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Recent progress in Mg-based alloys as a novel bioabsorbable biomaterials for orthopedic applications

Journal of Magnesium and Alloys 2022年第6期10卷 1428-1456页

作者： Fei Xing Shang Li Dongdi Yin Jichang Xie pol maria rommens Zhou Xiang Ming Liu Ulrike Ritz Orthopedic Research Institute Department of OrthopedicsWest China HospitalSichuan UniversityNo.37 Guoxue LaneChengduSichuan 610041China Department of Plastic and Burn Surgery West China HospitalSichuan UniversityNo.37 Guoxue LaneChengduSichuan 610041China Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuan 610031China Laboratoire Roberval FRE UTC-CNRS 2012Sorbonne universitésUniversitéde Technologie de CompiègneCentre de recherche RoyallieuCS60319Compiègne CEDEX 60203France Department of Orthopaedics and Traumatology Biomatics GroupUniversity Medical Center of the Johannes Gutenberg UniversityLangenbeckstr.1Mainz 55131Germany

Traditional orthopedic metal implants,such as titanium(Ti),Ti alloys,and cobalt-chromium(Co-Cr)alloys,cannot be degraded in *** patients is must always suffer a second operation to remove the ***,stress shielding,or stress protection occurs when traditional orthopedic metal implants are applied in fractures *** mechanical shunt produced by traditional orthopedic metal implants can cause bone loss over time,resulting in decreased bone strength and delayed fracture *** metals that‘biocorrode’are currently attracting significant interest in the orthopedics field due to their suitability as temporary *** one of the biodegradable metals,magnesium(Mg)and Mg alloys have gained interest in the field of medicine due to their low density,excellent biocompatibility,high bioresorbability,and proper mechanical ***,Mg ions released from the metal implants can promote osteogenesis and angiogenesis during the degradation process in vivo,which is substantially better for orthopedic fixation than other bioinert metal ***,this review focuses on the properties,fabrication,biological functions,and surface modification of Mg-based alloys as novel bioabsorbable biomaterials for orthopedic applications.

关键词： Magnesium Mg alloys Biomedical implants Bone regeneration Surface modification

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Mechanical characterization of rose bengal and green light crosslinked collagen scaffolds for regenerative medicine

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Regenerative Biomaterials 2021年第6期8卷 185-198页

作者： Joy Braun Stefanie Eckes Michelle Fiona Kilb Dirk Fischer Claudia Eßbach pol maria rommens Philipp Drees Katja Schmitz Daniela Nickel Ulrike Ritz Department of Orthopedics and Traumatology BiomaTiCSUniversity Medical CenterJohannes Gutenberg UniversityLangenbeckstraße 1Mainz 55131Germany Clemens-Schopf-Institute of Organic Chemistry and Biochemistry Technical University of DarmstadtAlarich-Weiss-Straße 4Darmstadt 64287Germany Berufsakademie Sachsen—Staatliche Studienakademie Glauchau University of Cooperative EducationKopernikusstraße 51Glauchau 08371Germany

Collagen is one of the most important biomaterials for tissue engineering *** its excellent biocompatibility,it shows the non-negligible disadvantage of poor mechanical *** crosslinking with rose bengal and green light(RGX)is an appropriate method to improve this *** development of collagen laminates is helpful for further adjustment of the mechanical properties as well as the controlled release of incorporated *** this study,we investigate the impact of crosslinking and layering of two different collagen scaffolds on the swelling behavior andmechanical behavior inmicro tensile tests to obtain information on its wearing comfort(stiffness,strength and ductility).The mechanical stability of the collagen material after degradation due to cell contact is examined using thickness *** is no linear increase or decrease due to layering homologous ***,a decrease in elongation at break,Young’s modulus and ultimate tensile strength are measured when the untreated monolayer is compared to the crosslinked ***,we can detect a connection between stability and cell *** results show that with variation in number and type of layers,collagen scaffolds with tailored mechanical properties can be *** a multi-layered structure enables the release of biomolecules into inner or outer layers for biomedical applications.

关键词： collagen type I collagen laminates rose bengal and green light crosslinking thickness analysis micro tensile testing cell-collagen interactions

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