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SAHA attenuates Takotsubo-like myocardial injury by targeting an epigenetic Ac/Dc axis

Signal Transduction and Targeted Therapy 2021年第5期6卷 1429-1432页

作者： Ishant Khurana Scott Maxwell Simon Royce prabhu mathiyalagan Tom Karagiannis Nadia Mazarakis Jitraporn Vongsvivut Harikrishnan K.N. Jun Okabe Keith Al-Hasani Chrishan Samuel Assam El-Osta Human Epigenetics Program Department of DiabetesCentral Clinical SchoolMonash UniversityMelbourneVICAustralia Cardiovascular Disease Program Monash Biomedicine Discovery Institute and Department of PharmacologyMonash UniversityClaytonVICAustralia Infrared Microspectroscopy Beamline ANSTO-Australian SynchrotronClaytonVICAustralia Department of Medicine and Therapeutics The Chinese University of Hong Kong(CUHK)Hong Kong SARHong Kong Institute of Diabetes and ObesityCUHKHong Kong SARPrince of Wales HospitalLi Ka Shing Institute of Health SciencesCUHKShatinHong KongChina University College Copenhagen Faculty of HealthDepartment of TechnologyBiomedical Laboratory ScienceCopenhagenDenmark

Dear Editor,Takotsubo syndrome(TS)is a stress-induced non-ischaemic cardiomyopathy that is more common in women,but is associated with higher morbidity and mortality in *** known as broken-heart syndrome,TS is characterised by transient left ventricular(LV)dysfunction independent of obstructive coronary artery *** is a polygenic condition and nowhere is this more evident than the use of positive inotropes,such as isoprenaline(ISO)in pre-clinical models.1 There is no standard therapy for broken-heart syndrome because the mechanisms underlying the condition remain ***,there is no consensus on predisposition for Takotsubo2 and our goal was to better understand the regulatory mechanism as a first step towards improved treatment *** acid or SAHA,a drug approved for cancer treatment by the US Food and Drug Administration has previously been shown to improve cardiopulmonary function.3 We tested the hypothesis that the cardioprotective benefit of SAHA in a pre-clinical model of Takotsubo is conferred by an epigenetic acetylation/deacetylation(Ac/Dc)axis.

关键词： SAHA Takotsubo protective

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A Novel Eccentric Intrusion Detection Model Based on Recurrent Neural Networks with Leveraging LSTM

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Computers, Materials & Continua 2024年第3期78卷 3089-3127页

作者： Navaneetha Krishnan Muthunambu Senthil Prabakaran Balasubramanian prabhu Kavin Kishore Senthil Siruvangur Kavitha Chinnadurai Jehad Ali Department of Computer Applications Karpagam College of EngineeringCoimbatore641032India Department of Computer Science and Engineering Karpagam College of EngineeringCoimbatore641032India Department of Data Science and Business Systems College of Engineering and TechnologySRM Institute of Science and TechnologyKattankulathur603203India Department of Computer Science and Engineering Sathyabama Institute of Science and TechnologyJeppiaar NagarRajiv Gandhi SalaiChennai600119India Department of AI Convergence Network Ajou UniversitySuwon16499Korea

The extensive utilization of the Internet in everyday life can be attributed to the substantial accessibility of online services and the growing significance of the data transmitted via the ***,this development has expanded the potential targets that hackers might *** adequate safeguards,data transmitted on the internet is significantly more susceptible to unauthorized access,theft,or *** identification of unauthorised access attempts is a critical component of cybersecurity as it aids in the detection and prevention of malicious *** research paper introduces a novel intrusion detection framework that utilizes Recurrent Neural Networks(RNN)integrated with Long Short-Term Memory(LSTM)*** proposed model can identify various types of cyberattacks,including conventional and distinctive *** networks,a specific kind of feedforward neural networks,possess an intrinsic memory *** Neural Networks(RNNs)incorporating Long Short-Term Memory(LSTM)mechanisms have demonstrated greater capabilities in retaining and utilizing data dependencies over extended *** such as data types,training duration,accuracy,number of false positives,and number of false negatives are among the parameters employed to assess the effectiveness of these models in identifying both common and unusual *** are utilised in conjunction with LSTM to support human analysts in identifying possible intrusion events,hence enhancing their decision-making capabilities.A potential solution to address the limitations of Shallow learning is the introduction of the Eccentric Intrusion Detection *** model utilises Recurrent Neural Networks,specifically exploiting LSTM *** proposed model achieves detection accuracy(99.5%),generalisation(99%),and false-positive rate(0.72%),the parameters findings reveal that it is superior to state-of-the-art techniques.

关键词： Cybersecurity intrusion detection machine learning leveraging long short-term memory(LLSTM) CICIDS2019 dataset innovative cyberattacks

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Pharmacological adjuvants for diabetic vitrectomy surgery

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World Journal of Methodology 2024年第4期14卷 84-90页

作者： Ramesh Venkatesh Chaitra Jayadev Vishma prabhu Priyanka Gandhi Rupal Kathare Naresh K Yadav Ayushi Choudhary Jay Chhablani Department of Ophthalmology Narayana NethralayaBangalore 560010India Department of Retina Narayana Nethralaya Eye InstituteBangalore 560010India Department of Vitreo Retina Narayana NethralayaRetina ServSuper Specialty Eye Hospital and Post Graduate Institute of OphthalmologyBangalore 560010India Department of Retina University of Pittsburg School of MedicinePittsburgPA 15213United States

Diabetic vitrectomy is a highly intricate surgical procedure performed during the advanced stages of diabetic retinopathy(DR).It is used to treat conditions such as tractional or combined retinal detachment,vitreous hemorrhage,and subhyaloid hemorrhage,which are all severe manifestations of proliferative *** results of the surgery are uncertain and *** surgery has made significant progress since the early stages of *** the past ten years,advancements in intravitreal pharmacotherapy have emerged,offering new possibilities to improve the surgical results for our *** the realm of medical terminology,an"adjunct"refers to a pharmaceutical or substance employed to aid or expedite the primary therapeutic intervention for a particular *** introduction has broadened the range of therapeutic choices that are accessible prior to,during,and following surgical *** review article will specifically analyze the pharmacological adjuncts used in diabetic vitrectomy surgery,with a focus on their role in facilitating or aiding specific steps of the *** implementation of this system of categorization offers benefits to the surgeon by allowing them to foresee potential difficulties that may occur during the surgical procedure and to choose the appropriate pharmacological agent to effectively tackle these challenges,thus enhancing surgical success rates.

关键词： Diabetic retinopathy Vitrectomy Intravitreal injections Anti-vascular endothelial growth factor Adjuvants Outcomes

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Paradigm shift in transfusion practices during early COVID-19 pandemic:A single center retrospective study

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World Journal of Virology 2024年第2期13卷 78-86页

作者： Sumukh Arun Kumar Sushmita prabhu Ankushi Sanghvi Maya Gogtay Mithil Gowda Suresh Harshit Khosla Yuvaraj Singh Ajay Kumar Mishra Susan George Department of Internal Medicine Saint Vincent HospitalWorcesterMA 01608United States Department of Hematology and Oncology University of Nebraska Medical CenterOmahaNE 68198United States Hospice and Palliative Care UTHSC and McGovern School of MedicineTexasTX 77030United States Department of Gastroenterology and Hepatology UMass Chan Medical SchoolWorcesterMA 01655United States Division of Cardiology Saint Vincent HospitalWorcesterMA 01608United States

BACKGROUND The advent of coronavirus disease 2019(COVID-19)unveiled the worst national blood crisis that the United States had witnessed in over a *** the pandemic influencing the different stages of the acquisition of blood products outside the hospital setting,we aimed to explore the possible barriers contributing to the shortage of blood products within the medical *** COVID era and pre-COVID *** We conducted a retrospective cross-sectional study on hospitalized patients distinguishing the pattern of blood transfusion during the COVID and pre-COVID era in a community *** was tabulated to include the number of red blood cell(RBC)transfusions and if transfusions met restrictive blood transfusion criteria as per institutional ***-square was applied to test the statistical association between qualitative *** t test and Mann Whitney U test were applied respectively to test the mean difference of quantitative *** A total of 208 patients were included in the study,of which 108 were during COVID era and 100 were during pre-COVID *** leading reason for admission in both the COVID era and pre-COVID era transfused patients was shortness of breath(53.7%and 36%P=0.001),followed by gastrointestinal bleeding(25.9%and 21%P=0.001).There was a higher percentage of RBC transfusions in the intensive care unit in the COVID-era group than in the pre-COVID era group(38.9%vs 22%,P=0.008).The restrictive transfusion criteria were met in 62%vs 79%in the COVID and pre-COVID eras,respectively(P=0.008).CONCLUSION The COVID-era group received RBC transfusions with less stringent adherence to restrictive blood transfusion practices in comparison to pre-COVID era group.

关键词： Blood transfusion Restrictive transfusion COVID-19 Pre-COVID-19 Blood shortage Pandemic

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An Advanced Dynamic Scheduling for Achieving Optimal Resource Allocation

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Computer Systems Science & Engineering 2023年第1期44卷 281-295页

作者： R.prabhu S.Rajesh Department of Computer Science and Engineering AAA College of Engineering and TechnologySivakasiTamilnaduIndia Department of Information Technology Mepco Schlenk Engineering College SivakasiTamilnadu India

Cloud computing distributes task-parallel among the various *** with self-service supported and on-demand service have rapid *** these applications,cloud computing allocates the resources dynami-cally via the internet according to user *** resource allocation is vital for fulfilling user *** contrast,improper resource allocations result to load imbalance,which leads to severe service *** cloud resources implement internet-connected devices using the protocols for storing,communi-cating,and *** extensive needs and lack of optimal resource allo-cating scheme make cloud computing more *** paper proposes an NMDS(Network Manager based Dynamic Scheduling)for achieving a prominent resource allocation scheme for the *** proposed system mainly focuses on dimensionality problems,where the conventional methods fail to address *** proposed system introduced three–threshold mode of task based on its size STT,MTT,LTT(small,medium,large task thresholding).Along with it,task mer-ging enables minimum energy consumption and response *** proposed NMDS is compared with the existing Energy-efficient Dynamic Scheduling scheme(EDS)and Decentralized Virtual Machine Migration(DVM).With a Network Manager-based Dynamic Scheduling,the proposed model achieves excellence in resource allocation compared to the other existing *** obtained results shows the proposed system effectively allocate the resources and achieves about 94%of energy efficient than the other *** evaluation metrics taken for comparison are energy consumption,mean response time,percentage of resource utilization,and migration.

关键词： Cloud computing resource allocation load balance dynamic scheduling dimensionality reduction

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Awareness and perspectives of audiologists on assessment and management of misophonia in India

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Journal of Otology 2023年第2期18卷 104-110页

作者： Sajana Aryal Prashanth prabhu All India Institute of Speech and Hearing MysoreIndia

Background:The assessment and management of misophonia need a team approach,and audiologists are essential team ***,the role of an audiologist in this condition is not well understood,and there is a lack of awareness even among professionals about their role in the assessment and management of ***:The main aim of our study is to document the present level of awareness and knowledge about misophonia assessment and management among audiologists in ***:A descriptive cross-sectional study was carried out among audiologists from all over *** statistical procedures were measured based on the type of questions being addressed,and a non-parametric chi-square test was done to see the association among ***:The results show a lack of knowledge about misophonia even among audiologists,as only 15.3%of the audiologist reported being confident in handling cases with ***:Although the exact assessment and management of misophonia is still the topic of debate,it is clear that audiologists are the team's key ***,the results clearly show a lack of confidence in handling cases of misophonia among audiologists in *** result shows the future need for Research in misophonia from an audiological perspective.

关键词： Misophonia Awareness Audiologists Viewpoint Assessment and management

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Auditory brainstem functioning in individuals with misophonia

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Journal of Otology 2023年第3期18卷 139-145页

作者： Sajana Aryal Prashanth prabhu All India Institute of Speech and Hearing Mysore570006India

Purpose:Misophonia is not investigated much from an audiological *** study aims to examine the processing of the auditory retro-cochlear pathways in individuals with ***:A cross-sectional study was conducted among university students who had *** revised Amsterdam Misophonia Scale was used to determine the severity of *** were divided into mild and moderate-severe misophonia and compared with the healthy control *** Brainstem Response testing was recorded from all the individuals with *** absolute latency,amplitude,inter-peak latency difference,and inter-rate latency difference were compared between the ***:One-way ANOVA result showed no significant difference in all the parameters of auditory brainstem response between the *** results are suggestive of normal brainstem processing in individuals with ***:The study concludes that the auditory pathway up to brainstem areas is intact in individuals with *** studies are essential on a larger population for generalizing the results.

关键词： Misophonia Brainstem pathway Brainstem response Neurophysiology Audiology

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Optimal Data Placement and Replication Approach for SIoT with Edge

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Computer Systems Science & Engineering 2022年第5期41卷 661-676页

作者： B.prabhu Shankar S.Chitra Department of Information Technology Er Perumal Manimekalai College of EngineeringHosur635117TamilnaduIndia Department of Computer Science and Engineering Er Perumal Manimekalai College of EngineeringHosur63117TamilnaduIndia

Social networks(SNs)are sources with extreme number of users around the world who are all sharing data like images,audio,and video to their friends using IoT *** concept is the so-called Social Internet of Things(SIot).The evolving nature of edge-cloud computing has enabled storage of a large volume of data from various sources,and this task demands an efficient storage *** this kind of large volume of data storage,the usage of data replication using edge with geo-distributed cloud service area is suited to fulfill the user’s expectations with low *** major issue is the way to store the data and replicate these large data items optimally and allocate the request from the data center *** efficient storage of these data,we use edge server,which is part of the cloud server,in this ***,the data are distributed and stored with quick access,which will reduce the latency with *** proposed data placement approach learns with machine learning(ML)algorithm called radial basis kernel function assisted with support vector machine(RBF-SVM)to classify the data center for storing the user and friend’s data from the SIoT *** learning algorithms will be used to predict the workload of the data stored in the data center as either edge or cloud depending on the existing time *** data placement with dynamic nature is also optimized using the proposed dynamic graph partitioning(GP)method to meet the individual user’s demand of low latency with minimum *** way will keep the SIoT data placement efficient and effective over ***,this proposed data placement and replication approach introduces three kinds of innovations compared with the existing data placement approach.(i)Rather than storing the user data in a single cloud,this study uses the edge server closest to the SIoT devices for faster access with reduced response time.(ii)The classification algorithm called RBF-SVM is used to find storage for

关键词： Data placement data replication social network social internet of things edge computing cloud computing graph partitioning support vector machine machine learning radial basis function latency storage cost

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OFDM-CFO and Resource Scheduling Algorithm Using Fuzzy Linear-CFO

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Intelligent Automation & Soft Computing 2023年第2期35卷 2513-2525页

作者： M.prabhu B.Muthu Kumar Department of Electronics and Communication Anna UniversityChennai600025India Department of Computer Science and Engineering Syed Ammal Engineering CollegeRamanathapuram623502India

Orthogonal Frequency-Division Multiplexing(OFDM)is the form of a digital system and a way of encoding digital data across multiple frequency com-ponents that are used in telecommunication *** Frequency Offset(CFO)inaccuracy is a major disadvantage of *** paper proposed a fea-sible and elegant fuzzy-based resource allocation technique,that overcomes the constraints of the *** suggested Fuzzy linear CFO estimation(FL-CFO)not only estimates the CFO with increased precision but also allocates resources effectively,and achieves maximum utilization of dynamic *** sug-gested FL-CFO error estimation algorithm in OFDM systems employing 1-bit Quadrate errors ADC(1-bit QE)is utilized to extract the precise ***-ally,the base station(BS)manages the Resource Units(RU),which could be used to distribute resources in such a manner that the user requests are *** assign resources to a certain job,fuzzy rules are *** the residence duration exceeds the resource requirement time then the particular resources are provided to the highest-priority *** a result,the job performance will not be halted due to a lack of allocated *** metrics such as utilization,rate of failure,and life span,as well as energy consumption,are used to assess the pro-posed FL-CFO.

关键词： Orthogonal frequency division multiplexing(OFDM) carrier

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Authentication of WSN for Secured Medical Data Transmission Using Diffie Hellman Algorithm

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Computer Systems Science & Engineering 2023年第6期45卷 2363-2376页

作者： A.Jenice prabhu D.Hevin Rajesh Arunachala College of Engineering for Women ManavilaiNagercoil629203India St.Xavier’s Catholic College of Engineering Nagercoil629003India

The applications of wireless sensor network(WSN)exhibits a significant rise in recent days since it is enveloped with various advantageous *** the medical field,the emergence of WSN has created marvelous changes in monitoring the health conditions of the patients and so it is attracted by doctors and *** assists in providing health care services without any delay and so it plays predominant role in saving the life of *** data of different persons,time,places and networks have been linked with certain devices,which are collectively known as Internet of Things(IOT);it is regarded as the essential requirement of people in recent *** the health care monitoring system,IOT plays a magnificent role,which has produced the real time monitoring of patient’s *** the medical data transmission is accomplished quickly with high security by the routing and key *** the data from the digital record system(cloud)is accessed by the patients or doctors,the medical data is transferred quickly through WSN by performing *** Probabilistic Neural Network(PNN)is utilized,which authenticates the shortest path to reach the destination and its performance is identified by comparing it with the Dynamic Source Routing(DSR)protocol and Energy aware and Stable Routing(ESR)*** performing routing,the secured transmission is achieved by key management,for which the Diffie Hellman key exchange is utilized,which performs encryption and decryption to secure the medical *** enables the quick and secured transmission of data from source to destination with improved throughput and delivery ratio.

关键词： Probabilistic neural network(PNN) diffie hellman key exchange internet of things(IOT) wireless sensor network(WSN)

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