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Insights on the Emerging Therapeutic Potential of Terpenoids as Anti-inflammatory Agents:A Scoping Review

Journal of Bio-X Research 2024年第1期7卷 20-35页

作者： Mohini Devi prabhjeet kaur bamrah Rajat Goyal Manjusha Choudhary Hitesh Chopra Institute of Pharmaceutical Sciences Kurukshetra UniversityKurukshetra 136119HaryanaIndia MM College of Pharmacy Maharishi Markandeshwar(Deemed to be University)Mullana-Ambala 133207HaryanaIndia Department of Biosciences Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennai 602105Tamil NaduIndia

Background:Inflammatory diseases are among the leading causes of health issues that considerably influence health care *** the notable advancements in medical treatment that have been made in recent years,natural products with biological activity still play essential roles in a variety of anti-inflammatory *** study and identification of novel treatments for the adverse effects of available synthetic anti-inflammatory agents warrant further ***:This study focused on the emerging therapeutic potential of terpenoid products as anti-inflammatory ***:The literature reveals that secondary metabolites obtained from medicinal plants,*** and terpenoids and their nanoformulations,are effective for the treatment of inflammation in *** terpenes are a broad class of secondary metabolites that are rich in monoterpenes,diterpenes,triterpenes,tetraterpenes,ceramides,and sesquiterpenes and have various therapeutic applications,such as antitumor,antibacterial,antimicrobial,analgesic and anti-inflammatory *** studies have shown that terpenes can decrease inflammation-associated symptoms by reducing the release of proinflammatory cytokines,including nuclear transcription factor-kappa B,interleukins,tumor necrosis factor-alpha,and other inflammatory ***:This review describes the latest knowledge of the different terpenoid-derived natural and synthetic compounds that have been isolated from plant sources in recent years and their anti-inflammatory potential and therapeutic mechanism of ***,this study focused on terpenoid-based nanoformulations with enhanced bioavailability and improved therapeutic efficacy as anti-inflammatory agents.

关键词： conditions. formulation considerably

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Antifertility potential of leaves and seeds of Delonix regia in female rats

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Asian pacific Journal of Reproduction 2023年第3期12卷 117-123,I0001,I0002页

作者： Garg Megha Sharma Aditi Choudhary Manjusha kaur prabhjeet Institute of Pharmaceutical Sciences Kurukshetra UniversityKurukshetraIndia

Objective:To evaluate the antifertility activity of hydroalcoholic extract of Delonix regia(*** Hook.)*** and seeds which are traditionally being used by Yanadi tribe to treat ***:Three experimental animal models,including anti-implantation,early abortifacient,and estrogenic activity in female rats,were used for evaluation of the antifertility activity of both extracts at two dose levels(250 and 500 mg/kg,orally).There were five groups in the anti-implantation and early abortifacient activity while six groups in estrogenic activity including the *** number of implants,resorptions,vaginal cornification,body weight,uterus weight,and biochemical parameters were ***:At doses 250 and 500 mg/kg,the leaf extract was found to have strong anti-implantation *** extract administered at the same doses also caused a significant rise in the number of resorptions,showing early abortifacient activity,increased uterine weight,and altered numerous biochemical ***,the seed extract only displayed slight anti-implantation activity at both ***:Based on these preliminary findings,we can conclude that the leaf extract outperformed the seed extract in terms of antifertility activity,exhibiting potent estrogenic,anti-implantation and early abortifacient activities in a dose-dependent *** findings are consistent with the literature study and corroborate to the antifertility activity of the plant.

关键词： Delonix regia Anti-implantation Early abortifacient Estrogenic Gulmohar Ovariectomy

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