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Signal Transduction and Targeted Therapy 2021年第10期6卷 2964-2966页

作者： Yingying Li Yongbo Peng Yan Tan Wenjing Xuan Ting Fu Xue-Qiang Wang Weihong Tan Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Bio-Sensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyAptamer Engineering Center of Hunan ProvinceHunan UniversityChangshaPR China Institute of Molecular Medicine(IMM) Renji HospitalShanghai Jiao Tong University School of Medicineand College of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghaiPR China The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital) Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhouZhejiangChina

Dear Editor,Artemisinin and its derivatives(AIDs)have recently been widely applied in cancer therapy as promising therapeutic agents owing to its hypotoxicity and special bioactivation *** numerous strategies have been established to improve the potency of AIDs,they are still relatively inefficacious against cancers,especially as a monotherapy.^(1)It is thus essential to develop novel approaches to considerably enhance their anticancer *** hypothesized that aptamers with specific recognition,high-affinity binding,and receptor-mediated internalization would promote the accumulation of AIDs inside the target cells and lead to death of the target cancer cells.^(2)

关键词： artesunate considerably cytotoxicity

Prices of Synthetic Rubbers Rose considerably

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China Chemical Reporter 2008年第16期19卷 27-27页

SBR In early May 2008,due to rapid ex-work price rise of SBR in major domestic producer,the price of SBR(styrene-butadiene rubber)was up *** late May,the price of SBR continued to increase considerably in response to the tense supply caused by the overhaul of SBR unit in CNPC Jilin Petrochemical Co.,*** May *** of May 22nd,China’s prices of SBR hit the historical high,and reached RMB21 800-22 200 and RMB22900-23 500/t for oil-extended SBR and rosin SBR *** Jilin Petrochemical Co.,Ltd.

关键词： CNPC rubber butadiene considerably rosin producer

PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha Lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

Distinct cortical connectome organization of hippocampal subfields is associated with episodic memory

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Science Bulletin 2025年第1期70卷 33-37页

作者： Debin Zeng Deyu Li Qiongling Li Yong He Shuyu Li Beijing Advanced Innovation Center for Biomedical Engineering School of Biological Science&Medical EngineeringBeihang UniversityBeijing 100083China State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China State Key Laboratory of Virtual Reaility Technology and Systems Beihang UniversityBeijing 100083China Beijing Key Laboratory of Brain Imaging and Connectomics Beijing Normal UniversityBeijing 100875China IDG/McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China Chinese Institute for Brain Research Beijing 102206China

The hippocampus is considerably important in terms of its phylogenetic origins and participates in an extensive array of cognitive tasks and behaviors[1].The hippocampus can be partitioned into subfields based on its ... 详细信息

关键词： partitioned considerably fields

Labor Decreases in Manufacturing But Increases in Service

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Beijing Review 2025年第2期68卷 27-27页

作者： Lan Xinzhen 不详

China conducts an economic census every five *** December 26,2024,the country published the results of its fifth national economic census,conducted in *** showed that China’s employment structure has changed considerably since the previous census:The number of people employed in secondary industries decreased,while the number in tertiary industries increased.

关键词： Service considerably fifth

Metal–Phenolic Network-Facilitated“Foe-to-Friend”Conversion of Melittin for Cancer Immunotherapy with Boosted Abscopal Effect

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Research 2023年第3期2023卷 727-739页

作者： Yuxin Guo Xinping Zhang Shao-Zhe Wang Hui-Heng Feng Shun-Yu Wu Fu-Gen Wu State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast University2 Sipailou RoadNanjing 210096P.R.China

As a naturally occurring cytolytic peptide,melittin(Mel)has strong cytolytic activity and is a potent therapeutic peptide for cancer ***,the serious hemolytic activity of Mel largely impedes its clinical *** this work,based on the strong interactions between proteins/peptides and polyphenols,we develop a tannic acid–Fe^(3+)metal–phenolic network(MPN)-based strategy that can convert Mel from foe to friend via shielding its positive charges and reducing its hemolytic ***,an immune adjuvant resiquimod(R848)is also introduced for immunostimulation,affording the final Mel-and R848-coloaded *** Mel-caused membrane disruption can induce immunogenic cell death for immunostimulation,R848 can act as an immune adjuvant to further facilitate the immunostimulatory effect,and the tannic acid–Fe^(3+)MPN-mediated Fenton reaction can produce reactive oxygen species for cancer *** experiments reveal that the nanodrug can effectively cause immunogenic cell death of tumor cells and arouse robust intratumoral and systemic antitumor *** the bilateral tumor-bearing mouse models,the nanodrug considerably destroys the primary tumor and also boosts the abscopal effect to ablate the distant ***,the MPN-facilitated“foe-to-friend”strategy may promote the practical applications of Mel and foster the development of cancer immunotherapeutics.

关键词： stimulation loaded considerably

Onset for the Electron Velocity Overshoot in Indium Nitride

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Chinese Physics Letters 2012年第12期29卷 177-180页

作者： Clóves G.Rodrigues Departamento de Matemática e Física Pontifícia Universidade Católica de Goiás CP 8674605-010 GoianiaGoiásBrazil

A theoretical study on the electron drift velocity and electron nonequilibrium temperature of indium nitride(InN)is *** is based on a nonlinear quantum kinetic theory which provides a description of the dissipative phenomena developing in the *** ultrafast time evolution of the electron drift velocity and electron nonequilibrium temperature is obtained,and overshoot effects are evidenced on both of *** overshoot onsets are shown to occur at 4 kV/cm,electric field intensity which is considerably smaller than those recently derived by resorting to Monte Carlo simulations.

关键词： nonequilibrium Electron considerably

Targeting mechanisms in cognitive training for neurodegenerative diseases

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Neural Regeneration Research 2021年第3期16卷 500-501页

作者： Annalena Venneri Riccardo Manca Linford Fernandes Oliver Bandmann Matteo De Marco Department of Neuroscience University of SheffieldSheffieldUK Department of Neurology Leeds Teaching Hospitals NHS TrustUK

"Cognitive training"(CT)is a label used to describe paper-and-pen or computerized exercises designed to engage a desired set of mental skills for the purpose of enhancing neurocognitive *** the literature on the topic is considerably rich(on PubMed,for the sole 2018,the use of"cognitive training"as title keyword returns 123 results),very few studies pose the fundamental question:“How does CT work?”

关键词： desired considerably cognitive

Modeling of solid oxide fuel cells

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Science Bulletin 2016年第17期61卷 1311-1312页

作者： Meng Ni Department of Building and Real Estate The Hong Kong Polytechnic University

Solid oxide fuel cell(SOFC)is a high temperature(800-1000℃)power source,which can directly convert the chemical energy of a fuel into electrical energy via electrochemical *** the energy conversion process is straightforward,the electric efficiency of SOFC(>50%)is considerably higher than that of conventional heat engines(<40%).Compared with low temperature fuel cells,such as proton exchange membrane fuel

关键词： SOFC considerably proton PEMFC stack convert electrolysis alkaline battery kinetics

Integration of body-mounted ultrasoft organic solar cell on cyborg insects with intact mobility

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npj Flexible Electronics 2022年第1期6卷 726-734页

作者： Yujiro Kakei Shumpei Katayama Shinyoung Lee Masahito Takakuwa Kazuya Furusawa Shinjiro Umezu Hirotaka Sato Kenjiro Fukuda Takao Someya Center for Emergent Matter Science RIKEN2-1 HirosawaWakoSaitama 351-0198Japan Department of Integrative Bioscience and Biomedical Engineering Center for Advanced Biomedical SciencesTWIns Waseda Univerisity2-2 Wakamatsu-choShinjuku-kuTokyo 162-8480Japan Department of Modern Mechanical Engineering Waseda University3-4-1 OkuboShinjuku-kuTokyo 169-8555Japan Department of Applied Chemistry and Food Science Faculty of Environmental and Information SciencesFukui University of Technology3-6-1 GakuenFukui 910-8505Japan School of Mechanical and Aerospace Engineering Nanyang Technological UniversityN3.2-01-2065 Nanyang DriveSingapore 637460Singapore Thin-Film Device Laboratory RIKEN2-1 HirosawaWakoSaitama 351-0198Japan Electrical and Electronic Engineering and Information Systems The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan

Cyborg insects have been proposed for applications such as urban search and ***-mounted energy-harvesting devices are critical for expanding the range of activity and functionality of cyborg ***,their power outputs are limited to less than 1 mW,which is considerably lower than those required for wireless locomotion *** area and load of the energy harvesting device considerably impair the mobility of tiny ***,we describe the integration of an ultrasoft organic solar cell module on cyborg insects that preserves their motion *** quantified system design strategy,developed using a combination of ultrathin film electronics and an adhesive-nonadhesive interleaving structure to perform basic insect motion,successfully achieved the fundamental locomotion of traversing and *** body-mounted ultrathin organic solar cell module achieves a power output of 17.2 *** demonstrate its feasibility by displaying the recharging wireless locomotion control of cyborg insects.

关键词： mounted harvesting considerably