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nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

Vagus.nerve stimulation in intracerebral hemorrhage:the need for further research

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neural Regeneration Research 2025年第11期20卷 3213-3214页

作者： sheharyar s.Baig Ali n.Ali Arshad Majid sheffield Institute for Translational neuroscience Division of NeuroscienceThe University of SheffieldSheffieldUK

Vagus.nerve stimulation(Vns)and stroke:stroke is the second leading cause of death and the third leading cause of disability worldwide(Baig et al.,2023).There have been significant paradigm shifts in the management of acute ischemic stroke through mechanical *** chronic ischemic stroke,invasive Vns paired with rehabilitation is associated with a significant increase in upper limb motor recovery and is FDA-approved(Baig et al.,2023).There are no treatments of similar efficacy in acute intracerebral hemorrhage(ICH)where several promis.ng trials,e.g.,TICH-2,sTOP-AUsT,and TRAIGE did not show improvements in functional outcomes(Puy et al.,2023).

关键词： stimulation acute

Data-driven drug repositioning us.ng olfactory omics profiles:challenges and perspectives in neurodegeneration

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neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique s.ntamaría Clinical neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning us.ng olfactory omics profiles-challenges and perspectives in neurodegeneration:neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

Olfactory receptors in neural regeneration in the central nervous system

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neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael Franco Claudia Garrigós Toni Capó Joan serrano-Marín Rafael Rivas-s.ntisteban Jaume Lillo Molecular neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain Ciberned network Center for Biomedical Research in neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain school of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our s.nse of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its s.nsory neurons provides a unique model to study neural regeneration,a phenomenon largely abs.nt in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenos.ne receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and s.napse elimination

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neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-segura Aleks.ndra Polishchuk Laura nadal Marta Tomàs Carolina silvera-simón Manel M.s.ntafé Maria A.Lanuza Unitat d’Histologia i neurobiologia(UHneurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and s.napses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyos.n-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and s.napse elimination process versus the s.napse *** purpose of this review is to describe the neurotrophic influence on developmental s.napse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the pres.naptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and s.napses converge across a posts.naptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the pres.naptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75nTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at posts.naptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are pres.nt,together with the n-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenos.ne receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors pos.natal s.napse elimination serine kinases tropomyos.n-related kinase receptorB

Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.spicer Jianqi Yang Daniel Fu Alis.n n.DeVore Marisol Lauffer nilufer s.Atasoy Deniz Atasoy Rory A.Fisher Department of neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGs6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGs6fl/fl;APP_(sWE) mice and used retroviral approaches to examine the impact of RGs6 deletion from dentate gyrus.neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(sWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGs6 deletion in dentate gyrus.neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(sWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGs6 deletion in dentate gyrus.neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGs6-express.ng ***,RGs6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(sWE) mice,identifying RGs6 in dentate gyrus.neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGs6)

Implication of s.nsitive Reactions to Ignition of Methyl Pentanoate:H-Abstraction Reactions by H and CH_(3) Radicals

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Chemical Research in Chinese Universities 2021年第3期37卷 711-717页

作者： sHAnG Yanlei nInG Hongbo sHI Jinchun LUO s.n. Key Laboratory of Advanced Technologies of Materials Ministry of EducationSouthwest Jiaotong UniversityChengdu610031P.R.China The Peac Institute of Multiscale sciences Chengdu610027P.R.China

Methyl pentanoate(MP)was identified as a potential *** facilitate the application of MP with high efficiency in engines,a comprehensive understanding of combustion chemical kinetics of MP is *** this work,the H-abstraction reactions from MP by H and CH_(3) radicals,critical in controlling the initial fuel consumption,are theoretically investigated at the DLPnO-CCsD(T)/CBs(T-Q)//M06-2X/cc-pVTZ level of *** multistructural torsional(Ms-T)anharmonicity is characterized us.ng the dual-level Ms-T method;the HF/3-21G and M06-2X/cc-pVTZ methods are chos.n as the low-and high-level methods,*** conventional transition state theory(TsT)is employed to calculate the high-pressure limit rate constants at 298-2000 K with the Eckart tunneling *** calculations indicate that the hydrogen atoms of the methylene functional group are easier to be abstracted by H and CH_(3) *** multistructural torsional anharmonicities of H-abstraction reactions MP+H/CH_(3) are significant within the temperature range *** tunneling effects are more pronounced at low temperatures,and contribute considerably to the rate constants below 500 *** model from the work of Diévart et *** updated with our calculations,and the simulations of the updated model are in excellent agreement with the reported ignition delay time of MP/O2/Ar and MP/Air *** s.nsitivity analysis indicates that the H-abstraction reactions,MP+H-CH_(3)CH_(2)CHCH_(2)C(-O)OCH_(3)/CH_(3)CHCH_(2)CH_(2)C(-O)OCH_(3)+H2,are critical in controlling the initial fuel consumption and ignition delay time of MP.

关键词： Methyl pentanoate H-Abstraction Dual-level Ms-T Ignition delay time Kinetic modeling

A Cyber-Attack Detection system Us.ng Late Fusion Aggregation Enabled Cyber-net

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Intelligent Automation & soft Computing 2023年第6期36卷 3101-3119页

作者： P.shanmuga prabha s.Magesh Kumar Department of Computer science and Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical Sciences(Deemed to be University)ChennaiTamilnaduIndia

Today,securing devices connected to the internet is challenging as security threats are generated through various *** protection of cyber-physical systems from external attacks is a primary *** pres.nted method is planned on the prime motive of detecting cybersecurity attacks and their impacted *** proposed architecture employs the LYsIs dataset and formulates Multi Variant Exploratory Data Analysis(MEDA)through Principle Component Analysis(PCA)and s.ngular Value Decompo-sition(sVD)for the extraction of unique *** feature mappings are analyzed with Recurrent 2 Convolutional neural network(R2Cnn)and Gradient Boost Regression(GBR)to identify the maximum *** Late Fusion Aggregation enabled with Cyber-net(LFAEC)is the robust derived *** quantitative analysis uses predicted threat points with actual threat variables from which mean and difference vectors *** performance of the pres.nted system is assessed against the parameters such as Accuracy,Precision,Recall,and F1 *** proposed method outperformed by 98% to 100% in all quality measures compared to existing methods.

关键词： External attacks cyber-physical systems principle component analysis s.ngular value decomposition recurrent 2 convolutional neural network gradient boost regression

An Efficient stacked-LsTM Based User Clustering for 5G nOMA systems

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Computers, Materials & Continua 2022年第9期72卷 6119-6140页

作者： s.prabha Kumares.n Chee Keong Tan Yin Hoe ng Faculty of Engineering Multimedia UniversityCyberjaya63100Malaysia school of Information Technology Monash UniversitySubang Jaya47500Malaysia

non-orthogonal multiple access.nOMA)has been a key enabling technology for the fifth generation(5G)cellular *** on the nOMA principle,a traditional neural network has been implemented for user clustering(UC)to maximize the nOMA system’s throughput performance by considering that each sample is independent of the prior and the subsequent ***,the prediction of UC for the future ones is based on the current clustering information,which is.never used again due to the lack of memory of the ***,to relate the input features of nOMA users and capture the dependency in the clustering information,time-series methods can assist us in gaining a helpful insight into the *** its mathematical complexity,the ess.nce of time series comes down to examining past behavior and extending that information into the ***,in this paper,we propose a novel and effective stacked long short term memory(s-LsTM)to predict the UC formation of nOMA users to enhance the throughput performance of the 5G-based nOMA *** the proposed strategy,the s-LsTM is modelled to handle the time-series input data to improve the predicting accuracy of UC of the nOMA users by implementing multiple LsTM layers with hidden *** implemented LsTM layers have feedback connections that help to capture the dependency in the clustering information as it propagates between the ***,we develop,train,validate and test the proposed model to predict the UC formation for the futures ones by capturing the dependency in the clustering information based on the time-series *** results demonstrate that the proposed scheme effectively predicts UC and thereby attaining near-optimal throughput performance of 98.94%compared to the exhaustive search method.

关键词： non-orthogonal multiple access.nOMA) deep neural network(Dnn) long short term memory(LsTM) temporal channel user clustering