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Topoisomerase I Inhibition Radiosensitizing Hepatocellular Carcinoma by RNF144A-mediated DNA-PKcs Ubiquitination and Natural Killer Cell Cytotoxicity

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 614-625页

作者： Chiao-Ling Tsai po-sheng yang Feng-Ming Hsu Ann-Lii Cheng Wan-Ni Yu Jason Chia-Hsien Cheng Graduate Institute of Clinical Medicine National Taiwan University College of MedicineChina Taipei Division of Radiation Oncology Department of OncologyNational Taiwan University HospitalChina Taipei Department of General Surgery Mackay Memorial HospitalChina Taipei Graduate Institute of Oncology National Taiwan University College of MedicineChina Taipei Cancer Center National Taiwan UniversityChina Taipei Taiwan Liposome Company China Taipei

Background and Aims: Topoisomerase I (TOP1) partici-pates the repair of DNA double-strand breaks (DSBs) upon radiation therapy (RT). RNF144A mediates ubiquitination of catalytic subunit of DNA protein kinase (DNA-PKcs), a critical factor in DSB repair. This study aimed to investigate the natural killer (NK) cell-mediated radiosensitization with TOP1 inhibition and the mechanism by DNA-PKcs/RNF144A. Methods: In vitro synergism with TOP1i or cocultured NK cells and RT were evaluated in human hepatocellular car-cinoma (HCC) cell lines (Huh7/PLC5) by clonogenic surviv-als. Orthotopic xenografts were treated with Lipotecan and/or RT. Protein expression was analyzed by western blotting, immunoprecipitation, subcellular fractionation, and confocal microscopy. Results: Lipotecan/RT had a superior synergis-tic effect to RT on HCC cells. Combined RT/Lipotecan reduced the xenograft size by 7-fold than RT (ppotecan caused more radiation-induced DNA damage and DNA-PKcs signaling. The expression of major histocompatibility com-plex class I-related chain A and B (MICA/B) on tumor cells is associated with the sensitivity to NK cell-mediated lysis. Cocultured NK and HCC cells with Lipotecan radiosensitized HCC cells/tissues with the expression of MICA/B. RNF144A increased more in Huh7 cells with combined RT/TOP1i, and reduced the prosurvival function of DNA-PKcs. The effect was reversed by inhibiting the ubiquitin/proteasome system. In comparison, RNF144A decreased through nuclear transloca-tion with the cumulated DNA-PKcs and radio-resistance of PLC5 cells. Conclusions: TOP1i reinforces NK cell-activated anti-HCC effect of RT through RNF144A mediated DNA-PKcs ubiquitination. RNF144A provides a reason for differentiating radiosensitization effect between HCC cells.

关键词： Hepatocellular carcinoma Radiotherapy DNA topoisomerase I Li-potecan RNF144A.

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Regulated reaction pathway of CO_(2)photoreduction into CH_(4)by metal atom pair sites

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Rare Metals 2024年第9期43卷 4620-4627页

作者： Dong-po He Guang-Bing Huang Jun Hu yang Wu Xiao-Dong Li Qing-Xia Chen Shan Zhu Wen-sheng Yan Jun-Fa Zhu yang Pan Xing-Chen Jiao Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China Hefei National Research Center for Physical Sciences at Microscale National Synchrotron Radiation LaboratoryUniversity of Science and Technology of ChinaHefei 230026China Max Planck Institute of Microstructure Physics Weinberg 206120 HalleGermany State Grid Anhui Electric power Research Institute Hefei 230601China

The carbon dioxide(CO_(2))reduction process involves complex protonation,making the resulting product often *** achieve the desired product,it is crucial to manipulate the reaction ***,we build the metal atom pair sites for selective CO_(2)photoreduction into *** a prototype,Ni atom pair sites loaded on the Mo S_(2)nanosheets were synthesized and verified by highresolution transmission electron microscopy(HRTEM),X-ray photoelectron spectroscopy(XPS)and X-rayabsorption near edge structure spectra(XANES).In-situ Fourier transform infrared spectroscopy(FTIR)monitors the*CHO group,a crucial intermediate in CH_(4)production,during CO_(2)photoreduction on the Ni-Mo S_(2)nanosheets,whereas this monitoring is not observed for the Mo S_(2)***,theoretical calculations disclose that over the Ni-Mo S_(2)nanosheet slab,the formation energy of*CHO intermediates is determined to be lower(0.585 e V)than the desorption energy of*CO intermediates for CO production(0.64 e V),implying the higher selectivity of CH_(4)production.

关键词： steps dioxide desired

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Predictors of the outcomes of acute-on-chronic hepatitis B liver failure

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World Journal of Gastroenterology 2012年第36期18卷 5078-5083页

作者： Hsiu-Lung Fan po-sheng yang Hui-Wei Chen Teng-Wei Chen De-Chuan Chan Chi-Hong Chu Jyh-Cherng Yu Shih-Ming Kuo Chung-Bao Hsieh Division of General Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical Center Division of General Surgery Department of SurgeryMackay Memorial Hospital School of Medicine University of PittsburghPittsburghPA 15261United States Division of Pediatric Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical Center

AIM： To identify the risk factors in predicting the out- come of acute-on-chronic hepatitis B liver failure pa- tients. METHODS： We retrospectively divided 113 patients with acute-on-chronic liver failure-hepatitis B virus （ACLF-HBV） and without concurrent hepatitis C or D virus infection and hepatocellular carcinoma into two groups according to their outcomes after anti-HBV therapy. Their demographic, clinical, and biochemical data on the day of diagnosis and after the first week of treatment were analyzed using the Mann-Whitney U test, Fisher＇s exact test, and a multiple logistic regres- sion analysis. RESULTS： The study included 113 patients （87 men and 26 women） with a mean age of 49.84 years. Fifty- two patients survived, and 61 patients died. Liver failure （85.2%）, sepsis （34.4%）, and multiple organ failure （39.3%） were the main causes of death. Mul- tivariate analyses showed that Acute Physiology and Chronic Health Evaluation （APACHE） Ⅱ scores ≥ 12 [odds ratio （OR） = 7.160, 95% CI： 2.834-18.092, P 〈 0.001] and positive blood culture （OR = 13.520, 95% CI： 2.740-66.721, P = 0.001） on the day of diagnosis and model for end-stage liver disease （MELD） scores 28 （OR = 8.182, 95% CI： 1.884-35.527, P = 0.005） after the first week of treatment were independent predictors of mortality. CONCLUSION： APACHE II scores on the day of diag- nosis and MELD scores after the first week of anti-HBV therapy are feasible predictors of outcome in ACLF- HBV patients.

关键词： Lamivudine Liver failure Hepatitis B virus Acute Physiology and Chronic Health Evaluation ]]score Model for end-stage liver disease scores

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Integration of 1H-NMR-Based Metabolomics Approach with Traditional Chinese Pulse Diagnosis to Evaluate the Qi-Enhancing Activity of Herbal Tea

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Chinese Medicine 2024年第3期15卷 49-74页

作者： Chia-Hsin Lin po-Jung Huang Chung-Hsuan Wang Mo-Rong Xu sheng-yang Wang Department of Forestry Chung Hsing University Taichung Fu Kang Traditional Chinese Medicine Clinic Nantou Special Crop and Metabolome Discipline Cluster Academy Circle Economy Chung Hsing University Taichung Agricultural Biotechnology Research Institute Academia Sinica Taipei City

Human metabolism is intricately linked to an individual’s health status. Regardless of living habits, it will be reflected in the metabolic characteristics of urine. The utilization of the 1H NMR-based metabolomics method has enabled examine the metabolomic changes in urine under various physiology conditions, providing valuable insights into metabolites. In this particular study, volunteers were divided into two groups based on the strength of their spleen pulses, using the pulse diagnosis method employed in traditional Chinese medicine. Subsequently, their urine samples were analyzed, revealing notable variances in urea, creatinine, citric acid, succinic acid, trimethylamine-N-oxide (TMAO), alanine, hippuric acid, and glycine between the two groups. Interestingly, individuals with weak spleen pulses showed significant improvements after consuming herbal tea. Furthermore, we conducted LC-MS analysis on herbal tea and performed adenosine triphosphate (ATP) activity tests on the C2C12 mouse skeletal muscle cell line. The results indicated that within a reasonable concentration range, exposure to herbal tea led to an increase in the mitochondrial ATP production capacity of C2C12 cells. These findings shed light on the relationship between traditional Chinese medicine pulse diagnosis and urine metabolites, highlighting their potential as non-invasive and straightforward health assessment indicators. They can aid in the preliminary determination of necessary dietary and lifestyle changes to enhance overall bodily health.

关键词： 1H-NMR Metabolomics Traditional Chinese Pulse Diagnosis Qi-Enhancing Herbal Tea

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One-step calcination synthesis of interface-coherent crystallized and surface-passivated LiNi_(0.5)Mn_(1.5)O_(4) for high-voltage lithium-ion battery

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Nano Research 2024年第5期17卷 4192-4202页

作者： Min Xu Bifu sheng Yong Cheng Junjie Lu Minfeng Chen Peng Wang Bo Liu Jizhang Chen Xiang Han Ming-sheng Wang Siqi Shi College of Materials Science and Engineering Co-Innovation Center of Efficient Processing and Utilization of Forest ResourcesNanjing Forestry UniversityNanjing 210037China State Key Laboratory of Physical Chemistry of Solid Surfaces College of MaterialsXiamen UniversityXiamen 361005China College of Mathematics and Physics Jinggangshan UniversityJi’an 343009China School of Materials Science and Engineering Shanghai UniversityShanghai 200444China Western Digital Corporation 951 Sandisk DrMilpitasCA 95035USA

LiNi_(0.5)Mn_(1.5)O_(4)(LNMO)with a spinel crystal structure presents a compelling avenue towards the development of economic cobalt-free and high voltage(~5 V)lithium-ion ***,the elevated operational voltage of LNMO gives rise to pronounced interfacial interactions between the distorted surface lattices characterized by Jahn-Teller(J-T)distortions and the electrolyte ***,a localized crystallized coherent LaNiO_(3) and surface passivated Li_(3)po_(4) layer is deposited on LNMO via a one-step calcination *** evidenced by transmission electron microscopy(TEM),time-of-flight secondary ion mass spectrometry(ToF-SIMS)and density functional theory(DFT)calculation,the epitaxial growth of LaNiO_(3) along the LNMO lattice can effectively stabilize the structure and inhibit irreversible phase transitions,and the Li_(3)po_(4) surface coating can prevent the chemical reaction between HF and transition metals without sacrificing the electrochemical *** addition,the ionic conductive Li_(3)po_(4) and atomic wetting inter-layer enables fast charge transfer transport ***,the LNMO material enabled by the lattice bonding and surface passivating features,demonstrates high performance at high current densities and good capacity retention during long-term *** rational design of interface coherent engineering and surface coating layers of the LNMO cathode material offers a new perspective for the practical application of high-voltage lithium-ion batteries.

关键词： high-voltage cathode interface-coherent surface passivating electrochemical performance

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Three types of promising functional building units for designing metal halide nonlinear optical crystals

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Chinese Journal of Structural Chemistry 2024年第6期43卷 8-11页

作者： Jiajing Wu Ru-Ling Tang sheng-Ping Guo School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou225002PR China Yunnan Key Laboratory of Electromagnetic Materials and Devices National Center for International Research on Photoelectric and Energy MaterialsSchool of Material and EnergyYunnan UniversityKunming650000PR China

Nonlinear optical(NLO)crystal materials greatly extend the tunable range of laser by frequency conversion,which promotes the rapid development of laser technology and plays an important role in many civil and military *** excellent and famous NLO crystals from the ultraviolet(UV)to visible to near infrared(NIR)regions have been developed,such as borates(KBe_(2)BO_(3)F_(2),β-BaB_(2)O_(4)),phosphates(KH_(2)po_(4),KTiOpo_(4)),chalcogenides(AgGaS_(2),AgGaSe_(2))and so on[1,2].

关键词： optical tunable designing

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Efficient capture of difluorocarbene by pyridinium 1,4-zwitterionic thiolates:A concise synthesis of difluoromethylene-containing 1,4-thiazine derivatives

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Chinese Chemical Letters 2024年第4期35卷 367-370页

作者： Zhiwei Chen Heyun sheng Xue Li Menghan Chen Xin Li Qiuling Song Institute of Next Generation Matter Transformation College of Materials Science&Engineering and College of Chemical Engineering at Huaqiao UniversityXiamen 361021China Fujian University Key Laboratory of Molecule Synthesis and Function Discovery College of ChemistryFuzhou UniversityFuzhou 350108China State Key Laboratory of Organometallic Chemistry and Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

A practical method for the construction of difluoromethylene-containing 1,4-thiazine moieties using readily available diethyl bromodifluoromethanephosphonate(BrCF_(2)po(OEt)_(2))as difluorocarbene precusor has been *** transformation features the efficient capture of difluorocarbene by pyridinium 1,4-zwitterionic thiolates.A series of structurally novel and functionalized difluoromethylene-containing 1,4-thiazine derivatives were thus synthesized in good yields.

关键词： Difluoromethylene Pyridinium 1 4-zwitterionic thiolates 1 4-Thiazine derivatives

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Fretting wear behaviour of high-nitrogen stainless bearing steel under lubrication condition

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Journal of Iron and Steel Research International 2020年第7期27卷 849-866页

作者： Huan Lin Mao-sheng yang Bai-po Shu College of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093YunnanChina Institute for Special Steel Central Iron and Steel Research InstituteBeijing 100081China

The fretting wear performance of high-nitrogen stainless bearing steel(40Cr15Mo2VN)under lubrication conditions was ***-based grease was preparedusing MoS2 and carbon nanotubes(CNTs)as *** 52100 steel ball was used in four-ball test to evaluate the extreme pressure property and wear resistance of *** four-ball test,the grease adding 0.8 mass%MoS2 and 0.8 mass%CNTs,respectively,was chosen and used for fretting *** 52100 ball and 40Cr15Mo2VN steel disc were used as the upper and lower samples for fretting *** results showed that wear power consumption increased with the increase in both sliding velocity and contact *** initial contact stress was 2.047 GPa,the main wear mechanisms were abrasive wear and plastic deformation as the velocity increased 0.028 to 0.112 m/*** the velocity was 0.028 m/s,the main wear mechanisms changed abrasive wear to adhesion wear and finally to abrasive wear and adhesion wear as the initial contact stress increased 1.788 to 2.579 *** volume loss grew sharply becaof the changes in wear *** this condition,the volume loss growth rate can be divided into three regions according to different wear power consumption ranges corresponding to different wear mechanisms.

关键词： High-nitrogen steel Sliding velocity Contact stress Adhesion wear Abrasive wear Wear power consumption

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瓶刷嵌段共聚物聚甲基丙烯酸甲酯-b-聚环氧乙烷的合成与乳液界面自组装制备结构色颜料

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高分子学报 2024年第11期55卷 1504-1517页

作者：黄凌峰宋东坡李悦生天津大学材料科学与工程学院天津300350

针对车漆涂料等应用场景对结构色材料较高的耐候性能要求,本工作利用有序自发乳化机制成功制备了聚甲基丙烯酸甲酯(PMMA)为骨架的有序多孔光子微球,展现了靓丽可调的结构色.通过原子转移自由基聚合(ATRP)合成了窄分子量分布的PMMA,并利... 详细信息

针对车漆涂料等应用场景对结构色材料较高的耐候性能要求,本工作利用有序自发乳化机制成功制备了聚甲基丙烯酸甲酯(PMMA)为骨架的有序多孔光子微球,展现了靓丽可调的结构色.通过原子转移自由基聚合(ATRP)合成了窄分子量分布的PMMA,并利用巯烯反应高效除去了因歧化终止而产生的端末双键,进一步利用酯化反应合成了末端带有降冰片烯单元的PMMA大单体.通过顺序开环易位聚合(ROMP)的合成方法,成功合成了(聚降冰片烯-g-聚甲基丙烯酸甲酯)-b-(聚降冰片烯-g-聚环氧乙烷)(PMMA-b-PEO)嵌段共聚物刷(BBCPs),数均分子量在174 kDa~359 kDa范围内可调,PDI维持在1.2以下.在有序自发乳化制备结构色颜料的过程中,采用生物来源、安全环保的苯甲醚作为油相溶剂替代甲苯,使得材料制备过程更加安全环保,消除了产物中可能的有害残留,有利于规模制备与应用.PMMA材质的结构色颜料预期具有良好的耐候性能,有望用于车漆涂料等应用场景.

关键词：嵌段共聚物自组装环保材料结构色

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LeCMPSO算法求解异构无人机协同多任务重分配问题

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控制理论与应用 2024年第6期41卷 1009-1017页

作者：王峰付青坡韩孟臣邢立宁吴虎胜武汉大学计算机学院湖北武汉430072 国防科技大学系统工程学院湖南长沙410073 武警工程大学装备管理与保障学院陕西西安710086

无人机系统在军事领域有着广泛应用,由于战场环境复杂多变,无人机遭遇突发状况后需进行任务重分配.异构无人机是指多种类型的无人机,可完成单一无人机无法完成的多类型复杂任务,异构无人机协同多任务重分配问题约束条件复杂且包含混合变... 详细信息

无人机系统在军事领域有着广泛应用,由于战场环境复杂多变,无人机遭遇突发状况后需进行任务重分配.异构无人机是指多种类型的无人机,可完成单一无人机无法完成的多类型复杂任务,异构无人机协同多任务重分配问题约束条件复杂且包含混合变量,现有多目标优化算法不能有效处理此类问题.为高效求解上述问题,本文构建多约束异构无人机协同多任务重分配问题模型,提出一种学习引导的协同多目标粒子群优化算法(LeCMPSO),该算法引入基于先验知识的初始化策略和基于历史信息学习的粒子更新策略,能有效避免不可行解的产生并提升算法的搜索效率.通过在4组实例上的仿真实验表明,与其他典型的协同进化多目标优化算法相比,所提算法在解集的多样性、收敛性及搜索时间方面均具有较好的性能.

关键词：无人机多任务重分配粒子群优化算法多目标优化协同进化

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