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Constructing low-dimensional perovskite network to assist efficient and stable perovskite solar cells

Journal of Energy Chemistry 2024年第9期96卷 625-632页

作者： Jinwen Gu Xianggang Sun pok fung chan Xinhui Lu Peng Zeng Jue Gong Faming Li Mingzhen Liu School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina Department of Physics The Chinese University of Hong Kong Shatin999077Hong KongChina Sichuan University-Pittsburgh Institute Sichuan UniversityChengdu 610065China State Key Laboratory Electronic Thin Film and Integrated Devices University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina

The use of low-dimensional(LD)perovskite materials is crucial for achieving high-performance perovskite solar cells(PSCs).However,LD perovskite films fabricated by conventional approaches give rise to full coverage of the underlying 3D perovskite films,which inevitably hinders the transport of charge carriers at the interface of ***,we designed and fabricated LD perovskite structure that forms net-like morphology on top of the underlying three-dimensional(3D)perovskite bulk *** net-like LD perovskite not only reduced the surface defects of 3D perovskite film,but also provided channels for the vertical transport of charge carriers,effectively enhancing the interfacial charge transfer at the LD/3D *** net-like morphological design comprising LD perovskite effectively resolves the contradiction between interfacial defect passivation and carrier extraction across the ***,the net-like LD perovskite morphology can enhance the stability of the underlying 3D perovskite film,which is attributed to the hydrophobic nature of LD *** a result,the net-like LD perovskite film morphology assists PSCs in achieving an excellent power conversion efficiency of up to 24.6%with over 1000 h long-term operational stability.

关键词： Low-dimensional perovskite Network Carrier transport Perovskite solar cell Stability

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A prospective cohort of men with localized prostate cancer on active surveillance protocol in Hong Kong,China:what did we learn?

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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu Ivan Ching-Ho Ko Cindy Yeuk-Lam Hong Samuel Chi-Hang Yee Jeremy Yuen-Chun Teoh Samson Yun-Sang chan Ho-Man Tam Chi-Kwok chan Chi-Fai Ng Peter Ka-fung Chiu SH Ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(AS)in the management of low-risk prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active Surveillance(PRIAS)protocol with local adaptation at SH Ho Urology Centre,Prince of Wales Hospital,Hong Kong,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PSAD)and the presence of the highest ProstateImaging-Reporting and Data System(PI-RADS)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PSAD>0.2 ng ml^(−2)or PI-RADS 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PSAD≤0.2 ng ml−2 and PI-RADS 2 or 3 *** study concludes that AS is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PSAD>0.2 ng ml^(−2)and PI-RADS 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk groups.

关键词： active surveillance cohort localized prostate cancer

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亚洲国家中药注册的统一方法（英文）

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Journal of Traditional Chinese Medical Sciences 2024年第2期 143-147页

作者： chan fung Vivian S.W. Independent Scholar

中药产业对公众健康和经济增长都至关重要。根据欧盟（EU）指令，在欧盟（传统）草药制品框架下，具有较长使用历史的草药可在欧盟注册。然而，本指令中有一条件，即只有在欧盟市场上至少有10-15年使用历史的草药才能被注册和/或获得上... 详细信息

中药产业对公众健康和经济增长都至关重要。根据欧盟（EU）指令，在欧盟（传统）草药制品框架下，具有较长使用历史的草药可在欧盟注册。然而，本指令中有一条件，即只有在欧盟市场上至少有10-15年使用历史的草药才能被注册和/或获得上市许可。作者认为，在欧盟监管框架内设定的在欧盟国家有10-15年使用历史的条件考虑了基因差异，基因差异可能导致不同世界人群的药物不良反应发生变化。考虑到这一概念，借鉴欧盟指令的主要内容到亚洲国家这些中药起源国是合理的。中国、新加坡、日本和韩国等国拥有完善的药品注册框架，最能够执行最佳实践和促进统一的区域内中药注册程序。此外，注册过程本身也允许在制品注册/上市许可前后系统地收集更多的安全性和有效性数据。这些都是未来药物开发的宝贵信息。中药的治疗价值是无限的，它被排除在欧盟的监管框架之外，在欧盟监管框架下有注册资格的中药数量有限，这限制了中药在现代药物中扩大使用范围和发扬光大的机会。在亚洲国家中尽早建立统一的基于风险的中药注册程序非常重要。这将强化数据库，以证实中药安全使用的历史，并进一步在亚洲地区内外保存和发扬中医的治疗价值。

关键词：中药人群遗传统一注册亚洲国家

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Inferior vena cava reconstruction in extended right hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 533-534页

作者： Karin KY Ho Sui Ling Sin Kin Pan Au Henry HY Lee Daniel TL chan Albert chan Department of Surgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina Department of Surgery Yan Chai Hospital7 Yan Chai StreetHong KongChina State Key Laboratory of Liver Research(Li Ka Shing Faculty of Medicine The University of Hong Kong)102 Pok Fu Lam RoadHong KongChina

To the Editor : Barcelona Clinic Liver Cancer(BCLC) Stage C hepatocellular carcinoma(HCC) with vascular invasion has been considered unresectable. However, the curative rate from systemic treatment is rather dismal. Even with the use of immunotherapy, complete remission is less than 10% [ 1 ]. On the contrary, recent advances in transplant oncology, especially in the application of liver transplant-related surgical techniques in complex liver resections, make the operation possible for patients with locally advanced HCC who were previously considered to be unresectable [ 2 ]. We hereby present the surgical management of a patient with giant HCC in right liver lobe with inferior vena cava(IVC) invasion.

关键词： invasion vena Liver

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Effects of SARS-CoV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease

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World Journal of Hepatology 2024年第2期16卷 211-228页

作者： Lung-Yi Mak Matthew Shing Hin Chung Xue Li Francisco Tsz Tsun Lai Eric Yuk Fai Wan Celine Sze Ling Chui Franco Wing Tak Cheng Esther Wai Yin chan Ching Lung Cheung Ivan Chi Ho Au Xi Xiong Wai-Kay Seto Man-fung Yuen Carlos King Ho Wong Ian Chi Kei Wong Department of Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Laboratory of Data Discovery for Health(D24H) Hong Kong Science and Technology ParkHong KongChina Department of Family Medicine and Primary Care The University of Hong KongHong KongChina School of Nursing The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Department of Practice and Policy University College LondonLondon WC1E 6BTUnited Kingdom Aston School of Pharmacy Aston UniversityBirmingham B47ETUnited Kingdom

BACKGROUND Chronic liver disease(CLD)was associated with adverse clinical outcomes among people with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** To determine the effects of SARS-CoV-2 infection on the incidence and treatment strategy of hepatocellular carcinoma(HCC)among patients with *** A retrospective,territory-wide cohort of CLD patients was identified from an electronic health database in Hong *** with confirmed SARS-CoV-2 infection[coronavirus disease 2019(COVID-19)+CLD]between January 1,2020 and October 25,2022 were identified and matched 1:1 by propensity-score with those without(COVID-19-CLD).Each patient was followed up until death,outcome event,or November 15,*** outcome was incidence of *** outcomes included all-cause mortality,adverse hepatic outcomes,and different treatment strategies to HCC(curative,non-curative treatment,and palliative care).Analyses were further stratified by acute(within 20 d)and post-acute(21 d or beyond)phases of SARS-CoV-2 *** rate ratios(IRRs)were estimated by Poisson regression *** Of 193589 CLD patients(>95%non-cirrhotic)in the cohort,55163 patients with COVID-19+CLD and 55163 patients with COVID-19-CLD were included after 1:1 propensity-score *** 249-d median follow-up,COVID-19+CLD was not associated with increased risk of incident HCC(IRR:1.19,95%CI:0.99-1.42,P=0.06),but higher risks of receiving palliative care for HCC(IRR:1.60,95%CI:1.46-1.75,P<0.001),compared to *** both acute and post-acute phases of infection,COVID-19+CLD were associated with increased risks of allcause mortality(acute:IRR:7.06,95%CI:5.78-8.63,P<0.001;post-acute:IRR:1.24,95%CI:1.14-1.36,P<0.001)and adverse hepatic outcomes(acute:IRR:1.98,95%CI:1.79-2.18,P<0.001;post-acute:IRR:1.24,95%CI:1.13-1.35,P<0.001),compared to *** Although CLD patients with SARS-CoV-2 infection were not associated with increased risk of HCC,they

关键词： SARS-CoV-2 infection Chronic liver disease Long COVID Post-COVID-19 syndrome Cirrhosis Hepatocellular carcinoma

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Duplex kidneys and the risk of urinary tract infection in children

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World Journal of Pediatrics 2022年第2期18卷 144-146页

作者： Chon In Kuok Wun fung Hui Winnie Kwai Yu chan Department of Paediatrics Queen Elizabeth Hospital30 Gascoigne RoadKowloonHong KongChina

Duplex kidney,also known as duplicated kidney or renal duplication,is a form of congenital anomaly of kidney and urinary tract(CAKUT)characterized by the presence of two pelvicalyceal systems,dividing a kidney into up... 详细信息

关键词： kidney Duplex urinary

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Classification of rectal cancer according to recurrence types-comparison of Japanese guidelines and Western guidelines

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World Journal of Clinical Cases 2022年第36期10卷 13284-13292页

作者： Hiroshi Miyakita Yutaro Kamei Lin fung chan Kazutake Okada Hajime Kayano Seiichiro Yamamoto Department of Digestive System Surgery Tokai University School of MedicineIsehara 259-1193KanagawaJapan

BACKGROUND Rectal cancer is characterized by more local recurrence(LR)and lung metastasis than colon ***,the diagnosis of rectal cancer is not standardized as there is no global consensus on its definition and *** classification of rectal cancer differs between Japanese and Western *** To clarify the characteristics of rectal cancer by comparing the tumor location and characteristics of rectal cancer with those of colon cancer according to each set of *** A total of 958 patients with Stage II and III colorectal cancer were included in the analysis:607 with colon cancer and 351 with rectal *** of rectal cancers was assessed by enema examination and rigid *** to Japan guidelines,rectal cancer is classified as Rb(below the peritoneal inversion),Ra(between the inferior margin of second sacral vertebrae and Rb)or RS(between Ra and sacral promontory).RESULTS There were no significant differences between RS rectal cancer and colon cancer in the rates of liver and lung metastasis or *** metastasis and LR were significantly more common among Rb rectal cancer(in Japan)than in colon cancer(P=0.0043 and P=0.0002,respectively).Lung metastases and LR occurred at significantly higher rates in rectal cancer measuring≤12 cm and≤10 cm than in colon cancers(P=0.0117,P=0.0467,P=0.0036,P=0.0010).Finally,the rates of liver metastasis,lung metastasis,and LR in rectal cancers measuring 11 cm to 15 cm were 6.9%,2.8%,and 5.7%,*** were equivalent to the rates in colon *** High rectal cancer may be treated with the same treatment strategies as colon *** was no difference in the classification of colorectal cancer between Japan and Western countries.

关键词： Colon cancer Metastasis Local recurrence Classification of rectal cancer Western guidelines Japanese guideline

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Recurrent pyogenic cholangitis:An indication for liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 396-398页

作者： Wong Hoi She Wing Chiu Dai James YY fung Tan To Cheung Albert CY chan Chung Mau Lo Department of Surgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina

To the Editor:Recurrent pyogenic cholangitis(RPC),also known as Hong Kong disease[1],is an unique disease entity with a decreasing *** is characterized by the formation of intrahepatic biliary pigmented stones,which r... 详细信息

关键词： cholangitis obstruction liver

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Toward haplotype studies in polyploid plants to assist breeding

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Molecular Plant 2021年第12期14卷 1969-1972页

作者： Yuxuan Yuan Armin Scheben David Edwards Ting-fung chan School of Life Sciences and State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongHong Kong SARChina Simons Center for Quantitative Biology Cold Spring Harbor LaboratoryCold Spring HarborNYUSA School of Biological Sciences and Institute of Agriculture The University of Western AustraliaPerthAustralia

THE IMPORTANCE OF POLYPLOIDS Polyploids are typically classified as either autopolyploids or allo-polyploids(Figure 1).Autopolyploids result from whole-genome duplication within the same species,while allopolyploids derive from the hybridization of different species followed by chromo-some ***,plant allopolyploids are thought to be the most common polyploids,although autopolyploid plants and allopolyploid plants might be at parity in numbers(Barker et al.,2016).During speciation,polyploidization allows plants to adapt to different environments(Soltis et al.,2009).Mutation and hybridization increase the heterozygosity of the genome,while genome rearrangements during polyploidization lead to the formation of new chromosomes and new chromosome rearrangements,which complicate polyploid genomes and the following studies.

关键词： breeding Figure

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Genotypes versus phenotypes:The potential paradigm shift in the diagnosis and management of pediatric neoplasms

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Pediatric Investigation 2020年第3期4卷 204-210页

作者： Godfrey Chi-fung chan Carol Matias chan Department of Paediatrics&Adolescent Medicine Hong Kong Children’s Hospital&Hong Kong University Shenzhen HospitalThe University of Hong KongHong KongChina Faculty of Medicine University of Central LancashireUK

The gold standard of cancer diagnosis has long been based on histological *** the rapid advancement of genetic medicine,such standard algorithm of diagnostic approach is facing a *** genetic findings have been changed from being a"supporting character"into the role of a"main character".More and more disease diagnosis and classification has to be defined by genetic *** this article,we focus on the challenges in the field of pediatric *** cited 2 scenarios where genetic information plays a pivotal role in identifying the underlying *** first scenario is that same genetic mutation can lead to variable clinical phenotypes,this includes EWSR1-PATZ1 fusion related neoplasms;BCOR neoplasms;and GATA-2 deficiency related immunodeficiency and myelodysplastic *** scenario is relatively more common that is the same clinical and histopathological phenotype with different underlying *** genotypes actually impact on the treatment response and *** used medulloblastoma as an *** fact,we can also find similar scenario in many pediatric cancers such as Ewing sarcoma,ependymoma,*** essence of this article is to remind clinicians of the rapid development in genetic medicine and it has been reshaping the landscape of the modern disease classification and therapeutic *** the near future,it may even lead to a paradigm shift in our disease diagnostic algorithm.

关键词： Genotype Phenotype Pediatric cancers

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