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In Vivo Animal Model Evaluation of a Powerful Oral Nanomedicine for Treating Breast Cancer in BALB/c Mice Using 4T1 Cell Lines without Chemotherapy

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Advances in Nanoparticles 2022年第3期11卷 73-109页

作者： Zahra Fakhroueian Alireza Massiha Pegah esmaeilzadeh Mehdi Assmar Afshin Zahedi pouriya esmaeilzadeh Sara Rezaei Shahab Rabiei Lalehdasht School of Chemical Engineering (Nanomedicine) College of Engineering University of Tehran Tehran Iran Department of Biotechnology Lahijan Branch Islamic Azad University Lahijan Iran Institute of Pharmacy Martin Luther University Halle Wittenberg Halle (Saale) Germany Department of Microbiology Lahijan Branch Islamic Azad University Lahijan Iran Department of Veterinary Pathology Islamic Azad University Rasht Branch Rasht Iran Department of Chemical Engineering Sharif University of Technology Tehran Iran Research Department Production and Laboratory Company ZFP Rasht Iran Department of Biology Faculty of Science Rasht Branch Islamic Azad University Guilan Iran

Nanopharmaceuticals containing quantum dot nanoparticles (Q-Dot NPs) for treating serious cancers such as breast cancer have made fantastic proposals. In this study, ZnO quantum dot NPs are formulated via ZnO@PVP nanopolymer as co-assistants coordinating with efficacious suitable wetting agents, PEG-binding compound, and W/O emulsifier for producing eco-friendly water-based nanodrug. Several characterization techniques containing SEM, TEM, FTIR, photoluminescence, zeta potential, and UV-Vis absorption were employed for ZnO Q-Dot NPs in nanodrug. This work aims to investigate the anti-tumor effects of such nanomedicine on the 4T1 breast cancer cell line in BALB/c mice, being elaborated through intraperitoneal, injection (IVP) and oral therapy. The impressive findings showed that ZnO nanodrug caused changes in blood factors, having the most effectiveness at 40 μg/ml concentration after two weeks of oral treatments. The significant increase in white blood cells (WBC) neutrophils and meaningful decreases in lymphocytes and especially cholesterol were powerful simultaneous impacts, successfully treating malignant breast cancer masses. In this significant animal model research for breast cancer, the sick mice recovered entirely and even had a safe space to mate. Histopathological results showed no evidence of breast tumor formation or metastasis in the group treated with nanodrug and their children. This nanomedicine has a therapeutic effect, and is ready to be applied for treating volunteer breast cancer patients. However, its prevention (inhibitory) effect can also be analyzed and added to current data in future studies.

关键词： Nanomedicine Nanodrug ZnO Q-Dot NPs In Vivo Breast Cancer BALB/c Mice 4T1 Cell Lines Metastasis Oral Treatment

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Synthesis and Characterization of Various Protein <i>α</i>-Lactalbumin Nanotubes Structures by Chemical Hydrolysis Method

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Advances in Nanoparticles 2013年第2期2卷 154-164页

作者： Pegah esmaeilzadeh Zahra Fakhroueian pouriya esmaeilzadeh Narges Mohammadi Biomedical Material Department Institute of Pharmacy Martin Luther University Halle-Wittenberg Germany College of Chemical Engineering University of Tehran Tehran Iran Department of Chemistry College of Science Alzahra University Tehran. Iran Process simulation and control Lab. Chemical Engineering Collage Iran University of Science and Technology (IUST) Tehran Iran

New water-based nanofluids including unparalleled milk protein α-lactalbumin hollow nano-bio-tubes using low cost, available and advanced partial chemical hydrolysis strategy in bottom-up nano-assembly have been employed in this work. The aqueous sol-gel chemistry in nanotechnology which we selected for this goal offers new fabrication as interesting smart protein nanotubes. The kinds of nanometer sized tubular structures such as waved, helically coiled, bent, bamboo-shaped, bead-like and branched single-walled protein nanotubes (SWPNTs) with a range of 3 - 8 nm in outer diameters were produced by this method. Complete characterization for natural produced nanotubes including SEM, TEM images, G bond and D bond in Raman spectroscopy, XRD patterns, DLS (Dynamic Light Scattering) and FTIR analysis were evaluated which they are most significant experiments in synthesized protein nanotubes soluble in clear water nanofluids and stabilization of transparent nanofluids was proved within more than one year after preparation. Various necessary ligand ion salts such as Mn2+, Zn2+ and Ca2+ or mixtures as bridge makers and producing biological self-assembly hollow SWPNTs were performed and we focused on new chemical technology under specific acidic hydrolysis method not conventional enzymatic proteolysis and applying surfactants, pH reagent, Tris-HCl buffer, polar solvent which could be produced by β-sheet stacked hydrolysed protein α-lactalbumin mechanism under appropriate conditions to achieving high efficiency new protein nanotubes skeleton. They can be promising materials applied in food science, diet nutrition, nanomedicine, nano-biotechnology and surgery.

关键词： Nanobiotechnology Milk Protein Nanotubes Helical Self-Assembly Water-Based Nanofluids Chemical Hydrolysis Nanomedicine

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