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Ce-and La-doped polymetallic layered double hydroxides for enhanced oxygen evolution reaction performance at high current density

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Science China Chemistry 2024年第8期67卷 2586-2598页

作者： Rinel R.Kimaka P. ping Wang miao He Senyao Meng Jiasai Yao Huawei Li Cheng Yang Zhenxing Li State Key Laboratory of Heavy Oil Processing College of New Energy and MaterialsChina University of Petroleum(Beijing)Beijing 102249China

Polymetallic layered double hydroxides are promising cost-effective catalysts for the oxygen evolution reaction(OER) due to their versatile anionic and cationic tunability. Nevertheless, several challenges persist, notably, issues related to low electrical conductivity, poor catalytic activity, and stability, especially at high current density. Herein, we report the design of Ce-and Ladoped Co Ni Fe-layered double hydroxide(Ce La Co Ni Fe-LDH) nanosheets through a facile and scalable in situ self-assembly strategy that displays enhanced OER activity. Experimental and theoretical investigations provide insights into the impact of Ceand La-doping by comparing Ce Co Ni Fe-LDH, La Co Ni Fe-LDH, and pristine Co Ni Fe-LDH, all synthesized using the same methodology. These results reveal that doping Ce^(3+)and La^(3+)into Co Ni Fe-LDH substantially improves its electronic structure,resulting in enhanced conductivity, more oxygen vacancies(Vo), electron interaction, and active site formation. Consequently,significantly reduced overpotentials of 175, 314, and 424 m V at 10, 100, and 500 m A cm^(-2), respectively, and a highly stable current density of 120 h in 1 M KOH were achieved. Notably, these performance metrics surpass those of unmodified LDHs and are competitive with many lanthanide-doped transition metal-based LDH electrocatalysts, as well as noble metal catalysts like ruthenium catalysts. This work represents a pioneering effort in doping Ce^(3+)and La^(3+)ions into a functional Co Ni Fe-based electrocatalyst, offering inspiring OER performance and scalability potential.

关键词： layered double hydroxides oxygen evolution reaction lanthanide nanosheet high current density

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Antigen-presenting effects of effector memory Vγ9Vδ2 T cells in rheumatoid arthritis

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Cellular & Molecular Immunology 2012年第3期9卷 245-254页

作者： Chaoying Hu Liu Qian Yi miao Qiuyu Huang ping miao ping Wang Qiwen Yu Hong Nie Jiying Zhang Dongyi He Rong Xu Xuehua Chen Bingya Liu Dongqing Zhang Shanghai Institute of Immunology Shanghai Jiao Tong University School of MedicineShanghaiChina Central laboratory Shanghai Xuhui Central HospitalShanghaiChina Guanghua Rheumatoid Arthritis Specialized Hospital ShanghaiChina Shanghai Jiao Tong University School of Medicine Ruijin HospitalShanghaiChina

Rheumatoid arthritis is an autoimmune disease that primarily affects the limbs, but the pathogenic mechanism remains unclear. 78 T cells, a T-cell subpopulation, are characterized by multiple biological functions and associated with a variety of diseases. This study investigated the antigen-presenting effects of γδ2 cells and their relationship with rheumatoid arthritis development. We found that Vγ9Vδ2 T cells （the predominant subtype of γδ T cells in peripheral blood） were activated by isopentenyl pyrophosphate to continuously proliferate and differentiate into effector memory cells. The effector memory Vγ9Vδ2 T cells exhibited phenotypic characteristics of specific antigen-presenting cells, including high HLA-DR and CD80/86 expression. These Vγ9Vδ2 T cells could present soluble antigens and synthetic peptides to CD4＋ T cells. Vγ9Vδ2 T cells with different phenotypes showed different cytokine secretion patterns. Effector memoryVγ9Vδ2 T cells simultaneously secreted not only interferon （IFN）-γbut also IL-17. The peripheral blood and joint synovial fluid from RA patients contained numerous heterogeneous γδ T cells that were predominantly effector memory Vγ9Vδ2 T cells with the ability to secrete inflammatory factors. We also found that γδ T cells had a similar antigen-presenting capability to B cells. These results suggest that during the development of rheumatoid arthritis, 78 T cells can aggravate immune dysfunction and produce abnormal immune damage by secreting cytokines and inducing inflammatory cells to participate in synergistic inflammatory responses. Furthermore, γδ T cells can behave similarly to B cells to present viral peptides and autoantigen peptides to CD4＋ T cells, thus sustaining CD4＋ T-cell activation.

关键词： antigen-presenting function rheumatoid arthritis γδT cell TEM Vγ9Vδ2 T cell

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NH_(+)^(4)/K^(+)-substitution-induced C–F–K coordination bonds for designing the highest-temperature hybrid halide double perovskite ferroelastic

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Chinese Chemical Letters 2023年第7期34卷 364-367页

作者： Chang-Feng Wang Na Wang Chao Shi Heng-Yun Ye Yi Zhang Le-ping miao Chaotic Matter Science Research Center Department of MaterialsMetallurgy and Chemistry.Jiangxi University of Science and TechnologyGanzhou 341000.China

Ferroelastic materials with switchable spontaneous strain possess widely potential applications in the field of energy and information ***,organic-inorganic hybrid halide double perovskites (OIHHDPs) have become a charming new platform for developing various functional materials,such as ferroelectrics,fluorescence and X–ray ***,OIHHDP ferroelastic materials,especially high-temperature ones,are ***,we initially synthesized an OIHHDP ferroelastic,(2,2-difluoroethanamine)_(2)[(NH_(4))InCl_6](1),which possesses a ferroelastic phase transition at 407 ***,thanks to the flexible B-site for OIHHDPs,we replaced the NH_(4)^(+) ions within[(NH_(4))InCl_6]_n^(2n–)formworks with K^(+)ions,which endows with coordination bonds between 2,2-difluoroethanamine organic cations and[KInCl_6]_n^(2n–)*** to the existence of coordination bonds,the phase transition temperature of (2,2-difluoroethanamine)_(2)[KInCl_6](2) can reach 458 *** far as we know,this value is the highest reported in OIHHDP *** work offers inspiration for the design of high-temperature OIHHDP phase transition materials including ferroelectrics and ferroelastics.

关键词： Lead-free Hybrid halide double perovskites Ferroelastics Phase transition Order-disorder

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Advancements in precision nanomedicine design targeting the anoikis-platelet interface of circulating tumor cells

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3457-3475页

作者： Manqing Tang Zhijie Zhang ping Wang Feng Zhao Lin miao Yuming Wang Yingpeng Li Yunfei Li Zhonggao Gao College of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Component-Based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Tumor metastasis,the apex of cancer progression,poses a formidable challenge in therapeutic *** tumor cells(CTCs),resilient entities originating from primary tumors or their metastases,significantly contribute to this process by demonstrating remarkable *** survive shear stress,resist anoikis,evade immune surveillance,and thwart *** comprehensive review aims to elucidate the intricate landscape of CTC formation,metastatic mechanisms,and the myriad factors influencing their *** signaling pathways,such as integrin-related signaling,cellular autophagy,epithelial-mesenchymal transition,and interactions with platelets,are examined in ***,we explore the realm of precision nanomedicine design,with a specific emphasis on the anoikis‒platelet *** innovative approach strategically targets CTC survival mechanisms,offering promising avenues for combatting metastatic cancer with unprecedented precision and *** review underscores the indispensable role of the rational design of platelet-based nanomedicine in the pursuit of restraining CTC-driven metastasis.

关键词： CTCs Anoikis Platelet Cancer stem cell Metastasis Platelet‒CTC interaction Platelet targeting Nanomedicines

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Efficacy of Raw Corn Starch in Insulinoma-Related Hypoglycemia:A Promising Supportive Therapy

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Chinese Medical Sciences Journal 2024年第2期39卷 102-110页

作者： Rong-Rong Li Wei Chen Xin-Hua Xiao miao Yu Fan ping Lian Duan Department of Clinical Nutrition Beijing Key Laboratory of the Innovative Development of Functional Staple and the Nutritional Intervention for Chronic DiseaseChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Endocrinology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Objective To investigate the efficacy of raw corn starch(RCS)in clinical management of insulinoma-induced *** We retrospectively collected clinical data of insulinoma patients who received RCS-supplemented diet preoperatively,and analyzed the therapeutic effects of the RCS intervention on blood glucose control,weight change,and its adverse *** The study population consisted of 24 cases of insulinoma patients,7 males and 17 females,aged 46.08±14.15 *** RCS-supplemented diet,all patients had frequent hypoglycemic episodes(2.51±3.88 times/week),concurrent with neuroglycopenia(in 83.3% of patients)and autonomic manifestations(in 75.0% of patients),with the median fasting blood glucose(FBG)of 2.70(interquartile range[IQR]:2.50-2.90)mmol/*** patients'weight increased by 0.38(IQR:0.05-0.65)kg per month,with 8(33.3%)cases developing overweight and 7(29.2%)cases developing *** patients maintained the RCS-supplemented diet until they underwent tumor resection(23 cases)and transarterial chemoembolization for liver metastases(1 case).For 19 patients receiving RCS throughout the day,the median FBG within one week of nutritional management was 4.30(IQR:3.30-5.70)mmol/L,which was a significant increase compared to pre-nutritional level[2.25(IQR:1.60-2.90)mmol/L;P<0.001].Of them,10 patients receiving RCS throughout the day for over four weeks had sustained improvement in FBG compared to pre-treatment[3.20(IQR:2.60-3.95)mmol/L vs.2.15(IQR:1.83-2.33)mmol/L;P<0.001].Five patients who received RCS only at night also had a significant increase in FBG within one week of nutritional management[3.50(IQR:2.50-3.65)mmol/L vs.2.20(IQR:1.80-2.60)mmol/L;P<0.001],but only one patient who continued to receive RCS for over four weeks did not have a significant improvement in *** improvement in weight gain was observed upon RCS *** diarrhea(2 cases)and flatulence(1 case)occurred,and were relieved by reduction of RCS ***

关键词： corn starch hypoglycemia insulinoma nutrition therapy

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LncRNA MEG3 Inhibits the Epithelial-mesenchymal Transition of Bladder Cancer Cells through the Snail/E-cadherin Axis

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当代医学科学（英文） 2024年第4期44卷 726-734页

作者： Liang WANG ping WANG Bing LIU Hui ZHANG Cheng-cheng WEI Ming XIONG Gang LUO miao WANG Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Clinical Laboratory Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Urology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China

Objective:This study aimed to investigate the role of the long noncoding RNA(lncRNA)maternally expressed gene 3(MEG3)in the epithelial-mesenchymal transition(EMT)of bladder cancer cells and the potential ***:Cell invasion,migration,and wound healing assays were conducted to assess the effects of MEG3 on the invasive and migratory capabilities of bladder cancer *** expression levels of E-cadherin were measured using Western blotting,RT-qPCR,and dual luciferase reporter *** immunoprecipitation and pull-down assays were performed to investigate the interactions between MEG3 and its downstream ***:MEG3 suppressed the invasion and migration of bladder cancer cells and modulated the transcription of *** binding of MEG3 to the zinc finger region of the transcription factor Snail prevented its ability to transcriptionally repress ***,MEG3 suppressed the phosphorylation of extracellular regulated protein kinase(ERK),c-Jun N-terminal kinase(JNK),and P38,thereby decreasing the expression of Snail and stimulating the expression of ***:MEG3 plays a vital role in suppressing the EMT in bladder cancer cells,indicating its potential as a promising therapeutic target for the treatment of bladder cancer.

关键词： Snail bladder cancer epithelial-mesenchymal transition long noncoding RNA maternally expressed gene 3

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晶体生长抑制剂含量对ZSM-5分子筛晶化合成及催化MTP反应性能的影响

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天然气化工—C1化学与化工 2018年第3期43卷 6-14页

作者：缪平北京低碳清洁能源研究所北京102209

向ZSM-5分子筛合成凝胶体系中加入尿素作为晶体生长抑制剂,可显著降低分子筛沿b轴方向的尺度,其片状结构分子筛有利于传质,用于催化甲醇转化制丙烯(MTP)反应时可抑制副反应,延长催化剂寿命。考察了尿素添加量对合成的分子筛及其对MTP反... 详细信息

向ZSM-5分子筛合成凝胶体系中加入尿素作为晶体生长抑制剂,可显著降低分子筛沿b轴方向的尺度,其片状结构分子筛有利于传质,用于催化甲醇转化制丙烯(MTP)反应时可抑制副反应,延长催化剂寿命。考察了尿素添加量对合成的分子筛及其对MTP反应性能的影响。结果表明:不加尿素合成的ZSM-5分子筛中孤立Al和配对Al各占50%,表面Al含量低于体相Al;加入尿素后孤立Al相对含量高达95%左右,且呈表面富铝的分布特点;添加不同尿素量的分子筛缺陷位量有所差异,与n(尿素)/n(SiO_2)为0.1制备的样品相比,n(尿素)/n(SiO_2)分别为0.5和1时,B酸位(Si-OH-Al)增加,内部硅羟基和硅羟基窝两种缺陷位减少;无论是否进行水热处理,添加尿素体系合成的ZSM-5活性和产品选择性显著优于不添加尿素合成的样品。结合ZSM-5分子筛扩散路径长短、酸性、Al分布、缺陷位种类和分布差异可知,晶粒尺度,孤立Al与配对Al含量是体系中加入尿素后合成样品性能提高的关键因素;合成体系中n(尿素)/n(SiO_2)在0.5~1范围内最佳。

关键词： ZSM-5分子筛尿素 Al分布酸性缺陷位甲醇制丙烯

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《巴黎手稿》价值论美学思想探析

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四川大学学报（哲学社会科学版） 2006年第2期 46-50页

作者：杨庙平四川大学文学与新闻学院四川成都610065

人们对于《巴黎手稿》美学思想研究的哲学方法论,经历了认识论、实践论以及价值论三个阶段。马克思《巴黎手稿》美学思想是以人的生存、发展为其关注对象的价值论美学思想。异化和美是马克思《巴黎手稿》价值论美学思想的核心范畴。价... 详细信息

人们对于《巴黎手稿》美学思想研究的哲学方法论,经历了认识论、实践论以及价值论三个阶段。马克思《巴黎手稿》美学思想是以人的生存、发展为其关注对象的价值论美学思想。异化和美是马克思《巴黎手稿》价值论美学思想的核心范畴。价值评价性、价值理想性、价值人文性、价值关系性以及价值宏观性五个方面,构成《巴黎手稿》价值论美学思想的主要特征。

关键词：马克思巴黎手稿》价值论美学异化

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SO42-/ZrO2轻质烷烃异构化催化剂的制备和工业应用进展

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化工进展 2019年第11期38卷 4930-4940页

作者：王锐阳雪缪平国家能源集团北京低碳清洁能源研究所

硫酸化氧化锆固体酸(SO4^2-/ZrO2)烷烃异构化催化剂兼具高活性、可再生和环境友好的优点,具有广阔的应用前景。本文综述了SO4^2-/ZrO2催化剂在轻质烷烃异构化中的工业应用进展,包括市场现状、现有技术、经济性等方面,并对专利和文献中... 详细信息

硫酸化氧化锆固体酸(SO4^2-/ZrO2)烷烃异构化催化剂兼具高活性、可再生和环境友好的优点,具有广阔的应用前景。本文综述了SO4^2-/ZrO2催化剂在轻质烷烃异构化中的工业应用进展,包括市场现状、现有技术、经济性等方面,并对专利和文献中报道的催化剂制备技术进行了论述总结。重点针对催化剂的关键制备参数以及对催化剂结构和异构化性能的影响进行了深入分析和探讨,包括氢氧化物前体的沉淀和焙烧条件、助剂的添加和改性作用、催化剂预处理条件和原料水含量的影响等。最后对催化剂开发和工业化中的难点给出了分析和建议,并展望了未来的催化剂发展方向,指出拓宽催化剂的原料适应性、发展新型制备技术和助剂体系、结合催化剂再生等工艺研究是未来的发展方向。

关键词：轻质烷烃异构化催化剂制备工业应用

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Research Progress of Pulmonary Sarcoidosis in Traditional Chinese Medicine and Western Medicine

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World Journal of Integrated Traditional and Western Medicine 2022年第6期8卷 34-44页

作者： miao ping YANG Zhi-xiu SUN Yu Heilongjiang Provincial Academy of Traditional Chinese Medicine Sciences Harbin 150000China

Objective:To summarize the current treatments of traditional Chinese medicine and Western medicine and to explore ideas for clinical treatments,rational use of traditional Chinese medicine,avoid medication errors,and make full use of the respective advantages of traditional Chinese medicine and Western medicine to achieve good ***:We selected recent articles on pulmonary sarcoidosis and clinical observation at home and abroad,and summarized relevant traditional Chinese medicine ***:At present,hormone therapy is preferred in western medicine,followed by antimetabolic drugs,Anti-TNF,and also potential drug therapeutic strategies,such as"CLEAR"regimen and new target *** Chinese medicine through syndrome differentiation,from the whole,flexible use of dispel evil,phlegm,blood circulation,dredging collaterals,qi and other methods to achieve the effect of ***:The treatment research results of pulmonary sarcoidosis are considerable,but there are still many risk factors in Western medicine,and the benefits and treatment indications of individual drugs are still under *** Chinese medicine has certain safety and efficacy in the prevention and treatment of pulmonary sarcoidosis,but it needs modern medical technology ***,the advantages of traditional Chinese and Western medicine should be fully combined to achieve the maximum treatment effects.

关键词： Pulmonary sarcoidosis Traditional Chinese medicine treatment Western medicine treatment Review

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