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一种特异性识别非小细胞肺癌A549细胞的小分子肽

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生物化学与生物物理进展 2007年第10期34卷 1080-1085页

作者：郭琳琅郭颖 DERICK lau 许寅超南方医科大学珠江医院广州510282 University of Californiaat Davis Cancer Center

应用"一个珠子一个化合物"的组合化学肽库,以期筛选得到特异性识别非小细胞肺癌细胞(A549)的小分子肽.初次筛选共得到29个与A549阳性结合的珠子,经氨基酸序列分析后发现含有-NGXG-肽链结构的序列共有10个.选择cNGQGEQc作进一步的细胞特... 详细信息

应用"一个珠子一个化合物"的组合化学肽库,以期筛选得到特异性识别非小细胞肺癌细胞(A549)的小分子肽.初次筛选共得到29个与A549阳性结合的珠子,经氨基酸序列分析后发现含有-NGXG-肽链结构的序列共有10个.选择cNGQGEQc作进一步的细胞特异性研究,发现cNGQGEQc与非小细胞肺癌A549、Calu-1及H178的粘附特异性明显高于其他细胞系,对cNGQGEQc的结构分析显示,-NGXG-及六肽长度对小分子肽与A549细胞的粘附非常重要.标记FITC的小分子肽cNGQGEQc能与A549细胞发生特异性结合.用抗整合素的抗体(!1～6,"v和#1～5)阻断小分子肽与A549细胞表面的相应受体结合,结果显示,α3与$亚单位的任何组合均对cNGQGEQc与A549细胞的粘附有明显的阻断作用.结果表明,小分子肽cNGQGEQc是通过细胞表面整合素α3与非小细胞肺癌A549发生特异性结合.

关键词：小分子肽组合化学非小细胞肺癌

On-chip single-photon chirality encircling exceptional points

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Chip 2023年第4期2卷 71-77页

作者： Zhen-Nan Tian Feng Yu Xu-lin Zhang Kai Ming lau Li-Cheng Wang Jensen Li C.T.Chan Qi-Dai Chen State Key Laboratory of Integrated Optoelectronics College of Electronic Sci-ence and EngineeringJilin UniversityChangchun 130012China Department of Physics The Hong Kong University of Science and TechnologyClear Water BayHong Kong 999077China

Exceptional points(EPs),which are typically defined as the degener-acy points of a non-Hermitian Hamiltonian,have been investigated in various physical systems such as photonic *** particular,the intriguing topological structures around EPs have given rise to novel strategies for manipulating photons and the underlying mechanism is especially useful for on-chip photonic *** some on-chip experiments with the adoption of lasers have been reported,EP-based photonic chips working in the quantum regime largely re-main *** the current work,a single-photon experiment was proposed to dynamically encircle an EP in on-chip photonic waveg-uides possessing passive anti-parity-time *** coinci-dences measurement reveals a chiral feature of transporting single photons,which can act as a building block for on-chip quantum de-vices that require asymmetric *** findings in the cur-rent work pave the way for on-chip experimental study on the physics of EPs as well as inspiring applications for on-chip non-Hermitian quantum devices.

关键词： Non-Hermitian photonics Photonic chip Exceptional points Single photons

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胰十二指肠切除术后高淀粉酶血症的研究进展

中国普通外科杂志 2024年第3期33卷 424-430页

作者：开塞尔·阿不都哈迪尔林海新疆医科大学第一附属医院胰腺外科新疆乌鲁木齐830000

胰十二指肠切除术(PD)术后并发症发生率高达40%,故对其并发症的早期预测及处理是有必要的。PD术后高淀粉酶血症(poh)被认为是术后早期并发症发生率及严重程度的预测因子,但因对血清淀粉酶活性升高的机制不明确,其意义和含义近些年以不... 详细信息

胰十二指肠切除术(PD)术后并发症发生率高达40%,故对其并发症的早期预测及处理是有必要的。PD术后高淀粉酶血症(poh)被认为是术后早期并发症发生率及严重程度的预测因子,但因对血清淀粉酶活性升高的机制不明确,其意义和含义近些年以不同的方式被解释。在此,笔者就poh概念的提出与发展历程、原因及影响、与术后急性胰腺炎及术后胰瘘之间的关系,以及防治措施等加以综述。

关键词：胰十二指肠切除术手术后并发症高淀粉酶血症胰腺炎胰腺瘘综述

Impacts of pollution heterogeneity on population exposure in dense urban areas using ultra-fine resolution air quality data

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Journal of Environmental Sciences 2023年第3期125卷 513-523页

作者： Wenwei Che Yumiao Zhang Changqing lin Yik Him Fung Jimmy C.H.Fung Alexis KHlau Division of Environment and Sustainability The Hong Kong University of Science and TechnologyClear Water BayHong KongChina Department of Mathematics The Hong Kong University of Science and TechnologyClear Water BayHong KongChina Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyClear Water BayHong KongChina Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality Hong Kong University of Science and TechnologyClear Water BayHong KongChina

Traditional air quality data have a spatial resolution of 1 km or above, making it challenging to resolve detailed air pollution exposure in complex urban areas. Combining urban morphology, dynamic traffic emission, regional and local meteorology, physicochemical transformations in air quality models using big data fusion technology, an ultra-fine resolution modeling system was developed to provide air quality data down to street level. Based on one-year ultra-fine resolution data, this study investigated the effects of pollution heterogeneity on the individual and population exposure to particulate matter(PM_(2.5)and PM_(10)),nitrogen dioxide(NO_(2)), and ozone(O_(3)) in Hong Kong, one of the most densely populated and urbanized cities. Sharp fine-scale variabilities in air pollution were revealed within individual city blocks. Using traditional 1 km average to represent individual exposure resulted in a positively skewed deviation of up to 200% for high-end exposure individuals. Citizens were disproportionally affected by air pollution, with annual pollutant concentrations varied by factors of 2 to 5 among 452 District Council Constituency Areas(DCCAs) in Hong Kong, indicating great environmental inequities among the population. Unfavorable city planning resulted in a positive spatial coincidence between pollution and population, which increased public exposure to air pollutants by as large as 46% among districts in Hong Kong. Our results highlight the importance of ultra-fine pollutant data in quantifying the heterogeneity in pollution exposure in the dense urban area and the critical role of smart urban planning in reducing exposure inequities.

关键词： Particulate matter Nitrogen dioxide Ozone Pollution heterogeneity Urban area

Comparative efficacy of traditional Chinese herbal injection for chronic renal failure:A systematic review and network meta-analysis of randomized controlled trials

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Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 83-99页

作者： Dongni Shi Feng Liang Xihong Wang Nana Wang lin Zhang Wanting Cui Jiashuai Deng Chung Tai lau Luofan Zhang Xuan Zhang School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China Department of Nephropathy First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China Ministry of Education Tianjin University of Traditional Chinese MedicineTianjin 301617China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China

Objective: To conduct a systematic review and network meta-analysis(NMA) for the comparison of the efficacy and safety of Chinese herbal injection(CHI) combined with Western medicine(WM) and WM monotherapy for chronic renal failure(CRF).Methods: Eight databases were searched from inception to August 30, 2022. Randomized controlled trials(RCTs) regarding the comparison of CHI-WM combination therapy and WM monotherapy were included. Literature search, risk-of-bias assessment, and data extraction were conducted by 2 reviewers independently. NMA was performed by Stata 14.0, R 4.0.4 software, and the latest risk of bias assessment tool 2(RoB 2).Results: A total of 53 RCTs were finally included, involving 4445 participants and 16 CHIs. RoB 2 showed that 2 of these studies had a high risk of bias. Tianqi injection(TQ) + WM was the most effective in reducing serum creatinine(Scr) level. Xingding injection(XD) + WM was the most effective in reducing blood urea nitrogen(BUN) and cystatin C(Cys C) levels. Guhong injection(GH) + WM had the highest endogenous creatinine clearance rate(Ccr). Shuxuetong injection(SXT) + WM was the most effective in improving the clinical effective rate. Danhong injection(DH) + WM resulted in the lowest 24-h urinary protein quantity(24 h-UPQ), while Danshen injection(DS) + WM led to the lowest blood uric acid(UA)level. Shenfu injection(SF) + WM was the most effective in increasing hemoglobin(Hb) ***: CHIs-WM combination therapy is more effective than WM monotherapy in treating *** all of the indicators, SK + WM may be the optimal treatment option for improving renal function in patients with CRF.

关键词： Chronic renal failure Chinese herbal injections Combination therapy Systematic review Network meta-analysis

Synthesis and Characterization of Ni-Zn Ferrite Nanoparticles (Ni0.25Zn0.75Fe2O4) by Thermal Treatment Method

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Advances in Nanoparticles 2013年第4期2卷 378-383页

作者： poh lin Leng Mahmoud Goodarz Naseri Elias Saion Abdul Halim Shaari Mazaliana Ahmad Kamaruddin Department of Physics Faculty of Science Malayer University Malayer Iran Department of Physics Faculty of Science Universiti Putra Malaysia Serdang Malaysia

Cubic structured nickel-zinc ferrite nanoparticles (Ni0.25Zn0.75Fe2O4) have been synthesized by thermal treatment method. In this procedure, an aqueous solution containing metal nitrates as precursors, polyvinyl pyrrolidone as a capping agent, and deionized water as a solvent were thoroughly stirred, dried at 353 K for 24 h, and crushed into powder before calcination to remove organic matters and crystallize the particles. The structure and particle size were characterized by X-ray powder diffraction and transmission electron microscopy. The average particle size increased from 7 to 25 nm with increase of calcination temperature from 723 to 873 K respectively. The magnetic properties were determined by vibrating sample magnetometer and electron paramagnetic resonance electron paramagnetic resonance at room temperature. By increasing the calcinations temperatures from 723 to 873 K it showed an increase of the magnetization saturation from 11 to 26 emu/g and the g-factor from 2.0670 to 2.1220. The Fourier transform infrared spectroscopy was used to confirm the presence of metal oxide bands at all temperatures and the removal of organic matters at 873 K.

关键词： Thermal Treatment Nickel Zinc Ferrite Nanoparticles Magnetic Property

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一种特异性识别小细胞肺癌细胞的小分子肽

生物化学与生物物理进展 2006年第6期33卷 562-566页

作者：郭琳琅郭颖 DERICK lau 肖莎许寅超申洪南方医科大学珠江医院广州510282 University of California at Davis Cancer Center USA 南方医科大学基础医学院病理学教研室广州510515

应用“一个珠子一个化合物”的组合化学肽库技术,筛选得到特异性识别小细胞肺癌细胞(DMS53)的小分子肽.初次筛选共得到32个与DMS53阳性结合的珠子,经氨基酸序列分析后发现,含有cNGRXXXc或cXNGRXXc肽链结构的序列共有10个.再次合成三种... 详细信息

应用“一个珠子一个化合物”的组合化学肽库技术,筛选得到特异性识别小细胞肺癌细胞(DMS53)的小分子肽.初次筛选共得到32个与DMS53阳性结合的珠子,经氨基酸序列分析后发现,含有cNGRXXXc或cXNGRXXc肽链结构的序列共有10个.再次合成三种有代表性的小分子肽,发现cFNGRQQc与DMS53的结合率明显高于其他小分子肽.选择cFNGRQQc作进一步的细胞特异性研究,发现cFNGRQQc与DMS53的粘附特异性明显高于其他细胞系,对cFNGRQQc的结构分析显示,-NGR-及六肽长度对小分子肽与DMS53细胞的粘附非常重要.用抗整合素、E-cadherin、NCAM及ICAM的抗体或多肽阻断小分子肽与DMS53细胞表面的相应受体结合,未见明显的阻断效应.小分子肽与DMS53细胞表面的结合位点有待于进一步证实.

关键词：小分子肽组合化学小细胞肺癌

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China CDC weekly 2022年第40期4卷 885-889,I0002-I0005页

作者： Yuan Bai Mingda Xu Caifen Liu Mingwang Shen lin Wang linwei Tian Suoyi Tan Lei Zhang Petter Holme Xin Lu Eric H.Y.lau Benjamin J.Cowling Zhanwei Du WHO Collaborating Centre for Infectious Disease Epidemiology and Control School of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Laboratory of Data Discovery for Health Limited(D24H) Hong Kong Science ParkHong Kong Special Administrative RegionChina China-Australia Joint Research Center for Infectious Diseases School of Public HealthXi’an Jiaotong University Health Science CenterXi’an CityShaanxi ProvinceChina Department of Genetics University of CambridgeCambridge CB23EHUK College of Systems Engineering National University of Defense TechnologyChangsha CityHunan ProvinceChina Department of Computer Science Aalto UniversityEspooFinland Center for Computational Social Science Kobe UniversityKobeJapan

Introduction:Minimizing the importation and exportation risks of coronavirus disease 2019(COVID-19)is a primary concern for sustaining the“Dynamic COVID-zero”strategy in *** estimation is essential for cities to conduct before relaxing border control ***:Informed by the daily number of passengers traveling between 367 prefectures(cities)in China,this study used a stochastic metapopulation model parameterized with COVID-19 epidemic characteristics to estimate the importation and exportation ***:Under the transmission scenario(R0=5.49),this study estimated the cumulative case incidence of Changchun City,Jilin Province as 3,233(95%confidence interval:1,480,4,986)before a lockdown on March 14,2022,which is close to the 3,168 cases reported in real life by March 16,*** a total of 367 prefectures(cities),127(35%)had high exportation risks according to the simulation and could transmit the disease to 50%of all other regions within a period from 17 to 94 *** average time until a new infection arrives in a location in 1 of the 367 prefectures(cities)ranged from 26 to 101 ***:Estimating COVID-19 importation and exportation risks is necessary for preparedness,prevention,and control measures of COVID-19—especially when new variants emerge.

关键词： Export Changchun prevention

Potential Antiviral Target for SARS-CoV-2:A Key Early Responsive Kinase during Viral Entry

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CCS Chemistry 2022年第1期4卷 112-121页

作者： Siwen Liu lin Zhu Guangshan Xie Bobo Wing-Yee Mok Zhu Yang Shaofeng Deng Siu-Ying lau Pin Chen Pui Wang Honglin Chen Zongwei Cai State Key Laboratory for Emerging Infectious Diseases Department of MicrobiologyThe University of Hong KongPok Fu LamHong Kong SAR 999077 State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityKowloonHong Kong SAR 999077 HKBU Shenzhen Institute of Research and Continuing Education Shenzhen 518000 Beijing Normal University-Hong Kong Baptist University United International College Zhuhai 519087

Currently,there is no effective antiviral medication for coronavirus disease 2019(COVID-19)and the knowledge on the potential therapeutic target is in great *** by a time-course transmission electron microscope(TEM)imaging,we analyzed early phosphorylation dynamics within the first 15 min during severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)viral *** on alterations in the phosphorylation events,we found that kinase activities such as protein kinase C(PKC),interleukin-1 receptor-associated kinase 4(IRAK4),MAP/microtubule affinity-regulating kinase 3(MARK3),and TANK-binding kinase 1(TBK1)were affected within 15 min of *** of the corresponding kinase inhibitors of PKC,IRAK4,and p38 showed significant inhibition of SARS-CoV-2 ***,proinflammatory cytokine production was reduced by applying PKC and p38 *** an acquisition of a combined image data using positiveand negative-sense RNA probes,as well as pseudovirus entry assay,we demonstrated that PKC contributed to viral entry into the host cell,and therefore,could be a potential COVID-19 therapeutic target.

关键词： SARS-CoV-2 viral entry phosphoproteomics early responsive kinase antiviral target PKC