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Induced pluripotent stem cell technology for spinal cord injury: a promising alternative therapy

Neural Regeneration Research 2021年第8期16卷 1500-1509页

作者： Yu Li ping-ping shen Bin Wang Clinical Stem Cell Center the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolSchool of Life ScienceNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and The Comprehensive Cancer Center the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolSchool of Life ScienceNanjing UniversityNanjingJiangsu ProvinceChina Clinical Stem Cell Center the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingJiangsu ProvinceChina

Spinal cord injury has long been a prominent challenge in the trauma repair process. Spinal cord injury is a research hotspot by virtue of its difficulty to treat and its escalating morbidity. Furthermore, spinal cord injury has a long period of disease progression and leads to complications that exert a lot of mental and economic pressure on patients. There are currently a large number of therapeutic strategies for treating spinal cord injury, which range from pharmacological and surgical methods to cell therapy and rehabilitation training. All of these strategies have positive effects in the course of spinal cord injury treatment. This review mainly discusses the problems regarding stem cell therapy for spinal cord injury, including the characteristics and action modes of all relevant cell types. Induced pluripotent stem cells, which represent a special kind of stem cell population, have gained impetus in cell therapy development because of a range of advantages. Induced pluripotent stem cells can be developed into the precursor cells of each neural cell type at the site of spinal cord injury, and have great potential for application in spinal cord injury therapy.

关键词： axon regeneration cell therapy functional recovery induced pluripotent stem cell mesenchymal stem cell neural cells neural precursor cell neural stem cell remyelination spinal cord injury stem cells

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Static Schedule Generation for Time-Triggered Ethernet Based on Fuzzy Particle Swarm Optimization

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Chinese Journal of Electronics 2019年第6期28卷 1250-1258页

作者： CHEN Huang WANG Lide shen ping DI Jun School of Electrical Engineering Beijing Jiaotong University

In time-triggered ethernet(TTEthernet),designing and optimizing the static scheduling of TT messages to improve the real-time performance of the whole network control system is important. When there is a high load on TTEthernet network communication,the conventional static scheduling policy introduces certain problems, such as increased packet loss rate,load imbalance, and transmission delay. Meanwhile,basic artificial intelligence algorithms generally features convergence within only a few steps, leading to higher probability to fall into a local optimal solution. To realize these targets, Fuzzy particle swarm optimization(FPSO)based on population diversity is established. By combining Particle swarm optimization(PSO) with a fuzzy algorithm,setting the adjustment of the inertia weight and the regulation of the mutation factor as the controlled variables of the Fuzzy logic controller(FLC), and adjusting the FLC inference rules, a novel static schedule generation for TTEthernet is proposed. Simulation results prove that,compared to the conventional rate-monotonic scheduling algorithm and the PSO algorithm, FPSO has a strong global search capability when the communication of the TTEthernet system is in a high-load state. FPSO improves the load balancing of the network and reduces the transmission delay of TT message packets. FPSO shows excellent ability to optimize scheduling tables and guarantee the real-time performance of the TTEthernet system.

关键词： Time-triggered ethernet(TTEthernet) Static schedule generation Fuzzy particle swarm optimization(FPSO) Fuzzy logic controller(FLC) Mutation factor Real-time performance Load balancing Transmission delay

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Geochemistry of ore-forming fluids and geological significance of the Kuoerzhenkuola gold field in Xinjiang, China

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Science China Earth Sciences 2005年第11期48卷 1921-1931页

作者： shen ping shen Yuanchao LIU Tiebing LI Guangming ZENG Qingdong Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China

The Kuoerzhenkuola gold field (including the Kuoerzhenkuola and the Buerkesidai gold deposits) is the most important one in the Sawuer gold belt, northern Xinjiang, China. Iso-topic studies including D, O, He, C, S, Pb and Sr reveal that the ore-forming fluids of the Kuo-erzhenkuola and the Buerkesidai deposits shared the same source: the water of ore fluids was magmatic water and minor meteoric water; the mineralizers and ore materials derived mainly from mantle beneath the island arc, and partially from crust. The ore-forming fluids of two depos-its are a mixture of mantle-derived fluids incorporated by crust-derived fluid, and meteoric water. Based on these results, combined with the consideration of the tectonic setting and geological features, we suggest that the two gold deposits in the Kuoerzhenkuola gold field, Sawur gold belt share the same genesis, and are volcanogenic hydrothermal gold deposits occurring in the same caldera.

关键词： ore-forming fluids, inclusions, isotope, volcanogenic late-stage hydrothermal gold deposits, Kuoerzhen-kuola gold field

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Main deposit styles and associated tectonics of the West Junggar region,NW China

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Geoscience Frontiers 2015年第2期6卷 175-190页

作者： ping shen Hongdi Pan Yuanchao shen Yuhong Yan Shihua Zhong Key Laboratory of Mineral Resources Institute of Geology and Geophysics Chinese Academy of Sciences College of Earth Sciences Chang’an University

The West Junggar region, located in the loci of the Central Asian Orogenic Belt, is a highly endowed metallogenic province with 〉100 tonnes Au, 〉0.7 Mt Cu, 〉0.3 Mt Mo, and 〉2.3 Mt chromite as well as significant amounts of Be and U. The West Junggar region has three metallogenic belts distributed systematically from north to south：（1） late Paleozoic Saur Au-Cu belt; （2） early Paleozoic Xiemisitai- Sharburt Be-U-Cu-Zn belt; （3） late Paleozoic Barluk-Kelamay Au-Cu-Mo-Cr belt. These belts host a number of deposits belonging to at least eight economically important styles, including epithermal Au, granite-related Be-U, volcanogenic massive sulfide （VMS） Cu-Zn, podiform chromite, porphyry Cu, hydrothermal quartz vein Au, porphyry-greisen Mo（-W）, and orogenic Au. These deposit styles are associated with the tectonics prevalent during their formation. Five tectonic-mineralized epochs can be recognized：（1） Ordovician subduction-related VMS Cu-Zn deposit; （2） Devonian ophiolite-related podiform chromite deposit; （3） early Carboniferous subductionrelated epithermal Au and porphyry Cu deposits; （4） late Carboniferous subduction-related granite-related Be-U, porphyry Cu, and hydrothermal quartz vein Au deposits; and （5） late Carboniferous to early Permian subduction-related por- phyry-greisen Mo（-W） and orogenic Au deposits.

关键词： Mineral deposit styles Metallogenic belts Tectonic-mineralized epoch West Jonggar Xinjiang

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Observation of pentaquark states and prospectives of further studies

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Science Bulletin 2015年第17期60卷 1549-1550页

作者： Cheng-ping shen Chang-Zheng Yuan School of Physics and Nuclear Energy Engineering Beihang University Institute of High Energy Physics Chinese Academy of Sciences

The quark model based on quark–antiquark mesons and three-quark baryons has been very successful in classifying the ***,quantum chromodynamics(QCD)does not forbid the existence of exotic hadronic states with other qu... 详细信息

关键词：五夸克态夸克胶子结构量子色动力学强子态夸克模型反夸克 QCD 杂交种

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A Novel Genetic Algorithm for Global Optimization

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Acta Mathematicae Applicatae Sinica 2020年第2期36卷 482-491页

作者： Chun-feng WANG Kui LIU Pei-ping shen College of Mathematics and Information.Henan Normal University Xinxiang 453007China Henan Engineering Laboratory for Big Data Statistical Analysis and Optimal Control School of Mathematics and Information SciencesHenan Normal UniversityXinxiang 453007 China

This paper presents a novel genetic algorithm for globally solving un-constraint optimization *** this algorithm,a new real coded crossover operator is proposed ***,for improving the convergence speed and the searching ability of our algorithm,the good point set theory rather than random selection is used to generate the initial population,and the chaotic search operator is adopted in the best solution of the current *** experimental results tested on numerical benchmark functions show that this algorithm has excellent solution quality and convergence characteristics,and performs better than some algorithms.

关键词： genetic algorithm good point set chaotic search continuous optimization

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Cluster and characteristic analysis of Shanghai metro stations based on metro card and land-use data

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Geo-Spatial Information Science 2020年第4期23卷 352-361页

作者： ping shen Linxin Ouyang Chong Wang Yin Shi Yiheng Su Guangzhou Urban Planning&Design Survey Research Institute GuangzhouChina Shanghai Tongji Urban Planning&Design Institute Co. Ltd.ShanghaiChina Tongji Architectural Design(Group)Co. Ltd.ShanghaiChina Shanghai Urban Planning and Design Research Institute ShanghaiChina

Metro is an important form of public transport in *** on the metro card data,we conduct the cluster analysis of Shanghai metro stations according to the pattern of passenger flow changing with *** the characteristics of travel time and surrounding land use are investigated for different types of stations to explore the relationship between urban land-use characteristics and travel activities reflected by passenger flow at metro *** is found that the passenger flow pattern of metro stations is closely related to the location conditions of stations and its surrounding land-use *** on various characteristics,285 metro stations are classified into four types,including residential-oriented stations,employmentoriented stations,employment-residence-oriented stations,and integrated functionaloriented stations,reflecting the interaction between spontaneous travel behavior and urban land-use characteristics and providing a reference for optimizing the urban functional structure and the spatial allocation of facilities.

关键词： Metro stations travel behavior pattern metro card data land use

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Isotopic composition charac-teristics and identification of immature and low-mature oils

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Chinese Science Bulletin 2001年第22期46卷 1923-1929页

作者： XU Yongchang shen ping LIU Wenhui GUAN ping HUANG Difan State Key Laboratory of Gas Geochemistry Lanzhou Institute of GeologyChinese Academy of SciencesLanzhou 730000China Department of Geology Peking UniversityBeijing 100871China Institution of Exploration&Development China Petroleum&NaturalGas Corporation LimitedBeijing 100083China

Isotopic composition characteristics and the significance of immature and low-mature oils are first systematically discussed. The carbon isotopes of the whole oil can be divided into two groups, one has δ13C main peak values ranging from -30‰ to -29 and the other from -27‰ to -25‰, they are related to lacustrine and salt-lake facies or swamp facies, respectively. The carbon isotopic fractionation among different group components is relatively small, usually less than 2‰ and the biggest difference in fractionation often occurs between saturated and aromatic fractions. Their δD values vary between -180‰ and -130‰. The main peak of their δD values concentrates between -170‰ and -150‰, suggesting a domination of lacustrine facies. However, the secondary peak ranges from -160‰ to -150‰, showing a frequent salinization of paleo-water bodies. The average δ13C values of the methane vary between -50‰ and -52‰, about 10‰ lighter than those of mature oils. There is a relatively good

关键词： immature and low-mature oil isotope associated gas.

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Palladium-Catalyzed Cyclocarbonylation of 2-Halobenzaldehyde and Hydrazines： A Facile Synthesis of 2-Aminoisoindolin-l-ones

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Chinese Journal of Chemistry 2013年第2期31卷 182-186页

作者： Chao Han Yang shen ping Lu Yanguang Wang Department of Chemistry Zhejiang University Hangzhou Zhejiang 310027 China

An efficient procedure for the synthesis of 2-aminoisoindolin-l-ones via a palladium-catalyzed three-component reaction of 2-halobenzaldehydes, hydrazines and carbon monoxide is reported. This cyclocarbonylation process can be performed smoothly under 1 atmospheric pressure of carbon monoxide to afford 2-aminoisoindolin- 1-ones in moderate to excellent yields.

关键词： cyclocarbonylation 2-aminoisoindolin-l-ones multicomponent reactions heterocycles

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Adult rhabdomyosarcoma originating in the temporal muscle,invading the skull and meninges:A case report

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World Journal of Clinical Cases 2021年第18期9卷 4866-4872页

作者： Geng-Huan Wang He-ping shen Zheng-Min Chu Jian shen Department of Neurosurgery The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Neurology The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Rhabdomyosarcoma(RMS)is a rare malignant tumor of mesenchymal origin that mainly affects *** cell/sclerosing RMS(SSRMS)is even *** is a new subtype that was added to the World Health Organization disease classification in *** the best of our knowledge,this is the first reported case of adult SSRMS disease classification originating in the temporal *** SUMMARY SSRMS originating in the temporal muscle of a male adult enlarged rapidly,destroyed the skull,and invaded the *** tumor was completely removed,and the postoperative pathological diagnosis was *** recovery was good and chemotherapy and radiotherapy were given after the *** up for 3 mo,no tumor *** RMS is one of the differential diagnoses for head soft tissue tumors with shortterm enlargement and skull *** computed tomography or magnetic resonance imaging is necessary for early detection of tumor invasion of the skull and brain tissue.

关键词： Rhabdomyosarcoma Temporal Muscle Skull Dura Mater Adult Case report

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