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HNRNPC as a pan-cancer biomarker and therapeutic target involved in tumor progression and immune regulation

Oncology research 2025年第1期33卷 83-102页

作者： Yuezhou zhang Zhao zhang Jinxin Dong Changan Liu Department of Hepatobiliary Surgery The Second Affiliated Hospital of Chongqing Medical University Chongqing 400016 China. Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical University Chongqing 400016 China.

Background:Aberrant expression of RNA-binding proteins (RBPs) has been linked to a variety of diseases, including hematological disorders, cardiovascular diseases, and multiple types of cancer. Heterogeneous nuclear ribonucleoprotein C (HNRNPC), a member belonging to the heterogeneous nuclear ribonucleoprotein (hnRNP) family, plays a pivotal role in nucleic acid metabolism. Previous studies have underscored the significance of HNRNPC in tumorigenesis; however, its specific role in malignant tumor progression remains inadequately characterized.Methods:We leveraged publicly available databases, including The Cancer Genome Atlas (TCGA), to explore the potential involvement of HNRNPC across various cancers. Additionally, we performed experimental validation studies focused on liver cancer.Results:Our analysis revealed that HNRNPC is overexpressed in a wide range of common malignancies, including liver and lung cancers, and is strongly linked to unfavorable outcomes. Furthermore, HNRNPC was observed to be closely linked to tumor immunity. Through immune checkpoint analysis and immune cell infiltration assessment, HNRNPC emerged as a potential target for modulating tumor immunotherapy. Notably, silencing of HNRNPC markedly inhibited the proliferation, metastasis, and infiltration of liver cancer cells.Conclusion:In summary, our findings highlight HNRNPC as a prognostic marker in various cancers, including liver cancer, and suggest its involvement in shaping the tumor immune microenvironment. These insights offer potential avenues for improving clinical outcomes in tumors with elevated HNRNPC expression, particularly through immunotherapeutic strategies.

关键词： Hepatocellular carcinoma Heterogeneous nuclear ribonucleoprotein C (HNRNPC) Immunotherapeutic target Pan-cancer analysis Prognostic biomarker Tumor immunity

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Indoor channel characteristics based on wideband MIMO measurements at 5.25 GHz

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The Journal of China Universities of Posts and Telecommunications 2008年第4期15卷 46-50页

作者： GAO Xin-ying zhang Jian-hua zhang ping Key Laboratory of Universal Wireless Communications Ministry of Education Wireless Technology Innovation Institute Beijing University of Posts and Telecommunications Beijing 100876 China

Extensive indoor channel measurements were conducted in Beijing with wideband multiple-input multiple-output （MIMO） sounder at 5.25 GHz. Both line-of-sight （LOS） and non-line-of-sight （NLOS） propagation were measured in the indoor office and hotspot scenarios. On the basis of measured data, statistical channel characteristics are presented in this article, including the empirical path loss （PL） models, three excess delay parameters, circular azimuth spread （CAS）, and circular elevation spread （CES）. Comparative analysis of different propagation mechanisms in two scenarios is conducted. These values are significant for indoor coverage and technical research of MIMO and orthogonal frequency division multiplexing （OFDM） for the international mobile telecommunications-advanced （IMT-Advanced） system.

关键词： channel measurement wideband MIMO path loss excess delay circular azimuth spread circular elevation spread IMT-Advanced

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Decision making module based on stochastic magnetic tunnel junctions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 202-209页

作者： Yifan Miao Li Zhao Yajun zhang Zhe Yuan Center for Advanced Quantum Studies and Department of Physics Beijing Normal University Institute for Nanoelectric Devices and Quantum Computing Fudan University Interdisciplinary Center for Theoretical Physics and Information Sciences Fudan University

In biological neural systems, noise is ubiquitous but does not affect the correct decisions made in the complex cognitive ***-making in biological neural system is typically achieved by accumulating input information over a period of *** by recent developments in neurosciences, we design a decision-making module based on spintronic devices, utilizing superparamagnetic tunnel junctions as artificial neurons. The feasibility of this decision-making module is verified through circuit simulations. Taking a multi-layer perceptron as an example, the module significantly improves the accuracy of the perceptron in the handwritten digit recognition task. Furthermore, the spintronic decision-making module offers advantages over the conventional pooling methods, such as adaptive decision time, high performance and the absence of analog-to-digital conversion. The decision-making module is flexible to be integrated into artificial neural networks and provides a general yet effective solution to enhance performance against device noise.

关键词： neuromorphic computing spintronics magnetic tunnel junction neural networks

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A quantum-search-based multi-classifier for image recognition

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 21-31页

作者： Lu Liu Xingyu Wu Lufan zhang Chuan Wang School of Artificial Intelligence Beijing Normal University Applied Optics Beijing Area Major Laboratory Beijing Normal University

The multi-class classification of images is a pivotal challenge within the realm of image processing. As the volume of visual data continues to expand, there is a burgeoning interest in harnessing the unique capabilities of quantum computation to augment the efficiency of classification tasks. However, many existing methods for training quantum image multi-classifiers parallel classical machine learning techniques, where the requisite circuit measurements increase linearly with the volume of training data. This work introduces a novel approach for training a quantum image multi-classifier based on the quantum search algorithm. We have meticulously conducted rigorous experiments on a handwritten digit dataset, a classic benchmark in the field. The results have been meticulously compared with previous works, and the comparative analysis not only validates the efficiency of our proposed approach, requiring only O(N/b) measurements during training, but also highlights a significant quadratic speedup of the algorithm.

关键词： quantum computation image recognition quantum search algorithm

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重组人血清白蛋白发酵过程表达期的定量研究

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生物工程学报 2003年第1期19卷 81-86页

作者：黄明志郭美锦储炬杭海峰庄英萍张嗣良华东理工大学生物反应器工程国家重点实验室国家生化工程技术研究中心生物工程学院上海200237

结合元素平衡和代谢平衡 ,建立了重组人血清白蛋白发酵过程表达期的数学模型 ,按单纯形多变量最优化方法估算了模型的未知参数 ,并探讨了导致表达期不同阶段产物形成速率存在差异的可能原因。该模型能较好地描述重组人血清白蛋白发酵过... 详细信息

结合元素平衡和代谢平衡 ,建立了重组人血清白蛋白发酵过程表达期的数学模型 ,按单纯形多变量最优化方法估算了模型的未知参数 ,并探讨了导致表达期不同阶段产物形成速率存在差异的可能原因。该模型能较好地描述重组人血清白蛋白发酵过程表达期中各宏观反应速率之间的关系 ,为重组人血清白蛋白的高效表达提供了线索。

关键词：重组人血清白蛋白发酵过程表达期定量研究代谢平衡元素平衡

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Bending mechanical properties of W/TiN/Ta composites with interfacial TiN coatings

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Rare Metals 2023年第5期42卷 1718-1723页

作者： Gao-Yong Xu Tong Zhou ying zhang Jin-ping Suo State Key Laboratory of Mould Technology Institute of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Tungsten is one of best candidates for plasma facing materials(PFMs)in fusion *** its application in fusion areas is strongly restricted by the inherent brittleness and high ductile-brittle transition *** improve the toughness of W-based materials,W/TiN/Ta-laminated composites were fabricated by spark plasma ***-point bending test was performed to investigate the bending mechanical *** crack propagation is the main crack propagation mode in W/TiN/Ta *** dissipation by interfacial debonding and crack deflection at interfaces as well as crack bridging by Ta foils and plastic deformation of Ta can contribute to the toughening of W/TiN/Ta *** existence of interfacial TiN coatings can act as weak points and promote interfacial *** coatings with(111)preferred orientation are found to be conducive to the strengthening of W/TiN/Ta composites.

关键词： Multilayer structure Interfacial TiN coatings Bending test Toughness

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Bronchial glomus tumor with calcification: A case report

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World Journal of Clinical Cases 2021年第14期9卷 3320-3326页

作者： ying zhang Qiu-ping zhang ying-Qun Ji Jian Xu Department of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina Department of Pathology The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina Department of Pulmonary and Critical Care Medicine Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of Pulmonary and Critical Care Medicine Dalian Municipal Central Hospital Affiliated of Dalian Medical UniversityDalian 116033Liaoning ProvinceChina

BACKGROUND Glomus tumors(GTs),defined by modified smooth cells and normal glomus body cells,usually present with a small mass occurring in the soft tissue or dermis of an extremity,especially in the subungual ***,other unusual sites,such as the respiratory tract,have also been *** are usually *** imaging findings are usually nonspecific and likely to appear as a well-delineated round mass that usually lacks *** our knowledge,we report the first case of bronchial GTs with calcification,reminding clinicians and radiologists that GT is one of the differential diagnoses when a calcified nodular mass is *** SUMMARY We report a case of a 33-yr-old Chinese man with cough and sputum for 11 d and hemoptysis for 5 *** computed tomography revealed a calcified nodular lesion on the compressed posterior wall of the lower left main bronchus and bronchiectasis in the lower lobe of the left *** confirm the characteristics of calcified nodules,we performed fiberoptic *** tumor tissue from the biopsy of bronchial mucosal lesions established the diagnosis of *** the patient had no life-threatening symptoms,he was not treated with *** follow-up for 25 mo showed that the patient survived well without any *** Bronchial GTs are usually not accompanied by calcification on computed tomography *** our knowledge,we report the first calcified bronchial *** recommend that clinicians consider GT as a possible differential diagnosis when a calcified mass of the bronchi is found.

关键词： Glomus tumor Imaging Calcified tumor Bronchus Case report

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鸟苷发酵过程的定量和优化:抑制NH_4^+离子积累提高了苷产量70%

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生物工程学报 2003年第2期19卷 200-205页

作者：黄明志蔡显鹏陈双喜储炬庄英萍张嗣良华东理工大学生物反应器工程国家重点实验室生化工程技术研究中心生物工程学院上海200237

基于质量守恒定律和代谢反应中间代谢物的拟稳态假设 ,定量研究了枯草芽孢杆菌 (Bacillussubtilis)代谢流分布随时间变化的特征。研究结果表明 ,在鸟苷发酵过程 40h左右 ,存在着从己糖单磷酸途径到酵解途径的代谢流迁移 ,所迁移的碳源... 详细信息

基于质量守恒定律和代谢反应中间代谢物的拟稳态假设 ,定量研究了枯草芽孢杆菌 (Bacillussubtilis)代谢流分布随时间变化的特征。研究结果表明 ,在鸟苷发酵过程 40h左右 ,存在着从己糖单磷酸途径到酵解途径的代谢流迁移 ,所迁移的碳源主要生成了氨基酸和有机酸。定量研究的结果 ,为发酵过程的工艺优化提供了重要依据。

关键词：代谢流迁移定量研究鸟苷枯草芽孢杆菌代谢流分布

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A two-parameter model for ion exchange process of ion-adsorption type rare earth ores

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Journal of Rare Earths 2020年第11期38卷 1251-1256,I0004页

作者： ping Long Guanshi Wang Chao zhang ying Huang Sihai Luo School of Resources and Environmental Engineering Jiangxi University of Science and TechnologyGanzhou 341000China Cooperative Innovation Center of Efficient Development and Application for Ionic Rare Earth Resources Jiangxi University of Science and TechnologyGanzhou 341000China School of Architectural and Surveying and Mapping Engineering Jiangxi University of Science and TechnologyGanzhou 341000China

The establishment of a mathematical model for the ion exchange process is key to creating a theoretical basis for the mining of ion-adsorption type rare earth *** samples from Xinfeng,Xunwu and Anyuan were used as the test ore samples in the present study and equilibrium batch tests of ore sample leaching using various ammonium sulfate concentrations were *** results show that,after leaching,there is a negative exponential relationship between the ratio of the solid-phase rare earth ion concentration to the aqueous-phase rare earth ion concentration and the initial ammonium ion ***,there is a linear relationship between the natural logarithm of the ratio of the solidphase ammonium ion concentration to the aqueous-phase ammonium ion concentration and the initial ammonium ion *** on the above two functional relationships,a two-parameter model for the equilibrium ion exchange process of ion-adsorption type rare earth ores was *** the established model to analyze the test data the model error for the Xunwu ore sample is found to be less than 5%.The proposed model is more accurate compared with the Kerr *** two-parameter model proposed in this study provides theoretical support for the numerical simulation of column leaching(in-situ leaching)of ion-adsorption type rare earth ores.

关键词： Ion-adsorption type rare earth ores Ion exchange Empirical model

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胰源性区域性门静脉高压的多层螺旋CT表现

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实用放射学杂志 2008年第5期24卷 635-638页

作者：殷小平李彩英张丹封海龙于勃河北医科大学第二医院医学影像科河北省保定市第二医院超声科河北省威县人民医院放射科河北石家庄050000

目的分析胰源性区域性门静脉高压(pancreatogenic segmental portal hypertension,PSPH)的多层螺旋CT(MSCT)表现和特征。方法对32例胰源性门静脉高压患者,使用16排多层螺旋CT行上腹部CT平扫、多期相增强扫描,采用多平面重组(MPR)、最大... 详细信息

目的分析胰源性区域性门静脉高压(pancreatogenic segmental portal hypertension,PSPH)的多层螺旋CT(MSCT)表现和特征。方法对32例胰源性门静脉高压患者,使用16排多层螺旋CT行上腹部CT平扫、多期相增强扫描,采用多平面重组(MPR)、最大密度投影(MIP)、容积再现(VR)等图像后处理技术显示异常的脾静脉及侧枝血管情况。结果脾静脉均有受压、血栓或受侵表现,孤立性脾静脉阻塞中,食管静脉(EV)、胃短静脉(SGV)、胃冠状静脉(CGV)、胃网膜静脉(GEV)、胃结肠干(GCT)曲张分别占9.37%,67.65%,65.63%,96.88%,28.13%;非孤立性脾静脉阻塞伴有肠系膜上静脉SMV阻塞时,其属支结肠右上静脉(RSCV)、胃结肠干(MCV)、胰十二指肠前上静脉(ASPDV)曲张例数分别为15.63%,18.75%,5.88%。同时伴门静脉海绵样变5例。结论MSCT及图像后处理系统对PRPH诊断具有重要价值。

关键词：胰腺疾病门静脉高压体层摄影术,X线计算机

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