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Chinese Neurosurgical Journal 2021年第2期7卷 131-136页

作者： Hui Ma Lian Xu Cui ping kuen lam Cindy S.W.Tong Kin K.Y.Lo George K.C.Wong Wai Sang Poon Division of Neurosurgery Chow Tai Fook-Cheng Yu Tung Surgical Stem Cell Research CenterDepartment of SurgeryThe Chinese University of Hong KongShatinHong KongSARChina Division of Neurosurgery Department of SurgeryFo Shan First People’s HospitalFoshanGuangdongChina

Background:Our previous studies showed that topical application of mesenchymal stem cells(MSCs)improved functional recovery in rat traumatic brain injury(TBI)model,and hypoxic precondition further enhanced the therapeutic effects of *** was no previous study on the attenuation of cerebral edema by *** investigated whether topical application of normoxic and hypoxic MSCs could reduce cerebral edema in an experimental TBI ***:Two million normoxic(N=24)and hypoxic(N=24)MSCs were applied topically to exposed the cerebral cortex in a controlled cortical impact(CCI)*** MSCs were fixed in position with fibrin *** treatment was given to control animals(TBI only:n=24).After surgery,four animals in each group were sacrificed daily(day 1 to day 6)for edema *** animals without TBI were used as reference(n=4).The expressions of GFAP,AQP4,and MMP9 were also investigated by immunofluorescence staining and RT-PCR at day ***:The edema peaked within 3 days after *** with the control,hypoxic MSCs reduced brain water content significantly(p<0.05).Both hypoxic and normoxic MSCs downregulated the expression of MMP9 and normalized AQP4 distribution to astrocyte end ***:Our preliminary study showed that topical application of hypoxic MSCs suppressed both vasogenic and cytotoxic edema formation.

关键词： Topical MSCs Cerebral edema TBI

Microelectrode Recording of Tissue Neural Oscillations for a Bionic Olfactory Biosensor

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Journal of Bionic Engineering 2012年第4期9卷 494-500页

作者： Qingjun Liu Fenni Zhang Ning Hu Hua Wang kuen Jimmy Hsia ping Wang Biosensor National Special Laboratory Department of Biomedical Engineering Zhejiang University Hangzhou 310027 P. R. China Key Laboratory of Biomedical Engineering of Education Ministry Department of Biomedical Engineering Zhejiang University Hangzhou 310027 P. R. China Department of Mechanical Science and Engineering University of Illinois at Urbana-Champaign Urbana IL 61801 USA

In olfactory research, neural oscillations exhibit excellent temporal regularity, which are functional and necessary at thephysiological and cognitive levels. In this paper, we employed a bionic tissue biosensor which treats intact epithelium as sensing element to record the olfactory oscillations extracellularly. After being stimulated by odorant of butanedione, the olfactory receptor neurons generated different kinds of oscillations, which can be described as pulse firing oscillation, transient firing oscillation, superposed firing oscillation, and sustained firing oscillation, according to their temporal appearances respectively. With a time-frequency analysis of sonogram, the oscillations also demonstrated different frequency properties, such as δ, θ, α, β and γ oscillations. The results suggest that the bionic biosensor cooperated with sonogram analysis can well improve the in- vestigation of olfactory oscillations, and provide a novel model for artificial olfaetion sensor design.

关键词： bionic sensor olfactory epithelium microelectrode array (MEA) neural oscillation olfactory bioscnsor

Role of retained austenite in advanced high-strength steel:ductility and toughness

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Journal of Iron and Steel Research International 2024年第9期31卷 2079-2089页

作者： Vung lam Nuam Hao Zhang Ying-chun Wang Zhi-ping Xiong National Key Laboratory of Science and Technology on Materials under Shock and Impact School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing100081China Tangshan Key Laboratory of High-Performance Metals and Ceramics Tangshan Research Institute BITTangshan063000HebeiChina

Enhancing the ductility and toughness of advanced high-strength steels is essential for the wide range of promising *** retained austenite(RA)is a key phase due to the austenite-to-martensite transformation and its transformation-induced plasticity *** is commonly accepted that slow RA-to-martensite transformation is beneficial to ductility;therefore,the RA fraction and stability should be carefully *** RA stability is related to its morphology,size,carbon content,neighboring phase and ***,these factors are *** is noteworthy that the influence of RA on ductility and fracture toughness is not consistent because of their difference in stress *** is no clear relationship between fracture toughness and tensile ***,it is important to understand the role of RA in *** toughness is enhanced during the RA-to-martensite transformation,while the fracture toughness is decreased due to the formation of fresh and brittle *** a result,the findings regarding to the effect of RA on fracture toughness are *** investigations should be conducted in order to fully understand the effects of RA on ductility and fracture toughness,which can optimize the combination of ductility and toughness in AHSSs.

关键词： Retained austenite Ductility Toughness TRIP effect Steel

Disclosure of charge storage mechanisms in molybdenum oxide nanobelts with enhanced supercapacitive performance induced by oxygen deficiency

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Rare Metals 2021年第9期40卷 2447-2454页

作者： ping Qin Shi-Qing Zhang Ken-Kin-lam Yung Zhi-Feng Huang Biao Gao Department of Physics Golden Meditech Centre for NeuroRegeneration SciencesHong Kong Baptist University(HKBU)Kowloon 999077Hong KongChina Institute of Advanced Materials State Key Laboratory of Environmental and Biological AnalysisHong Kong Baptist University(HKBU)Kowloon 999077Hong KongChina HKBU Institute of Research and Continuing Education Shenzhen 518000China State Key Laboratory of Refractories and Metallurgy and Institute of Advanced Materials and Nanotechnology Wuhan University of Science and TechnologyWuhan 430081China

Molybdenum oxide(MoO_(3)), with superior features of multi-electrochemical states, high theoretical capacitance, and low cost, is a desirable supercapacitor electrode material but suffers from low conductivity and insufficient active sites. The MoO_(3) capacitance can be largely amplified by introducing oxygen(O) vacancies, but the mechanisms at the atomic scale are still ***, O vacancies are created at the O2 and O3 sites in the MoO_(3) nanobelts by carbonization to maximize the supercapacitance in the MoO_(2.39). The supercapacitive storage is mainly ascribed to the proton adsorption at the O1 sites to create Mo–OH, leading to an expansion of the interlayer spacing along the lattice B-axis. Roughly 98% of the initial supercapacitance is retained after 1000 cycles,due to the reversible change in the interlayer spacing. Our results provide an insight into the oxygen deficiency-related mechanisms of the supercapacitive performance at the atomic scale and devise a facile method to enhance the supercapacitance for energy storage and conversion.

关键词： Charge storage mechanisms Oxygen vacancies MoO3 nanobelts Supercapacitance

Targeting mesenchymal stem cell therapy for severe pneumonia patients

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World Journal of Stem Cells 2021年第2期13卷 139-154页

作者： Guy lam Yuan Zhou Jia-Xian Wang Yat-ping Tsui School of Biomedical Sciences University of Hong KongHong Kong 999077China Research and Development Help Therapeutics Co.Ltd.Nanjing 211100Jiangsu ProvinceChina

Pneumonia is the inflammation of the lungs and it is the world’s leading cause of death for children under 5 years of *** latest coronavirus disease 2019(COVID-19)virus is a prominent culprit to severe *** the pandemic running rampant for the past year,more than 1590000 deaths has occurred worldwide up to December 2020 and are substantially attributable to severe pneumonia and induced cytokine *** therapeutic approaches in addition to the vaccines and drugs under development are hence greatly sought *** harnessing stem cells and their derivatives have been established by basic research for their versatile capacity to specifically inhibit inflammation due to pneumonia and prevent alveolar/pulmonary fibrosis while enhancing antibacterial/antiviral immunity,thus significantly alleviating the severe clinical conditions of *** recent clinical trials,mesenchymal stem cells have shown effectiveness in reducing COVID-19-associated pneumonia morbidity and mortality;positioning these cells as worthy candidates for combating one of the greatest challenges of our time and shedding light on their prospects as a nextgeneration therapy to counter future challenges.

关键词： Pneumonia Human mesenchymal stem cells Immunomodulation Alveolar protection Pandemic challenge Clinical trials

Indocyanine green lymphangiography-guided liposuction in breast cancer-related lymphedema treatment-patient selection and technique

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Plastic and Aesthetic Research 2020年第2期7卷 30-36页

作者： Hin-Lun Liu Melody Man-kuen Wong Joseph Hon-ping Chung Division of Plastic and Reconstructive Surgery Department of SurgeryThe University of Hong KongQueen Mary HospitalHong Kong SARChina

Aim:The rationale of using liposuction to treat lymphedema is that the chronic inflammatory process of lymphedema results in fat *** authors describe the technique of indocyanine green lymphangiography-guided liposuction,its rationale,and our patient selection criteria for better clinical ***:Thirty-two patients underwent liposuction for breast cancer-related *** green lymphangiography was performed prior to *** patients without linear and splash patterns in indocyanine green lymphangiography,circumferential liposuction was performed *** patients who had linear or splash patterns,liposuction was not performed at regions with remaining functional lymphatic *** were assessed using circumferential reduction ***:At a mean follow-up of 24.5±6.5 months,all(100%)patients had a reduction in limb circumferences after *** mean circumference reduction rate was 67.6%±27.9%.Conclusion:Liposuction is a valuable treatment for breast cancer-related *** believe patients with fat predominant lymphedema are the best candidates for liposuction.

关键词： Lymphedema breast cancer-related lymphedema liposuction indocyanine green lymphangiography

Psychometrics of the chronic liver disease questionnaire for Southern Chinese patients with chronic hepatitis B virus infection

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World Journal of Gastroenterology 2009年第26期15卷 3288-3297页

作者： Elegance Ting Pui lam Cindy Lo kuen lam Ching Lung Lai Man Fung Yuen Daniel Yee Tak Fong Department of Medicine The University of Hong Kong Department of Nursing Studies The University of Hong Kong

AIM： To test the psychometric properties of a Chinese [（Hong Kong） HK] translation of the chronic liver disease questionnaire （CLDQ）. METHODS： A Chinese （HK） translation of the CLDQ was developed by iterative translation and cognitive debriefing. It was then administered to 72 uncomplicated and 78 complicated chronic hepatitis B （CriB） patients in Hong Kong together with a structured questionnaire on service utilization, and the Chinese （HK） SF-36 Health Survey Version 2 （SF-36v2）. RESULTS： Scaling success was ≥ 80% for all but three items. A new factor assessing sleep was found and items of two （Fatigue and Systemic Symptoms） subscales tended to load on the same factor. Internal consistency and test-retest reliabilities ranged from 0.58-0.90 for different subscales. Construct validity was confirmed by the expected correlations between the SF-36v2 Health Survey and CLDQ scores. Mean scores of CLDQ were significantly lower in complicated compared with uncomplicated CHB, supporting sensitivity in detecting differences between groups.CONCLUSION： The Chinese （HK） CLDQ is valid, reliable and sensitive for patients with CHB. Some modifications to the scaling structure might further improve its psychometric properties,

关键词： Chronic liver disease Health-related quality of life Hepatitis B Southern Chinese Validity

Total Ginsenoside Extract from Panax ginseng Enhances Neural Stem Cell Proliferation and Neuronal Differentiation by Inactivating GSK-3β

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Chinese Journal of Integrative Medicine 2022年第3期28卷 229-235页

作者： LIN Kai-li ZHANG Ji CHUNG Hau-lam WU Xin-yi LIU Bin ZHAO Bo-xin SZE Stephen Cho-wing ZHOU ping-zheng YUNG Ken Kin-lam ZHANG Shi-qing School of Public Health Guangzhou Medical UniversityGuangzhou(511436)China Department of Biology Hong Kong Baptist University(HKBU)Hong Kong Special Administrative Region(999077)China HKBU Shenzhen Research Institute and Continuing Education ShenzhenGuangdong Provinee(518057)China Department of Plastic Surgery Zhujiang HospitalSouthern Medical UniversityGuangzhou(510515)China Guangzhou Institute of Cardiovascular Disease the Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou(510260)China Department of Pharmacy Nan fang HospitalSouther n Medical Un iversityGuan gzhou(510515)China Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou(510515)China

Objective:To study the effects of total ginsenosides(TG)extract from Panax ginseng on neural stem cell(NSC)proliferation and differentiation and their underlying ***:The migration of NSCs after treatment with various concentrations of TG extract(50,100,or 200μg/mL)were *** proliferation of NSCs was examined by a combination of cell counting kit-8 and neurosphere *** differentiation mediated by TG extract was evaluated by Western blotting and immunofluorescence staining to monitor the expression of nestin and microtubule associated protein 2(MAP2).The GSK-3β/β-catenin pathway in TG-treated NSCs was examined by Western blot *** NSCs with constitutively active GSK-3βmutant were made by adenovirus-mediated gene transfection,then the proliferation and differentiation of NSCs mediated by TG were further ***:TG treatment significantly enhanced NSC migration(P<0.01 or P<0.05)and increased the proliferation of NSCs(P<0.01 or P<0.05).TG mediation also significantly upregulated MAP2 expression but downregulated nestin expression(P<0.01 or P<0.05).TG extract also significantly induced GSK-3βphosphorylation at Ser9,leading to GSK-3βinactivation and,consequently,the activation of the GSK-3β/β-catenin pathway(P<0.01 or P<0.05).In addition,constitutive activation of GSK-3βin NSCs by the transfection of GSK-3βS9 A mutant was found to significantly suppress TG-mediated NSC proliferation and differentiation(P<0.01 or P<0.05).Conclusion:TG promoted NSC proliferation and neuronal differentiation by inactivating GSK-3β.

关键词： ginsenoside neural stem cell proliferation neuronal differentiation GSK-3β

Memory-enhanced noiseless cross-phase modulation

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Light(Science & Applications) 2012年第1期1卷 6-10页

作者： Mahdi Hosseini Stojan Rebic Ben M Sparkes Jason Twamley Ben C Buchler ping K lam Centre for Quantum Computation and Communication Technology Department of Quantum ScienceThe Australian National UniversityCanberraAustralia Centre for Engineered Quantum Systems Department of Physics&AstronomyMacquarie UniversityNorth Ryde NSW 2109Australia

Large nonlinearity at the single-photon level can pave the way for the implementation of universal quantum ***,realizing large and noiseless nonlinearity at such low light levels has been a great challenge for scientists in the past ***,we propose a scheme that enables substantial nonlinear interaction between two light fields that are both stored in an atomic *** and quantum simulations demonstrate the feasibility of achieving large cross-phase modulation(XPM)down to the single-photon *** proposed scheme can be used to implement parity gates from which CNOT gates can be ***,we present a proof of principle experimental demonstration of XPM between two optical pulses:one stored and one freely propagating through the memory medium.

关键词： CNOT gate cross-phase modulation electromagnetically induced transparency parity gate quantum memory

SYNTHESIS AND PHOTOLUMINESCENCE OF AN ANTHRACENE-CONTAINING HYPERBRANCHED POLY(ARYLENEETHYNYLENE)

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Chinese Journal of Polymer Science 2005年第6期23卷 665-669页

作者： Yong-qiang Dong Zhen Li Jacky W. Y. lam Yu-ping Dong Xin-de Feng Ben-zhong Tang Department of Polymer Science and Engineering College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Department of Chemistry Center for Display Research The Hong Kong University of Science ＆ Technology Clear Water Bay Kowloon Hong Kong China

A hyperbranched poly（aryleneethynylene） containing anthracene chromophore was synthesized by palladiumcatalyzed cross-coupling reaction of 2,4,6-triiodophenyl 9-anthracenylcarboxylate with 9,9-bis[4-（2-propynyloxy）phenyl]- 9H-fluorene. The structure and properties of the polymer are characterized and evaluated by NMR, IR, UV, PL and TGA analyses. The polymer is soluble in common organic solvents, possesses high thermal stability （Td 〉 330℃）, and emits a strong blue light of 465 nm in both solution and solid states.

关键词： Hyperbranched polymer Cross-coupling Blue light emission