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Abducens nerve palsy during pegvisomant therapy in an acromegalic patient

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Open Journal of Internal Medicine 2013年第2期3卷 66-69页

作者： Esra Hatipoglu Hasan Kepicoglu Emel Basar Nurperi Gazioglu Civan Islak Sabahattin Saip pinar kadioglu Department of Neurology Cerrahpasa Faculty of Medicine Istanbul University Istanbul Turkey Department of Neurosurgery Cerrahpasa Faculty of Medicine Istanbul University Istanbul Turkey Department of Ophthalmology Cerrahpasa Faculty of Medicine Istanbul University Istanbul Turkey Department of Radiology Cerrahpasa Faculty of Medicine Istanbul University Istanbul Turkey Division of Endocrinology and Metabolism Department of Internal Medicine Cerrahpasa Faculty of Medicine Istanbul University Istanbul Turkey

Pegvisomant is a recent treatment modality of acromegaly, which is most effective in regulating IGF-1 levels. Tumor growth has been reported in 5% of the acromegaly cases treated with pegvisomant. Herein we report a case of acromegaly resistant to surgical treatment, radiotherapy and medical therapy with a somatostatin analogue and cabergolin. Due to presence of pituitary tumor with cavernous sinus invasion and unremitting disease activity pegvisomant therapy was initiated. She developed left abducens nerve palsy after pegvisomant treatment. The objective of this report is to emphasize the value of close follow-up of the acromely cases under pegvisomant therapy, especially if they have cavernous sinus infiltrating tumor. A 44-year-old woman with acromegaly presented with visual defect and diplopia on left lateral gaze. Her complaint developed 3 years after initiation of pegvisomant therapy. Her neurologic examination was consistent with mild abducens nerve palsy on left side. Other causes for abducens nerve palsy were excluded. Pegvisomant was discontinued upon patient request. Although sella MRI did not reveal a tumor growth, even minimal growth within cavernous sinus can cause cranial nerve involvement. Therefore close and careful follow-up of cavernous sinus infiltrating tumors after pegvisomant therapy is crucial to early recognition of complications.

关键词： Acromegaly Pegvisomant Tumor Growth Cavernous Sinus Abduscence Nerve palsy

Everything Is a Circle: A New Universal Orbital Model

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Advances in Aerospace Science and Technology 2024年第3期9卷 94-116页

作者： Asli pinar Tan Independent Scientist in Electrical and Electronics Engineer Istanbul Trkiye

Based on measured astronomical position data of heavenly objects in the Solar System and other planetary systems, all bodies in space seem to move in some kind of elliptical motion with respect to each other. According to Kepler’s 1st Law, “orbit of a planet with respect to the Sun is an ellipse, with the Sun at one of the two foci.” Orbit of the Moon with respect to Earth is also distinctly elliptical, but this ellipse has a varying eccentricity as the Moon comes closer to and goes farther away from the Earth in a harmonic style along a full cycle of this ellipse. In this paper, our research results are summarized, where it is first mathematically shown that the “distance between points around any two different circles in three-dimensional space” is equivalent to the “distance of points around a vector ellipse to another fixed or moving point, as in two-dimensional space”. What is done is equivalent to showing that bodies moving on two different circular orbits in space vector-wise behave as if moving on an elliptical path with respect to each other, and virtually seeing each other as positioned at an instantaneously stationary point in space on their relative ecliptic plane, whether they are moving with the same angular velocity, or different but fixed angular velocities, or even with different and changing angular velocities with respect to their own centers of revolution. This mathematical revelation has the potential to lead to far reaching discoveries in physics, enabling more insight into forces of nature, with a formulation of a new fundamental model regarding the motions of bodies in the Universe, including the Sun, Planets, and Satellites in the Solar System and elsewhere, as well as at particle and subatomic level. Based on the demonstrated mathematical analysis, as they exhibit almost fixed elliptic orbits relative to one another over time, the assertion is made that the Sun, the Earth, and the Moon must each be revolving in their individual circular orb

关键词： Solar System Planetary System Planet Satellite Earth Moon Topology Circle Sun Ellipse Orbit Trajectory Orbital Mechanics

The ability of biostimulants and copper-containing fungicide to protect cotton against chilling stress

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Journal of Cotton Research 2024年第3期7卷 223-230页

作者： ERGIN Nurgül KULAN Engin Gokhan HARMANCI pinar KAYA Mehmet Demir Faculty of Agriculture and Natural Sciences Department of Field CropsBilecik Seyh Edebali UniversityBilecikTürkiye Faculty of Agriculture Department of Field CropsEskisehir Osmangazi UniversityEskisehirTürkiye

Background Cotton(Gossypium hirsutum L.),adapted to tropical and subtropical regions of the world,is highly sensitive to low temperatures throughout its life *** objective of this study was to evaluate the mitigating effects of different doses of animal-derived(0.25%,0.50%,and 1.00% Isabion■),seaweed-based(0.165%,0.330%,and 0.660% Proton■)biostimulants,as well as a copper(Cu)-containing fungicide application,on cotton cultivar Lazer seedlings at the four true leaves(V4)*** plants were exposed to a low temperature of 5℃for 48 h,and the changes in morphological(seedling fresh and dry weight,plant height,and stem diameter)and physiological parameters(leaf temperature,chlorophyll content,relative water content,electrolyte leakage,and relative injury)were *** The results revealed that chilling stress reduced plant growth,while biostimulants helped protect the plants and overcome the adverse effects of *** chilling stress,there was a considerable reduction in seedling fresh weight(SFW),seedling dry weight(SDW),plant height(PH),stem diameter(SD),leaf temperature(LT),and relative water content(RWC).Cotton seedlings treated with the animal-derived biostimulants showed significantly enhanced SFW,SDW,PH,SD,LT,chlorophyll content(Chl),electrolyte leakage(EL),and relative injury(RI),although there were no positive changes in *** significant differences in the morphological traits were observed among the doses of seaweed *** SDW,PH,EL,and RI,the best results were obtained with the application of a fungicide containing *** These results show the efficiency of the biostimulant and fungicide treatments in mitigating low-temperature stress in cotton *** a copper-containing fungicide to cotton seedlings helped to counteract the negative effects of low-temperature stress and to protect the plants from damage by maintaining electrolyte *** the biostimulant applications,all levels of animal-derive

关键词： Gossypium hirsutum L. Cold stress Electrolyte leakage

Epidemic management in a measles outbreak in 2023,the return of vaccine-preventable diseases:A single center,retrospective observational study

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Asian Pacific Journal of Tropical Medicine 2024年第3期17卷 110-118页

作者： Sevgi Aslan Tuncay Gulsen Akkoc Seyhan Yilmaz Burcu Parlak pinar Canizci Erdemli Aylin Dizi Isik Didem Buyuktas Aytac Meryem Cagla Abaci Capar Eda Kepenekli Kadayifci Marmara University Faculty of Medicine Department of Pediatric Infectious DiseaseIstanbulTurkey

Objective:To investigate the importance of immunization in preventing measles infection and to determine the most useful laboratory tests for confirmation of ***:This study included pediatric cases evaluated with a presumed diagnosis of measles between December 2022 and June 2023,at Marmara University Pendik Training and Research *** effects of vaccination status and underlying disease on the clinical course,treatments,and complications were ***:In total,117 patients were enrolled in the study with a median age of 80 months(IQR:32.5-125.0).Twelve patients with contact history were asymptomatic and had an underlying disorder,and intravenous immunoglobulin was given to them for post-exposure ***-one patients had confirmed measles *** treatment was given to three patients(a newborn,a girl with rhabdomyosarcoma,and a healthy boy)with respiratory ***-eight percent of confirmed measles cases were unvaccinated,and all hospitalized cases were unvaccinated or *** full-vaccinated children had confirmed measles *** PCR from nasopharyngeal swabs was negative in all of them,and their diagnosis was established with anti-measles IgM ***:The measles vaccine is the most effective way to protect from measles and measles-related *** measles can also occur in fully vaccinated patients,the disease is milder than in unvaccinated *** ELISA and RT-PCR tests together may be beneficial in patients with high clinical suspicion for early diagnosis.

关键词： Measles Outbreak Vaccination Vitamin A Ribavirin

Slender reinforced concrete shear walls with high-strength concrete boundary elements

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Frontiers of Structural and Civil Engineering 2023年第1期17卷 138-151页

作者： Mohammad SYED pinar OKUMUS Department of Civil Structural and Environmental EngineeringUniversity at BuffaloBuffaloNY 14260USA

Reinforced concrete structural walls are commonly used for resisting lateral forces in buildings. Owing to the advancements in the field of concrete materials over the past few decades, concrete mixes of high compressive strength, commonly referred to as high-strength concrete (HSC), have been developed. In this study, the effects of strategic placement of HSC on the performance of slender walls were examined. The finite-element model of a conventional normal-strength concrete (NSC) prototype wall was validated using test data available in extant studies. HSC was incorporated in the boundary elements of the wall to compare its performance with that of the conventional wall at different axial loads. Potential reductions in the reinforcement area and size of the boundary elements were investigated. The HSC wall exhibited improved strength and stiffness, and thereby, allowed reduction in the longitudinal reinforcement area and size of the boundary elements for the same strength of the conventional wall. Cold joints resulting from dissimilar concrete pours in the web and boundary elements of the HSC wall were modeled and their impact on behavior of the wall was examined.

关键词： slender walls high-strength concrete rectangular and barbell-shaped walls cold joints

Tamarindus indica and its health related effects

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Asian Pacific Journal of Tropical Biomedicine 2014年第9期4卷 676-681页

作者： pinar Kuru Marmara University School of Medicine Medical InternIstanbulTurkey

Tamarindus[Tamarindus indica L.(***)],belongs to the family Leguminosae(Fabaceae),commonly known as Tamarind tree,is one of the fruit tree species that is used as traditional *** aim of this article is to review the current literatue on health related effect of *** review about this plant was conducted between 2003 and 2014 through Pubmed and *** keywords Tamarind,*** were used for *** the health related articles *** tree is found especially in the Indian subcontinent,Africa,Pakistan,Bangladesh,Nigeria and most of the tropical *** is preferred to be used for abdominal pain,diarrhea and dysentery,some bacterial infections and parasitic infestations,wound healing,constipation and *** is a rich source of most of the essential amino acids and phytochemicals,and hence the plant is reported to possess antidiabetic,antimicrobial,antivenomic,antioxidant,antimalarial,cardioprotective,hepatoprotective,antiasthmatic,laxative and anti-hyperlipidemir *** has ameliorative effects on many *** can also be preferred as a nutritious support for malnourished patients as it is cheap and easy to *** effects should be clarified with further research.

关键词： Tamarind Antioxidant Phytochemicals Nutrition Tryptophan

On the Use of Nanofluids in Solar Energy Applications

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Journal of Thermal Science 2020年第3期29卷 513-534页

作者： CUCE Erdem CUCE pinar Mert GUCLU Tamer BESIR Ahmet Burhaneddin Department of Mechanical Engineering Faculty of EngineeringRecep Tayyip Erdogan UniversityZihni Derin Campus53100 RizeTurkey Low/Zero Carbon Energy Technologies Laboratory Faculty of EngineeringRecep Tayyip Erdogan UniversityZihni Derin Campus53100 RizeTurkey Department of Energy Systems Engineering Faculty of EngineeringRecep Tayyip Erdogan UniversityZihni Derin Campus53100 RizeTurkey

Renewable energy technologies are in the centre of interest to narrow the gap between fossil fuels and clean energy *** dominant role of solar energy systems among the alternatives is beyond question owing to being associated with an infinite energy source,well-documented theory,simplicity,eco-friendly structure and notably higher energy and exergy efficiency range compared to other ***,in solar energy systems,conventional working fluids with poor thermophysical properties are still *** other words,further improvements are still available in the said systems by the use of unique nanoparticles with superior thermal,electrical,optical and mechanical *** the scope of this research,the applications of nanofluids in various solar energy systems such as tracking and non-tracking solar collectors,photovoltaic/thermal systems,solar thermoelectric devices,solar stills,solar thermal energy storage systems,solar greenhouses and solar ponds are comprehensively *** comparisons and discussions are proposed for the potential impacts of various nanofluids on coefficient of performance(COP)and thermodynamic performance figures of solar energy systems such as energy and exergy efficiency,effectiveness and *** challenges of nanofluids are also addressed which need to be resolved in further works.

关键词： nanofluids solar energy applications thermal and electrical performance COP cost

Neutrophil-to-lymphocyte ratio in ocular diseases: a systematic review

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International Journal of Ophthalmology(English edition) 2019年第12期12卷 1951-1958页

作者： Bengi Ece Kurtul pinar Altiaylik Ozer University Tayfur Ata Sokmen Faculty of Medicine Hatay 31040Turkey Department of Ophthalmology Ufuk University Faculty of MedicineAnkara 06830Turkey

AIM: To summarize the results of studies investigating neutrophil-to-lymphocyte ratio(NLR) and to identify the role of NLR in ocular diseases. METHODS: With the aim of identifying the studies related to NLR, a search was conducted on http://***/pubmed by utilizing the key words "neutrophil lymphocyte ratio, ocular diseases, and eye diseases" up to February 2018. All of the original articles were assessed according to date of publications, countries, clinics and topics. Studies about ocular inflammatory diseases were evaluated according to their qualifications, review methods and results. RESULTS: A total of 4473 publications, including original research articles and reviews were screened. The number of publications was shown a regular logarithmic increase over the years. The majority of studies were performed by clinics in Turkey and many of these publications were performed by oncology and cardiology clinics. A total of 75 publications were identified to be about ocular diseases. CONCLUSION: Elevated NLR as a cheap, reproducible, and readily available marker could be used as a diagnostic and/or prognostic marker in ocular diseases.

关键词： neutrophil-to-lymphocyte ratio ocular diseases inflammation publication

How did hepatitis B virus effect the host genome in the last decade?

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World Journal of Hepatology 2014年第12期6卷 851-859页

作者： pinar Ozkal-Baydin Ankara University Stem Cell Institute 06520 Ankara Turkey

The principal reason of chronic liver disease,cirrhosis and hepatocellular carcinoma is chronic viral hepatitis all over the *** B virus(HBV)has some mutagenic effects on the host *** may be exhibiting these mutagenic effects through integrating into the host genome,through its viral proteins or through some epigenetic mechanisms related with HBV *** review aims to summarize the molecular mechanisms used by HBV for effecting host genome determined in the last *** focus will be on the effects of integration,HBV proteins,especially HBV X protein and epigenetic mechanisms on the host *** interactions between HBV and the host genome also forms the underlying mechanisms of the evolution of hepatocellular carcinoma.

关键词： Hepatitis B virus Host genome Integration Hepatitis B virus proteins Epigenetic