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生物组学研究杂志(英文) 2024年第1期07卷 36-43页

作者： mohanty Swati Sucharita mohanty Sumit Subhadarshi Panda Soumya Surath Sahoo Chita Ranjan mohanty prafulla kumar Padhy Rabindra Nath Siksha O Anusandhan University Institute of Medical Sciences and SUM Hospital Bhubaneswar Odisha India Regional Medical Research Centre Bhubaneswar Bhubaneswar Odisha India Khallikote Unitary University Brahmapur Odisha India

There were 2.3 million new cases of breast cancer registered in 2020, establishing it as the world’s leading cancer. The regular exposure of breast cells to circulating ovarian sex hormones may contribute to cancer growth at all stages. A literature review was performed by downloading research articles from PubMed Central, with keywords such as breast cancer, hormone exposure in breast cancer, estrogen/progesterone exposure in breast cancer, and breast cancer risk factors. Since breast cancer is a hormone-related disease, several factors that influence hormonal conditions or are indicators of alterations in hormonal conditions have been linked with the risk for breast cancer. Likewise, an elevated risk for breast cancer has been related to reproductive history and exogenous estrogen exposure because they may amplify lifetime estrogen exposure. All these factors address the total cumulative exposure to circulating ovarian sex hormones that a female is vulnerable to in her lifetime. A healthy lifestyle, a more extended breastfeeding period, and regular physical activity may help lower one’s risk. This review summarizes the factors that increase the risk of estrogen/progesterone (hormone receptor) receptor-positive breast cancer due to overall cumulative estrogen exposure, with an understanding of estrogen biosynthesis mechanisms and estrogen receptor signaling.

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Obesity as potential breast cancer risk factor for postmenopausal women

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Genes & Diseases 2021年第2期8卷 117-123页

作者： Swati Sucharita mohanty prafulla kumar mohanty Cytogenetics Laboratory P.G.Department of ZoologyUtkal UniversityBhubaneswar751004OdishaIndia

Breast cancer is the second highest prevalent cancer globally after lung cancer with 2.09 million cases during *** about 1.9 billion were overweight and over 650 million out of these were obese during *** is a significant relationship between breast cancer risk and *** menopause and premenopausal obesity diminish the risk whereas postmenopausal obesity amplifies the risk,because adipose tissue acts as the major reservoir for estrogen biosynthesis after *** estrogen levels in serum along with enhanced peripheral site production of estrogen have been viewed as major reasons of developing breast cancer in overweight postmenopausal *** review explains body fat as a peripheral site for estrogen biosynthesis,estrogen exposure affecting body fat distribution,and the mechanism of estrogen production from body fats.

关键词： Adipocyte Aromatase Breast cancer Estrogen Obesity

Tubularized incised plateurethroplasty and grafted tubularized incised plate urethroplasty: systematic review, metaanalysis and trial sequential analysis

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World Journal of Pediatric Surgery 2024年第1期7卷 10-19页

作者： Nitinkumar Borkar Charu Tiwari Abhijit Nair Debajyoti mohanty C K Sinha Jai kumar Mahajan Paediatric Surgery All India Institute of Medical Sciences-RaipurRaipurChhattisgardhIndia Department of Anaesthesiology Ibra HospitalbraOman General Surgery All India Institute of Medical Sciences-RaipurRaipurChhattisgardhIndia Paediatric Surgery St George's University Hospitals NHS Foundation TrustLondonUK Pediatric Surgery PGIMERChandigarhIndia

Background Hypospadias is one of the most common genital birth *** are around 300 various techniques available for the repair of *** study aims to compare the reported outcomes of Tubularized incised plate urethroplasty(TIP)and Grafted TIP(GTIP)repair in children undergoing primary *** This meta-analysisadhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines,and we framed our research question using the population,intervention,control and outcomes *** conducted comprehensive electronic searches across various databases,employing a Boolean search strategy with predefined search *** randomized controlled trials(RCTs)were included for quantitative *** Totally,10 RCTs met our inclusion criteria for quantitative *** results indicated that urethrocutaneous fistula,glans dehiscence,and stricture rates were comparable between the two *** incidence of meatal stenosis was found to be significantly lower in the GTIP group with a relative risk(RR)of 0.32(95%confidence interval(Cl)0.15 to 0.67).Conclusion The coucomes UCF,glans dehiscence,and stricture rates were comparable between the two ***,the incidence of meatal stenosis was found to be significantly lower in the grafted TIP *** terms of operative time,our quantitative synthesis demonstrated that the TIP group had a shorter operative time than the GTIP group with significant heterogeneity.

关键词： plate grafted analysis

Noscapine shows antimalarial activity against Plasmodium falciparum 3D7,its clinical isolate Pf140/SS,and Plasmodium berghei ANKA

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 350-358页

作者： Swaraj kumar Babu Sameer Maharana Satyaranjan Chhatria Dibya Ranjan Sahoo Ashirbad Nanda Satish Kanhar Prativa KBehera Sanjib mohanty Pradeep kumar Naik Praveen Kishore Sahu Centre of Excellence in Natural Products and Therapeutics Department of Biotechnology and BioinformaticsSambalpur UniversityJyoti ViharSambalpur OdishaIndia Department of Molecular Biology and Infectious Diseases Community Welfare Society HospitalRourkelaOdishaIndia Molecular&Immunology Laboratory Infectious Disease Biology UnitIspat General HospitalRourkelaOdishaIndia Department of Pharmacy Centurion University of Technology and ManagementBhubaneswarOdishaIndia

Objective:To evaluate the antimalarial activity of noscapine against Plasmodium falciparum 3D7 strain(Pf3D7),its clinical isolate(Pf140/SS),and Plasmodium berghei ANKA(PbA).Methods:Using ring-stage survival assay,phenotypic assessments,and SYBR-green-based fluorescence assay,the antimalarial activities of noscapine were assessed compared with dihydroartemisinin(DHA)in in vivo and in vitro *** addition,hemolysis and cytotoxicity tests were carried out to evaluate its ***-PCR assay was also conducted to determine the effect of noscapine on papain-like cysteine protease Plasmodium falciparum falcipain-2(PfFP-2).Results:The antimalarial efficacy of noscapine against Pf3D7 and Pf140/SS was comparable to DHA,with IC50 values of(7.68±0.88)and(5.57±0.74)nM/mL,respectively,and>95%inhibition of PbA infected *** also showed a safe profile,as evidenced by low hemolysis and cytotoxicity even at high ***,PfFP-2 expression was significantly inhibited in both noscapine-treated Pf3D7 and Pf140/SS(P<0.01).Conclusions:Noscapine has antimalarial properties comparable to standard antimalarial DHA with better safety profiles,which may be further explored as a therapeutic candidate for the treatment of malaria.

关键词： Malaria Plasmodium falciparum Plasmodium berghei Noscapine Antimalarial Dihydroartemisinin Cytotoxicity Falcipain-2

Germplasm Resources,Genes and Perspective for Aromatic Rice

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Rice science 2023年第4期30卷 294-305页

作者： prafulla kumar BEHERA Debabrata PANDA Department of Biodiversity and Conservation of Natural Resources Central University of OdishaKoraput 764003OdishaIndia

Aromatic rice is considered an important commodity in the global market because of its strong aroma and eating and cooking *** countries,such as India and Pakistan,are the leading traders of Basmati rice,whereas Thailand is the major supplier of Jasmine rice in the international *** strong aroma of rice is associated with more than 300 volatile compounds,among which 2-acetyl-1-pyrroline(2-AP)is the principal component.2-AP is a phenotypic expression of spontaneous mutations in the recessive gene OsBadh2 or *** present review focuses on the origin,evolution and diversity of genetic resources of aromatic rice available worldwide.A brief discussion is presented on the genes responsible for quality traits along with details of their molecular *** compilation and discussion will be useful for future breeding programs and the biofortification of quality traits of aromatic rice to ensure food security and nutritional need.

关键词： aromatic rice 2-acetyl-1-pyrroline polyamine degradation pathway quality trait

Estimation of discharge and its distribution in compound channels

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Journal of Hydrodynamics 2014年第1期26卷 144-154页

作者： mohanty Prabir kumar KHATUA Kishanjit kumar Department of Civil Engineering National Institute of TechnologyRourkelaOrissaIndia

Results of research into a compound channel having width ratio （a） in excess of 11 are presented in the form of boun-dary shear distributions across the compound cross section. New relationship is derived between the percentage of shear carried by the flood plains （%S fp ） and the percentage of area occupied by the flood plains （%Afp ） . The equation so derived is taken as the basis to develop a new methodology to predict the stage discharge relationship specifically for wide compound channels using Darcy＇s friction factor （ f ） for the main channel and flood plain regions. The methodology also is used for compound channels with smaller width ratios by applying the appropriate relation for %S fp derived earlier by different researchers and seems to work well. Next, as a corollary to the methodology, separate formulae are proposed to estimate flow distribution in main channel and flood plain regions. The proposed method and its corollary are tested for their validity against well-published small-scale data series of pre-vious researchers along with some large-scale data series from EPSRC-FCF （A-Series） compound channel experiments and very good agreement is observed between the measured values and predicted values for total flow as well as zonal distribution of flow. The methodology is also applied to some compound river section data published in literature and is found to serve well the purpose of predicting flow in real world application. This new method gives the least RMS value of error for discharge prediction compared with some other well-known methods used for estimating stage-discharge relation in compound channels by considering all data sets.

关键词： compound channels boundary shear stage-discharge relationship discharge distribution friction factor

Drought Tolerance in Rice: Focus on Recent Mechanisms and Approaches

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Rice science 2021年第2期28卷 119-132页

作者： Debabrata PANDA Swati Sakambari MISHRA prafulla kumar BEHERA Department of Biodiversity and Conservation of Natural Resources Central University of OrissaKoraput 764021OdishaIndia

Drought stress is a serious limiting factor to rice production,which results in huge economic *** is becoming a more serious issue with respect to the global climate *** in view of the current and forecasted global food demand,it has become essential to enhance the crop productivity on the drought-prone rainfed lands with *** order to achieve the production target from rainfed areas,there is a requirement of rice varieties with drought tolerance,and genetic improvement for drought tolerant should be a high priority theme of research in the *** for drought tolerant rice varieties is a thought-provoking task because of the complex nature and multigenic control of drought tolerant traits would be a major bottleneck for the current research.A great progress has been made during last two decades in our understanding of the mechanisms involved in adaptation and tolerance to drought stress in *** this review,we highlighted the recent progresses in physiological,biochemical and molecular adaptation of rice to drought tolerance.A brief discussion on the molecular genetics and breeding approaches for drought tolerance in rice will be focused for the future crop improvement program for development of drought tolerant rice varieties.

关键词： drought stress drought adaptation rice water deficit tolerance

Sorption behavior of coal for implication in coal bed methane an overview

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International Journal of Mining Science and Technology 2017年第2期27卷 307-314页

作者： Manasi Manjari mohanty Bhatu kumar Pal N.I.T. Rourkela 769008OdishaIndia Mining Engineering Department N.I.T Rourkela 769008OdishaIndia

CBM has been recognized as a significant natural gas resource for a long time. Recently, CO_2 sequestration in coalbeds for ECBM has been attracting growing attention because of greater concerns about the effects of greenhouse gases and the emerging commercial significance of CBM. Reservoir-simulation technology,as a useful tool of reservoir development, has the capability to provide us with an economic means to solve complex reservoir-engineering problems with efficiency. The pore structure of coal is highly heterogeneous, and the heterogeneity of the pores depends on the coal type and rank.

关键词： ECBM Greenhouse gases Sequestration Adsorption and desorption Porosity and permeability

Laboratory investigation on damping characteristics of homogeneous and stratified soil-ash system

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第10期15卷 2757-2777页

作者： Amit kumar Ram Supriya mohanty Department of Civil Engineering Indian Institute of Technology(BHU)VaranasiVaranasi221005India

In this study,the damping responses of uniform soil,equi-proportional fly ash,and local soil as a single unit were *** large-strain cyclic triaxial tests were performed for the specimen compacted at the desired density(95%e99%of maximum dry density).The compacted specimens were tested under the loading frequency of 0.3e1 Hz with medium confinement of 70e100 ***,the unsymmetrical behavior of the hysteresis loop was analyzed using three different damping estimation approaches,*** hysteresis loop(SHL),asymmetric hysteresis loop(ASHL),and the modified American Society for Testing and Materials(ASTM)*** outcome of the study shows for fly ash,local soil,and layered soil-ash,the ASHL technique has the highest damping value,followed by ASTM and then the SHL *** specimens prepared under high density and subjected to high confinement show low damping ***,the specimens tested at high frequency exhibits high damping ***,the damping value of fly ash determined using the SHL and ASHL methods has a similar profile and reaches a maximum at 1%shear strain value before *** composite stratified deposit exhibits more dependency on relative compaction,confining pressure,and less on loading *** on the results,it is highly recommended to use the ASHL approach,especially under large strain conditions irrespective of soil *** maximum damping ratio of stratified deposits is always in between the damping ratio of local soil and fly *** damping ratio of stratified soil and local soil is slightly larger than that of the other soils,although the damping ratio of fly ash is equivalent to that of the sand and clayey *** results may be helpful in the accurate determination of the damping properties of the layered soil-ash system that is required in the seismic response analysis.

关键词： Homogeneous soil Stratified soil-ash system Damping behavior Cyclic triaxial test Asymmetric hysteresis loop Model fitting

State of the art review on physiochemical and engineering characteristics of fly ash and its applications

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International Journal of Coal Science & Technology 2022年第1期9卷 21-45页

作者： Amit kumar Ram Supriya mohanty Department of Civil Engineering Indian Institute of Technology(Banaras Hindu University)Varanasi 221005India

The focus of this study is to critically review the physiochemical and engineering properties of the fly ash and its applications in various *** utilization of fly ash has become a widespread area,but the amount of utilization is still a serious *** has many beneficial qualities(such as pozzolanic property,fineness,spherical shape,lightweight,etc.),which enhance its properties and make it suitable for its utilization as a new construction *** the bulk utilization of fly ash,it should be employed in the areas independent of any other *** that,the disposal problem can be reduced *** knowledge of its physiochemical characteristic helps in the judgment of appropriate fly ash for any particular type of *** ash can be utilized in other areas such as asphalt concrete,geopolymer concrete,ground improvement,agricultural sector,roller compacted concrete,brick,*** will reduce the existing ashes,and also the disposal problem can be solved *** implementation of fly ash must be avoided below the natural ground water level and below 4°C temperature conditions.

关键词： Fly ash Chemical property Engineering property Construction material