检索结果-南通市图书馆

Enzymatic and chemo-enzymatic strategies to produce highly valuable chiral amines from biomass with ω-transaminases on 2D zeolites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2022年第9期9卷 10-18页

作者： J.miguel Carceller Karen S.Arias Maria J.Climent Sara Iborra Avelino Corma Instituto de Tecnologia Química (UPV-CSIC) Universitat Politècnica de València

Amino transaminases(ATAs) have been supported on a 2D ITQ-2 zeolite through electrostatic interactions, resulting in a highly stable active biocatalyst to obtain a variety of valuable chiral amines starting from prochiral ketones derived from biomass. We have extended the biocatalyst applications by designing a chemo-enzymatic process that allows, as the first step, prochiral ketones to be obtained from biomass-derived compounds through an aldol condensation–reduction step using a bifunctional metal/base catalyst. The prochiral ketone is subsequently converted into the chiral amine using the immobilized ATA. We show that it is feasible to couple both steps in a semi-continuous process to produce industrially relevant chiral amines with yields of >95% and ～100% enantiomer excess.

关键词： amino transaminase ITQ-2 zeolite chemo-enzymatic process biomass semi-continuous process Pd/MgO

加夫列尔·加西亚·马尔克斯图书馆,巴塞罗那,西班牙

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

世界建筑 2024年第5期 76-81页

作者：无 Elena Orte Guillermo Sevillano Marta Romero Jesús Lopez Luis Sierra Ana Patricia Minguito Pablo Corroto María Abellán Sara Contreras RitaÁlvarez Tabio miguelÁngel Maure Jesús Granada(摄影) SUMA建筑设计事务所不详

加布里埃尔·加西亚·马尔克斯图书馆是巴塞罗那的第40座图书馆,也是巴塞罗那30年计划的结晶。该计划旨在建立一个由优秀社区与区域设施组成的密集网络。这座图书馆位于圣马蒂德普罗旺斯区,为53,000人提供服务。关联式建筑图书馆被设计... 详细信息

加布里埃尔·加西亚·马尔克斯图书馆是巴塞罗那的第40座图书馆,也是巴塞罗那30年计划的结晶。该计划旨在建立一个由优秀社区与区域设施组成的密集网络。这座图书馆位于圣马蒂德普罗旺斯区,为53,000人提供服务。关联式建筑图书馆被设计成一座雕塑式实体建筑,让人联想到堆叠的书籍及其折叠的书页。该馆坐落在一处高架广场上,方便周围行人来往。同时,它又在空地上悬挑而出,门廊由现有的树木环绕,形成了一座城市大厅。不同大小及结构的开口定义了其不同立面与周围环境的关系。

关键词：巴塞罗那普罗旺斯周围环境加布里埃尔加西亚·马尔克斯图书馆关联式西班牙

维普期刊数据库

Central nervous system stimulation therapies in phantom limb pain:a systematic review of clinical trials

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第1期17卷 59-64页

作者： M.Ángeles García-Pallero Diana Cardona Lola Rueda-Ruzafa miguel Rodriguez-Arrastia Pablo Roman Hospital Universitario Central de Asturias AsturiasSpain Department of Nursing Science Physiotherapy and MedicineUniversity of AlmeríaAlmeríaSpain Department of Functional Biology and Health Sciences Faculty of Biology-CINBIOUniversity of VigoVigoPontevedraSpain Faculty of Health Sciences Pre-Department of NursingJaume I UniversityCastello de la PlanaSpain Research Group CYS Faculty of Health SciencesJaume I UniversityCastello de la PlanaSpain

Phantom limb pain is a chronic pain syndrome that is difficult to cope *** neurostimulation treatment is indicated for refractory neuropathic pain,there is scant evidence from randomized controlled trials to recommend it as the treatment ***,a systematic review was performed to analyze the efficacy of central nervous system stimulation therapies as a strategy for pain management in patients with phantom limb pain.A literature search for studies conducted between 1970 and September 2020 was carried out using the MEDLINE and Embase *** of The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline were *** were a total of 10 full-text articles retrieved and included in this *** brain stimulation,repetitive transcranial magnetic stimulation,transcranial direct current stimulation,and motor cortex stimulation were the treatment strategies used in the selected clinical *** transcranial magnetic stimulation and transcranial direct current stimulation were effective therapies to reduce pain perception,as well as to relieve anxiety and depression symptoms in phantom limb pain ***,invasive approaches were considered the last treatment option as evidence in deep brain stimulation and motor cortex stimulation suggests that the value of phantom limb pain treatment remains ***,the findings on use of these treatment strategies in other forms of neuropathic pain suggest that these invasive approaches could be a potential option for phantom limb pain patients.

关键词： central nervous system stimulation neuromodulation neuropathic pain phantom limb pain systematic review

维普期刊数据库

How AI-enabled SDN technologies improve the security and functionality of industrial IoT network:Architectures,enabling technologies,and opportunities

在线全文

学校读者我要写书评

暂无评论

Digital Communications and Networks 2023年第6期9卷 1351-1362页

作者： Jinfang Jiang Chuan Lin Guangjie Han Adnan MAbu-Mahfouz Syed Bilal Hussain Shah miguel Martínez-García Department of Internet of Things Engineering Hohai UniversityChangzhou213022China Software College Northeastern UniversityShenyang110819China Council for Scientific and Industrial Research(CSIR) Pretoria0184South Africa School of Computing and Mathematics Manchester Metropolitan UniversityManchesterM156BHUK Department of Aeronautical and Automotive Engineering Loughborough UniversityLoughboroughLE113TTUK Department of Electrical and Electronic Engineering Science University of JohannesburgJohannesburgSouth Africa

The ongoing expansion of the Industrial Internet of Things(IIoT)is enabling the possibility of effective Industry 4.0,where massive sensing devices in heterogeneous environments are connected through dedicated communication *** brings forth new methods and models to fuse the information yielded by the various industrial plant elements and generates emerging security challenges that we have to face,providing ad-hoc functions for scheduling and guaranteeing the network ***,the large development of SoftwareDefined Networking(SDN)and Artificial Intelligence(AI)technologies have made feasible the design and control of scalable and secure IIoT *** paper studies how AI and SDN technologies combined can be leveraged towards improving the security and functionality of these IIoT *** surveying the state-of-the-art research efforts in the subject,the paper introduces a candidate architecture for AI-enabled Software-Defined IIoT Network(AI-SDIN)that divides the traditional industrial networks into three functional *** with this aim in mind,key technologies(Blockchain-based Data Sharing,Intelligent Wireless Data Sensing,Edge Intelligence,Time-Sensitive Networks,Integrating SDN&TSN,Distributed AI)and improve applications based on AISDIN are also ***,the paper also highlights new opportunities and potential research challenges in control and automation of IIoT networks.

关键词： Industrial internet of things(IIoT) Industry 4.0 Artificial intelligence(AI) Machine intelligence Software-defined networking(SDN)

What do we know about pseudodementia?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

General Psychiatry 2023年第4期36卷 231-238页

作者： SaloméMouta Isabel Fonseca Vaz miguel Pires Sara Ramos Diana Figueiredo Departamento de Psiquiatria e Saúde Mental Unidade Local de Saude da Guarda EPEGuardaPortugal Departamento de Saúde Mental Unidade Local de Saúde de Matosinhos EPEMatosinhosPortugal

Depression and dementia can lead to generalised cognitive and memory ***,differentiating these disorders is important and *** is a term used clinically to describe symptoms that resemble dementia but are caused by other conditions(most frequently depression),rather than being recognised as an official *** is characterised by a cognitive impairment that mimics dementia but which does not have its origin in neurological degeneration,deriving instead from functional psychiatric *** condition is more commonly observed in older adults(particularly those over the age of 50 or 60 years),and its risk factors overlap with those for *** is essentially characterised by deficits in memory,executive function and speech and,therefore,can easily be confused with dementia,although there are aspects that allow its *** pseudodementia can be difficult,especially as there is significant overlap between its symptoms and those of other ***,it is important to recognise characteristic aspects of this disorder,as its correct identification is essential for proper treatment.

关键词： degeneration overlap instead

Searching for ductile superconducting Heusler X_(2)YZ compounds

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2023年第1期9卷 919-927页

作者： Noah Hoffmann Tiago F.T.Cerqueira Pedro Borlido Antonio Sanna Jonathan Schmidt miguel A.L.Marques Institut für Physik Martin-Luther-Universität Halle-WittenbergD-06099 HalleGermany CFisUC Department of PhysicsUniversity of CoimbraRua Larga 3004-516 CoimbraPortugal Max-Planck-Institut für Mikrostrukturphysik Weinberg 2D-06120 HalleGermany

Heusler compounds attract a great deal of attention from researchers thanks to a wealth of interesting properties,among which is *** we perform an extensive study of the superconducting and elastic properties of the cubic(full-)Heusler family using a mixture of ab initio methods,as well as interpretable and predictive machine-learning *** analyzing the statistical distributions of these properties and comparing them to anti-perovskites,we recognize universal behaviors that should be common to all conventional superconductors while others turn out to be specific to the material *** total,we discover a total of eight hypothetical materials with critical temperatures above 10 K to be compared with the current record of T_(c)=4.7 K in this ***,we expect most of these materials to be highly ductile,making them potential candidates for the manufacture of wires and tapes for superconducting magnets.

关键词： ductile compounds superconducting

European legal framework related to underground mining and tunnelling concerning commission directive (EU) 2017/164, 31 January establishing a fourth list of indicative occupational exposure limit values

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2020年第4期30卷 541-545页

作者： miguel Tato Diogo Department of Mining Engineering Faculty of EngineeringUniversity of PortoPorto 4200-465Portugal

Directive(EU)2017/164 establishes a fourth list of indicative occupational exposure limit values(IOELVs)to protect workers from risks of exposure to hazardous *** states that in underground mining and tunnelling,Member States may benefit from a transitional period regarding IOELVs for nitrogen monoxide,nitrogen dioxide,and carbon monoxide,during which the existing established IOELVs may be *** European Advisory Committee on Health and Safety at Work questions the technical feasibility of the proposed IOELVs in underground mining(CO,NO and NO2)and tunnelling(NO and NO2).Challenges arise concerning the availability of measurement methodologies for compliance with proposed IOELVs(NO2)in underground mining and tunnelling environments.

关键词： Nitrogen monoxide Nitrogen dioxide Carbon monoxide IOELVs European Directive 2017/164 Underground mining Tunnelling

维普期刊数据库

Receptor of advanced glycation end-products axis and gallbladder cancer:A forgotten connection that we should reconsider

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第39期28卷 5679-5690页

作者： Armando Rojas Cristian Lindner Iván Schneider Ileana Gonzàlez miguel Angel Morales Biomedical Research Laboratories Catholic University of MauleTalca 34600000MauleChile Medicine Faculty Catholic University of MauleTalca 34600000MauleChile Department of Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000SantiagoChile

Compelling evidence derived from clinical and experimental research has demonstrated the crucial contribution of chronic inflammation in the development of neoplasms,including gallbladder *** this regard,data derived from clinical and experimental studies have demonstrated that the receptor of advanced glycation end-products(RAGE)/AGEs axis plays an important role in the onset of a crucial and long-lasting inflammatory milieu,thus supporting tumor growth and *** are formed in biological systems or foods,and food-derived AGEs,also known as dietary AGEs are known to contribute to the systemic pool of *** they bind to RAGE,the activation of multiple and crucial signaling pathways are triggered,thus favoring the secretion of several proinflammatory cytokines also involved in the promotion of gallbladder cancer invasion and *** the present review,we aimed to highlight the relevance of the association between high dietary AGEs intakes and high risk for gallbladder cancer,and emerging data supporting that dietary intervention to reduce gallbladder cancer risk is a very attractive approach that deserves much more research efforts.

关键词： Gallbladder cancer Advanced glycation end-products Receptor of advanced glycation end-products Chronic inflammation Nutrition

Diabetic foot ulcer:A comprehensive review of pathophysiology and management modalities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第8期11卷 1684-1693页

作者： Joel M Raja miguel A Maturana Sharif Kayali Amir Khouzam Nephertiti Efeovbokhan Department of Internal Medicine University of Tennessee Health Science CenterMemphisTN 38119United States Department of Cardiology NEA Baptist JonesboroJonesboroAR 72401United States

Diabetic foot ulcer (DFU) is a debilitating and severe manifestation ofuncontrolled and prolonged diabetes that presents as ulceration, usually locatedon the plantar aspect of the foot. Approximately 15% of individuals with diabeteswill eventually develop DFU, and 14%-24% of them will require amputation ofthe ulcerated foot due to bone infection or other ulcer-related complications. Thepathologic mechanisms underlying DFU are comprise a triad: Neuropathy,vascular insufficiency, and secondary infection due to trauma of the *** local and invasive care along with novel approaches like stem celltherapy pave the way to reduce morbidity, decrease amputations, and preventmortality from DFU. In this manuscript, we review the current literature withfocus on the pathophysiology, preventive options, and definitive management ofDFU.

关键词： Diabetes Ulcer Foot Antibiotics Revascularization Cell therapy