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Praziquantel decreases fecundity in Schistosoma mansoni adult worms that survive treatment:evidence from a laboratory life-history trade-offs selection study

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Infectious Diseases of Poverty 2017年第1期6卷 988-998页

作者： poppy h.l.l.mberton Christina l.Faust Joanne P.Webster Institute for Biodiversity Animal Healthand Comparative Medicine&Wellcome Centre for Molecular ParasitologyCollege of MedicalVeterinary&Life SciencesUniversity of GlasgowG128QQGlasgowUK london Centre for Neglected Tropical Disease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonSt Mary’s CampusW21PGLondonUK Centre for Endemic Emerging and Exotic DiseasesThe Royal Veterinary CollegeUniversity of LondonLondon AL97TAUK

Background:Mass drug administration of praziquantel is the World health Organization’s endorsed control strategy for schistosomiasis.A decade of annual treatments across sub-Saharan Africa has resulted in significant reductions of infection prevalence and intensity levels,although‘hotspots’*** drug treatments place strong selective pressures on parasites,which may affect life-history traits that impact transmission *** drug treatment responses and the evolution of such traits can help inform on how to minimise the risk of drug resistance developing,maximise sustainable control programme success,and improve diagnostic ***:We performed a four-generation Schistosoma mansoni praziquantel selection experiment in mice and *** used three *** lines:a praziquantel-resistant isolate(R),a praziquantel-susceptible isolate(S),and a coinfected line(RS),under three treatment regimens:untreated,25 mg/kg praziquantel,or 50 mg/kg *** traits,including parasite adult-worm establishment,survival,reproduction(fecundity),and associated morbidity,were recorded in mice across all four *** variables were tested in a series of generalized linear mixed effects models to determine which factors had a significant influence on parasite life-history traits in definitive hosts under different selection ***:Praziquantel pressure significantly reduced adult-worm burdens across all generations and isolates,including within ***,previous drug treatment resulted in an increase in adult-worm establishment with increasing generation from P1 to *** highest worm numbers were in the co-infected RS *** treatment decreased adult-worm burden,but had a larger negative impact on the mean daily number of miracidia,a proxy for fecundity,across all three parasite ***:Our predicted cost of resistance was not supported by the traits we measured within the murine host.

关键词： Schistosoma mansoni Biomphalaria Mouse Praziquantel Resistance Establishment Survival Fecundity Trade-offs

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Predictors of 30-day readmission following pancreatic surgery:A retrospective review

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hepatobiliary & Pancreatic Diseases International 2018年第3期17卷 269-274页

作者： leo I.Amodu Jamil Alexis Aron Soleiman Meredith Akerman poppy Addison Toni Iurcotta horacio l.Rodriguez Rilo Department of Surgery Hofstra-Northwell School of Medicine Pancreas Disease Center Northwell Health Department of Biostatistics Feinstein Institute for Medical Research

Background： Pancreatectomies have been identified as procedures with an increased risk of *** surgical patients, readmissions within 30 days of discharge are usually procedure-related. We sought to determine predictors of 30-day readmission following pancreatic resections in a large healthcare ***： We retrospectively collected information from the records of 383 patients who underwent pancreaticresections from 2004–2013. To find the predictors of readmission in the 30 days after discharge,we performed a univariate screen of possible variables using the Fisher’s exact test for categorical variables and the Mann–Whitney U test for continuous variables. Multivariate analysis was used to determinethe independent factors.

关键词： Pancreatic Predictors Readmission Resection Risk30-day

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Outcomes following operative vs. non-operative management of blunt traumatic pancreatic injuries: a retrospective multi-institutional study

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Burns & Trauma 2016年第4期4卷 316-322页

作者： poppy Addison Toni Iurcotta leo I.Amodu Geoffrey Crandall Meredith Akerman Daniel Galvin Annemarie Glazer Nathan Christopherson Jose Prince Matthew Bank Christopher Sorrentino Joaquin Cagliani Jeffrey Nicastro Gene Coppa Ernesto P.Molmenti horacio l.Rodriguez Rilo Department of Surgery Hofstra-Northwell School of MedicineHempsteadNYUSA Pancreas Disease Center Northwell HealthManhassetNYUSA Department of Surgery Hofstra-Northwell School of MedicineHempsteadNYUSA Department of Biostatistics Feinstein Institute for Medical ResearchManhassetNYUSA Pancreas Disease Center Northwell HealthManhassetNYUSA Department of Surgery Hofstra-Northwell School of MedicineHempsteadNYUSA Pancreas Disease Center Northwell HealthManhassetNYUSA Northwell health 900 Northern BoulevardSuite 150Great NeckNY 11020USA

Background:Traumatic pancreatic injuries are rare,and guidelines specifying management are controversial and difficult to apply in the acute clinical *** to sparse data on these injuries,we carried out a retrospective review to determine outcomes following surgical or non-surgical management of traumatic pancreatic *** hypothesize a higher morbidity and mortality rate in patients treated surgically when compared to patients treated ***:We performed a retrospective review of data from four trauma centers in New York from 1990–2014,comparing patients who had blunt traumatic pancreatic injuries who were managed operatively to those managed *** compared continuous variables using the Mann-Whitney U test and categorical variables using the chi-square and Fisher’s exact *** analysis was performed to determine the possible confounding factors associated with mortality in both treatment ***:Twenty nine patients were managed operatively and 32 *** was a significant difference between the operative and non-operative groups in median age(37.0 vs.16.2 years,P=0.016),grade of pancreatic injury(grade I;30.8 vs.85.2%,P value for all comparisonslood transfusion(55.2 vs.15.6%,P=0.0012),other abdominal injuries(79.3 vs.38.7%,P=0.0014),pelvic fractures(17.2 vs.0.00%,P=0.020),intensive care unit(ICU)admission(86.2 vs.50.0%,P=0.003),median length of stay(lOS)(16.0 vs.4.0 days,Plity(27.6 vs.3.1%,P=0.010).Conclusions:Patients with traumatic pancreatic injuries treated operatively were more severely injured and suffered greater complications than those treated *** greater morbidity and mortality associated with these patients warrants further study to determine optimal triage strategies and which subset of patients is likely to benefit from surgery.

关键词： Injury Management Non-operative Operative Pancreas Trauma

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Feasible Evaluation of Neutron Capture Therapy for hepatocellular Carcinoma Using Selective Enhancement of Boron Accumulation in Tumour with Intra-Arterial Administration of Boron-Entrapped Water-in-Oil-in-Water Emulsion

Feasible Evaluation of Neutron Capture Therapy for Hepatocel...

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作者： h.Yanagie h.Kumada T.Nakamura S.higashi I.Ikushima M.Suzuki K.Ono M.Eriguchi h.Takahashi Department of Nuclear Engineering & Management Graduate School of EngineeringThe University of Tokyo Proton Medical Research Center University of Tsukuba Japan Atomic Energy Rsearch Institute

INTRODUCTION:We would like to apply BNCT,to radioresistant conditions as locally advanced or local recurrence of breast cancer,hepatocellular carcinoma,metastatic liver turnout,or lung *** of hepatocellular carcinomas(hCC) are thought to be incurable, and limited surgical operation,chemotherapy,or radiation therapies are available for a prolonged *** poppy-seed oil(IPSO) has a property of depositing itself selectively in the cells of *** et al prepared a

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淡色亮片

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游艇业 2012年第9期 87-87页

作者： Oceen.l

Jade 偏爱Bling Bling晚装，但其廊型还是非常少女的。单色两片结合少女的廊型，将闪耀的甜美同时hOlD住。宽松的金色Separates 不会像poppy的礼服来得性感闪耀，反而有优雅甜美之感。领部拼色的长裙也十分简约。离不开文艺女青年的调子。

关键词：服装工业服装设计品牌时尚

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2甲4氯对罂粟SOD、POD酶活性及膜脂过氧化作用的影响

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南方农业学报 2011年第3期42卷 257-260页

作者：王鑫吕苗苗郭平毅原向阳程强山西农业大学农学院山西太谷030801 太原市星火技术发展中心太原030009

【目的】探索一种高效、快速、安全的灭杀罂粟的化学防除方法,为利用除草剂快速灭杀罂粟提供理论基础和技术依据。【方法】在罂粟花蕾期用不同浓度的2甲4氯对植株进行喷施,喷后连续采样4d测定叶片相对含水量(RWC)、丙二醛(MDA)含量、质... 详细信息

【目的】探索一种高效、快速、安全的灭杀罂粟的化学防除方法,为利用除草剂快速灭杀罂粟提供理论基础和技术依据。【方法】在罂粟花蕾期用不同浓度的2甲4氯对植株进行喷施,喷后连续采样4d测定叶片相对含水量(RWC)、丙二醛(MDA)含量、质膜相对透性(RC)、超氧化物岐化酶(SOD)及过氧化物酶(POD)活性,研究各生理指标与处理浓度及处理时间的关系。【结果】随着2甲4氯浓度的升高,罂粟叶片POD、SOD活性和相对含水量随着喷药时间的延长呈下降趋势,在喷药后第4d,8g/l2甲4氯浓度处理的罂粟叶片POD、SOD活性和相对含水量最小,活性最低;MDA含量和细胞质膜相对透性随2甲4氯浓度增加呈先升高后降低的趋势。【结论】1、2、4、8g/l2甲4氯浓度处理在喷后4d左右均可有效灭杀罂粟植株,且浓度越高灭杀时间越短。在实际应用时需根据环境条件和时间要求,选择相应的药剂浓度。

关键词：罂粟 2甲4氯酶活性膜脂过氧化

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