Efficient capture of difluorocarbene by pyridinium 1,4-zwitterionic thiolates:A concise synthesis of difluoromethylene-containing 1,4-thiazine derivatives

作     者：Zhiwei Chen Heyun Sheng Xue Li Menghan Chen Xin Li Qiuling Song Zhiwei Chen;Heyun Sheng;Xue Li;Menghan Chen;Xin Li;Qiuling Song

作者机构：Institute of Next Generation Matter TransformationCollege of Materials Science&Engineering and College of Chemical Engineering at Huaqiao UniversityXiamen 361021China Fujian University Key Laboratory of Molecule Synthesis and Function DiscoveryCollege of ChemistryFuzhou UniversityFuzhou 350108China State Key Laboratory of Organometallic Chemistry and Key Laboratory of Organofluorine ChemistryShanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第4期

页      面：367-370页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Financial support from National Natural Science Foundation of China(Nos.21931013 and 22271105) Natural Science Foundation of Fujian Province(No.2022J02009) Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University the Instrumental Analysis Center of Huaqiao University for analysis support the Subsidized Project for Cultivating Postgraduates’Innovative Ability in Scientific Research of Huaqiao University 

主　　题：Difluoromethylene Pyridinium 1 4-zwitterionic thiolates 1 4-Thiazine derivatives 

摘      要：A practical method for the construction of difluoromethylene-containing 1,4-thiazine moieties using readily available diethyl bromodifluoromethanephosphonate(BrCF_(2)PO(OEt)_(2))as difluorocarbene precusor has been *** transformation features the efficient capture of difluorocarbene by pyridinium 1,4-zwitterionic thiolates.A series of structurally novel and functionalized difluoromethylene-containing 1,4-thiazine derivatives were thus synthesized in good yields.