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Clinical and Pathological Implications of Increases in Tonsillar CD19+CD5+B Cells,CD208+Dendritic Cells,and IgA1-positive Cells of Immunoglobulin A Nephropathy

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Current Medical Science 2022年第1期42卷 93-99页

作者： Yang CAI Mei-xue CHEN Yuan-jun DENG Le-le LIU Xue-ping LIN ping-fan lu Yi-yan GUO Min HAN Division of Nephrology Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Several studies indicated that tonsillectomy can improve the prognosis of patients with immunoglobulin A nephropathy(IgAN).However,the relationship between tonsillar immunity and IgAN is still ***:A total of 14 IgAN patients were recruited in the current study from May 2015 to April 2016 in Tongji Hospital.B cells,dendritic cells(DCs),and IgAl positive cells in human tonsils were detected using immunofluorescence and *** between these cells and clinicopathologic features were evaluated.

关键词： IgA nephropathy tonsil B cells dendritic cells IgAl-positive cells

Interleukin-7 Is Associated with Clinical and Pathological Activities in Immunoglobulin A Nephropathy and Protects the Renal Proximal Tubule Epithelium from Cellular Fibrosis

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Current Medical Science 2021年第5期41卷 880-887页

作者： Yuan-jun DENG Xue-ping LIN Xiao-qing LI ping-fan lu Yang CAI Le-le LIU Guang-chang PEI Min HAN Department of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Diagnosis of immunoglobulin A nephropathy(IgAN)requires the evaluation of renal biopsy ***,renal biopsy is an invasive procedure and is not frequently performed for various ***,recognized noninvasive biomarkers for predicting IgAN progression are urgently ***:In the present study,we included 86 IgAN patients with renal biopsy from June 2015 to May 2016 and had their plasma interleukin-7(IL-7)level measured with *** association between the plasma IL-7 level and clinico-pathological characteristics was *** staining was used to assay the in situ expression of IL-7 in *** blotting was perfonned to examine the production of extracellular matrix,p-mTOR and the markers of autophagy under the treatment of IL-7 after TGF-β1 stimulation in renal tubular epithelial ***:IL-7 was significantly decreased in patients with IgAN compared to healthy subjects(2.3077 vs.8.6294 pg/mL,Plue in patients at the time of biopsy indicated a poor renal *** addition,IL-7 was over-expressed in renal tubular epithelial cells and significantly attenuated transforming growth factor β1-induced extracellular matrix production by suppression of cellular autophagy via activation of mTOR1 ***:These results suggested that IL-7 might be a noninvasive biomarker for predicating *** protected renal proximal tubular epithelial cells from cellular fibrosis by inhibiting autophagy via mTORl signaling.

关键词： IgA nephropathy biomarker IL-7 cellular fibrosis

Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression

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World Journal of Psychiatry 2025年第1期15卷 54-62页

作者： Juan Liu Yan-ping Guo Yan-Mei lu Bei-Lin Wang Department of Urology Surgery Zhumadian Central HospitalZhumadian 463000Henan ProvinceChina Department of Psychiatry Zhumadian Mental HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer *** epirubicin(EPI)is recommended by the European Association of Urology and can improve prognosis,its long-term use can cause toxic side effects,reduce treatment compliance,and increase psycho-logical ***,an appropriate intervention mode is *** This was a retrospective study including 110 patients with urinary system tumors and depression admitted to Zhumadian Central Hospital between March 2021 and July *** were divided into conventional(n=55)and joint inter-vention(n=55)*** conventional group received mitomycin and routine nursing,while the joint intervention group received EPI and mindfulness *** groups underwent three cycles of *** function(CD4+cells,CD8+cells,CD4+/CD8+ratio),tumor marker levels[urinary bladder cancer antigen(UBC),bladder tumor antigen(BTA)and nuclear matrix protein 22(NMP22)],quality of life questionnaire-core 30(QLQ-C30),17-item Hamilton depression scale(HAMD-17),and cancer-related fatigue[cancer fatigue scale(CFS)]were *** reactions and nursing satisfaction were recorded and *** Post-intervention,CD4+,CD8+,and CD4+/CD8+levels increased in both groups,with the joint intervention group showing more significant improvement(PluSION EPI combined with mindfulness intervention significantly improved clinical outcomes in patients with urinar

关键词： Urinary system tumor Bladder cancer Prostate cancer Depression Epirubicin

Unifying logic rules and machine learning for entity enhancing

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Science China(Information Sciences) 2020年第7期63卷 142-160页

作者： Wenfei fan ping lu Chao TIAN School of Informatics University of Edinburgh Shenzhen Institute of Computing Sciences Shenzhen University Beijing Advanced Innovation Center for Big Data and Brain Computing Beihang University Alibaba Group

This paper proposes a notion of entity enhancing, which unifies entity resolution and conflict resolution, to identify tuples that refer to the same real-world entity and at the same time, correct semantic inconsistencies. We propose to unify rule-based and machine learning(ML) methods for entity enhancing, by embedding ML classifiers as predicates in logic rules. We model entity enhancing by extending the chase. We show that the chase warrants correctness justification and the Church-Rosser property. Moreover, we settle fundamental problems associated with entity enhancing, including the enhancing, consistency, satisfiability,and implication problems, ranging from NP-complete and coNP-complete to Π~p-complete. Taken together,these provide a new theoretical framework for unifying entity resolution and conflict resolution.

关键词： logic rules machine learning entity enhancing entity resolution conflict resolution

The circuit design and optimization of quantum multiplier and divider

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Science China(Physics,Mechanics & Astronomy) 2022年第6期65卷 11-25页

作者： Hai-Sheng Li ping fan Haiying Xia Gui-lu Long College of Electronic Engineering Guangxi Normal UniversityGuilin 541004China College of Information Engineering East China JiaoTong UniversityNanchang 330013China Department of Physics Tsinghua UniversityBeijing 100084China State Key Laboratory of Low-Dimensional Quantum Physics Tsinghua UniversityBeijing 100084China Beijing National Research Center for Information Science and Technology Beijing 100084China Beijing Academy of Quantum Information Sciences Beijing 100193China

A fault-tolerant circuit is required for robust quantum computing in the presence of ***+T circuits are widely used in fault-tolerant *** a result,reducing T-depth,T-count,and circuit width has emerged as important optimization goals.A measure-and-fixup approach yields the best T-count for arithmetic operations,but it requires quantum *** paper proposes approximate Toffoli,TR,Peres,and Fredkin gates with optimized T-depth and *** that,we implement basic arithmetic operations such as quantum modular adder and subtractor using approximate gates that do not require quantum ***,taking into account the circuit width,T-depth,and T-count,we design and optimize the circuits of two multipliers and a *** to the comparative analysis,the proposed multiplier and divider circuits have lower circuit width,T-depth,and T-count than the current works that do not use the measure-and-fixup ***,the proposed second multiplier produces approximately 77%T-depth,60%T-count,and 25%width reductions when compared to the existing multipliers without quantum measurements.

关键词： quantum multiplier quantum divider quantum fault-tolerant circuit quantum computing

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Efficient quantum arithmetic operation circuits for quantum image processing

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Science China(Physics,Mechanics & Astronomy) 2020年第8期63卷 33-45页

作者： Hai-Sheng Li ping fan Haiying Xia Huiling Peng Gui-lu Long College of Electronic Engineering Guangxi Normal UniversityGuilin 541004China College of Information Engineering East China JiaoTong UniversityNanchang 330013China Department of Physics Tsinghua UniversityBeijing 100084China Beijing Academy of Quantum Information Sciences Beijing 100193China Frontier Science Center for Quantum Information Beijing 100084China

Efficient quantum circuits for arithmetic operations are vital for quantum algorithms.A fault-tolerant circuit is required for a robust quantum computing in the presence of *** circuits based on Clifford+T gates are easily rendered ***,reducing the T-depth and T-Count without increasing the qubit number represents vital optimization goals for quantum *** this study,we propose the fault-tolerant implementations for TR and Peres gates with optimized T-depth and ***,we design fault-tolerant circuits for quantum arithmetic operations using the TR and Peres ***,we implement cyclic and complete translations of quantum images using quantum arithmetic operations,and the scalar matrix *** analysis and simulation results reveal that the proposed arithmetic and image operations are *** instance,cyclic translations of a quantum image produce 50%T-depth reduction relative to the previous best-known cyclic translation.

关键词： quantum arithmetic operation quantum fault tolerant circuit quantum computation quantum image processing

Diagrams of Hopf algebras with the Chevalley property

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Applied Mathematics(A Journal of Chinese Universities) 2016年第3期31卷 367-378页

作者： fan Zhong-ping lu Di-ming YU Xiao-lan School of Mathematical Science Ocean University of China Department of Mathematics Zhejiang University Department of Mathematics Hangzhou Normal University

In this paper, we study non-cosemisimple Hopf algebras through their underlying coalgebra structure. We introduce the concept of the maximal pointed subcoalgebra/Hopf sub- algebra. For a non-cosemisimple Hopf algebra A with the Chevalley property, if its diagram is a Nichols algebra, then the diagram of its maximal pointed Hopf subalgebra is also a Nichols algebra. When A is of finite dimension, we provide a necessary and sufficient condition for A＇s diagram equaling the diagram of its maximal pointed Hopf subalgebra.

关键词： Hopf algebra coalgebra coradical Nichols algebra pointed Chevalley property

Immunoproteomic Assay of Antigenic Surface Proteins in Streptococcus equi ssp. zooepidemicus

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Agricultural Sciences in China 2011年第7期10卷 1096-1105页

作者： MAO Ying fan Hong-jie ZHOU Yong-hua lu Cheng-ping Key Laboratory of Animal Disease Diagnostic and Immunology Ministry of Agriculture/College of Veterinary Medicine Nanjing Agricultural University Nanjing 210095 P.R.China Jiangsu Institute of Parasitic Diseases Wuxi 214064 P.R.China

Streptococcus equi ssp. zooepidemicus （S. zooepidemicus） is a zoonotic pathogen with worldwide distribution. Lacking suitable vaccine and virulent maker is still bottleneck to control this infection. An immunoproteomic approach has been used to screen the membrane-associated and cell wall-associated proteins of S. zooepidemicus isolate in China CY to discover vaccine candidate antigens and therapeutic agents. Finally, 11 membrane-associated proteins, and 13 cell wall-associated proteins were successfully identified. BLAST （***） results also indicated that nucleotide sequences of majority identified proteins shared high homology （60%） with S. zooepidemicus, except for AC1-3, AC5, AC8, and AC13. Moreover, genes for 7 of the identified proteins were detected from CY; compared with ST171, 3 of them （AM1, AM8 and AC11） were only found in virulent strains （CY）. All of the proteins identified in this study remain not to be reported in S. zooepidemicus. Some of the proteins serve a vital role in the immune system and reproduction of host species according to available data, while the functions of the rest were seldom researched.

关键词： membrane-associated proteins (MAP) cell wall-associated proteins (CP) immunoproteomics S. zooepidemicus

An Improved Upper Bound on the Linear 2-arboricity of 1-planar Graphs

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Acta Mathematica Sinica,English Series 2021年第2期37卷 262-278页

作者： Juan LIU Yi Qiao WANG ping WANG lu ZHANG Wei fan WANG Department of Mathematics Zhejiang Normal UniversityJinhua 321004P.R.China School of Management Beijing University of Chinese MedicineBeijing 100029P.R.China Department of Mathematics and Statistics St.Francis Xavier UniversityAntigonishNova ScotiaCanada

The linear 2-arboricity la2(G) of a graph G is the least integer k such that G can be partitioned into k edge-disjoint forests,whose component trees are paths of length at most *** this paper,we prove that if G is a 1-planar graph with maximum degree Δ,then la_(2)(G)≤[(Δ+1)/2]+*** improves a known result of Liu et al.(2019) that every 1-planar graph G has la_(2)(G)≤[(Δ+1)/2]+*** also observe that there exists a 7-regular 1-planar graph G such that la2(G)=6=[(Δ+1)/2]+2,which implies that our solution is within 6 from optimal.

关键词： 1-planar graph linear 2-arboricity edge-partition maximum degree