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Food and Nutrition Sciences 2020年第6期11卷 509-522页

作者： Astha Dwivedi Sandeep Kumar Sharmistha Singh poonam chandra mittal Department of Biochemistry Faculty of Science University of Allahabad Allahabad India

Aims: Obesity is the major contributor of the metabolic syndrome (MetS), but a unique phenotype of obesity known as metabolically healthy obese (MHO) shows healthier metabolic profile; however understanding of their biochemical correlates is poorly understood. Obesity is defined by Body mass index (BMI), but controversy exists regarding ethnic-specific BMI cut-offs. The present study used the Asian Indian BMI cut-offs to assess relationships of MHO phenotypes with oxidative stress (OS) and inflammation. Methods: In this case-control study, 299 metabolically-healthy (MH) respondents were divided into four groups as per Asian criteria for obesity: MH non-obese (MHNO), MH overweight (MHOW), MHO and MH severely obese (MHSO). Their oxidative stress and pro-inflammatory markers were measured. Results: Levels of hydroxyl radicals (·OH), fluorescent oxidation products (FLOP), MDA, PCO and inflammatory markers CRP, TNF-α, IL-6 were highest in MHSO pheno

关键词： Metabolically Healthy Obesity Metabolic Syndrome Risk Factors Oxidative Stress Inflammatory Markers

Total Antioxidant Status and Other Markers to Distinguish Severely Obese Volunteers with and without Metabolic Syndrome

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Food and Nutrition Sciences 2019年第6期10卷 648-663页

作者： Sharmistha Singh Astha Dwivedi Sandeep Kumar poonam chandra mittal Department of Biochemistry Faculty of Science University of Allahabad Allahabad India

Obesity (Ob) is an accepted major risk factor for the metabolic syndrome (MetS), a combination of at least three of five risk factors, which predispose to high oxidative stress (OS), but all obese do not show symptoms of MetS. There is dearth of data comparing OS homeostasis of severely obese adults with and without MetS, and need for biomarkers to help in differential diagnosis. Erythrocytic lipid and protein damage markers, malondialdehyde (MDA) and protein carbonyl (PCO), antioxidant enzymes erythrocytic superoxide dismutase(SOD), catalase (CAT), plasma glutathione peroxidase (GPX), and total antioxidant capacity (TAC) as ferric-reducing-ability-of-plasma (FRAP) were compared to understand OS homeostasis among 102 severely Ob (body mass index > 30), 102 Ob with severe (z-score > 2) MetS as per National Cholesterol Education Program-Adult Treatment Panel III guidelines and 100 healthy non-obese Controls. MDA/PCO and all antioxidant enzymes were lowest for ObMetS, followed by Ob, indicating greater damage to protein moieties of the erythrocytic membrane. Multiple regression analysis confirmed z-scores > 2 as significant predictor of lowered enzymes and TAC. Receiver Operator Curve analysis predicted that TAC was the most potential biomarker for the diagnosis and prognosis of MetS with an Odds Ratio of 88.5 indicating the high probability that FRAP would be low for ObMetS (z-score > 2) than for Ob with BMI > 30, but z-scores < 1. TAC is qualified as the most effective biomarker to distinguish between severely obese respondents with and without metabolic syndrome, and as a useful candidate for study of homeostatic breakdown in metabolic syndrome and the importance of z-score in assessment of MetS in obese respondents.

关键词： Obesity Body Mass Index Metabolic Syndrome Z-Score Total Antioxidant Capacity Biomarker

Spectral studies of transition metal complexes with 25, 26 dioxo1,6,12,17,23,24 hexaazacyclohexacosa 1,5,12,16 tetraene macrocyclic ligand (L)

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Open Journal of Inorganic Chemistry 2013年第4期3卷 109-115页

作者： Sulekh chandra poonam Pipil Department of Chemistry Rajdhani College University of Delhi New Delhi India Department of Chemistry Zakir Husain Delhi College University of Delhi New Delhi India

Mn(II), Co(II), Ni(II) and Cu(II) complexes with this ligand (L) i.e. 25, 26 dioxo1,6,12,17,23,24 hexaazacyclohexacosa1,5,12,16 tetraene have been prepared. All the complexes were characterized by elemental analysis, molar conductance measurements, magnetic susceptibility measurements, mass, i.r. electronic, and e.p.r. spectral studies. The molar conductance measurements in DMF indicate that the Mn(II), Co(II), and Cu(II) are non-electrolyte whereas the complexes of Ni(II) are electrolyte. Thus, these complexes may by formulated as [M(L)X2] and [Ni(L)]X2 (where M = Mn(II), Co(II) and Cu(II) and X = C1- and ). All the complexes are of the high spin type expected Ni(II) complexes which are diamagnetic. On the basis of spectral studies, an octahedral geometry may be assigned of Mn(II) and Co(II). Square planar is for Ni(II) complexes, and tetragonal geometry for Cu(II) complexes.

关键词： Mass IR Magnetic Moment Electronic EPR X-Ray Diffraction Studies

Synthesis, Spectral Characterization and Biological Evaluation of Chromium(III) Complexes of Schiff Base

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Open Journal of Inorganic Chemistry 2014年第2期4卷 30-40页

作者： Sulekh chandra poonam Pipil Department of Chemistry Rajdhani College University of Delhi Delhi India Department of Chemistry Zakir Husain Delhi College University of Delhi Delhi India

Complexes of chromium(III) metal ion with schiff base i.e. 2,3,9,10 tetraphenyl-1,4,8,11-tetra- azacyclotetradeca-1,3,8,10 tetraene. (BPD) 2,4,10,12-tetramethyl-1,5,9,13-tetraazacyclohexadeca- 1,4,9,12 tetraene. (ADP) 2,3,9,10 tetramethyl 1,4,8,11 tatraazatetredeca-1,3,8,10 tetraene (DDP) have been synthesized and characterized by elemental analysis, molar conductance, magnetic susceptibility measurements, electronic and epr spectral studies. On the basis of elemental analysis the complexes were found to have composition CrLX3 (X = Cl-, , NCS-), Molar conductance, measured in DMF solution of these complexes indicates that the complexes are 1:1 electrolytes in nature, therefore the complexes may be formulated as [CrLX2]X. These complexes show magnetic moment in the range of 3.80 - 3.84 B.M. corresponding to three unpaired electrons. EPR and electronic spectral studies reveal that the complexes possess six-coordinated octahedral geometry. The ligand field parameters were calculated using various energy level diagrams. In vitro synthesized compounds and metal salts have also been tested against some species of plant pathogenic fungi and bacteria in order to assess their antimicrobial properties.

关键词： Mass IR Magnetic Moment Electronic EPR & Biological Activity