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Asian Journal of Traditional Medicines 2023年第4期18卷 143-162页

作者： Ajay Kumar Meena poorna venktaraman Mohit Motiwale Ravindra Singh Kusuma Ganji N.Srikanth K.S.Dhiman Regional Ayurveda Research Institute AamkhoGwalior 474009India Captain Srinivasa Murthy Central Ayurveda Research Institute Chennai 600106India Central Council for Research in Ayurvedic Sciences Ministry of AYUSHGovt.of IndiaNew Delhi 110058India

Shodhana(purification/detoxification)is an important aspect of *** has been described in several important pieces of *** this study,we performed shodhana process on Langali(Gloriosa superba Linn.)tubers of family Liliaceae,a semi-woody herbaceous climber with significant therapeutic *** compared the unprocessed(before purification)and processed(after purification)samples based on the phytochemical,physicochemical,and chromatographic study,including HPTLC,HPLC,GC-MS and *** changes were observed in profiling after the shodhana *** plant contains colchicine,known for its toxic effects,particularly ***,we quantified colchicine in the unprocessed and processed samples of Gloriosa superba *** using HPLC *** showed that the percentage of colchicine was reduced by 13.67%in chloroform extract and 20.97%in ethanol extracts after the shodhana process.

关键词： Shodhana HPLC LC-MS GC-MS colchicine Gloriosa superba toxicity Ayurveda

Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology

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World Journal of Gastroenterology 2021年第21期27卷 2850-2870页

作者： Sarah Musa Hammoudeh Arabella Musa Hammoudeh poorna Manasa Bhamidimarri Bassam Mahboub Rabih Halwani Qutayba Hamid Mohamed Rahmani Rifat Hamoudi Sharjah Institute for Medical Research College of MedicineUniversity of SharjahSharjah 27272United Arab Emirates College of Medicine University of SharjahSharjah 27272United Arab Emirates General Surgery Department Tawam HospitalSEHAAl-Ain 15258United Arab Emirates Rashid Hospital 315 Umm Hurair SecondDubai Health AuthorityDubai 4545United Arab Emirates Meakins-Christie Laboratories McGill UniversityQuebec H4A 3J1MontrealCanada Division of Surgery and Interventional Science University College LondonLondon W1W 7TYUnited Kingdom

BACKGROUND The coronavirus disease 2019(COVID-19),a pandemic contributing to more than 105 million cases and more than 2.3 million deaths worldwide,was described to be frequently accompanied by extrapulmonary manifestations,including liver *** dysfunction and elevated liver enzymes were observed in about 53%of COVID-19 *** To gain insight into transcriptional abnormalities in liver tissue of severe COVID-19 patients that may result in liver *** The transcriptome of liver autopsy samples from severe COVID-19 patients against those of non-COVID donors was *** expressed genes were identified from normalized RNA-seq data and analyzed for the enrichment of functional clusters and *** differentially expressed genes were then compared against the genetic signatures of liver diseases including cirrhosis,fibrosis,non-alcoholic fatty liver disease(NAFLD),and hepatitis A/B/*** expression of some differentially expressed genes was assessed in the blood samples of severe COVID-19 patients with liver dysfunction using *** Analysis of the differential transcriptome of the liver tissue of severe COVID-19 patients revealed a significant upregulation of transcripts implicated in tissue remodeling including G-coupled protein receptors family genes,DNAJB1,IGF2,EGFR,and ***,the differential transcriptome of severe COVID-19 liver tissues substantially overlapped with the disease signature of liver diseases characterized with pathological tissue remodeling(liver cirrhosis,Fibrosis,NAFLD,and hepatitis A/B/C).Moreover,we observed a significant suppression of transcripts implicated in metabolic pathways as well as mitochondrial function,including cytochrome P450 family members,ACAD11,CIDEB,GNMT,and ***,drug and xenobiotics metabolism pathways are significantly suppressed suggesting a decrease in liver detoxification *** correspondence with the RNA-seq data analysis,we observ

关键词： COVID-19 Hepatic dysfunction Tissue remodeling Metabolic pathways Drug metabolism Hepatic detoxification

Neutralizing possibilities of whole virion and mRNA vaccine triggered antibodies of Wuhan strain of SARS-CoV-2 with receptor binding domains of spike proteins of Delta and Omicron strains

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Asian Pacific Journal of Tropical Medicine 2023年第2期16卷 92-94,I0008页

作者： Shilpa Barthwal Bennet Angel Annette Angel Vinod Joshi BM Shareef Nuzhat M Peer poorna Khaneja Ambreen S Khan Bhawna Sharma Neha Singh Ramesh Joshi Komal Tomar Kiran Yadav Satendra P Singh Advance Centre for Virology&Immunology Sharda UniversityGreater NoidaU.P.201310India Sharda School of Agricultural Sciences Sharda UniversityGreater NoidaU.P.201310India Department of Microbiology School of Medical Sciences&ResearchSharda HospitalGreater NoidaU.P.201310India

Mutations in the receptor binding domain(RBD)of SARS-CoV-2 spike protein have given birth to the new variants of concern *** and Omicron *** we are using vaccines which are either mRNA of spike protein of Wuhan strain or its whole virion vaccine,these vaccines will trigger antibodies to be able to bind with the epitopes of spike protein of Wuhan *** appears a need to study whether vaccine generated circulating neutralizing antibodies in vaccinated people are able to neutralize the receptor binding domain of spike protein of currently circulating Delta and Omicron strains as *** need to address this contention in two phases:first to undertake docking studies of vaccine generated antibodies with Wuhan,Delta and Omicron strains and second to conduct the wet lab studies and observe antigen-antibody bindings employing Immunofluorescence and Cryo-Electron Microscopic *** present paper reports results of docking studies using bioinformatic softwares to provide the baseline information for wet lab studies.

关键词： vaccine antibodies neutral

DNA damage in exfoliated buccal cells and antioxidant status of saliva in brain tumour patients

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海南医学院学报 2010年第10期16卷 1269-1274页

作者： Revathi P Shenoy Anumeha Vatsa Swagatika Sahoo Rajashree Rana Guruprasad Nayak poorna Bhat Guruprasad Kalthur Anjali Rao Department of Biochemistry and Division of Reproductive Medicine Kasturba Medical College and Hospital Manipal University Department of Obstetrics and Gynecology Division of Reproductive MedicineKasturba Medical College and Hospital Manipal University

The present investigation was carried out in exfoliated buccal cells and saliva collected from pre-operative brain tumour patients. The DNA damage in these cells was assessed by alkaline comet assay and micronucleus (MN) assay. Salivary flow rate, pH, osmolality, total antioxidant activity (AOA) and vitamin C levels were also assessed in unstimulated whole saliva of these patients. In the comet assay a significant increase in the tail length (P<0.02) was observed when control and malignant groups were compared. A significant (P<0.02) difference in tail length was also noted between benign and malignant groups. Non significant results were found when control and benign groups were compared. Further, a marked increase in % MN (P<0.002) was observed when control and benign groups were compared. A significant increase in % MN (P<0.029) was also observed in benign cases when compared to malignant tumours. No significance was obtained when % MN in control and malignant cases was compared. Moreover, salivary flow rate and pH was significantly decreased and osmolality was markedly increased in brain tumour patients. The AOA levels in saliva were markedly decreased in brain tumours and vitamin C levels exhibited no change when compared to controls. Thus, as noted above susceptibility to free radical induced DNA damage also exists in the exfoliated buccal cells conducive to the lowered salivary antioxidant status of brain tumour patients.

关键词：脑肿瘤临床 DNA 治疗

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地磁逆转突发和星际灾变幕

地质科技通报 1987年第4期 62-66页

作者： poorna C.Pal ,魏敏

在绝灭事件和古陨石坑年龄的记录中,所观测出的26—32百万年周期性,是由周期性的行星表面自然轰击造成,这种可能性好像已成事实,这一天文钟(astronomical clock)也影响到地磁逆转.然而,在地磁逆转记录中,观测到一个近似30百万年的谐波,... 详细信息

在绝灭事件和古陨石坑年龄的记录中,所观测出的26—32百万年周期性,是由周期性的行星表面自然轰击造成,这种可能性好像已成事实,这一天文钟(astronomical clock)也影响到地磁逆转.然而,在地磁逆转记录中,观测到一个近似30百万年的谐波,现在发现这个时限具有随机性,而早期报道的32—34百万年的逆转记录,可能是一个较好的人工测定的基础数据.在此,我们考查了地磁逆转和那些在频繁逆转期间发生的灾变幕之间的时间关系.由于地磁历史包括频繁逆转的长期阶段与固定极性阶段交替的历史,所以,我们的合理判断是,在频繁逆转的相对不稳定期间,地磁场对灾变应该是最敏感的.在地磁逆转频率中,我们发现突发间隔大约为30百万年,这和灾变幕是一致的.这些突发可以看作是地球灾变的地磁待征,我们倾向把它们归因于在轰击期间增加了地核紊流的结果.在固定极性的长期阶段,逆转突发的消失归因于这些阶段地磁动力的双稳定振荡失灵.

关键词：地磁陨石坑归因紊流磁学天体碰撞坑冲击地貌流体流动卡洛夫牛津期二叠纪极性逆转变质岩冲击岩第三纪始新世诺利期

Fabrication, Characterization and Machining of Al6061 Reinforced with Red Mud Composite

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Journal of Minerals and Materials Characterization and Engineering 2022年第1期10卷 28-42页

作者： poorna Chandra V. Ravi Kumar R. Kiran D. V. Ravi Kumar C. R. Prakash Rao R. Suresh Department of Mechanical Engineering Global Academy of Technology Bengaluru India Department of Industrial & Automation Engineering VTU PG Centre Mysuru India

The Metal Matrix Composites application has increased in many areas of science and technology, because of its additional physical, wear and mechanical properties. In comparison with all MMC’s, aluminum-based MMC’s are finding wide applications due to their better strength to weight ratio, better stiffness, and high thermal conductivity as well as very good wear and corrosion properties. The properties of a composite mainly depend on better distribution of reinforcement in the matrix, which is very difficult to achieve. Basically Redmud is a byproduct of alumina, and it is waste product obtained during Bayer’s process. This waste product must be recycled else it may be dangerous to the environment. Redmud can be used as reinforcement for aluminium composites in order to achieve better properties. The proposed research work includes preparation of Aluminum 6061-Red mud metal matrix composites using liquid metallurgy route following stir casting technique. An alloy Al6061 containing 0.60 percent silicon and Magnesium of 0.82 percent was used as the matrix material. Two different compositions of the Aluminum 6061-Red mud composites are prepared in addition to the base matrix and evaluated for mechanical properties also the force acting on the cutting tool at different spindle speeds during machining of the composite materials were analyzed.

关键词： Al6061 Redmud Machining MMC’s Cutting Force Measurement

Experimental Study on Polymer Nanocomposites Based Strain Sensors for Structural Health Monitoring

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Journal of Minerals and Materials Characterization and Engineering 2021年第5期9卷 512-527页

作者： R. Kiran K. R. Prakash poorna Chandra V. Ravi Kumar P. B. Asha C. R. Prakash Rao Department of Mechanical Engineering Global Academy of Technology Bengaluru India Department of Mechanical Engineering NIE Mysuru India

The aim is to develop a mechanically flexible polymer nanocomposite film-based strain sensors that could act towards sustainable structural health monitoring for civil structures. The developed polymer nanocomposite film combinations will be monitored for their structural, electrical and mechanical behaviors and the optimized formulations will be tried for strain sensing applications. The films were cast by using PVA as the base polymer and copper doped silver nitrate as the nanofiller along with the use of glycine as fuel which is a combination of silver and copper nitrate. After preparing the films, they were tested for conductivity under tensile loading using a digital multi meter connected to a UTM. The samples were subjected to XRD, FTIR and SEM for further analysis. The results of the experiments shown I-V characteristics of PVA-CuAgO composites from 5% to 25% CuAgO have been increased tremendously with the incorporation of filler material. For 100 V, the maximum current value obtained for plain PVA is only 7.7E-8 A, whereas CuAgO particles shown 0.0025 A at 5% reinforcements and further increased nearly to 0.025 A for 25% of CuAgO particles into the PVA matrix.

关键词： Polymer Nanocomposites

Influence of Machining Parameter on Tool Life While Machining Hybrid Metal Matrix Composites

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Journal of Minerals and Materials Characterization and Engineering 2020年第6期8卷 440-458页

作者： C. R. Prakash Rao V. Ravi Kumar D. V. Ravi Kumar poorna Chandra M. Vedavyasa M. S. Rajagopal Department of Mechanical Engineering Global Academy of Technology Bengaluru India Department of Mechanical Engineering Dayananda Sagar University Bangalore India

A metal matrix composite constitutes a continuous metallic matrix and a discontinuous phase known as reinforcement. The hybrid metal matrix composites (Hmmcs) have been used to manufacture drive shafts, disc brake rotors, brake drums, connecting rods pistons, engine block cylinder liners for automotive and rail vehicle applications. The Hmmcs castings of diameter 120 mm and length 300 mm were prepared through sand mould technique following stir casting methodology. The cast components further subjected to evaluation of physical properties and machining tests using two grades of coated inserts and PCD inserts. The experiments were carried out following ISO 3685 standards. The coating thickness of the TiN coated and TiAlN coated inserts were measured using Kalo testing method; the results of the test show that the interface of the substrate and coating was free from the porosity, and the coating thickness of TiN coating was 4.84 microns and TiAlN coating was measured 4.6 microns. The results of the experiments show that performance of the PCD insert was better than coated inserts at 0.1 mm/rev feed; however at 0.2 mm/revolution feed PCD insert failed by micro chipping of cutting edge while ma

关键词： Composites Hybrid Metal Matrix Composites Coated Inserts PCD Inserts Turning Tool Life Testing