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A challenging case of alpha-fetoprotein-result discrepancies in a patient with chronic hepatitis B

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Gastroenterology Report 2020年第6期8卷 484-486,I0003页

作者： pir a.shah Allison Onken Rizwan Ishtiaq Muhammad H.Maqsood Shyam S.Patel Karen J.Campoverde Reyes Adrianna Z.Herskovits Daryl T.Y.Lau Department of Medicine Liver CenterDivision of GastroenterologyBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Department of Pathology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Introduction Alpha-fetoprotein(AFP)is the most abundant serum protein found in the human fetus,produced by the yolk sac and the liver[1].The levels of maternal serum AFP reach a peak value at28-32 weeks of gestation and decrease rapidly after birth and usually drop to the normal at 8-12 months of *** normal serum AFP level for an adult is<20 ng/mL[2].In contrast,livertumor cells usually synthesize and secrete an increased level of *** ultrasound and AFP are generally recommended as the screening modality for HCC for patients at risk for development of hepatocellular carcinoma(HCC)[1].AFP-L3,an isoform of AFP that binds Lens culinaris agglutinin,can be particularly useful in the early identification of aggressive HCC[2].These assays,however,can generate false-positive and false-negative AFP *** patients with advanced HCC,20%had normal AFP levels,whereas some patients with liver diseases had significant AFP elevation without liver cancer in long-term surveillance[3].Elevated AFP levels could be associated with active liver diseases with hepatocyte regeneration[4,5].In that setting,the AFP level will decline with improvement of the underlying liver *** case illustrated the dilemma and uncertainties as a result of persistent abnormal AFP values after extensive clinical investigations.

关键词：甲胎蛋白 fetus false

An update on the management of chronic hepatitis D

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Gastroenterology Report 2019年第6期7卷 396-402,I0001页

作者： pir Ahmad shah Saad Choudhry Karen J.Campoverde Reyes Daryl T.Y.Lau Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Neuroendocrine Unit Massachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Hepatitis D virus(HDV)infection is associated with severe liver-related morbidity and *** prevalence of HDV is rising especially among people who abuse drugs and immigrants from endemic *** diagnostic assays with enhanced sensitivity and specificity are essential for screening at-risk *** recently,interferon has been the only treatment for hepatitis *** efficacy is,however,limited and it is associated with significant side effects.A number of novel antiviral agents that target various stages of the HDV life cycle show promising *** are currently in different phases of clinical *** review focuses on the changing epidemiology,novel therapeutic agents,and updated management of chronic hepatitis delta.

关键词： chronic hepatitis D HDV therapy HDV diagnostics interferon myrcludex B lonafarnib

Paraneoplastic syndromes in cholangiocarcinoma

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World Journal of Hepatology 2020年第11期12卷 897-907页

作者： Saad Ur Rahman Muhammad Khawar Sana Zabreen Tahir Aamir Ali pir Ahmad shah Department of Medicine King Edward Medical UniversityLahore 54000PunjabPakistan Department of Neurology Brigham and Women’s HospitalBostonMA 02115United States Department of Radiology Beth Israel Deaconess Medical CenterBostonMA 02215United States Department of Medicine University of Texas Health Science CenterSan AntonioTX 78229United States

Paraneoplastic syndromes are the symptoms or signs which result from damage to tissues that are distant from the site of malignancy,due to complex interactions between the body’s immune system and malignant ***(CCA)is an aggressive epithelial malignancy of hepatobiliary tree and it is found to be associated with various paraneoplastic *** syndromes can present as dermatological,neurological,renal,hematological,or multi-systemic *** suspicion and timely recognition of these syndromes can lead to early diagnosis of covert malignancies like *** management plan remains the removal of the underlying cause which in this case is CCA.

关键词： Cholangiocarcinoma Paraneoplastic syndrome Malignancy Immune system Biliary tree Multi-organ

Seroprevalence of Toxoplasma gondii infection in domestic animals of Mohmand agency,Pakistan

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Journal of Coastal Life Medicine 2013年第1期 72-75页

作者： Mudassir shah Muhammad Zahid Aftab Alam Sthanadar pir Asmat Ayesha Kausar Abdul Hamid Jan Department of Zoology Islamia College University PeshawarKPPakistan Department of Zoology University of PeshawarKPPakistan

Objective:To determine the prevalence of toxoplasmosis among domestic animals of Mohmand Agency,***:Indirect haemagglutination test was used to detect Toxoplasma gondii(***)antibodies in the ***:Out of 384 domestic animals,124(32.29%)were seropositive for antibodies of *** antibodies were detected in 56 out of 104 examined goats(53.84%).The seropositivity in male and female goats were 20(38.46%)and 36(69.23%)*** seropositivity of *** in sheep was 36%(n=100)while the prevalence in female sheep was higher(41.66%)as compared to male sheep(30.76%).A total of 8 out of 48 male cows were detected seropositive(16.66%)and 8 out of 32 female cows were detected seropositive(25%).Lowest prevalence was detected in buffaloes which was 16%(n=100).Out of 52 male buffaloes 4 were detected seropositive for *** antibodies(7.69%)while in female buffaloes was 25%(n=48).The seroprevalence of *** antibodies was higher in goats and lower in ***:The findings of the present study indicate that *** infection is high in domestic animals in Mohmand agency,Pakistan,which has implications for public health in this *** control strategies and suitable measures should be carried out rationally in this region,in order to lower the risk of exposure to ***.

关键词： Antibodies Domestic animals Seroprevalence Toxoplasma gondii

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基于人群参考基因组的结构变异检测

基于人群参考基因组的结构变异检测

作者： pir Noman Ahmad 哈尔滨工业大学

学位级别：硕士

结构变异（SV）在人类基因组中广泛存在。结构变异在长度,来源,功能影响上区别于其他类型的变异。人类基因组计划中结构变异检测的目标是通过在少量的正常个体中使用双端测序方法来识别和分类超过5kb的In Del（插入和删除）和倒位变异。... 详细信息

结构变异（SV）在人类基因组中广泛存在。结构变异在长度,来源,功能影响上区别于其他类型的变异。人类基因组计划中结构变异检测的目标是通过在少量的正常个体中使用双端测序方法来识别和分类超过5kb的In Del（插入和删除）和倒位变异。在SV的特性描述上的进展有限,大部分的SV依然是未知的。千人基因组计划的数据集中包括26个种群。其中的超种群共包括2504个个体。我们将其按照大陆划分,以削减时间和复杂性。我们的研究基于SAS超种群（CHS,CHB）。我们使用人群参考基因组来检测变异,使用工具来比对,然后检测SV。有两种方法执行此过程,我们采用的第一种方法使用了主流的工具来进行比对。当我们得到SAM格式的准确read比对结果后,我们需要将其转换为BAM格式。用于建索引,read比对和变异检测的工具分别是BWA,samtools和Delly,GATK。这种方法虽然高效,准确,但是消耗了太多时间,代价大。第二种方法是直接采用了来自于千人基因组计划的VCF数据。这两种过程是为了得到不一致的read。两种方法都更好用。当我们从群体样本中得到不一致read时,我们将会合并不一致read到参考基因组中,们得到了一个新的参考基因组。这个新的参考基因组比之前的要更好。然后我们重新比对reads到这个新的参考基因组上。比对后的reads创造了新reads簇。超种群中大部分的变异被发现了。他们大部分是来自于千人基因组计划。所有在SAS超种群中发现的变异都来自低覆盖的数据。这意味着种群特异变异保持非特性描述。这是因为大量的变异是低频的。本研究中,我们将收集并使用千人基因组计划的高不确定SAS系谱的全基因组测序数据。

关键词：结构变异 BAM SNP 千人基因组计划 BWA

金属-有机框架材料对废水中污染物的吸附研究进展

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材料导报 2021年第11期35卷 11099-11109页

作者：附青山张磊张伟 Ismail pir Muhammad 陈雪丹龚敏何平王祖波四川轻化工大学材料科学与工程学院四川643000 中昊黑元化工研究设计院有限公司四川643000

可用的清洁水资源缩减已成为全球面临的重要危机。引起该危机的主要原因是各种污染物因生产、生活或事故排入水体导致水体污染。因此,解决水资源危机的关键在于对污水处理和再生。多种污水处理和再生方法应运而生,其中吸附法因处理效率... 详细信息

可用的清洁水资源缩减已成为全球面临的重要危机。引起该危机的主要原因是各种污染物因生产、生活或事故排入水体导致水体污染。因此,解决水资源危机的关键在于对污水处理和再生。多种污水处理和再生方法应运而生,其中吸附法因处理效率高、操作简便、成本低而被广泛应用到污水处理中。吸附法的关键在于吸附剂的选择和应用。应用于水处理的传统吸附剂,如活性炭、沸石、天然粘土、活性氧化铝等,在面对复杂水体环境和各种性质迥异的污染物时已不能符合水污染处理的更高标准。因此,新型吸附剂的开发与应用成为吸附领域研究热点。金属有机框架(Metal-organic frame,MOF)材料,一类金属离子或金属簇与有机配体之间自组装配位形成的化合物,具有高比表面积、高孔隙率和可控的孔结构,已成为吸附领域冉冉升起的新星。目前MOF材料作为水处理吸附剂的研究主要集中在:(1)各种MOF材料对不同污染物的吸附性能研究,以揭示相关吸附规律;(2)MOF材料自身功能化或MOF复合材料的制备,以改善自身稳定性,提高其吸附性能或实现选择性吸附;(3)MOF衍生碳吸附材料的研究,以应对恶劣水体环境或极端水处理条件。本文对单一MOF材料、功能化MOF材料、MOF衍生碳材料吸附去除水体中有机染料、其他有机污染物、重金属离子的相关研究进行了综述。概述了多种MOF材料对不同污染物的吸附性能,总结了针对吸附应用的多种MOF功能化方式及其吸附效果的改进,归纳了多种MOF衍生碳材料作为吸附剂在水处理中的应用,指出了目前MOF吸附材料在水处理中存在的主要问题,并提出了解决这些问题的思路。

关键词：水处理金属有机框架吸附法有机污染物重金属离子多孔碳

Boronate affinity molecularly imprinted polymers combined with surface enhanced Raman Scattering（SERS） for the detection of glycoproteins

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Boronate affinity molecularly imprinted polymers combined wi...

Research on the Fault-Tolerant Edge-Pancyclicity of Two Kinds of Variants of Hypercubes

第二十届全国色谱学术报告会及仪器展览会

作者： pir Muhammad Zhen Liu State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Nanjing University

＜正＞Glycoproteins play essential roles in many biological processes,such as molecularrecognition,inter-and intracellular signaling,immune response and so *** addition,many glycoproteins are used as biomarkers for disease diagnostics in the clinical *** are present in very low abundance along with interfering species in biological ***,highly selective andsensitive detection ofglycoproteinsis extremely *** has been an essential tool for the

关键词： Molecularly imprinted polymers(MIP) Boronate affinity glycoproteins Surface enhanced Raman Scattering(SERS)

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Research on the Fault-Tolerant Edge-Pancyclicity of Two Kind...

作者： pir Dino Soomro 大连理工大学

学位级别：硕士

图论在互连网络拓扑结构的构建中起着非常重要和突出的作用。通过应用,在互联网络领域,它极大地增加了不同学者对其驱动范围。此外,容错边泛圈性和路径嵌入也涉及到学者们收集这些准则在测量网络容错性方面的有用性方面。n维莫比乌斯立... 详细信息

图论在互连网络拓扑结构的构建中起着非常重要和突出的作用。通过应用,在互联网络领域,它极大地增加了不同学者对其驱动范围。此外,容错边泛圈性和路径嵌入也涉及到学者们收集这些准则在测量网络容错性方面的有用性方面。n维莫比乌斯立方体MQ和n维交叉立方体CQ作为超立方体的变型网络起着重要的作用。它们包含一些优于超立方体的属性。许多大规模网络,涉及多个连接的数量,由于它们中的意外故障而容易失败。本研究对MQ的容错边泛圈性进行了考察和研究,发现如果n-3个错误顶点和/或边包含在MQ(n ≥ 3)中,那么对于MQ中的任何无故障边e和6 ≤ l ≤ 2-fv的任意整数1,都存在包含边e的长度为1的无故障圈在MQ中,其中由fv表示故障顶点的数目。还研究了CQ的容错边泛圈性,即如果存在n-2个错误顶点和/或边包含在CQ(n ≥ 5)中,那么对于CQ中的任何无故障边uv和长度为6≤l ≤ 2-fv的任何整数l除了 l = 7,都存在包含边uv的长度为l的无故障圈在CQ中,其中由fv表示故障顶点的数目。我们的结果证明,当大规模并行计算系统的大规模拓扑结构被构造在莫比乌斯立方体MQ和交叉立方体CQ上时,该系统具有更有效的应用环结构并行算法的通信效率的能力比存在错误的边和顶点的超立方体网络。

关键词：组合数学莫比乌斯立方体交叉立方体边泛圈性点泛圈性容错和互连网络

Prevalence and Perceptions about Migraine among Students and Patients in Khyber Pakhtunkhwa Province, Pakistan

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Advances in Bioscience and Biotechnology 2014年第6期5卷 508-516页

作者： Muhammad Zahid Aftab Alam Sthanadar Muhammad Kaleem Muhammad Latif Iram Alam Sthanadar pir Asmat Ali Irum Alam Sthanadar Muhammad Ismail Noreen Imtiaz Mudassir shah Department of Zoology Islamia College University Peshawar Pakistan Government Degree College Dara Adam Kheil Kohat Pakis-tan

Migraine is a common neurological disorder, prevalent in almost all over the world population and being considered as the 13th major medical disorder among other major disorders across the globe, generally characterized with unilateral or bilateral headache, nausea and vomiting. In developing world, countries like Pakistan, most of the patients are not well aware of migraine headaches, as usually taken for simple headache due to no proper awareness. Usually it is not a contagious condition and most of the time it is recoded as episodic in nature. To assess the migraine, its frequency, symptoms, usual triggers and patients’ perceptions, the present study was conducted. For this purpose a prospective study was carried out based on properly designed questionnaire. The data were collected from 7 educational institutes, including students of Islamia College Peshawar, University of Peshawar, Khyber Medical College, Engineering University Peshawar, Fatima Jinnah College Peshawar, Commerce College Peshawar and Agriculture University Peshawar. Part of data was also collected from patients visiting Khyber Teaching Hospital Peshawar for their headache problems. A total of 270 questionnaires were filled up. About 81 (30.00%) headache cases were recorded, fulfilling the International criteria of Headache. Out of 81 recorded cases, 31 (38.3%) patients were of migraine with aura and 50 (61.7%) were of migraine without aura condition. The prevalence of migraine in the study population was found to be 30.00%. The frequency of female migraine patients was higher i.e. 31 (34.1%) than the male sufferers 50 (27.9%). The present study clearly showed that the higher frequency (65.0%) of migraine exists in the age group of above 30 years age. The most prevalent trigger was found to be tension, which was in parallel followed by the lack of sleep or oversleeping. A family history for migraine was found in migraine patients. Usually the condition was found to limit the routine activities of p

关键词： Migraine Migraine with Aura (MWA) Migraine without Aura (MWOA) International Headache Society (IHS)