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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue liN Yu-ping wei Hua FU Yu ZHOU Yue-hong FANG Zhao-{2. QIU xiao-tang WANG Mei li Qing-bo li Shan-shan WANG Shi-dong DAI Fang liu Zhen-jie ZHAO ling WEN Jian-xuan WU li-yan ZENG {2.-yan zhang Jin-ming LU Qi-yun he liu SONG wei SUN Lu LUO Lu-lu he Jia-li XIE Wen-wen liANG Qing-shun HUANG Yuan ZHU Sheng-ling LONG Jie-er GAO Zhi-juan WEN Ze-huai li Chun-ji OUYANG Wen-wei li Geng WU ming-{2. li An-xiang HUANG Jin-zhu Sanjoy K Paul TANG Xian-yu FAN guan-jie department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of guangzhou university of Chinese Medicine Guangzhou510120China department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China guangdong Provincial Academy of Chinese Medical sciences Guangzhou510120China department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2.16 and May 30,2.18 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2.weeks and followed by a 2.week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12.weeks)and were followed up for 12.*** primary outcome was change in TCSS-TS score at 12.and 2. *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632.patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12.week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(Phe reduction of TCSS-TS score at 12.weeks and the increase of SNCV of median nerve at 2. weeks in the control group were greater than those in the intervention group(Phe number of adverse events did not differ significantly between groups(P>0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

Continuous age-and sex-specific reference ranges of liver enzymes in Chinese children and application in pediatric non-alcoholic fatty liver disease

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World Journal of Pediatrics 2024年第9期20卷 949-956页

作者： Zhao-Yuan Wu Si-wei Chi liu-Jian Ouyang {2.-Qin Xu Jing-Nan Chen Bing-Han Jin Rahim Ullah Xue-lian Zhou Ke Huang guan-ping Dong Zhe-ming li Ying Shen Jie Shao Yan Ni Jun-Fen Fu Qiang Shu wei Wu department of Endocrinology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child Health3333 Binsheng RoadHangzhou310051China department of Data and information Children’s HospitalZhejiang University School of MedicineHangzhouChina department of Child health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina department of Thoracic&Cardiovascular Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children’s Regional Medical Center3333 Binsheng RoadHangzhou310051China

Background Alanine aminotransferase(ALT)is widely used to screen patients with hepatic ***,the current reference ranges(<50 U/L)were developed by laboratories and have not been validated in populations with a large nu... 详细信息

Background Alanine aminotransferase(ALT)is widely used to screen patients with hepatic ***,the current reference ranges(lidated in populations with a large number of healthy *** This study collected venous blood and anthropometric data from a total of 13,2.7 healthy children aged 3 months to 18 years who underwent routine physical examinations in the department of Pediatric *** applied the least mean square algorithm to establish age-and sex-related reference percentiles of serum levels of *** validation,we recruited 42.6 children and adolescents with obesity/overweight who underwent evaluation and metabolic tests in the *** receiver operating characteristic curves,we determined age-and sex-specific upper limit percentiles of liver enzymes for fatty liver *** This study revealed a significant correlation between serum transaminase levels and age and sex(Phese transaminase levels exhibited age-and sex-specific *** individuals in the non-alcoholic fatty liver disease(NAFLD)cohort,elevated ALT levels displayed a positive association with clinical markers of disease severity,including homeostatic model assessment of insulin resistance,waist-hip ratio,and serum uric acid levels(Phe receiver operating characteristic curves,ALT levels at the 92.58th percentile for boys and the 92.07th percentile for girls yielded the highest accuracy and *** This study provides age-and sex-specific reference ranges for ALT,aspartate aminotransferase,andγ-glutamyltransferase in Chinese children and adolescents,making it the largest population study to ***,the study establishes a precise upper limit for ALT levels,facilitating their use in NAFLD screening.

关键词： Alanine aminotransferase Childhood Fatty liver diseases

The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2.2.

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Cancer Communications 2024年第1期44卷 127-172页

作者： Feng-Hua Wang xiao-Tian zhang Lei Tang Qi Wu Mu-Yan Cai Yuan-Fang li Xiu-Juan Qu Hong Qiu Yu-Jing zhang Jie-Er Ying Jun zhang ling-Yu Sun Rong-Bo lin Chang Wang Hao liu Miao-Zhen Qiu Wen-Long guan Sheng-Xiang Rao Jia-Fu Ji Yan Xin wei-Qi Sheng hui-Mian Xu Zhi-wei Zhou Ai-ping Zhou Jing Jin Xiang-lin Yuan Feng Bi Tian-Shu liu Han liang Yan-Qiao zhang Guo-Xin li Jun liang Bao-Rui liu lin Shen Jin li Rui-Hua Xu department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijingP.R.China department of Radiology Peking University Cancer HospitalBeijingP.R.China department of Endoscopy Center Peking University Cancer HospitalBeijingP.R.China department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhouGuangdongP.R.China department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoningP.R.China department of Medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiP.R.China department of Radiotherapy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China department of Medical Oncology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China department of Surgical Oncology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China department of Medical Oncology Fujian Cancer HospitalFuzhouFujianP.R.China Tumor Center The First Hospital of Jilin UniversityChangchunJilinP.R.China department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China department of Radiology Zhongshan HospitalFudan UniversityShanghaiP.R.China department of

The 2.2. update of the Chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in China,reflecting the latest advancements in evidence-based medicine,healthcare resource availability,and precision *** updates address the differences in epidemiological characteristics,clinicopatho-logical features,tumor biology,treatment patterns,and drug selections between Eastern and Western gastric cancer *** revisions include a structured template for imaging diagnosis reports,updated standards for molecular marker testing in pathological diagnosis,and an elevated recommendation for neoadju-vant chemotherapy in stage III gastric *** advanced metastatic gastric cancer,the guidelines introduce new recommendations for immunotherapy,anti-angiogenic therapy and targeted drugs,along with updated management strategies for human epidermal growth factor receptor 2.heR2.-positive and deficient DNA mismatch repair(dMMR)/microsatellite instability-high(MSI-H)***,the guidelines offer detailed screening recommendations for hereditary gastric cancer and an appendix listing drug treatment regimens for various stages of gastric *** 2.2. CSCO Clinical Guidelines for Gastric Cancer updates are based on both Chinese and international clinical research and expert consensus to enhance their applicability and relevance in clinical practice,particularly in the heterogeneous healthcare landscape of China,while maintaining a commitment to scientific rigor,impartiality,and timely revisions.

关键词： Chinese Society of Clinical Oncology(CSCO) gastric cancer diagnosis surgery neoadjuvant adjuvant radiotherapy chemotherapy targeted therapy immunotherapy

Modeling and simulation of ion channels and action potentials in taste receptor cells

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science China(life sciences) 2009年第11期52卷 1036-1047页

作者： CheN PeiHua1, liu xiao-dong2. {2. wei1, ZHOU Jun1, WANG ping1, YANG wei3 & LUO JianHong3 1Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, department of Biomedical Engineering, Zhejiang university, Hangzhou 31002., China 2.alcium Signals Lab, department of Biomedical Engineering and Neuroscience, Johns Hopkins university, Baltimore, MD 2.2.5, USA 3department of Neurobiology, Institute for Neuroscience, Zhejiang university School of Medicine, Hangzhou 310058, China 1. Biosensor National Special Laboratory Key Laboratory of Biomedical Engineering of Ministry of Education Department of Biomedical Engineering Zhejiang University Hangzhou 310027 China 2. Calcium Signals Lab Department of Biomedical Engineering and Neuroscience Johns Hopkins University Baltimore MD 21205 USA 3. department of Neurobiology Institute for Neuroscience Zhejiang University School of Medicine Hangzhou 310058 China

Based on patch clamp data on the ionic currents of rat taste receptor cells, a mathematical model of mammalian taste receptor cells was constructed to simulate the action potentials of taste receptor cells and their corresponding ionic components, including voltage-gated Na+ currents and outward delayed rectifier K+ currents. Our simulations reproduced the action potentials of taste receptor cells in response to electrical stimuli or sour tastants. The kinetics of ion channels and their roles in action potentials of taste receptor cells were also analyzed. Our prototype model of single taste receptor cell and simulation results presented in this paper provide the basis for the further study of taste information processing in the gustatory system.

关键词： taste receptor cell action potential modeling and simulation Na+ channel delayed rectifier K+ channel

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： xiao-Yun Zhao Shao-lin Xiong Xiang-Yang Wen Xin-Qiao li Ce Cai Shuo xiao Qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-Yuan liao Yan-Qiu zhang Yue Huang Lu li Xing Wen Fei zhang Jing Duan Chen-wei Wang Dong-li Shi Peng zhang Qi-Bin Yi Chao-Yang li Yan-Bing Xu xiao-Hua liang Ya-Qing liu Da-li zhang Xi-Lei Sun Fan zhang Gang Chen Huan-Yu Wang Sheng Yang xiao-Jing liu Min Gao Mao-Shun li Jin-Zhou Wang Xing Zhou Yi Zhao Wang-Chen Xue Chao Zheng Jia-Cong liu Xing-Bo Han Jin-ling Qi Jia Huang Ke-Ke zhang Can Chen Xiong-Tao Yang Dong-Jie Hou Yu-Sa Wang Rui Qiao Xiang Ma xiao-Bo li ping Wang Xin-Ying Song li-ming Song Shi-Jie Zheng Bing li Hong-Mei zhang Yue Zhu wei Chen Jian-Jian he Zhen zhang Jin Hou Hong-Jun Wang Yan-Chao Hao Xiang-Yu Wang Zong-Yuan Yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao xiao-Fei Lan Yan-Guo li Gang li Xu-Fang li Fang-Jun Lu Hong Lu Bin Meng Feng Shi hui Wang hui-Zhen Wang Yu-Peng Xu Jia-wei Yang Xue-Juan Yang Shuang-Nan zhang Chao-Yue zhang Cheng-Mo zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of sciences Chinese Academy of SciencesBeijing 100049China School of information science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space science College China West Normal UniversityNanchong 637002China department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun university of science and Technology Changchun 130022China Chinese Academy of sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2.2. December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

A Localization Method of High Energy Transients for All-sky Gamma-ray Monitor

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Research in Astronomy and Astrophysics 2024年第10期24卷 25-35页

作者： Yi Zhao Wangchen Xue Shaolin Xiong Qi Luo Yuanhao Wang Jiacong liu heng Yu xiaoyun Zhao Yue Huang Jinyuan liao Jianchao Sun xiaobo li Qibin Yi Ce Cai Shuo xiao Shenglun Xie Chao Zheng Yanqiu zhang Chenwei Wang Wenjun Tan Zhiwei Guo Chaoyang li Zhenghua An Gang Chen Yanqi Du Min Gao Ke Gong Dongya Guo Jiang he Jianjian he Bing li Gang li Xinqiao li Jing liang xiaohua liang Yaqing liu Xiang Ma Rui Qiao liming Song Xinying Song Xilei Sun Jin Wang ping Wang Xiangyang Wen Hong Wu Yanbing Xu Sheng Yang Dali zhang Fan zhang Hongmei zhang Peng zhang Shu zhang Zhen zhang Shijie Zheng Keke zhang Xingbo Han Haiyan Wu Hu Tai Hao Geng Gaopeng Lu wei Xu Fanchao Lyu Hongbo zhang Fangjun Lu Shuangnan zhang department of Astronomy Beijing Normal UniversityBeijing 100875China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of sciences Beijing 100049China School of Physics and Optoelectronics Xiangtan UniversityXiangtan 411105China College of Physics Hebei Normal UniversityShijiazhuang 050024China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China School of Physics and Electronic science Guizhou Normal UniversityGuiyang 550001China Institute of Astrophysics Central China Normal UniversityWuhan 430079China College of physics sciences Technology Hebei UniversityBaoding 071002China Physics and Space science College China West Normal UniversityNanchong 637002China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China College of Electronic and information Engineering Tongji UniversityShanghai 201804China Innovation Academy for Microsatellites of Chinese Academy of sciences Shanghai 201304China National Space science Center Chinese Academy of SciencesBeijing 100190China School of Earth and Space sciences University of Science and Technology of ChinaHefei 230026China Electronic information School Wuhan UniversityWuhan 430072China Key Laboratory of Transportation Meteorology of China Meteorological Administration Nanjing Joint Institute for Atmospheric SciencesNanjing 210000China Key Laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

Fast and reliable localization of high-energy transients is crucial for characterizing the burst properties and guiding the follow-up *** based on the relative counts of different detectors has been widely used for all-sky gamma-ray *** are two major methods for this count distribution localization:χ^(2.minimization method and the Bayesian *** we propose a modified Bayesian method that could take advantage of both the accuracy of the Bayesian method and the simplicity of the χ^(2.*** comprehensive simulations,we find that our Bayesian method with Poisson likelihood is generally more applicable for various bursts than the χ^(2.method,especially for weak *** further proposed a location-spectrum iteration approach based on the Bayesian inference,which could alleviate the problems caused by the spectral difference between the burst and location *** method is very suitable for scenarios with limited computation resources or timesensitive applications,such as in-flight localization software,and low-latency localization for rapidly follow-up observations.

关键词： methods:data analysis methods:analytical (stars:)gamma-ray burst:general

Identification of Immunodominant Th1-type T cell Epitopes from Schistosoma japonicum 2. kDa Glutathione-S-transferase,a Vaccine Candidate

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Acta Biochimica et Biophysica Sinica 2005年第11期37卷 751-758页

作者： guang-Fu li Yong WANG Zhao-Song zhang Xin-Jun WANG Min-Jun JI Xiang ZHU Feng {2. xiao-ping CAI Hai-wei WU guan-ling WU department of Pathogenic Biology,Nanjing Medical university,Nanjing 2.002.,China departmentofPathogenicBiology NanjingMedicalUniversityNanjing210029China

Th1-type cytokines produced by the stimulation of Th1-type epitopes derived from definedschistosome-associated antigens are correlated with the development of resistance to the parasite *** mansoni 2. kDa glutathione-S-transferase(Sm2.GST),a major detoxification enzyme,hasbeen recognized as a vaccine candidate and a phase Ⅱ clinical trial has been carried *** immunizedwith recombinant Schistosoma japonicum 2.GST(Sj2.GST)have shown immune protection against theparasite *** the present study,six candidate peptides(P1,P2.P3,P4,P7 and P8)from Sj2.GSTwere predicted,using software,to be T cell epitopes,and peptides P5 and P6 were designed by extendingfive amino acids at the N-terminal and C-terminal of P1,*** peptide 190-2.1 aa in Sj2.GSTcorresponding to the Th1-type epitope(190-2.1 aa)identified from Sm2.GST was selected and named *** nine candidate peptides were synthesized or produced as the fusion protein with thioredoxin in thepET32.(+)/BL2.(DE3)*** capacity to induce a Th1-type response in vitro was measured usinglymphocyte proliferation,cytokine detection experiments and flow *** results showed that P6(73-86 aa)generated the strongest stimulation effect on T cells among the nine candidate peptides,and drovethe highest level of IFN-γ and ***,P6 is a functional Th1-type T cell epitope that is differentfrom that in Sm2.GST,and will be useful for the development of effective vaccines which can triggeracquired immunity against ***,our strategy of identifying the Th1-type epitope by acombination of software prediction and experimental confirmation provides a convenient and cost-savingalternative approach to previous methods.

关键词： Schistosoma japonicum epitope Sj2.GST Th1 epitope IFN-γ

Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2.Omicron strain infection in China:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan liu Rui-Xia Ma Xian-Bao Cao Hua zhang S{2.-Hong Zhou wei-Hong Jiang Yan Jiang Jing-Wu Sun Qin-Tai Yang Xue-Zhong li Ya-Nan Sun li Shi Min Wang Xi-Cheng Song Fu-Quan Chen xiao-Shu zhang Hong-Quan wei Shao-Qing Yu Dong-Dong Zhu Luo Ba Zhi-wei Cao Xu-ping xiao Xin wei Zhi-Hong lin Feng-Hong Chen Chun-guang Shan guang-Ke Wang Jing Ye Shen-Hong Qu Chang-Qing Zhao Zhen-lin Wang Hua-Bin li Feng liu xiao-Bo Cui Sheng-Nan Ye Zheng liu Yu Xu xiao Cai wei Huang Ru-Xin zhang Yu-lin Zhao Guo-Dong Yu guang-Gang Shi Mei-ping Lu Yang Shen Yu-Tong Zhao Jia-Hong Pei Shao-Bing Xie Long-Gang Yu Ye-Hai liu Shao-wei Gu Yu-Cheng Yang Lei Cheng Jian-Feng liu Graduate School of beijing university of Chinese Medicine BeijingChina department of Otorhinolaryngology head and Neck Surgery China-Japan Friendship HospitalBeijingChina department of Otorhinolaryngology head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina department of Otorhinolaryngology head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina department of Otorhinolaryngology head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina department of Otorhinolaryngology head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina department of Otorhinolaryngology head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina department of Otorhinolaryngology head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina department of Otorhinolaryngology head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina department of Otorhinolaryngology head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina department of Otorhinolaryngology head and Neck Surgery Peking University People's HospitalBeijingChina department of Otorhinolaryngology head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina department of Otorhinolaryngology head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease control and Prevention LanzhouChina department of Otorhinolaryngology head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina department of Otorhinolaryngology head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between December 2.,2.2.,and February 2.,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.2. and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12.days,respectively,with 0.5%of patients having symptoms lasting for more than 2. *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2.virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2.vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

Gene Transcription Profile in Mice Vaccinated with Ultraviolet-attenuated Cercariae of Schistosoma japonicum Reveals Molecules Contributing to Elevated IFN-γ Levels

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Acta Biochimica et Biophysica Sinica 2005年第4期37卷 254-264页

作者： Xiang ZHU Zhao-Song zhang Min-Jun JI Hai-wei WU Yong WANG {2.-ping CAI Lei zhang Shu-Ying HU lin-lin FU Feng liu Chuan SU guan-ling WU department of Pathogenic Biology,Nanjing Medical university.Nanjing 2.002..China departmentofPathogenicBiology NanjingMedicalUniversityNanjing210029China

Vaccination with ultraviolet-attenuated cercariae of Schistosoma japonicum induced protectiveimmunity against challenge infection in experimental animal *** preliminary study on the transcrip-tion levels of IFN-γ and IL-4 in splenic CD4~+ T cells revealed that attenuated cercariae elicited predomi-nantly a Th1 response in mice at the early stage,whereas normal cercariae stimulated primarily Th2.dependent *** analysis on the gene profile of the skin-draining lymph nodes demonstratedthat the levels of IFN-γ were significantly higher in vaccinated mice than those in infected mice at day 4,7and 14 post-vaccination or ***,for IL-12.and IL-4,the potent inducers of Th1 andTh2.responses,respectively,as well as IL-10,there were no differences over the course of the experimentbetween the infected and vaccinated *** explore the underlying factors that may potentially contributeto elevated IFN-γ in vaccinated mice,the mRNA profiles of the skin-draining lymph nodes at day 4 post-exposure were compared using oligonucleotide *** the 847 probe sets with increased signalvalues,we focused on chemokines,cytokines and relevant receptors,which were validated by semi-quantitativeRT-PCR,A comprehensive understanding of the immune mechanisms of attenuated cercariae-inducedprotection may contribute to developing efficient vaccination strategies against ***,especiallyduring the early stare of infection.

关键词： Schistosoma japonicum attenuated cercariae oligonucleotide microarray IFN-γ chemokines