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Genetic variables of the glutamatergic system associated with treatment-resistant depression:A review of the literature

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World Journal of Psychiatry 2022年第7期12卷 884-896页

作者： Estela Saez Leire Erkoreka Teresa Moreno-Calle Belen Berjano Ana Gonzalez-pinto Nieves Basterreche Aurora Arrue Department of Psychiatry Barrualde-Galdakao Integrated Health OrganizationOsakidetza-Basque Health ServiceGaldakao 48960Spain Mental Health Network Group Biocruces Bizkaia Health Research InstituteBarakaldo 48903Spain Department of Neurosciences University of the Basque Country UPV/EHULeioa 48940Spain Department of Psychiatry Araba Integrated Health OrganizationOsakidetza-Basque Health ServiceCIBERSAMVitoria-Gasteiz 01004Spain Severe Mental Disorders Group Bioaraba Health Research InstituteVitoria-Gasteiz 01009Spain Zamudio Hospital Bizkaia Mental Health NetworkOsakidetza-Basque Health ServiceZamudio 48170Spain Integrative Research Group in Mental Health Biocruces Bizkaia Health Research InstituteBarakaldo 48903Spain Neurochemical Research Unit Bizkaia Mental Health NetworkOsakidetza-Basque Health ServiceBarakaldo 48903Spain

Depression is a common,recurrent mental disorder and one of the leading causes of disability and global burden of disease *** to 15%-40%of cases do not respond to diverse pharmacological treatments and,thus,can be defined as treatment-resistant depression(TRD).The development of biomarkers predictive of drug response could guide us towards personalized and earlier *** evidence points to the involvement of the glutamatergic system in the pathogenesis of ***,the N-methyl-D-aspartic acid receptor(NMDAR)andα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor(AMPAR),which are targeted by ketamine and esketamine,are proposed as promising pathways.A literature search was performed to identify studies on the genetics of the glutamatergic system in depression,focused on variables related to NMDARs and *** review highlights GRIN2B,which encodes the NR2B subunit of NMDAR,as a candidate gene in the pathogenesis of *** addition,several studies have associated genes encoding AMPAR subunits with symptomatic severity and suicidal *** genes encoding glutamatergic receptors could,therefore,be candidate genes for understanding the etiopathogenesis of TRD,as well as for understanding the pharmacodynamic mechanisms and response to ketamine and esketamine treatment.

关键词： Genetics N-methyl-D-aspartic acid receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor Treatment-resistant depression Ketamine Esketamine

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Single Layer Centrifugation with Androcoll-E^(TM) improved progressive motility and percentage of live spermatozoa with intact acrosome of chilled stallion semen but did not have an effect on DNA integrity

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Open Journal of Animal Sciences 2012年第3期2卷 159-165页

作者： Ana Luisa Costa Ana Martins-Bessa Ana Rebello de Andrade Tiago Guimaraes Maria Rosa Rebordao Sandra Gamboa Pedro pinto Bravo Maria José correia Jorge Colaco Isabel Gaivao António Rocha Centro de Ciencia Animal e Veterinária(CECAV) University of Trás-os-Montes e Alto DouroQuinta de PradosVila RealPortugal Veterinary Degree Universty of Tras-os-Montes e Alto DouroQuinta de PradosVila RealPortugal Centro de Estudos em Ciencia Animal(CECA) Instituto de Ciencias Biomedicas Abel Salazar(ICBAS)University of PortoOportoPortugal Coimbra Higher School of Agriculture Sao Martinho do BispoCoimbraPortugal Alter Real Foundation Alter do ChaoPortugal

A significant number of stallions produce low quality ejaculates with high sensibility to chilling. Single Layer Centrifugation (SLC) with Andro-coll-ETM has been presented as an efficient method of selecting good quality spermatozoa. In the current study, changes in sperm quality (motility, viability, acrosome integrity and DNA damage) occurring during storage at 5?C for a maximum of 72 h, were investigated. For that, one ejaculate from 12 stallions was split in two aliquots: control and SLC-selected. Both aliquots were chilled and stored at 5?C and spermatozoa were evaluated for motility, viability and acrosome integrity at 24, 48 and 72 h post collection. DNA damage was evaluated at 48 h post collection using the comet assay. In the SLC-selected aliquots, there was a significant improvement in terms of progressive motility (0 h: P = 0.005;24 h: P 0.05). SLC with Androcoll-ETM improved semen quality prolonging sperm longevity of chilled semen (P = 0.012). This positive effect was more evident in ejaculates most sensitive to chilling that had a sharp decrease in motility in the first 24 h of refrigeration and for all ejaculates at 72 h post-chilling. Therefore, this method reveals to be a useful technique for selecting spermatozoa and maintain sperm quality during storage.

关键词： Stallion Sperm Single Layer Centrifugation Androcoll-ETM Membrane Integrity Comet assay Component Formatting Style Styling

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The Ideational Elements of Brazil’s Arab Strategy:An Assessment(2002-2010)

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Asian Journal of Middle Eastern and Islamic Studies 2015年第4期9卷 100-120,I0006页

作者： Vânia Carvalho pinto Institute of International Relations University of Brasilia

Relations between the countries of Latin America and the Middle East have been an under researched topic within their respective fields.②This can be attributed,at least partly,to the fact that both regions have a comparatively low level of diplomatic and economic interactions,when contrasted,for example,with relations between Latin America and the European Union,or between the Gulf Cooperation Council and *** the specific case of Brazil,even though the latter has decades old relations with selected Arab countries,such as Iraq,very little has been written about its interactions with the Arab world in *** of the reasons for this may be attributed to the dearth of issues of high politics underscoring this relationship,issues that if present could assist in capturing media and academic *** article seeks to contribute to the study of both regions by focusing on a particular moment of Brazilian foreign policy when relations with the Arab world were at their peak in terms of visibility.

关键词： Brazil and the Middle East Latin America International Relations Brazil and the Gulf

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Iconography of the 1755 Lisbon Earthquake

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Episodes 2006年第3期29卷 227-228页

作者： Manuel S. pinto Centro de Estudos de História e Filosofia da Ciěncia e da Técnica S. A. Ciěncias Sociais Jurídicas e Políticas Unive rsidade de Aveiro- 3819 Aveiro PORTUGAL

Here is a fine book with a timely publication date： 2005 marked the 250th anniversary of the great Lisbon earthquake. Among the many books and papers that were published about the catastrophe in 2005, in Portugal and elsewhere, lconography of the 1755 Lisbon Earthquake stands out because of its excellent illustrations and a most readable text. Intended for readers interested in the history of geological sciences, and also for those interested in natural catastrophes that generated philosophical and theological controversies in Europe, the book commemorates the event in a truly distinctive way.

关键词：葡萄牙地震里斯本自然突变

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The Aging Bladder in Females Evaluated by Urodynamics

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Open Journal of Urology 2017年第3期7卷 54-64页

作者： M. C. de Albuquerque Neto Leslie Clifford Noronha Araujo Thome Decio Pinheiro Barros Junior Joao Luiz Amaro Flavia Cristina Morone pinto Fabio de Oliveira Vilar Salvador Vilar correia Lima Urologic Department Clinical Hospital Federal University of Pernambuco UFPE Recife Brazil Urologic Service Botucatu Medical School Paulista State University UNESP Botucatu Brazil Postgraduate Program in Surgery Department of Surgery Center for Health Sciences Federal University of Pernambuco UFPE Recife Brazil

Aim: To determine whether bladder functions deteriorate with age. Methods: Data contained in electronic medical record (INFOMED?) were used in this institutional retrospective review. Analysis was done on the urodynamic studies in women over 18 years old conducted between May 2011 and November 2015. Patients with previous history of pelvic surgery or radiotherapy, neurological disease, vaginal prolapse greater than grade I, congenital urogenital malformations, urinary obstructive disease, diabetes, or the use of any medication that could interfere with bladder function were excluded from the analysis. The urodynamic parameters analyzed were the Maximum Cystometric Capacity (MCC), Voiding Volume (VV), Maximum Flow (Qmax), Bladder Compliance (BC), Detrusor Pressure at Maximum Flow (PdetQmax), Bladder Contractility Index (BCI), Bladder Voiding Efficiency (BVE) and Post-Void Residual Urine Volume (PVR). Patients were further stratified in five groups according to age (A—18 to 40;B—41 to 50;C—51 to 60;D—61 to 70;E—over 70 years old). Results: Out of 3103 urodynamic studies analyzed, 719 were eligible for the study. The average age of patients was 49.3 (+13.2) years old and in all evaluated parameters, statistically significant correlation between age and decline of bladder function was obtained (p Conclusions: This study showed a decline in bladder storage function (reduction in MCC and BC) and in bladder emptying function (reduction in Qmax, PdetQmax, VV, BCI and BVE with an increase in PVR) with age.

关键词： Aging Urinary Bladder Diseases Urinary Bladder Neurogenic Overactive Urodynamics

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Artisanal ceramic factories using wood combustion:A nanoparticles and human health study

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Geoscience Frontiers 2022年第1期13卷 488-497页

作者： Kátia Martinello James C.Hower Diana pinto Carlos E.Schnorr Guilherme L.Dotto Marcos Leandro Silva Oliveira Claudete G.Ramos Instituto Inanís Rua Felizardo FurtadoPorto AlegreBrazil Department of Civil and Environmental Universidad de la CostaCUCCalle 58#55–66BarranquillaAtlánticoColombia University of Kentucky Department of Earth&Environmental SciencesLexingtonKY 40506USA University of Kentucky Center for Applied Energy Research2540 Research Park DriveLexingtonKY 40511USA Centro de Estudos em Estresse Oxidativo-Departamento de Bioquímica-Instituto de Ciências Básicas da Saúde-Universidade Federal do Rio Grande do Sul(UFRGS) Porto AlegreRSBrazil Chemical Engineering Department Federal University of Santa MariaUFSMRoraima Avenue1000Santa MariaRS97105-900Brazil Departamento de Ingeniería Civil y Arquitectura Universidad de LimaAvenida Javier Prado Este 4600–Santiago de Surco 1503Peru

The ceramics industry,resulting from developments of modern compounds,is a segment of great influence in worldwide *** ceramic factories based on wood combustion have significant risks for the creation and discharge of atmosphere nanoparticles(NPs)and ultra-fine particles(UFPs).At present,there is insufficient recognition on the influence of engineered-NPs on the atmosphere and *** improvements are indispensable to diminish contact with *** present study demonstrates the main NPs and UFPS present in an area of intense artisanal wood-combustion ceramic *** matter was sampled for morphological,chemical,and geochemical studies by sophisticated electron microbeam microscopy,X-Ray Diffraction,and Raman *** NPs configuration(10 nm)were produced around the studied artisanal ceramic *** study presents an indication of the recent information on population and work-related contact to NPs in the artisanal ceramic factories and their influence on health.

关键词： Ceramic manufacturing Nanoparticles Advanced characterization Multiple impacts

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Gastrointestinal complications after kidney transplantation

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World Journal of Gastroenterology 2020年第38期26卷 5797-5811页

作者： Rossella Gioco Daniela Corona Burcin Ekser Lidia Puzzo Gaetano Inserra Flavia pinto Chiara Schipa Francesca Privitera Pierfrancesco Veroux Massimiliano Veroux General Surgery Unit University Hospital of CataniaCatania 95123Italy Department of Biomedical and Biotechnological Sciences University of CataniaCatania 95123Italy Department of Surgery Indiana University School of MedicineIndianapolisIN 46202United States Pathology Unit Department of Medical and Surgical Sciences and Advanced TechnologiesUniversity of CataniaCatania 95123Italy Gastroenterology Unit Department of Clinical and Experimental MedicineUniversity of CataniaCatania 95100Italy Organ Transplant Unit University Hospital of CataniaCatania 95123Italy General Surgery Unit Organ Transplant UnitUniversity Hospital of CataniaCatania 95123Italy Department of Medical and Surgical Sciences and Advanced Technologies University Hospital of CataniaCatania 95123Italy

Gastrointestinal complications are common after renal transplantation,and they have a wide clinical spectrum,varying from diarrhoea to post-transplant inflammatory bowel disease(IBD).Chronic immunosuppression may increase the risk of post-transplant infection and medication-related injury and may also be responsible for IBD in kidney transplant re-cipients despite *** the various forms of post-transplant colitis is challenging,since most have similar clinical and histological ***-related colitis are the most frequently encountered colitis after kidney transplantation,particularly those related to the chronic use of mycophenolate mofetil,while de novo IBDs are quite *** review will explore colitis after kidney transplantation,with a particular focus on different clinical and histological features,attempting to clearly identify the right treatment,thereby improving the final outcome of patients.

关键词： Inflammatory bowel disease Kidney transplantation Solid organ transplantation Crohn disease Ulcerative colitis Mycophenolate mofetil colitis Mycophenolate mofetil Colitis Cytomegalovirus

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Clinical evidences, personal experiences, recent applications

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World Journal of Dermatology 2012年第3期1卷 13-23页

作者： Luca Negosanti Valentina pinto Rossella Sgarzani Plastic Surgery Department S.Orsola-Malpighi University Hospital

Management of difficult wounds can be a complex,challenging and expensive task,especially for wounds showing a slow healing *** negative pressure(TNP)therapy has greatly improved difficult wounds *** allows to treat patient on an outpatient management,to reduce the complication rate with shorter hospital stay,to avoid frequent dressings with expensive advanced materials and allow a lower commitment of health *** Assisted Closure(VAC)system is a therapeutic device based on the administration of a controlled TNP introduced by Morykwas and Argenta in *** is indicated in different kinds of wound,but clinical evidences are present only for few of *** this work we summarize indications and recommendations for VAC therapy and we analyze the actual better choice of treatment based on evidences and personal experience in order to stimulate further *** we introduce recent applications of VAC system such as Prevena,VAC Instill and VAC Via Prevena is a system based on TNP indicated in the management of closed wounds that present risk factors for *** Instill is a system that allows to associate TNP and topical administration of solutions,such as antibiotics or disinfectants,to treat specific type of *** Via is a device based on TNP,characterized by little dimen-sion and a preset system that allow the treatment of little wounds for 7 d,with no impairment for the *** aim of our paper is to describe a report of VAC therapy use in order to stimulate further studies and to define the level of evidence of VAC therapy.

关键词： Topical negative pressure Wound Vacuum Vacuumm Assisted Closure iabetic foot Pressure ulcers

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Improvement of Amplitude-Shift-Keying Signal Quality by Employing an Effective Spectrum Equalization Method in a Combined FSK／ASK Modulation Scheme

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Chinese Physics Letters 2005年第8期22卷 1948-1950页

作者：忻向军 P.S.André A.L.J.Teixeira 徐重秀 AnaFerreira TiagoSilveira P.M.Monteiro F.daRocha J.L.pinto SchoolofElectronicEngineering BeijingUniversityofPostsandTelecommunicationsBeijing100876//InstituteofTelecommunicationsCampusdeSantiago3810-193AveiroPortugal InstituteofTelecommunications CampusdeSantiago3810-193AveiroPortugal//DepartmentofPhysicsUniversityofAveiroCampusdeSantiago3810-193AveiroPortugal SchoolofElectronicEngineering BeijingUniversityofPostsandTelecommunicationsBeijing100876 InstituteofTelecommunications CampusdeSantiago3810-193AveiroPortugal SiemensSA R.IrmāosSiemensno1Alfragide2720-093AmadoraPortugal InstituteofTelecommunications CampusdeSantiago3810-193AveiroPortugal//DepartmentofElectronicTelecommunicationsUniversityofAveiroCampusdeSantiago3810-193AveiroPortugal

A simple, economical and applicable spectrum equalization method is implemented by employing a reshaping filter in the combined frequency-shift-keying/amplitude-shift-keying modulation scheme to improve the quality of... 详细信息

关键词： IP ATM FSK ASK

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The cardiovascular aspects of a Ménière’s disease population——A pilot study

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Journal of Otology 2019年第2期14卷 51-56页

作者： Angela Reis Rego David Dias Ana pinto SANDra Sousa e Castro Telma Feliciano Cecília Almeida e Sousa ENT Department Centro Hospitalar e Universitário do Porto Largo do Prof.Abel Salazar

Introduction:MD is considered a rare *** adequate model that explains MD's pathophysiology is not well ***,the vascular theory of the disease has been ***:To characterize a MD population according to its cardiovascular risk and correlate it to the MD clinical ***:In this retrospective chart study the data of 31 MD patients observed between January 2017 and April 2018 in a tertiary university hospital were *** included in the study were diagnosed according to the Barany Society *** follow-ups,patients with autoimmune disease,atopy or allergy,major psychiatric disease and migraine were ***,gender,cardiovascular risk factors,audiometric and vestibular parameters,occurrence of MD attacks in the previous 6 months,vestibular medication in course and time course of MD were recorded and compared between groups(with and without cardiovascular risk factors).Results:31 patients(61.3%females)mean aged 60.3 years(±9.7)were studied.74%of the population had at least one risk factor and 51.6%of patients had attacks in the last 6 *** was a statistically significant difference in the occurrence of MD attacks in the last 6 months(p=0.014)between MD patients with and without risk *** PTA thresholds were higher and speech discrimination was lower in individuals with more cardiovascular risk ***:Treatment of MD focusing on vascular risk factors may allow a better control of symptoms and result in a decreased need for ablative procedures in this disorder.

关键词： Meniere disease Cardiovascular disease Hypertension Prognosis

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