Insights on the Emerging Therapeutic Potential of Terpenoids as Anti-inflammatory Agents:A Scoping Review

作     者：Mohini Devi Prabhjeet Kaur Bamrah Rajat Goyal Manjusha Choudhary Hitesh Chopra 

作者机构：Institute of Pharmaceutical SciencesKurukshetra UniversityKurukshetra 136119HaryanaIndia MM College of PharmacyMaharishi Markandeshwar(Deemed to be University)Mullana-Ambala 133207HaryanaIndia Department of BiosciencesSaveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennai 602105Tamil NaduIndia 

出 版 物：《Journal of Bio-X Research》 (生物组学研究杂志（英文）)

年 卷 期：2024年第7卷第1期

页      面：20-35页

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

主　　题：conditions. formulation considerably 

摘      要：Background:Inflammatory diseases are among the leading causes of health issues that considerably influence health care *** the notable advancements in medical treatment that have been made in recent years,natural products with biological activity still play essential roles in a variety of anti-inflammatory *** study and identification of novel treatments for the adverse effects of available synthetic anti-inflammatory agents warrant further ***:This study focused on the emerging therapeutic potential of terpenoid products as anti-inflammatory ***:The literature reveals that secondary metabolites obtained from medicinal plants,*** and terpenoids and their nanoformulations,are effective for the treatment of inflammation in *** terpenes are a broad class of secondary metabolites that are rich in monoterpenes,diterpenes,triterpenes,tetraterpenes,ceramides,and sesquiterpenes and have various therapeutic applications,such as antitumor,antibacterial,antimicrobial,analgesic and anti-inflammatory *** studies have shown that terpenes can decrease inflammation-associated symptoms by reducing the release of proinflammatory cytokines,including nuclear transcription factor-kappa B,interleukins,tumor necrosis factor-alpha,and other inflammatory ***:This review describes the latest knowledge of the different terpenoid-derived natural and synthetic compounds that have been isolated from plant sources in recent years and their anti-inflammatory potential and therapeutic mechanism of ***,this study focused on terpenoid-based nanoformulations with enhanced bioavailability and improved therapeutic efficacy as anti-inflammatory agents.