检索结果-南通市图书馆

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan ping Yu Emily Choi Michael qJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation and catalytic properties of ZrO_2-Al_2O_3 composite oxide supported nickel catalysts for methane reforming with carbon dioxide

引用

Journal of Environmental Sciences 2004年第2期16卷 316-320页

作者： HAOZheng-ping HUChun JIANGZheng G.q.LU ResearchCenterforEeo-EnvironmentalSciences ChineseAcademyofSciencesBeijing100085China. DepartmentofChemicalEngineering UniversityofQueenslandSt.LuciaQLD4072Australia

ZrO 2-Al 2O 3 composite oxides and supported Ni catalysts were prepared, and characterized by N 2 adsorption /desorption, X-ray diffraction(XRD) an d X-ray photoelectron spectroscopy(XPS) techniques. The catalytic performance and carbon deposition was also investigated. This mesoporous composite oxide is shown to be a promising catalyst support. An increase in the catalytic activity and stability of methane and carbon dioxide reforming reaction was resulted from the zirconia addition, especially at 5wt% ZrO 2 content. The Ni catalyst supported ZrO 2-Al 2O 3 has a strong resistance to sintering and the carbon deposition in a relatively long-term reaction.

关键词： oxides catalytic properties methane reforming carbon deposition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of vibration reduction level in an 8/6 switched reluctance machine by active vibration cancellation

引用

Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第10期11卷 808-816页

作者： Xu LIU Zai-ping PAN Z. q. ZHU School of Electrical Engineering Zhejiang University Hangzhou 310027 China Department of Electronic and Electrwal Engmeermg University of Sheffield Sheffield S1 3JD UK

This paper proposes an analytical model for predicting the maximum vibration reduction level in a four-phase 8/6 switched reluctance machine(SRM) by employing active vibration cancellation(AVC),one of the most effective and convenient methods for reducing the vibration and acoustic noise produced by *** on the proposed method,the factors that influence the vibration reduction level are analyzed in *** relationships between vibration and noise reduction levels at resonance frequency and rotor speed are ***,it is shown that a large damping factor will lead to smaller vibration reduction level with AVC while,in contrast,a large resonance frequency will increase the vibration reduction *** finite element analyses and experiments were carried out on a prototype 8/6 SRM to validate the proposed method.

关键词： Active vibration cancellation Analytical model Switched reluctance machine Vibration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simulation Analysis of Deformation Control for Magnetic Soft Medical Robots

引用

IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 794-796页

作者： Jingxi Wang Baoyu Liu Edmond q.Wu Jin Ma ping Li Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of Education Beijing Advanced Innovation Center for Biomedical Engineeringthe School of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China IEEE the Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China the Department of Aerospace Medicine Air Force Medical UniversityXi’an 710032China

Dear Editor,This letter presents a biocompatible cross-shaped magnetic soft robot and investigates its deformation mode control strategy through COMSOL modeling and *** soft robots offer novel avenues for precise trea... 详细信息

关键词： robot simulation COMSOL

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Position Errors and Interference Prediction-Based Trajectory Tracking for Snake Robots

引用

IEEE/CAA Journal of Automatica Sinica 2023年第9期10卷 1810-1821页

作者： Dongfang Li Yilong Zhang ping Li Rob Law Zhengrong Xiang Xin Xu Limin Zhu Edmond q.Wu IEEE School of Electrical Engineering and Automation Fuzhou UniversityFuzhou 350108 the Sino-US Global Logistics Institute Shanghai Jiao Tong UniversityShanghai 200240 the Key Laboratory for Agricultural Machinery Intelligent Control and Manufacturing of Fujian Education Institutions Fuzhou 350108China School of Biological Science and Medical Engineering and the Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beihang UniversityBeijing 100191China University of Macao Macao 999078China School of Automation Nanjing University of Science and TechnologyNanjing 210094China College of Intelligence Science and Technology National University of Defence TechnologyChangsha 410073China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China

This work presents a trajectory tracking control method for snake *** method eliminates the influence of time-varying interferences on the body and reduces the offset error of a robot with a predetermined *** optimized line-of-sight(LOS)guidance strategy drives the robot’s steering angle to maintain its anti-sideslip ability by predicting position errors and ***,the predictions of system parameters and viscous friction coefficients can compensate for the joint torque control *** compensation is adopted to enhance the compatibility of a robot within ever-changing *** and experimental outcomes show that our work can decrease the fluctuation peak of the tracking errors,reduce adjustment time,and improve accuracy.

关键词： Anti-sideslip compensation snake robot trajectory tracking

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of Burden Descent Model for Burden Distribution in Blast Furnace

引用

Journal of Iron and Steel Research International 2016年第8期23卷 765-771页

作者： ping ZHOU Peng-yu SHI Yan-po SONG Kai-le TANG Dong FU Chenn q.ZHOU School of Energy Science and Engineering Central South University Center for Innovation through Visualization and Simulation Purdue University Calumet

Mathematical models for burden descending process have been applied to obtain whole burden structures in blast furnace,whereas the accuracy of those burden descent models has not been sufficiently *** evaluation method based on timeline burden profiles was established to q.antitatively evaluate the error between experimental and modeled burden *** existing burden descent models were utilized to describe the burden structure of a 1/20 scaled warm blast *** modeling conditions including initial burden profile,descending volumes in each time interval,and normalized descending velocity distribution were determined via special image processing *** burden structures were evaluated combined with the published experimental *** is found that all the models caught the main profile of the burden ***,the improved nonuniform descent model（Model IV）shows the highest level of precision especially when burden descends with unstable velocity distribution ***,the traditional nonuniform descent model（Model III）may also be desirable to model the burden descending process when the burden descending velocity presents a linear ***,the uniform descent model（Model I）might be the first option for roughly predicting burden structure.

关键词： burden descending descent normalized utilized scaled sufficiently modeled desirable q.antitatively

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Static Three-Body Potential in Baryons

引用

Chinese Physics Letters 1998年第8期15卷 555-557页

作者： LIU Jue-ping WANG ping Department of Physics Wuhan UniversityWuhan 430072

The first principle of q.antum chromodynamics is used to calculate the static perturbative three-body potential between three valence quarks in baryons,which is gauge invariant and flavor-dependent,and of magnitude of the same order as the next non-leading static q-q *** effect on an S-state baryon composed of three valence quarks of equal mass may be viewed as a slight increase of the constituent quark masses with respect to those in mesons.

关键词： potential. quark valence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Fairness-Enhanced Intelligent MAC Scheme Using q-Learning-Based Bidirectional Backoff for Distributed Vehicular Communication Networks

引用

Tsinghua Science and Technology 2023年第2期28卷 258-268页

作者： ping Wang Shuai Wang College of Information Science and Technology Donghua UniversityShanghai 201620China

With the increasing attention to front-edge vehicular communication applications,distributed resource allocation is beneficial to the direct communications between vehicle ***,in highly dynamic distributed vehicular networks,quality of service(qoS)of the systems would degrade dramatically because of serious packet collisions in the absence of sufficient link *** on the fairness optimization,a q-learning-based collision avoidance(qCA)scheme,which is characterized by an ingenious bidirectional backoff reward model RqCA corresponding to arbitrary backoff stage transitions,has been proposed in an intelligent distributed media access control *** qCA,an intelligent bidirectional backoff agent based on the Markov decision process model can actively motivate each vehicle agent to update itself toward an optimal backoff sub-intervel BSIopt through either positive or negative bidirectional transition individually,resulting in the distinct fair communication with a proper balance of the resource *** to the reinforcement learning theory,the problem of goodness evaluation on the backoff stage self-selection policy is equal to the problem of maximizing q function of the vehicle in the current *** final decision on BSI_(opt) related to an optimal contention window range was solved through maximizing the q value or q_(max).The ε-greedy algorithm was used to keep a reasonable convergence of the q_(max) *** the fairness evaluation of qCA,four kinds of dynamic impacts on the vehicular networks were investigated:mobility,density,payload size,and data rate with a network simulator ***,qCA can achieve fair communication efficiently and robustly,with advantages of superior Jain’s fairness index,relatively high packet delivery ratio,and low time delay.

关键词： media access control(MAC) fairness q-learning-based collision avoidance(qCA) bidirectional backoff agent vehicular communication networks

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A reversible microarray immobilization strategy based on thiol-quinone reaction

引用

Chinese Chemical Letters 2022年第1期33卷 213-216页

作者： Ling Feng ping Wang Yi Feng Jie Zhang qingxin Chen Yusheng Xie Jingdong Luo Jiang Xia Shao q.Yao Hongyan Sun Cancer and Aging Research Institution School of Life ScienceShandong University of TechnologyZibo 255000China Department of Chemistry and COSDAF(Centre of Super-Diamond and Advanced Films) City University of Hong KongHong KongChina Key Laboratory of Biochip Technology Biotech and Health CentreShenzhen Research Institute of City University of Hong KongShenzhen 518057China College of Food Engineering Qingdao Institute of TechnologyQingdao 266300China Department of Chemistry The Chinese University of Hong KongHong KongChina Department of Chemistry National University of SingaporeSingapore 117543Singapore

Microarray technology has been widely applied in biomedical *** key to microarray study is to develop efficient immobilization *** this study,we designed a new reversible microarray immobilization method based on thiol-quinone reaction.A quinone-functionalized slide was fabricated through H_(2)O_(2)treatment of dopamine-coated *** thiol-containing molecules can be anchored onto the quinone-functionalized slides via thioether linker,which could be cleaved under H_(2)O_(2) treatment to regenerate quinone groups on the *** highly versatile approach can be widely used for immobilization of various thiol-containing molecules.

关键词： Reversible Microarray Biochip Thiol-quinone reaction Peptides Thiol-proteins

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Development and test of a multifactorial parameterization scheme of land surface aerodynamic roughness length for flat land surfaces with short vegetation

引用

Science China Earth Sciences 2016年第11期59卷 281-295页

作者： ZHANG q.ang YAO Tong YUE ping Institute of Arid Meteorology of CMA Key Laboratory of Arid Climatic Change and Disaster Reduction of Gansu Province Key Open Laboratory of Arid Climatic Change and Disaster Reduction of CMA Lanzhou 730020 China Meteorological Bureau of Gansu Lanzhou 730020 China College of Atmospheric Sciences Lanzhou University Lanzhou 730000 China

Aerodynamic roughness length is an important physical parameter in atmospheric numerical models and microme- teorological calculations, the accuracy of which can affect numerical model performance and the level of micrometeorological computations. Many factors influence the aerodynamic roughness length, but formulas for its parameterization often only con- sider the action of a single factor. This limits their adaptive capacity and often introduces considerable errors in the estimation of land surface momentum flux （friction velocity）. In this study, based on research into the parameterization relations between aerodynamic roughness length and influencing factors such as windrow conditions, thermodynamic characteristics of the sur- face layer, natural rhythm of vegetation growth, ecological effects of interannual fluctuations of precipitation, and vegetation type, an aerodynamic roughness length parameterization scheme was established. This considers almost all the factors that af- fect aerodynamic roughness length on flat land surfaces with short vegetation. Furthermore, using many years＇ data recorded at the Semi-Arid Climate and Environment Observatory of Lanzhou University, a comparative analysis of the application of the proposed parameterization scheme and other experimental schemes was performed. It was found that the error in the friction velocity estimated by the proposed parameterization scheme was considerably less than that estimated using a constant aero- dynamic roughness length and by the other parameterization schemes. Compared with the friction velocity estimated using a constant aerodynamic roughness length, the correlation coefficient with the observed friction velocity increased from 0.752 to 0.937, and the standard deviation and deviation decreased by about 20% and 80%, respectively. Its mean value differed from the observed value by only 0.004 m s-l and the relative error was only about 1.6%, which indicates a significant decrease in the estima

关键词： Flat land surface with short vegetation Multifactorial influence Aerodynamic roughness length Parameterizationscheme Friction velocity

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：