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Insights into stem cell therapy for diabetic retinopathy: a bibliometric and visual analysis

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Neural Regeneration Research 2021年第1期16卷 172-178页

作者： Xiang-Jun Li Chun-yan Li Dan Bai Ying Leng Department of Ophthalmology Affiliated Hospital of Beihua UniversityJilinJilin ProvinceChina Department of Endocrinology Affiliated Hospital of Beihua UniversityJilinJilin ProvinceChina

Stem cells have been confirmed to be involved in the occurrence and development of diabetic retinopathy;however,the underlying mechanisms remain *** this study,we used Citespace software to visually analyze 552 articles exploring the stem cell-based treatment of diabetic retinopathy over the past 20 years,which were included in the Web of Science Core *** found the following:(1)a co-citation analysis of the references cited by all 552 articles indicated 15 *** cluster#0,representing the stem cell field,some highly cited landmark studies emerged between 2009–*** example,endothelial progenitor cells and diabetic retinopathy gradually received the full attention of scholars,in terms of their relationship and therapeutic *** researchers also verified the potential of adipose-derived stem cells to differentiate into stable retinal perivascular cells,using a variety of animal models of retinal vascular *** of these achievements provided references for the subsequent stem cell research.(2)An analysis of popular keywords among the 552 articles revealed that,during the past 20 years,a relative increase in basic research articles examining stem cells and endothelial progenitor cells for the treatment of diabetic retinopathy was *** contents of these articles primarily involved the expression of vascular endothelial growth factor,vascular regeneration,oxidative stress,and inflammatory response.(3)A burst analysis of keywords used in the 552 articles indicated that genetic and cytological research regarding the promotion of angiogenesis was an issue of concern from 2001 to 2012,including several studies addressing the expression of various growth factor genes;from 2014 to 2020,mouse models of diabetic retinopathy were recognized as mature animal models,and the most recent research has focused on macular degeneration,macular edema,neurodegeneration,and inflammatory changes in diabetic animal models.(4)Globally,the current

关键词： diabetes diabetic retinopathy epithelial cells macula progenitor cells retina stem cells visual analysis

Crosslinking acrylamide with EDTA-intercalated layered double hydroxide for enhanced recovery of Cr(Ⅵ)and Congo red:Adsorptive and mechanistic study

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Frontiers of Environmental Science & Engineering 2020年第3期14卷 189-201页

作者： Jing Li Haiqin Yu Xue Zhang Rixin Zhu Liangguo yan School of Water Conservancy and Environment University of JinanJinan 250022China

We prepared ethylenediaminetetraacetic acid(EDTA)-intercalated MgAl-layered double hydroxide(LDH-EDTA),then grafted acrylamide(AM)to the LDH-EDTA by a cross-linking method to yield a LDH-EDTA-AM composite;we then evaluated its adsorptive ability for Congo red(CR)and hexavalent chromium(Cr(Ⅵ))in single and binaiy adsorption *** adsorption process on LDH-EDTA-AM for CR and Cr(Ⅵ)achieved equilibrium quickly,and the removal efficiencies were minimally affected by initial *** maximum uptake quantities of CR and Cr(Ⅵ)on LDH-EDTAAM were 632.9 and 48.47 mg/g,*** mixed systems,chromate removal was stimulated by the presence of CR,while the adsorption efficiency of C R was almost not influenced by coexisting Cr(Ⅵ).The mechanisms involved electrostatic attraction,surface complexation,and anion exchange for the adsorption of both hazardous *** the Cr(Ⅵ)adsorption process,reduction also took *** removal efficiencies in real contaminated water were all higher than those in the laboratory solutions.

关键词： Chromate Dye adsorption Simultaneous removal Cross-linking method Amino functionalization

Experimental of combustion instability in NTO/MMH impinging combustion chambers

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Chinese Journal of Aeronautics 2020年第5期33卷 1476-1485页

作者： Anlong yanG Bin LI Yu yan Shuaijie XUE Lixin ZHOU Science and Technology on Liquid Rocket Engine Laboratory Xi’an Aerospace Propulsion InstituteXi’an 710100China

This paper presents an experimental study into dynamics of chamber pressure and heat release rate during self-excited spinning and standing azimuthal mode in NTO/MMH (nitrogen tetroxide/monomethylhydrazine) impinging combustion *** cases including two combustion chamber configurations were *** operating conditions of all unstable cases were located in the instability region according to Hewitt empirical *** results show that chamber pressure oscillations keep pace with the corresponding OH*chemiluminescence intensity over the whole combustion region in the spinning and standing *** is indicated that the Rayleigh index is positive over the whole combustion area in all the unstable cases.A significant supersonic flame front structure of the first-order spinning mode was found in a cylindrical chamber,which means that a detonation wave could exist in the cylindrical chamber without a center *** pressure and heat release rate oscillations at the pressure node are nonnegligible although their amplitudes are lower than those at the pressure antinode in the first-order standing mode with an annular ***,the dominant frequency of pressure and heat release rate oscillations at the pressure node is twice as high as that at the pressure antinode.

关键词： Atomization Combustion stability Impinging jet injector Klystron effect Liquid rocket engine

The Research for Surface Properties of Steel Slag Powder and High-Temperature Rheological Properties of Asphalt Mortar

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Journal of Wuhan University of Technology(Materials Science) 2023年第5期38卷 1096-1104页

作者： WANG Yefei YUAN yan yanG Lihong LIU Yong CHEN Yiwen College of Civil Engineering Fuzhou UniversityFuzhou 350108China Fujian Road&Bridge Construction Co. LtdFuzhou 350108China

In order to evaluate the feasibility of steel slag powder as filler,the coating properties of steel slag and limestone aggregate were compared by water boiling test,the micro morphology difierences between steel slag powder and mineral powder(limestone powder)were compared by scanning electron microscope(SEM),and the high-temperature rheological properties of asphalt mortar with difierent ratio of filler quality to asphalt quality(F/A)and difierent substitution rates of mineral powder(S/F)were studied by dynamic shear rheological *** results show that the surface microstructure of steel slag powder is more abundant than that of mineral powder,and the adhesion of steel slag to asphalt is better than that of *** the same temperature,the lower the ratio of S/F is,the greater the rutting factor and complex modulus will *** addition,the complex modulus and rutting factor of the asphalt mortar increase with the increase of F/A,and the filler type and F/A have a negligible efiect on the phase angle.

关键词： steel slag powder asphalt mortar microcosmic adhesion high-temperature rheological properties

Enhanced Fatigue Property of Welded S355J2W Steel by Forming a Gradient Nanostructured Surface Layer

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Acta Metallurgica Sinica(English Letters) 2020年第9期33卷 1252-1258页

作者： Lu An yan-Tao Sun Shan-Ping Lu Zhen-Bo Wang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

Welded joints are usually characterized by microstructural and compositional inhomogeneities, which may significantly degrade their fatigue properties and result in unpredictable failures. The present work demonstrates a novel and simple method to effectively optimize the microstructure in the surface layer and promote the fatigue properties of welded specimens. By a recently developed approach—surface mechanical rolling treatment(SMRT), a gradient nanostructured surface layer is formed on welded S355 J2 W steel specimens. The mean grain size is refined to nanometer scale, and the hardness is significantly enhanced in the SMRT surface layer. Independent of the initially inhomogeneous microstructure and hardness distributions, the microstructure and hardness distributions in the surface layers are comparable on different zones of a welded specimen after SMRT with the same procedure. Consequently, fatigue property of the SMRT specimens is significantly enhanced relative to that of the as-welded specimens within the high cycle fatigue regime.

关键词： Gradient nanostructured Surface mechanical rolling treatment S355J2W steel Welded Fatigue

A Novel Neighborhood-Weighted Sampling Method for Imbalanced Datasets

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Chinese Journal of Electronics 2022年第5期31卷 969-979页

作者： GUANG Mingjian yan Chungang LIU Guanjun WANG Junli JIANG Changjun Key Laboratory of Embedded System and Service Computing Tongji University Ministry of Education National (Province-Ministry Joint) Collaborative Innovation Center for Financial Network Security Tongji University

The weighted sampling methods based on k-nearest neighbors have been demonstrated to be effective in solving the class imbalance problem. However,they usually ignore the positional relationship between a sample and the heterogeneous samples in its neighborhood when calculating sample weight. This paper proposes a novel neighborhood-weighted based sampling method named NWBBagging to improve the Bagging algorithm’s performance on imbalanced datasets. It considers the positional relationship between the center sample and the heterogeneous samples in its neighborhood when identifying critical samples. And a parameter reduction method is proposed and combined into the ensemble learning framework, which reduces the parameters and increases the classifier’s diversity. We compare NWBBagging with some state-of-the-art ensemble learning algorithms on 34 imbalanced datasets, and the result shows that NWBBagging achieves better performance.

关键词： parameter reduction method neighborhood-weighted sampling method pattern classification class imbalance problem NWBBagging k-nearest neighbors sampling methods imbalanced datasets nearest neighbour methods ensemble learning algorithm Bagging algorithm

Game-theoretical Model for Dynamic Defense Resource Allocation in Cyber-physical Power Systems Under Distributed Denial of Service Attacks

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 41-51页

作者： Bingjing yan Pengchao Yao Tao yang Boyang Zhou Qiang yang the College of Electrical Engineering Zhejiang UniversityHangzhou 310027China Zhejiang Lab Hangzhou 311100China

Electric power grids are evolving into complex cyber-physical power systems(CPPSs)that integrate advanced information and communication technologies(ICTs)but face increasing cyberspace threats and *** study considers CPPS cyberspace security under distributed denial of service(DDoS)attacks and proposes a nonzero-sum game-theoretical model with incomplete information for appropriate allocation of defense resources based on the availability of limited *** time delay is applied to quantify the expected utility as CPPSs have high time requirements and incur massive damage DDoS *** resource allocation strategies are adopted by attackers and defenders under the three cases of attack-free,failed attack,and successful attack,which lead to a corresponding consumption of resources.A multidimensional node value analysis is designed to introduce physical and cybersecurity *** experiments and numerical results demonstrate the effectiveness of the proposed model for the appropriate allocation of defense resources in CPPSs under limited resource availability.

关键词： Game theory complex cyber-physical power system(CPPS) multidimensional evaluation distributed denial of service(DDoS)attack

Fabrication of Ordered Micro/Nanostructures Using Probe‑Based Force‑Controlled Micromachining System

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Chinese Journal of Mechanical Engineering 2022年第6期35卷 178-193页

作者： yanquan Geng Yuzhang Wang Jianxiong Cai Jingran Zhang Yongda yan Key Laboratory of Micro‑systems and Micro‑structures Manufacturing of Ministry of Education Harbin Institute of TechnologyHarbin 150001China Center for Precision Engineering Harbin Institute of TechnologyHarbin 150001China College of Mechanical and Electric Engineering Changchun University of Science and TechnologyChangchun 130000China

This paper presents a probe-based force-controlled nanoindentation method to fabricate ordered micro/*** the experimental and finite element simulation approaches are employed to investigate the influence of the interval between the adjacent indentations and the rotation angle of the probe on the formed micro/*** non-contacting part between indenter and the sample material and the height of the material pile-up are two competing factors to determine the depth relationship between the adjacent *** the one array indentations,nanostructures with good depth consistency and periodicity can be formed after the depth of the indentation becoming stable,and the variation of the rotation angle results in the large difference between the morphology of the formed nanostructures at the bottom of the one array *** addition,for the indentation arrays,the nanostructures with good consistency and periodicity of the shape and depth can be generated with the spacing greater than 1μ***,Raman tests are also carried out based on the obtained ordered micro/nanostructures with Rhodamine probe *** indentation arrays with a smaller spacing lead to better the enhancement effect of the substrate,which has the potential applications in the fields of biological or chemical molecular detection.

关键词： Ordered micro/nanostructure Probe-based micromachining In-process force-controlled Indentation array Micro cutting

Significant influence of trace Li on the mechanical properties, corrosion behavior, and antibacterial properties of biodegradable Zn–4Cu alloys

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Journal of Materials Science & Technology 2023年第20期151卷 245-257页

作者： Shiyu Huang Heng Liu yanjing Su Lijie Qiao Yu yan Beijing Advanced Innovation Center for Materials Genome Engineering Corrosion and Protection CenterInstitute for Advanced Materials and TechnologyUniversity of Science and TechnologyBeijing 100083China

In this work,trace Li was introduced to strengthen Zn–4Cu *** results indicated that trace amounts of Li contributed to a significant increase in strength,resulting in an acceptable loss of elongation at ***,Li in the form of LiZn_(4) led to more intensive galvanic corrosion,which accelerated the early corrosion *** release of a large amount of Zn^(2+),caused by the addition of Li,affected the phase composition of the main Zn-containing corrosion ***,the inhibition effect of the alloy on Staphylococcus aureus(***)was enhanced by the addition of 0.02 wt.%Li.

关键词： Microalloying Zn-Cu alloy LiZn_(4)/Zn pairs Biodegradable mechanism SKPFM