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Scenario Ge.e.ation for Cooling,Heating,and Power Loads Using Ge.e.ative Moment Matching Networks

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CSee Journal of Power and e.e.gy Systems 2022年第6期8卷 1730-1740页

作者： Wenlong Liao Yusen Wang Yuelong Wang Kody powell Qi Liu Zhe Yang Department of e.e.gy Technology Aalborg UniversityAalborg 9220Denmark School of e.e.trical engineering and Computer Science KTH Royal Institute of TechnologyStockholmSE-10044Sweden State Grid Tianjin Chengxi e.e.tric Power Supply Branch Tianjin 300100China Department of Chemical engineering University of UtahUT 84112America Key Laboratory of Smart Grid of Ministry of education Tianjin UniversityTianjin 300072China

Scenario ge.e.ations of cooling,heating,and power loads are of great significance for the.e.onomic operation and stability analysis of integrated e.e.gy *** this paper,a novel deep ge.e.ative network is proposed to model cooling,heating,and power load curves based on ge.e.ative moment matching networks(GMMNs)whe.e.an auto-encoder transforms highdimensional load curves into low-dimensional latent variables and the maximum mean discrepancy repre.e.ts the similarity metrics between the ge.e.ated samples and the real *** training the model,the new scenarios are ge.e.ated by feeding Gaussian noises to the scenario ge.e.ator of the *** the.e.plicit density models,the proposed GMMN does not need to artificially assume the probability distribution of the load curves,which leads to stronger *** simulation results show that the GMMN not only fits the probability distribution of multiclass load curves very well,but also accurately captures the shape.e.g.,large peaks,fast ramps,and fluctuation),frequency-domain characteristics,and temporal-spatial correlations of cooling,heating,and power ***,the.e.ergy consumption of ge.e.ated samples closely re.e.bles that of real samples.

关键词： Deep learning ge.e.ative moment matching networks integrated e.e.gy systems scenario ge.e.ations

Comparative.e.ficacy of gypsy moth(Lepidoptera:e.e.idae.e.tomopathogens on transgenic blight-tolerant and wild-type American,Chine.e.and hybrid chestnuts(Fagales:Fagace.e.

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Insect Science 2020年第5期27卷 1067-1078页

作者： Aaron J.Brown Andrew e.Newhouse William A.powell Dylan Parry Department of environmental and Forest Biology College of Environmental Science and ForestryState University of New YorkSyracuseNY13210USA

American chestnut(Castanea dentata[Marsh.]Borkh.)was once the dominant hardwood species in eastern North America before an exotic fungal pathogen,Cryphonec-tria parasitica(Murrill)Barr,functionally eliminated it across its *** promising approach toward restoring American chestnut to natural forests is de.e.opment of blight-tolerant trees using ge.e.ic ***,transformation and related processes can result in unexpected and unintended phenotypic changes,potentially altering ecologi-cal *** assess unintended tritrophic impacts of transgenic American chestnut on plant herbivore interactions,gypsy moth(Lymantria dispar L.)caterpillars we.e.fed leaf disks excised from two transgenic e.e.ts,Darling 54 and Darling 58,and four control American chestnut *** disks we.e.previously treated with an LDso dose of either the spe.e.-specific Lymantria dispar multiple nucleopolyhedrovirus(LdMNPV)or the ge.e.alist pathogen Bacillus thuringiensis ***(Btk).Mortality was quantified and compared to water blank *** genotype had a strong e.e.t on the.e.ficacies of both *** mortality from Btk-treated foliage from only one transgenic e.e.t,Darling 54,diffe.e. from its isogenic progenitor,ellis l,but was similar to an unre-lated wild-type American chestnut *** efficacy was unaffected by ge.e.ic *** suggest that although ge.e.ic modification of trees may affect interactions with other nontarget organisms,this may be due to insertion effects,and varia-tion amnon diMte.e.t genvtypes(wlether uasgeic ul wild-typc)iupaults a giealci change in response than transge.e.pre.e.ce.

关键词： Bacillus thuringiensis LdMNPV nontarget restoration tri-trophic unin-tended effects

The small hive beetle Aethina tumida： A review of its biology and control measures

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Current Zoology 2013年第5期59卷 644-653页

作者： Andrew G. S. CUTHBeRTSON Maureen e. WAKeFIeLD Michelle.e. powell Gay MARRIS He.e. ANDeRSON Giles e. BUDGe James J. MATHeRS Lisa F.BLACKBURN Mike A. BROWN The Food and environment Re.e.rch Agency Sand Hutton York YO41 1LZ UK

The small hive beetle.e.hina tumidais an endemic parasitic pest and scavenger of colonies of social bees indigenous to sub-Saharan Africa. In this region this species rarely inflicts se.e.e damage on strong colonies since the bees have de.e.oped strategies to combat them. Howe.e.,A. tumidahas since ‘escaped’ from its native home and has re.e.tly invaded areas such as North America and Australia whe.e.its economic impact on the apiculture industry has been significant. Small hive beetle, should it become.e.tablished within europe, repre.e.ts a real and live threat to the UK bee keeping industry. He.e.we review the biology and current pest status ofA. tumidaand up to-date re.e.rch in terms of both chemical and biological control used against this honey bee pest.

关键词：生物控制生物学甲虫蜂房澳大利亚有害生物蜜蜂撒哈拉

培美曲塞加铂类联合或不联合帕博利珠单抗对初治转移性非鳞状NSCLC患者的疗效与安全性分析：KeYNOTe-189研究方案指定的最终分析

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中国肺癌杂志 2022年第6期25卷 443-456页

作者：周彩存 Delvys RODRíGUeZ-ABReU S.F.powell M.J.HOCHMAIR S.GAD GeeL e.e.TeBAN e.FeLIP G.SPeRANZA F.De ANGeLIS M.DóMINe S.Y.CHeNG H.G.BISCHOFF N.Pe.e. M.ReCK R.HUI e.B.GARON M.BOYeR T.KURATA J.YANG M.C.PIeTANZA F.SOUZA M.C.GARASSINO 同济大学附属上海市肺科医院肿瘤科 Medical Oncology Complejo Hospitalario Universitario Insular Materno-Infantil de Gran CanariaUniversidad de Las Palmas de Gran Canaria Oncology Sanford Health 4. Department of Respiratory and Critical Care MedicineKarl Landsteiner Institute of Lung Research and Pulmonary Oncology Thoracic Oncology Karmanos Cancer InstituteWayne State University Department of Medical Oncology Hospital Universitario Central de Asturias Medical Oncology Department Vall d'Hebron UniversityVall d'Hebron Institute of Oncology (VHIO) 8. Centre Integre de Cancerologie de la MontérégieH?pital Charles-Le Moyne 9. Medical Oncology DepartmentHospital Universitario Fundacidn Jiménez DiazIIS-FJD Sunnybrook Health Sciences Centre Thoraxklinik Heidelberg Department of Oncology Shaare Zedek Medical Center LungenClinic Airway Research Center NorthGerman Center for Lung Research Department of Medical Oncology Westmead Hospital and University of Sydney Department of Medicine David Geffen School of Medicine at UCLA Department of Medical Oncology Chris O'Brien Lifehouse Department of Thoracic Oncology Kansai Medical University Hospital Merck & Co. Inc. Fondazione IRCCS Istituto Nazionale dei Tumori University of Chicago Medicine & Biological Sciences Knapp Center for Biomedical Discovery

背景在KeYNOTe-189此项Ⅲ期研究(NCT02578680)中,与安慰剂联合培美曲塞加铂类相比,帕博利珠单抗联合培美曲塞加铂类化疗(培美曲塞-铂类)显著改善了初治转移性非鳞状非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的总生存期(over... 详细信息

背景在KeYNOTe-189此项Ⅲ期研究(NCT02578680)中,与安慰剂联合培美曲塞加铂类相比,帕博利珠单抗联合培美曲塞加铂类化疗(培美曲塞-铂类)显著改善了初治转移性非鳞状非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的总生存期(overall survival,OS)和无进展生存期(progression-free survival,PFS)。本研究报告了研究方案指定的最终分析的疗效结局,包括从培美曲塞-铂类交叉至帕博利珠单抗治疗的患者,以及完成35个周期(约2年)帕博利珠单抗治疗组的疗效。方法符合条件的患者以2:1随机分配至帕博利珠单抗,每3周一次,200 mg (n=410)或安慰剂(n=206)(共35周期,约2年),加上4个周期的培美曲塞(500 mg/m~2)和由研究者选择的每3周顺铂(75 mg/m~2)或卡铂(曲线下面积5 mg/min/mL)治疗,随后使用培美曲塞直至疾病进展。若符合纳入标准,分配至安慰剂联合培美曲塞加铂类治疗的患者可在疾病进展时转向帕博利珠单抗治疗。主要研究终点为OS和PFS。结果中位随访31.0个月,无论PD-L1的表达水平如何,与安慰剂联合培美曲塞-铂类治疗相比,帕博利珠单抗联合培美曲塞-铂类治疗可使患者的OS[风险比(hazard ratio,HR)为0.56;95%可信区间(confidence interval,CI) 0.46-0.69]和PFS (HR=0.49;95%CI:0.41-0.59)显著获益。接受帕博利珠单抗联合培美曲塞-铂类治疗的患者客观缓解率(objective response rate,ORR)(48.3%vs 19.9%)和第二次/后续无进展生存期(PFS2;HR=0.50;95%CI:0.41-0.61)均得到改善。安慰剂联合培美曲塞-铂类组的84例患者(40.8%)交叉至帕博利珠单抗治疗组。72.1%的接受帕博利珠单抗联合培美曲塞-铂类的患者和66.8%的接受安慰剂联合培美曲塞-铂类的患者发生了3级-5级不良事件。56例患者完成了35个周期(约2年)的帕博利珠单抗治疗;ORR为85.7%,53例(94.6%)患者存活至数据截止时间。结论与安慰剂联合培美曲塞-铂类治疗相比,帕博利珠单抗联合培美曲塞-铂类可持续提高疗效,且安全性可控。该研究结果支持将帕博利珠单抗联合培美曲塞-铂类作为初治转移性非鳞状NSCLC患者的一线治疗方案。

关键词：帕博利珠单抗化疗非鳞状非小细胞肺癌

Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment epithelium over Time

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Genomics, Proteomics & Bioinformatics 2021年第2期19卷 223-242页

作者： Grace.e.Lidgerwood Anne Senabouth Casey J.A.Smith-Anttila Vikkitharan Gnanasambandapillai Dominik C.Kaczorowski Daniela Amann-Zalcenstein erica L.Fletcher Shalin H.Naik Alex W.Hewitt Joseph e.powell Alice Pebay Department of Anatomy and Neuroscience The University of MelbourneParkvilleVIC 3010Australia Department of Surgery The University of MelbourneParkvilleVIC 3010Australia Centre for e.e.Re.e.rch Australia Royal Victorian Eye and Ear HospitalEast MelbourneVIC 3002Australia Garvan Weizmann Centre for Cellular Genomics Garvan Institute of Medical ResearchThe Kinghorn Cancer CentreDarlinghurstNSW 2010Australia Single Cell Open Re.e.rch endeavour The Walter and Eliza Hall Institute of Medical ResearchParkvilleVIC 3052Australia Immunology Division The Walter and Eliza Hall Institute of Medical ResearchParkvilleVIC 3052Australia Department of Medical Biology The University of MelbourneParkvilleVIC 3010Australia School of Medicine Menzies Institute for Medical ResearchUniversity of TasmaniaHobartTAS 7005Australia UNSW Cellular Genomics Futures Institute School of Medical SciencesUniversity of New South WalesSydneyNSW 2052Australia

Human pluripotent stem cell(h PSC)-derived progenies are immature versions of cells,pre.e.ting a potential limitation to the accurate modelling of diseases associated with maturity or ***,it is important to characterise how closely cells used in culture re.e.ble their native *** order to se.e.t appropriate time points of retinal pigment epithelium(RPe)cultures that reflect native counterparts,we characterised the transcriptomic profiles of the h PSC-derived RPe cells from 1-and 12-month *** diffe.e.tiated the human embryonic stem cell line H9 into RPe cells,performed single-cell RNA-sequencing of a total of 16,576 cells to assess themolecular changes of the RPe cells across the.e.two culture time *** results indicate the stability of the RPe transcriptomic signature,with no evidence of an epithelial–me.e.chymal transition,and with the maturing populations of the RPe observed with time in *** of Ge.e.Ontology pathways re.e.led that as the cultures age,RPe cells upregulate.e.pression of ge.e. involved in metal binding and antioxidant *** might reflect an increased ability to handle oxidative stress as cells *** with native human RPe data confirms a maturing transcriptional profile of RPe cells in *** results suggest that long-term in vitro culture of RPe cells allows the modelling of specific phenotypes observed in native mature *** work highlights the transcriptional landscape of h PSC-derived RPe cells as they age in culture,which provides a re.e.ence for native and patient samples to be benchmarked against.

关键词： Human embryonic stem cell Human pluripotent stem cell Retinal pigment epithelium Single-cell RNA sequencing Ageing

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PLGA nanodepots co-encapsulating prostratin and anti-CD25 enhance primary natural killer cell antiviral and antitumor function

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Nano Re.e.rch 2020年第3期13卷 736-744页

作者： elizabeth e.Swee.e. Preethi B.Balakrishnan Allison B.powell Allan Bowen Indra Sarabia Rachel A.Burga R.Brad Jones Alberto Bosque C.Russell Y.Cruz Rohan Fernandes The George Washington Cancer Center The George Washington UniversityWashingtonDC20052USA Center for Cancer and Immunology Re.e.rch Children’s National Health SystemWashingtonDC20010USA Department of Microbiology Immunologyand Tropical MedicineThe George Washington UniversityWashingtonDC20052USA Infectious Disease Division Weill Cornell Medical CollegeNew YorkNY10065USA View author publications Department of Medicine The George Washington UniversityWashingtonDC20052USA

Natural killer(NK)cells are attractive.e.fector cells of the innate immune system against human immunodeficiency virus(HIV)and ***,NK cell therapies are limited by the fact that target cells evade NK cells,for example,in latent re.e.voirs(in HIV)or through upregulation of inhibitory signals(in cancer).To address this limitation,we describe a biodegradable nanoparticlebased“priming”approach to enhance the cytotoxic efficacy of peripheral blood mononuclear cell-derived NK *** pre.e.t poly(lactic-co-glycolic acid)(PLGA)nanodepots(NDs)that co-encapsulate prostratin,a latency-re.e.sing agent,and anti-CD25(aCD25),a cell surface binding antibody,to enhance primary NK cell function against HIV and *** utilize a nanoemulsion synthesis sche.e.to encapsulate both prostratin and aCD25 within the PLGA NDs(termed Pro-aCD25-NDs).Physicochemical characterization studies of the NDs demonstrated that our synthesis sche.e.resulted in stable and monodisperse *** NDs successfully re.e.sed both active prostratin and anti-CD25,and with controllable re.e.se *** Pro-aCD25-NDs we.e.administe.e. in an in vitro model of latent HIV and acute T cell leukemia using J-Lat 10.6 cells,the NDs we.e.observed to prime J-Lat cells resulting in significantly increased NK cell-mediated cytotoxicity compared to free prostratin plus anti-CD25,and other *** findings demonstrate the feasibility of using our Pro-aCD25-NDs to prime target cells for enhancing the cytotoxicity of NK cells as antiviral or antitumor agents.

关键词： poly(lactic-co-glycolic acid)(PLGA)nanodepots natural killer(NK)cells human immunodeficiency virus(HIV) cancer latency-re.e.sing agent antibody

Coordinated AR and microRNA regulation in prostate cancer

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Asian Journal of Urology 2020年第3期7卷 233-250页

作者： Ieva eringyte Joanna N.Zamarbide Losada Sue M.powell Charlotte L.Bevan Claire.e.Fletcher Imperial Centre for Translational and experimental Medicine Department of Surgery and CancerImperial College LondonHammersmith HospitalLondonUnited Kingdom

The androgen re.e.tor(AR)remains a key driver of prostate cancer(PCa)progression,e.e. in the advanced castrate-resistant stage,whe.e.testicular androgens are *** is the.e.ore of critical importance to understand the molecular mechanisms governing its activity and regulation during prostate ***(miRs)are small w22 nt noncoding RNAs that regulate target ge.e.often through association with 30 untranslated regions(30UTRs)of *** display dysregulation during cancer progression,can function as oncoge.e. or tumour suppressors,and are increasingly recognised as targets or regulators of hormonal ***,understanding factors which modulate miRs synthesis is *** is increasing evidence for complex and dynamic bi-directional cross-talk between the multi-step miR bioge.e.is cascade and the AR signalling axis in *** review summarises the wealth of mechanisms by which miRs are regulated by AR,and conversely,how miRs impact AR’s transcriptional activity,including that of AR splice *** addition,we assess the implications of the convergence of the.e.pathways on the clinical employment of miRs as PCa biomarkers and therapeutic targets.

关键词： MicroRNA Androgen re.e.tor Androgen Prostate cancer Hormone Non-coding RNA

Mechanical suppression of breast cancer cell invasion and paracrine signaling to osteoclasts requires nucleo-cytoske.e.al connectivity

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Bone Re.e.rch 2020年第4期8卷 393-405页

作者： Xin Yi Laura e.Wright Gabriel M.Pagnotti Gunes Uzer Katherine M.powell Joseph M.Wallace Uma Sankar Clinton T.Rubin Khalid Mohammad The.e.a A.Guise William R.Thompson Department of Physical Therapy School of Health and Rehabilitation SciencesIndiana UniversityIndianapolisIN 46202USA Department of Medicine Division of EndocrinologySchool of MedicineIndiana UniversityIndianapolisIN 46202USA Department of Mechanical and Biomedical engineering Boise State UniversityBoiseID 83725USA Department of Biomedical engineering Purdue School of Engineering and TechnologyPurdue UniversityIndianapolisIN 46202USA Department of Anatomy&Cell Biology Indiana UniversityIndianapolisIN 46202USA Department of Biomedical engineering Stony Brook UniversityStony BrookNY 11794USA

e.e.cise be.e.its the musculoske.e.al system and reduces the.e.fects of *** effects of e.e.cise are multifactorial,whe.e.metabolic changes and tissue adaptation influence *** signals,a principal component of e.e.cise,are anabolic to the musculoske.e.al system and restrict cancer *** examined the mechanisms through which cancer cells sense and respond to low-magnitude mechanical signals introduced in the form of ***-magnitude,high-frequency vibration was applied to human breast cancer cells in the form of low-intensity vibration(LIV).LIV decreased matrix invasion and impaired secretion of osteolytic factors PTHLH,IL-11,and ***,paracrine signals from mechanically stimulated cancer cells,reduced osteoclast diffe.e.tiation and resorptive *** the nucleus by knockdown of SUN1 and SUN2 impaired LIV-mediated suppression of invasion and osteolytic factor *** increased cell stiffness;an effect de.e.dent on the LINC *** data show that mechanical vibration reduces the metastatic potential of human breast cancer cells,whe.e.the nucleus serves as a mechanosensory apparatus to alter cell structure and intercellular signaling.

关键词： invasion impaired ske.e.al

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Macrophage secretory products induce an inflammatory phenotype in hepatocytes

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World Journal of Gastroenterology 2012年第15期18卷 1732-1744页

作者： Michelle Melino Victoria L Gadd Ge.e.V Walker Richard Skoien He.e. D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson elizabeth e powell Centre for Liver Disease Re.e.rch School of MedicineThe University of QueenslandPrincess Alexandra HospitalBrisbane 4102QueenslandAustralia Department of Gastroenterology and Hepatology Princess Alexandra HospitalBrisbane 4102QueenslandAustralia Institute for Molecular Bioscience and Australian Infectious Diseases Re.e.rch Centre The University of QueenslandBrisbane 4072QueenslandAustralia Diamantina Institute The University of QueenslandBrisbane 4102QueenslandAustralia

AIM:To investigate the influence of macrophages on hepatocyte phenotype and ***:Macrophages we.e.diffe.e.tiated from THP-1 monocytes via phorbol myristate acetate stimulation and the.e.fects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression *** in vivo re.e.ance of the.e.findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)***:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,Pegulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA *** analysis re.e.led significant upregulation of lipocalin-2(17-fold,P ed with inflammation,and substantial downregulation of pathways related to hepatocyte *** patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver *** performance liquid chromatography-tandem mass spectrometry analysis identified e.e.ated le.e.s of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,Pe-conditioned media treated HepG2 *** patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of ***:Secre.e. macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participat

关键词：细胞分泌肝细胞诱导 mRNA表达 HepG2细胞丙型肝炎病毒转化生长因子 MMP-9