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Microfluidic bubble-generator enables digital light processing 3D printing of porous structures

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Aggregate 2024年第1期5卷 280-291页

作者： Philipp Weber Ling Cai Francisco Javier Aguilar Rojas Carlos Ezio Garciamendez-Mijares Maria Celeste Tirelli Francesco Nalin Jakub Jaroszewicz wojciech Swi eszkowski Marco Costantini Yu Shrike Zhang Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMassachusettsUSA Institute of Physical Chemistry—Polish Academy of Sciences KasprzakaPoland Biomaterials Group Materials Design DivisionFaculty of Materials Science and EngineeringWarsaw University of TechnologyWoloskaPoland

Three-dimensional(3D)printing is an emerging technique that has shown promising success in engineering human tissues in recent *** development of vatphotopolymerization printing modalities has significantly enhanced the complexity level for 3D printing of various functional structures and ***,the development of microfluidic chip systems is an emerging research sector with promising medical *** work demonstrates the coupling of a digital light processing(DLP)printing procedure with a microfluidic chip system to produce size-tunable,3D-printable porosities with narrow pore size distributions within a gelatin methacryloyl(GelMA)hydrogel *** is found that the generation of size-tunable gas bubbles trapped within an aqueous GelMA hydrogel-precursor can be controlled with high ***,the porosities are printed in two-dimensional(2D)as well as in 3D using the DLP *** addition,the cytocompatibility of the printed porous scaffolds is investigated using fibroblasts,where high cell viabilities as well as cell proliferation,spreading,and migration are *** is anticipated that the strategy is widely applicable in a range of application areas such as tissue engineering and regenerative medicine,among others.

关键词： 3D printing biofabrication bubble digital light processing microfluidics porous

Inflammatory myofibroblastic tumor from molecular diagnostics to current treatment

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Oncology Research 2024年第7期32卷 1141-1162页

作者： PAULINA CHMIEL ALEKSANDRA SŁOWIKOWSKA ŁUKASZ BANASZEK ANNA SZUMERA-CIEĆKIEWICZ BARTŁOMIEJ SZOSTAKOWSKI MATEUSZ J.SPAŁEK TOMASZŚWITAJ piotr RUTKOWSKI ANNA M.CZARNECKA Department of Soft Tissue/Bone Sarcoma and Melanoma Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland Faculty of Medicine Medical University of WarsawWarsaw02-091Poland Department of Pathology Maria Sklodowska Curie National Research Institute of OncologyWarsaw02-781Poland Department of Radiotherapy Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland

Inﬂammatory myoﬁbroblastic tumor(IMT)is a rare neoplasm with intermediate malignancy characterized by a propensity for recurrence but a low metastatic *** challenges arise from the diverse pathological presentation,variable symptomatology,and lack of different imaging ***,IMT is identiﬁed by the fusion of the anaplastic lymphoma kinase(ALK)gene,which is present in approximately 70%of cases,with various fusion partners,including ran-binding protein 2(RANBP2),which allows conﬁrmation of the *** surgery is the preferred approach for localized tumors,the optimal long-term treatment for advanced or metastatic disease is difﬁcult to deﬁ*** therapies are crucial for achieving sustained response to treatment within the context of genetic alteration in ***,an ALK tyrosine kinase inhibitor(TKI),was ofﬁcially approved by the US Food and Drug Administration(FDA)in 2020 to treat IMT with ALK ***,most patients face resistance and disease progression,requiring consideration of sequential *** radiotherapy with targeted therapy appears to be beneﬁcial in this *** promising results have also been achieved with immunotherapy,indicating potential for combined therapy ***,deﬁned recommendations are still *** review analyzes the available research on IMT,including genetic disorders and their impact on the course of the disease,data on the latest targeted therapy regimens and the possibility of developing immunotherapy in this indication,as well as summarizing general knowledge about prognostic and predictive factors,also in terms of resistance to systemic therapy.

关键词： Inﬂammatory myoﬁbroblastic tumor(IMT) Epithelioid inﬂammatory myoﬁbroblastic sarcoma Tyrosine kinase inhibitors(TKI) Anaplastic lymphoma kinase(ALK)

Targeting miRNA by CRISPR/Cas in cancer:advantages and challenges

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Military Medical Research 2024年第3期11卷 345-373页

作者： Bashdar Mahmud Hussen Mohammed Fatih Rasul Snur Rasool Abdullah Hazha Jamal Hidayat Goran Sedeeq Hama Faraj Fattma Abodi Ali Abbas Salihi Aria Baniahmad Soudeh Ghafouri-Fard Milladur Rahman Mark C.Glassy wojciech Branicki Mohammad Taheri Department of Biomedical Sciences Cihan University-ErbilErbilKurdistan Region 44001Iraq Department of Clinical Analysis College of PharmacyHawler Medical UniversityErbilKurdistan Region 44001Iraq Department of Pharmaceutical Basic Science Faculty of PharmacyTishk International UniversityErbilKurdistan Region 44001Iraq Medical Laboratory Science Lebanese French UniversityErbilKurdistan Region 44001Iraq Department of Biology College of EducationSalahaddin University-ErbilErbilKurdistan Region 44001Iraq Department of Medical Laboratory Science Komar University of Science and TechnologySulaymaniyah 46001Iraq Department of Medical Microbiology College of Health SciencesHawler Medical UniversityErbilKurdistan Region 44001Iraq Department of Biology College of ScienceSalahaddin University-ErbilErbilKurdistan Region 44001Iraq Center of Research and Strategic Studies Lebanese French UniversityErbil 44001Iraq Institute of Human Genetics Jena University Hospital07747 JenaGermany Department of Medical Genetics School of MedicineShahid Beheshti University of Medical SciencesTehran 374-37515Iran Department of Clinical Sciences MalmöSection for SurgeryLund University22100 MalmöSweden Translational Neuro-Oncology Laboratory San Diego(UCSD)Moores Cancer CenterUniversity of CaliforniaSan DiegoCA 94720USA Faculty of Biology Institute of Zoology and Biomedical ResearchJagiellonian University31-007 KrakówPoland Urology and Nephrology Research Center Shahid Beheshti University of Medical SciencesTehran 374-37515Iran

Clustered regulatory interspaced short palindromic repeats(CRISPR)has changed biomedical research and provided entirely new models to analyze every aspect of biomedical sciences during the last *** the study of cancer,the CRISPR/CRISPR-associated protein(Cas)system opens new avenues into issues that were once unknown in our knowledge of the non-coding genome,tumor heterogeneity,and precision ***/Cas-based geneediting technology now allows for the precise and permanent targeting of mutations and provides an opportunity to target small non-coding RNAs such as microRNAs(miRNAs).However,the development of effective and safe cancer gene editing therapy is highly dependent on proper design to be innocuous to normal cells and prevent introducing other *** study aims to highlight the cutting-edge approaches in cancer-gene editing therapy based on the CRISPR/Cas technology to target miRNAs in cancer ***,we highlight the potential challenges in CRISPR/Cas-mediated miRNA gene editing and offer advanced strategies to overcome them.

关键词： CRISPR CRISPR/Cas9 CRISPR/Cas12 Gene editing miRNAs Cancer therapy

Revisiting the standards of cancer detection and therapy alongside their comparison to modern methods

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World Journal of Methodology 2024年第2期14卷 17-37页

作者： piotr Gromek Zuzanna Senkowska Elzbieta Pluciennik Zbigniew Pasieka Lin-Yong Zhao Adrianna Gielecinska Mateusz Kciuk Karol Klosinski Zaneta Kaluzinska-Kolat Damian Kolat Department of Functional Genomics Medical University of LodzLodz 90-752LodzkiePoland Department of Biomedicine and Experimental Surgery Medical University of LodzLodz 90-136LodzkiePoland Department of General Surgery&Laboratory of Gastric Cancer State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Gastric Cancer Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Molecular Biotechnology and Genetics University of LodzLodz 90-237LodzkiePoland Doctoral School of Exact and Natural Sciences University of LodzLodz 90-237LodzkiePoland

In accordance with the World Health Organization data,cancer remains at the forefront of fatal *** upward trend in cancer incidence and mortality has been observed globally,emphasizing that efforts in developing detection and treatment methods should *** diagnostic path typically begins with learning the medical history of a patient;this is followed by basic blood tests and imaging tests to indicate where cancer may be located to schedule a needle *** initiation of diagnosis is crucial since delayed cancer detection entails higher costs of treatment and ***,there is a need for novel cancer detection methods such as liquid biopsy,elastography,synthetic biosensors,fluorescence imaging,and reflectance confocal *** therapeutic methods,although still common in clinical practice,pose many limitations and are ***,there is a dynamic advancement of clinical research and the development of more precise and effective methods such as oncolytic virotherapy,exosome-based therapy,nanotechnology,dendritic cells,chimeric antigen receptors,immune checkpoint inhibitors,natural product-based therapy,tumor-treating fields,and photodynamic *** present paper compares available data on conventional and modern methods of cancer detection and therapy to facilitate an understanding of this rapidly advancing field and its future *** evidenced,modern methods are not without drawbacks;there is still a need to develop new detection strategies and therapeutic approaches to improve sensitivity,specificity,safety,and ***,an appropriate route has been taken,as confirmed by the approval of some modern methods by the Food and Drug Administration.

关键词： Cancer detection Liquid biopsy Synthetic biosensors Fluorescence imaging Reflectance confocal microscopy Elastography Cancer therapy Tumor-treating fields Oncolytic virotherapy Nanotechnology

Magnetocaloric effect of LaFe_(11.35)Co_(0.6)Si_(1.05) alloy

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Rare Metals 2022年第5期41卷 1563-1569页

作者： piotr Gebara Institute of Physics Czestochowa University of Technology42-200 CzestochowaPoland

The aim of the present paper was to study the large magnetocaloric effect observed in LaFe_(11.35)Co_(0.6)Si_(1.05)alloy. X-ray diffraction(XRD) result reveals a coexistence of two crystalline phases: a dominant La(Fe,Si)_(13)-type and a minor a-Fe(Co,Si). It is confirmed by the Mössbauer spectroscopy and microstructural observations accompanied by an energy-dispersive spectroscopy(EDS) analysis. The value of the magnetic entropy changes(|S_(M)|) in the vicinity of the Curie temperature(TC= 268 K) was calculated using thermomagnetic Maxwell relation, and it equals to 21.4 J·kg^(-1)·K^(-1) under the change in an external magnetic field of μ_(0)ΔH = 3T. The investigation of magnetic phase transition was carried out using the Landau theory, an analysis of the field dependences of the magnetic entropy change and universal scaling curve, revealing the second order of phase transition in the studied material.

关键词： X-ray diffraction M?ssbauer spectroscopy Magnetocaloric effect

Investigation of the porous drag and permeability at the porous-fluid interface: Influence of the filtering parameters on Darcy closure

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Particuology 2023年第7期78卷 122-135页

作者： wojciech Sadowski Francesca di Mare Chair of Thermal Turbomachines and Aeroengines Department of Mechanical EngineeringRuhr University BochumUniversitatsstr.15044801Germany

The porous-fluid interface encompasses a region bridging the flow inside a porous medium and a free-flowing *** the context of volume-averaged simulations,it can be described by a set of gradually changing parameters defining the porous medium,mainly porosity and *** this paper,both the permeability and the porous-induced drag force are evaluated a-priori,by explicitly filtering a set of Particle-Resolved Simulations(PRS)of the flow in the channel partially occupied by the porous *** porous matrices are considered and the influence of the geometry and filtering parameters on the macroscopic quantities is ***,the focus is placed on the requirements for the kernel type and size to perform filtering accurately,and their impact on the distribution of permeability at the *** performance of the typically used models for the permeability is compared to the explicitly filtered ***,a new model for permeability and the drag force is introduced,taking into account the information about the fltering size and non-uniformity of the velocity *** model greatly improves the prediction of velocity at the porous-fluid interface and serves as a proof of concept that a successful porous drag model should strive to include information about both parameters.

关键词： Porous-fluid interface Explicit filtering Permeability Porous drag

Analysis of erosion rill development under rainfall events using structure-from-motion photogrammetry——a case study from Kielce(Holy Cross Mts.,Poland)

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Journal of Mountain Science 2022年第5期19卷 1231-1244页

作者： piotr Tomasz KOPYSC Jan Kochanowski University Institute of Geography and Environmental SciencesUniwersytecka 725-406 KielcePoland

The development of erosive landforms such as rills,ditches,slits,and gullies depends on many environmental factors;thus,the rate of the development of each individual form *** this paper,the author presents a case study of two erosion rills located on a hiking trails(Holy Cross Mts.)resulting after 2 years of monitoring in which the process of their evolution was precisely *** established,such landforms develop over time with variable rates and can represent multiple different ***,the final result of the rill development hardly reminds their original form and does not allow for interpretation of the events that affected it in the recent ***,the main objective was to determine the volumetric changes of erosion rills created by the surface runoff on both sections,during two years of *** objectives included a description of the physical and meteorological parameters,important in the development process and a comparison of them to the volumetric changes of each *** the Structure-from-motion(Sf M)photogrammetry technique,monitoring procedures have been performed quickly offering sufficient *** direct comparison,the digital elevation model of difference(Do D)method was used,enabling the calculation of *** results showed that the erosion to deposition ratio was more disproportionate during storm events or periods with higher depth of *** erosion to deposition balance for the entire monitoring period was negative and equal to 1448.84 kg or 410 Mg/ha for the first erosion rill and 1059.5 kg or 300 Mg/ha for the second *** erosion rills developed *** first erosion rill developed by linear cut into deeper and wider form,while the other,steeper rill,evolved from plunge pools merging together into deeper and wider form.

关键词： Erosion SfM DoD Rainfall Microtopography

Influence of seven levels of chemical/biostimulator protection on amino acid profile and yield traits in wheat

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The Crop Journal 2022年第4期10卷 1198-1206页

作者： piotr Iwaniuk Rafal Konecki piotr Kaczynski Alua Rysbekova Bozena Lozowicka Institute of Plant Protection-National Research Institute Chelmonskiego 22 Street15–195 BialystokPoland Kazakh National Agrarian Research University Department of Plant ProtectionAbai Avenue 8Almaty 050010Kazakhstan

Biostimulators combined with pesticides can reduce the need for chemical crop protection to yield healthy wheat with high grain quality and nutritional *** goal of this four-year field study was an assessment of the effects of seven levels of sulfonylurea herbicide,morpholine and triazole fungicides,and humic biostimulator protection on concentrations of 20 amino acids(AAs)and on yield parameters under diverse climatic *** of pesticides and biostimulators reduced amino acid *** applied alone reduced AAs ***(herbicide+fungicide)protection or its combination with humic biostimulator were the most effective strategies for increasing yield,thousand-kernel weight,spike number,grain surface area,and wet *** dosages of fungicides showed effects on AA content and crop parameter values similar to those of the recommended dosages of fungicides and are in line with the European Commission’s “From Farm to Fork”*** biostimulators as agents supporting pesticide protection should be optimized for wheat growth stage to achieve the most desirable wheat parameters and implemented in agricultural practice.

关键词： Amino acids Biostimulators Plant protection products Wheat quality Yield

Classical Radicals of Invariants of Algebraic Skew Derivations

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Algebra Colloquium 2022年第1期29卷 53-66页

作者： Jeffrey Bergen piotr Grzeszczuk Faculty of Computer Science Bialystok University of Technology BiaiystokPoland

Let σ be an automorphism and δ be a q-skew σ-derivation of an F-algebra *** prove that if A is semiprimitive and δ is algebraic,then the subalgebra A^(δ)={r∈A|δ(r)=0}has nilpotent Jacobson *** this result,we obtain similar relations for the Baer prime radical,the Levitzki locally nilpotent radical,and the Kothe nil radical when the field F is *** we apply it to actions of the n^(2)-dimensional Taft Hopf algebra T_(n2)(q)and the q-analogue U_(q)(sl(2))of the enveloping algebra of the Lie algebra sl(2).

关键词： skew derivations invariants Jacobson radical