Comparative Study of Inflammatory and Oxidative Stress Biomarkers in Different Metabolically Healthy Obesity Phenotypes

作     者：Astha Dwivedi Sandeep Kumar Sharmistha Singh Poonam Chandra Mittal Astha Dwivedi;Sandeep Kumar;Sharmistha Singh;Poonam Chandra Mittal

作者机构：Department of Biochemistry Faculty of Science University of Allahabad Allahabad India 

出 版 物：《Food and Nutrition Sciences》 (食品与营养科学（英文）)

年 卷 期：2020年第11卷第6期

页      面：509-522页

学科分类：07[理学] 0701[理学-数学] 070101[理学-基础数学] 

主　　题：Metabolically Healthy Obesity Metabolic Syndrome Risk Factors Oxidative Stress Inflammatory Markers 

摘      要：Aims: Obesity is the major contributor of the metabolic syndrome (MetS), but a unique phenotype of obesity known as metabolically healthy obese (MHO) shows healthier metabolic profile; however understanding of their biochemical correlates is poorly understood. Obesity is defined by Body mass index (BMI), but controversy exists regarding ethnic-specific BMI cut-offs. The present study used the Asian Indian BMI cut-offs to assess relationships of MHO phenotypes with oxidative stress (OS) and inflammation. Methods: In this case-control study, 299 metabolically-healthy (MH) respondents were divided into four groups as per Asian criteria for obesity: MH non-obese (MHNO), MH overweight(MHOW), MHO and MH severely obese (MHSO). Their oxidative stress and pro-inflammatory markers were measured. Results: Levels of hydroxyl radicals (·OH), fluorescent oxidation products (FLOP), MDA, PCO and inflammatory markers CRP, TNF-α, IL-6were highest in MHSO pheno