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Praziquantel decreases fecundity in Schistosoma mansoni adult worms that survive treatment:evidence from a laboratory life-history trade-offs selection study

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Infectious Diseases of Poverty 2017年第1期6卷 988-998页

作者： poppy h.l.lamberton Christina l.Faust Joanne P.Webster Institute for Biodiversity Animal Healthand Comparative Medicine&Wellcome Centre for Molecular ParasitologyCollege of MedicalVeterinary&Life SciencesUniversity of GlasgowG128QQGlasgowUK london Centre for Neglected Tropical Disease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonSt Mary’s CampusW21PGLondonUK Centre for Endemic Emerging and Exotic DiseasesThe Royal Veterinary CollegeUniversity of LondonLondon AL97TAUK

Background:Mass drug administration of praziquantel is the World health Organization’s endorsed control strategy for schistosomiasis.A decade of annual treatments across sub-Saharan Africa has resulted in significant reductions of infection prevalence and intensity levels,although‘hotspots’*** drug treatments place strong selective pressures on parasites,which may affect life-history traits that impact transmission *** drug treatment responses and the evolution of such traits can help inform on how to minimise the risk of drug resistance developing,maximise sustainable control programme success,and improve diagnostic ***:We performed a four-generation Schistosoma mansoni praziquantel selection experiment in mice and *** used three *** lines:a praziquantel-resistant isolate(R),a praziquantel-susceptible isolate(S),and a coinfected line(RS),under three treatment regimens:untreated,25 mg/kg praziquantel,or 50 mg/kg *** traits,including parasite adult-worm establishment,survival,reproduction(fecundity),and associated morbidity,were recorded in mice across all four *** variables were tested in a series of generalized linear mixed effects models to determine which factors had a significant influence on parasite life-history traits in definitive hosts under different selection ***:Praziquantel pressure significantly reduced adult-worm burdens across all generations and isolates,including within ***,previous drug treatment resulted in an increase in adult-worm establishment with increasing generation from P1 to *** highest worm numbers were in the co-infected RS *** treatment decreased adult-worm burden,but had a larger negative impact on the mean daily number of miracidia,a proxy for fecundity,across all three parasite ***:Our predicted cost of resistance was not supported by the traits we measured within the murine host.

关键词： Schistosoma mansoni Biomphalaria Mouse Praziquantel Resistance Establishment Survival Fecundity Trade-offs

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harnessing endothelial cells and vascularization strategies for nerve regeneration

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Neural Regeneration Research 2024年第11期19卷 2337-2338页

作者： Papon Muangsanit poppy Smith Virology and Cell Technology Research Team National Center for Genetic Engineering and Biotechnology(BIOTEC)National Science and Technology Development Agency(NSTDA)PathumthaniThailand UCl Centre for Nerve Engineering UCLLondonUK Department of Pharmacology UCL School of PharmacyUCLLondonUK

Peripheral nerves are essential components of the human body’s communication system,transmitting signals between the central nervous system and various body *** resulting from trauma or disease can result in debilitating sensory and motor *** injuries,particularly those resulting in significant gaps in the nerve tissue,pose a formidable challenge for clinicians and *** their limitations,including limited availability and donor site morbidity,nerve autografts remain the clinical gold standard for treating nerve injuries.

关键词： injuries nerves donor

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Predictors of 30-day readmission following pancreatic surgery:A retrospective review

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hepatobiliary & Pancreatic Diseases International 2018年第3期17卷 269-274页

作者： leo I.Amodu Jamil Alexis Aron Soleiman Meredith Akerman poppy Addison Toni Iurcotta horacio l.Rodriguez Rilo Department of Surgery Hofstra-Northwell School of Medicine Pancreas Disease Center Northwell Health Department of Biostatistics Feinstein Institute for Medical Research

Background： Pancreatectomies have been identified as procedures with an increased risk of *** surgical patients, readmissions within 30 days of discharge are usually procedure-related. We sought to determine predictors of 30-day readmission following pancreatic resections in a large healthcare ***： We retrospectively collected information from the records of 383 patients who underwent pancreaticresections from 2004–2013. To find the predictors of readmission in the 30 days after discharge,we performed a univariate screen of possible variables using the Fisher’s exact test for categorical variables and the Mann–Whitney U test for continuous variables. Multivariate analysis was used to determinethe independent factors.

关键词： Pancreatic Predictors Readmission Resection Risk30-day

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Biodiesel production from waste cooking oil using calcium oxide derived from scallop shell waste

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Clean Energy 2024年第2期8卷 113-126页

作者： poppy Puspitasari Diki Dwi Pramono Davi Nur Fiansyah Avita Ayu Permanasari Nandang Mufti Jeefferie Abd Razak Department of Mechanical and Industrial Engineering Universitas Negeri MalangMalangIndonesia Centre of Advanced Material and Renewable Energy Universitas Negeri MalangMalangIndonesia Department of Physics Faculty of Mathematics and Natural SciencesUniversitas Negeri MalangMalangIndonesia Fakulti Kejuruteraan Pembuatan Universiti Teknikal Malaysia MelakaMelakaMalaysia

Biodiesel is one of the alternative forms of diesel fuel and can be obtained using the transesterification process of waste cooking oil with a catalyst to accelerate the *** heterogeneous catalyst from waste scallop shells is used due to its potential for being reused in the subsequent transesterification *** catalysts can also be recycled,contributing to their environmentally friendly *** study aims to identify the performance of recycling a calcium oxide(CaO)catalyst from scallop shell waste on synthesis *** method used is the transesterification method with the basic ingredients of waste cooking oil using a CaO ***,after the transesterification process is complete,the catalyst is separated from the biodiesel and recycled to be reused in the transesterification process up to five *** biodiesel samples obtained are identified for yield value,physico-chemical properties,thermal properties and performance.X-ray diffraction characterization results for the CaO catalyst show that it has a crystal size of 67.83 *** electron microscope characterization shows that it has spherical particle *** transform infrared characterization shows the presence of Ca-O *** highest biodiesel yield value of 74.23%is obtained in biodiesel Cycle *** flash point value of biodiesel samples ranges from 141.2℃ to 149℃.Further,all of the biodiesel samples exhibit a cetane number of *** highest lower heating value of 38.22 MJ/kg is obtained in biodiesel Cycle 1 and the viscosity of the biodiesel samples ranges from 5.65 to 5.88 *** density of the biodiesel samples ranges from 881.23 to 882.92 kg/***,ester functional groups(C=O)and methyl functional groups have been successfully formed in all samples,with the methyl oleate compound observed as dominating the biodiesel *** cloud point value of the biodiesel samples ranges from 12℃ to 13℃,and their pour point value ranges from 10℃ to

关键词： biodiesel CaO catalyst waste cooking oil scallop shell

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Outcomes following operative vs. non-operative management of blunt traumatic pancreatic injuries: a retrospective multi-institutional study

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Burns & Trauma 2016年第4期4卷 316-322页

作者： poppy Addison Toni Iurcotta leo I.Amodu Geoffrey Crandall Meredith Akerman Daniel Galvin Annemarie Glazer Nathan Christopherson Jose Prince Matthew Bank Christopher Sorrentino Joaquin Cagliani Jeffrey Nicastro Gene Coppa Ernesto P.Molmenti horacio l.Rodriguez Rilo Department of Surgery Hofstra-Northwell School of MedicineHempsteadNYUSA Pancreas Disease Center Northwell HealthManhassetNYUSA Department of Surgery Hofstra-Northwell School of MedicineHempsteadNYUSA Department of Biostatistics Feinstein Institute for Medical ResearchManhassetNYUSA Pancreas Disease Center Northwell HealthManhassetNYUSA Department of Surgery Hofstra-Northwell School of MedicineHempsteadNYUSA Pancreas Disease Center Northwell HealthManhassetNYUSA Northwell health 900 Northern BoulevardSuite 150Great NeckNY 11020USA

Background:Traumatic pancreatic injuries are rare,and guidelines specifying management are controversial and difficult to apply in the acute clinical *** to sparse data on these injuries,we carried out a retrospective review to determine outcomes following surgical or non-surgical management of traumatic pancreatic *** hypothesize a higher morbidity and mortality rate in patients treated surgically when compared to patients treated ***:We performed a retrospective review of data from four trauma centers in New York from 1990–2014,comparing patients who had blunt traumatic pancreatic injuries who were managed operatively to those managed *** compared continuous variables using the Mann-Whitney U test and categorical variables using the chi-square and Fisher’s exact *** analysis was performed to determine the possible confounding factors associated with mortality in both treatment ***:Twenty nine patients were managed operatively and 32 *** was a significant difference between the operative and non-operative groups in median age(37.0 vs.16.2 years,P=0.016),grade of pancreatic injury(grade I;30.8 vs.85.2%,P value for all comparisonslood transfusion(55.2 vs.15.6%,P=0.0012),other abdominal injuries(79.3 vs.38.7%,P=0.0014),pelvic fractures(17.2 vs.0.00%,P=0.020),intensive care unit(ICU)admission(86.2 vs.50.0%,P=0.003),median length of stay(lOS)(16.0 vs.4.0 days,Plity(27.6 vs.3.1%,P=0.010).Conclusions:Patients with traumatic pancreatic injuries treated operatively were more severely injured and suffered greater complications than those treated *** greater morbidity and mortality associated with these patients warrants further study to determine optimal triage strategies and which subset of patients is likely to benefit from surgery.

关键词： Injury Management Non-operative Operative Pancreas Trauma

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用荟萃分析法评估酵母培养物对奶牛生产性能的影响

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饲料工业 2013年第19期34卷 40-44页

作者： Gerald D.poppy 钟懿华(译) 美国达农威公司美国依阿华州锡达拉匹兹52404

以荟萃分析方法(meta-analysis)总结评估某一酵母培养物产品对改善奶牛生产性能的功效。其结果已于2012年发表于国际奶牛研究权威期刊——美国乳业科学期刊(*** Sci.95:6027-6041)。共计有36篇经同行评审的试验研究论文达到了荟萃分析... 详细信息

以荟萃分析方法(meta-analysis)总结评估某一酵母培养物产品对改善奶牛生产性能的功效。其结果已于2012年发表于国际奶牛研究权威期刊——美国乳业科学期刊(*** Sci.95:6027-6041)。共计有36篇经同行评审的试验研究论文达到了荟萃分析特定的质量要求。研究结果显示,给奶牛饲喂该酵母培养物每天能额外增加1.18 kg的乳产量、1.61 kg的3.5%乳脂校正乳产量、1.65 kg的能量校正乳产量、0.06 kg的乳脂肪产量与0.03 kg的乳蛋白产量。在干物质采食量方面,对泌乳初期奶牛(泌乳天数小于70 d)而言,该酵母培养物每天能增加0.62 kg的干物质采食量,而对于泌乳中、后期(泌乳天数大于70 d)的奶牛,饲喂该酵母培养物则每天可减少0.78 kg的干物质采食量。

关键词：荟萃分析法酵母培养物奶牛

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An Interdisciplinary Challenge： Method Triangulation in the Field of Brain Development and Motivation

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Psychology Research 2012年第11期2卷 627-636页

作者： Diana Raufelder Danilo Jagenow Frances hoferichter R. poppy Wilkinson Frances hoferichterFreie Universitat Berlin Germany Concordia University Montreal Canada

An investigation of the development of adolescents" motivation and achievement in school demonstrates how psychology and neuroscience can profit from each other in an empirical and therefore epistemological way through method triangulation. Based on a method triangulative technique that directly links quantitative, experimental, and qualitative data (Treumann, 2005), an interdisciplinary longitudinal (two measure points) study was designed to bridge the gap between neuroscience and psychology in the field of brain development and motivation in adolescence. By using this triangulative technique, the authors minimize the weaknesses of each method and maximize their strengths by combining disparate but complementary approaches. Future implications and challenges of method triangulation in the field of psychology research are discussed.

关键词：三角测量大脑发育跨学科神经科学心理学学习动机测量方式测量方法

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耶尔时尚节的新“女王”

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数码设计（surface） 2010年第6期 86-91页

作者： poppy lai@ENAVANT

第25届耶尔时尚节的评审结果于5月4号揭晓，数额高达十五万欧元的奖金落入了比利时人的腰包——来自比利时的女装设计师亚历山德拉·维索尔伦（Alexandra Verschueren）赢得今年耶尔最高殊荣“lOREAl PROFESSIONNEl”奖项，同时“UOREAl... 详细信息

第25届耶尔时尚节的评审结果于5月4号揭晓，数额高达十五万欧元的奖金落入了比利时人的腰包——来自比利时的女装设计师亚历山德拉·维索尔伦（Alexandra Verschueren）赢得今年耶尔最高殊荣“lOREAl PROFESSIONNEl”奖项，同时“UOREAlRFESSIONNEl”将为她举办个人的时装秀。

关键词：时尚比利时设计师时装秀女装

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