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Radical Hysterectomy in Cervical Cancer: Patients’ Epidemiological and Clinical Profiles and Perioperative Outcome in Two Referral Hospitals in Cameroon

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Open Journal of Obstetrics and Gynecology 2024年第3期14卷 466-479页

作者： Théophile Njamen Nana Robert Tchounzou Fulbert Nkwele Mangala Alphonse Ngalame Henri Essome Sedrick Tiokeng Sidonie Noa Ananga Andrew Tassang Humphry Tatah Neng Isaac Mboh Eyong Gaetan Andre Wambo Simo Felix Adolphe Elong Fidelia Kobenge Mbi junior Cédric Nana Njamen Charlotte Tchente Nguefack Thomas Obinchemti Egbe Gregory Ekane Halle Emile Telesphore Mboudou Marcellin Ngowe Ngowe Department of Obstetrics and Gynaecology Douala General Hospital Douala Cameroon Department of Obstetrics and Gynaecology Faculty of Health Sciences University of Buea Buea Cameroon Department of Obstetrics and Gynaecology Douala Gynaeco-Obstetric and Pediatric Hospital Douala Cameroon Department of Surgery and Specialties Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Department of Pathology Douala General Hospital Douala Cameroon Faculté Des Sciences De La Santé Université Joseph Kizerbo Ouagadougou Burkina Faso

Background: Cervical cancer (CC) is one of the most frequent cancers and the leading cause of death from gynecological cancer in Low and middle income countries, Cameroon inclusive. Surgery is the primary treatment modality when the disease is diagnosed at early stage. Radical hysterectomy in cervical cancer has not been evaluated in recent years in Cameroon. The purpose of this study is thus to evaluate the epidemiological and clinical features and short term outcomes of patients who underwent surgery. Patients and methods: This retrospective study was conducted at the Douala Gynaeco-obstetric and Pediatric Hospital and the Douala General Hospital. Cervical cancer patients who underwent Radical hysterectomy between January 2015 and December 2020 were included. A pre-established data collection tool was used to record socio-demographic, clinical and outcomes information from patients’ files;additional outcome information was obtained from phone calls. Descriptive analysis was done using the SPSS version 26. Bivariate analysis was used to determine associations between disease and patients characteristics and occurrence of adverse postoperative outcome. P value of 0.05 was considered. Results: Sixty one patients were enrolled. Their ages ranged from 33 to 74 years with a mean age of 51.95 ± 10.29 years. Over 85% of women were married, 65.57% were unemployed and 86.88% were multiparous. Only 28% had never done cervical cancer screening. Most patients had stage IB1 to IB2 stage disease (57.1%). Less than 9% underwent radical hysterectomy and 8 of those (13.11%) suffered intraoperative complications. Twenty-five patients (40.98%) presented immediate and short term complications. There was no significant association between the disease or patients’ characteristics and adverse outcomes. Conclusion: Cervical cancer patients are relatively young in our settings and only 9% of them reach the hospital at early stage. Postoperative adverse outcomes rate is higher than that rep

关键词： Cervical Cancer Radical Hysterectomy Epidemiological and Clinical Profiles Outcomes Cameroon

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Sorption and desorption behavior of residual antidepressants and caffeine in freshwater sediment and sewage sludge

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International Journal of Sediment Research 2022年第3期37卷 346-354页

作者： Ismael Laurindo Costa junior Christiane Schinneider Machado Adelmo Lowe Pletsch Yohandra Reyes Torres Department of Chemistry Federal University of Technology-Paraná (UTFPR) Department of Chemistry State University of Midwest (UNICENTRO)

The use of antidepressants is widespread in modern times. Thus, they present a potential risk for ecosystems due to occurrence in domestic sewage containing unaltered metabolites and structures, even after the treatment plants have processed the sewage. The current research investigated the sorption and desorption of antidepressants(citalopram, venlafaxine, fluoxetine, sertraline, and amitriptyline) and caffeine from freshwater sediment and sewage sludge. The samples of freshwater sediment were collected in a river spring in an area with few anthropogenic sources of pollution and samples of sewage sludge were taken from stabilization ponds of a sewage treatment. The matrices were mainly composed of organic fractions, sediment of humic nature, and aliphatic biomolecules in sludges. The presence of silt and clay in the sediment proved to be important for the sorption process when compared to the flocs and colloidal structure of the sludge. The kinetic study indicated pseudo-first order behavior. The Freundlich isotherm was satisfactorily used in the interpretation of sorption and desorption for all analytes and matrices. The high percentages obtained for desorption suggest analyte mobility, which is more intense in the sludge than in the sediment since each matrix has a different composition. It can be considered that the information obtained here reinforces the ecotoxicological concern with respect to pharmacological residues in the environment, as processes of retention by sorption in the sludge and the sediment have been confirmed, as well as the preferential partition of some analytes by the aqueous phase.

关键词： Emerging pollutants Drugs Persistence Partition Mobility Sorption

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Land Use Capability and the Sustainable Scale: An Overview of Agriculture in São Paulo State, Brazil

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Natural Resources 2022年第8期13卷 171-180页

作者： Oscar Sarcinelli ademar Ribeiro Romeiro Lauro Charlet Pereira Sergio Gomes Tosto Núcleo de Economia Agrícola e Meio Ambiente Universidade Estadual de Campinas (UNICAMP) Campinas Brazil EMBRAPA Meio Ambiente Jaguariúna Brazil EMBRAPA Territorial Campinas Brazil

Establishing a sustainable scale in natural resources management enables effective economic and ecological policies and guarantees the long-term sustainability of economic production. In agriculture, land evaluations determine the land use sustainable scales, that is, those that avoid land degradation and allow the provision of food, wood, energy, and ecosystem services over time. The paper assessed São Paulo State’s agricultural sustainability by analyzing the current land use adequacy to the land use capability map that follows FAO 1976 “guide for land evaluation” and was applied to São Paulo by the State Agricultural Secretariat. Results indicate inefficiencies in land use at the state level, where more than one-third of agricultural lands do not satisfy technical land capability indications. According to technical land use capability, more than 4.5 million hectares are being underused (economic inefficiency) and another 2.2 million hectares are being overused (environmental inefficiency). Pasturelands represent the most unsustainable land use, where 3.7 million hectares are allocated in high quality lands with high agricultural production potential, and another 0.7 million hectares are allocated in lands with very low quality for agriculture, most of than area degraded. To achieve sustainability, lands with high agricultural production potential should be used to improve agriculture and food production and, on the other hand, lands with very low agricultural production potential should be used for wood production, agroforestry, ecotourism and natural ecosystems conservation. Our results provide a framework for improving land use policies in São Paulo State and highlight an opportunity to achieve land use sustainability.

关键词： Land Use Planning Land Capability Agricultural Sustainability

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COVID-19 impact in Crohn’s disease patients submitted to autologous hematopoietic stem cell transplantation

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World Journal of Hematology 2024年第1期11卷 1-8页

作者： Milton Artur Ruiz Roberto Luiz Kaiser junior Lilian Piron-Ruiz Tainara Souza Pinho Lilian Castiglioni Luiz Gustavo de Quadros Department of Bone Marrow Transplantation Associação Portuguesa de BeneficênciaSão Josédo Rio Preto SP 15090470Brazil Department of Surgery Kaiser Hospital DiaSão Josédo Rio Preto 08010-150São PauloBrazil Department of Bone Marrow Transplantation Beneficência Portuguesa HospitalSão Josédo Rio Preto 15090470São PauloBrazil FAMERP Faculdade de Medicina de São Josédo Rio PretoSão Josédo Rio Preto 15090000São PauloBrazil Beneficência Portuguesa Hospital ABC Medical SchoolSão Bernardo 15015110São PauloBrazil

BACKGROUND Severe acute respiratory syndrome coronavirus 2 is the virus responsible for coronavirus disease 2019(COVID-19),a disease that has been blamed for inducing or exacerbating symptoms in patients with autoimmune ***'s disease(CD)is an inflammatory bowel disease that affects genetically susceptible patients who develop an abnormal mucosal immune response to the intestinal *** who underwent hematopoietic stem cell transplantation(HSCT)are considered at risk for *** To describe for the first time the impact of COVID-19 in CD patients who had undergone autologous,non-myeloablative *** In this descriptive study a series of 19 patients were diagnosed with positive *** two patients there were reports of the occurrence of two infectious *** related to HSCT,such as time elapsed since the procedure,vaccination status,CD status before and after infection,and clinical manifestations resulting from COVID-19,were *** Among the patients with COVID-19,three,who underwent Auto HSCT less than six months ago,relapsed and one,in addition to the CD symptoms,started to present thyroid impairment with positive *** one of the patients required hospitalization for five days to treat COVID-19 and remained in CD clinical *** patients reported late symptoms that may be related to *** were no deaths,and a statistical evaluation of the series of COVID-19 patients compared to those who did not present any infectious episode did not identify significant differences regarding the analyzed *** Despite the change in CD status in three patients and the presence of nine patients with late symptoms,we can conclude that there was no significant adverse impact concerning COVID-19 in the evaluated patients who underwent HSCT to treat CD.

关键词： Inflammatory bowel disease Crohn disease SARS-CoV-2 COVID-19 Autologous hematopoietic stem cell transplantation Stem cell therapy

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GIS-based spatial prediction of landslide using road factors and random forest for Sichuan-Tibet Highway

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Journal of Mountain Science 2022年第2期19卷 461-476页

作者： YE Cheng-ming WEI Rui-long GE Yong-gang LI Yao Jose Marcato junior Jonathan LI Key Laboratory of Earth Exploration and Information Technology of Ministry of Education Chengdu University of TechnologyChengdu 610059China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China Faculty of Engineering Architecture and Urbanism and GeographyFederal University of Mato Grosso do SulCampo Grande 79070-900Brazil Department of Geography and Environmental Management University of WaterlooWaterlooONN2L 3G1Canada

Accurate evaluation of landslide susceptibility is very important to ensure the safe operation of mountain *** Sichuan-Tibet Highway,which traverses the east of the Tibetan Plateau,frequently encounters natural *** studies generally use statistical methods to analyze the hazards along the Sichuan-Tibet *** this research,we present two road factors,namely aspect to road and road profile to increase the accuracy of landslide susceptibility mapping by considering the influence of landslide movement direction on ***,the aspect to road,which represents the impact of different landslide movement directions on the highway,was extracted by combining road direction with mountain ***,the road profile,which reflects the subgrade structure between the road and surrounding mountains,was extracted according to the terrain ***,the landslide susceptibility maps were produced based on the random forest(RF)method by using 473 landslides and 10 conditioning factors,including road factors(aspect to road,road profile)and primitive factors(slope,aspect,curvature,relief amplitude,peak ground acceleration,crustal movement velocity,faults,rainfall).The area under the receiver operating characteristic curve(AUC)and the Gini importance were used to evaluate the performance of proposed road *** AUC values on two groups that add road factors and only use primitive factors were 0.8517 and 0.8243,*** Gini importance indicated that road profile(0.123)and aspect to road(0.116)have a significant contribution to landslides compared with the primitive *** results of multi-collinearity analysis and frequency ratio confirmed the suitability of the road factors for predicting hazards along the highway.

关键词： Landslide susceptibility Spatial modeling Random forest Sichuan-Tibet Highway

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Genetic identification and reiterated captures suggest that the Astyanax mexicanus El Pachón cavefish population is closed and declining

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Zoological Research 2023年第4期44卷 701-711页

作者： Laurent Legendre Julie Rode Isabelle Germon Marie Pavie Carla Quiviger Maxime policarpo Julien Leclercq Stéphane Père Julien Fumey Carole Hyacinthe Patricia Ornelas-García Luis Espinasa Sylvie Rétaux Didier Casane UniversitéParis-Saclay CNRSIRDUMRÉvolutionGénomesComportement etÉcologieGif-sur-Yvette 91190France Objectif Sciences International NGO OSI-Panthera ProgramGeneva 99140Switzerland Institut de Neuroscience Paris-Saclay UniversitéParis-Saclay and CNRSSaclay 91400France Institut Pasteur UniversitéParis CitéCNRS UMR 2000Microbial Paleogenomics UnitParis 75015France Institut Pasteur UniversitéParis CitéBioinformatics and Biostatistics HubParis 75015France Department of Genetics Harvard Medical SchoolBlavatnik InstituteBoston MA 02115USA Colección Nacional de Peces Departamento de ZoologíaInstituto de BiologíaUniversidad Nacional Autónoma de MéxicoMéxico DF CP 04510México School of Science Marist CollegePoughkeepsieNew York 12601USA UniversitéParis Cité UFR Sciences du VivantParis 75013France Zoological Institute Department of Environmental SciencesUniversity of BaselBaselSwitzerland

The sizes of Astyanax mexicanus blind cavefish populations of North-East Mexico are demographic parameters of great importance for investigating a variety of ecological,evolutionary,and conservation ***,few estimates have been *** these mobile animals living in an environment difficult to explore as a whole,methods based on capture-mark-recapture are appropriate,but their feasibility and interpretation of results depend on several assumptions that must be carefully ***,we provide evidence that minimally invasive genetic identification from captures at different time intervals(three days and three years)can give insights into cavefish population size dynamics as well as other important demographic parameters of *** also provide tools to calibrate sampling and genotyping efforts necessary to reach a given level of *** results suggest that the El Pachón cave population is currently very small,of an order of magnitude of a few hundreds of individuals,and is distributed in a relatively isolated *** probable decline in population size in the El Pachón cave since the last census in 1971 raises serious conservation issues.

关键词： Cavefish Population size Conservation Swabbing Genetic identification

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Impacts of global warming on southern California's winegrape climate suitability

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Advances in Climate Change Research 2020年第3期11卷 279-293页

作者： Corrie MONTE VERDE Fernando DE sales Geography Department San Diego State UniversitySan DiegoCA92182USA Center for Climate and Sustainability Studies San Diego State UniversitySan DiegoCA92182USA

Southern California has seen a resurgence of winegrowing regions in the past few decades,however the future of winegrape climatic suitability in the area has not been exhaustively *** study evaluated the future climate suitability for the cultivation of winegrape and potential global warming impacts on southern California's winegrowing regions through a series of high-resolution surface air temperature and precipitation projections obtained with the WRF-SSIB regional climate *** reveal that by mid-21st-century the surface air temperature will increase by approximately 1.2℃,while average precipitation will decrease by as much as 11%in the southern winegrowing areas under the Intergovernmental Panel on Climate Change high greenhouse-gas emissions *** of bioclimatic suitability indices indicate increases in heat accumulation for all major winegrowing areas;including an increase of about 10% in growing-degree day,while morning low temperatures in September may experience increases of approximately 11% in the future,thus impacting negatively the ripening stage of grapevines and leading to changes in wine composition and ***,the extent of areas classified under the cool to warm climate suitability categories could decrease by nearly 42% in the study area by *** in southern California are already warm and dry for viticulture and continuing heat accumulation increase,along with rainfall reduction,could potentially place additional stress to winegrape crop in the area,including advanced phenological timing and moisture deficit stress that could lead to decreases in *** projected decline in viticulture suitability highlights the need for adaptive capacity within this sector to mitigate the impacts of global *** mitigating strategies include planting hotter climate grape varieties,moving vineyards to regions that are more suitable in the future,and adopting dry-farming techniques.

关键词： Global warming Winegrape suitability Regional climate modeling Bioclimatic indices Dynamical downscaling

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Analysis of a New Composite Material for Watercraft Manufacturing

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Journal of Marine Science and Application 2016年第3期15卷 336-342页

作者： Alexandre Wahrhaftig Henrique Ribeiro ademar Nascimento Milton Filho Department of Construction and Structures Polytechnic School Federal University of Bahia Rua Aristides Novis 02 5° andar Federacao Salvador BA Brazil CEP: 40210-910 Bahia Federal Institute of Education Science and Technology Rua Emidio dos Santos Barbalho Salvador BA Brazil CEP." 40301-015 Brazil CEP." 40210-910 Department of Mechanical Engineering Polytechnic School Federal University of Bahia Rua Aristides Novis 02 5° andar Federagao Salvador BA Brazil CEP." 40210-910 Research and Education Center in Composite Materials (CEPEC) Avenida Laurindo ROgis 360 Cond. Castro Alves BL. llA AP 412 Bela Vista de Brotas Salvador BA Brazil CEP: 40240-550

In this paper, we investigate the properties of an alternative material for use in marine engineering, namely a rigid and light sandwich-structured composite made of expanded polystyrene and fiberglass. Not only does this material have an improved section modulus, but it is also inexpensive, light, easy to manipulate, and commercially available in various sizes. Using a computer program based on the finite element method, we calculated the hogging and sagging stresses and strains acting on a prismatic boat model composed of this material, and determined the minimum sizes and maximum permissible stresses to avoid deformation. Finally, we calculated the structural weight of the resulting vessel for comparison with another structure of comparable dimensions constructed from the commonly used core material Divinycell.

关键词： naval construction computational analysis composite material sandwich-structure expanded polystyrene fiberglass composite structure concepts finite element method economic viability

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Advanced Game Development with Programmable Graphics Hardware 1

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2005年

作者： Watt Alan policarpo Fabio

ISBN: (数字)9780429062636

ISBN: (纸本)9780367446475

Written for game programmers and developers, this book covers GPU techniques and supporting applications that are commonly used in games and similar real-time 3D applications. The authors describe the design of programs and systems that can be used to implement games and other applications whose requirements are to render real-time animation sequen

关键词： Computer games

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Controlling flowering of Medicago sativa(alfalfa)by inducing dominant mutations

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Journal of Integrative Plant Biology 2022年第2期64卷 205-214页

作者： Maurizio junior Chiurazzi Anton Frisgaard Nørrevang Pedro García Pablo D.Cerdán Michael Palmgren Stephan Wenkel NovoCrops Center University of CopenhagenThorvaldsensvej 40Frederiksberg C1871 Denmark Copenhagen Plant Science Centre University of CopenhagenThorvaldsensvej 40Frederiksberg C1871 Denmark Department of Plant and Environmental Sciences University of CopenhagenThorvaldsensvej 40Frederiksberg C1871 Denmark Fundación Instituto Leloir IIBBA-CONICETAvenida Patricias Argentinas 435Buenos Aires1405 Argentina

Breeding plants with polyploid genomes is challenging because functional redundancy hampers the identification of loss-of-function *** sativa is tetraploid and obligate outcrossing,which together with inbreeding depression complicates traditional breeding approaches in obtaining plants with a stable growth *** dominant mutations would provide an alternative strategy to introduce domestication traits in plants with high gene *** we describe two complementary strategies to induce dominant mutations in the *** genome and how they can be relevant in the control of flowering ***,we outline a genome-engineering strategy that harnesses the use of microProteins as developmental *** are small proteins that appeared during genome evolution from genes encoding larger *** allows us to retrace evolution and create microProtein-coding genes de ***,we provide an inventory of genes regulated by microRNAs that control plant *** respective gene transcripts microRNA-resistant by inducing point mutations can uncouple microRNA ***,we investigated the recently published genomes of *** and provide an inventory of breeding targets,some of which,when mutated,are likely to result in dominant traits.

关键词： flowering time genome-engineering Medicago sativa microProtein microRNA

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