numbers were found in the higher diameter classes. Species such as Acacia catechu, Anogeissus latifolius, Dalbergia sissoo, Engelhardtia spicata, Lannea coromandelica, Mallotus philippensis and Pinus roxburghii have the larg- est number of saplings and seedlings in the lower DBH classes, suggesting that they have good regeneration potential. Other spec es such as Aegle marmelos, Bauhinia variegata, Bombax ceiba, Cassia fistula, Erythrina variegata, Haldinia ：cordifolia, Mangifera indica, Ougeinia oojeinensis, Phyllanthus emblica, Syzygium cumini, Terminalia alata and Toona hexandra have either no or very small number of saplings in the lower DBH classes which indicates that the status of these species implies poor regeneration.

关键词： Garhwal Himalaya disturbances regeneration tree species

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