How did hepatitis B virus effect the host genome in the last decade?
How did hepatitis B virus effect the host genome in the last decade?作者机构：Ankara University Stem Cell Institute 06520 Ankara Turkey
出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)
年 卷 期：2014年第6卷第12期
页 面：851-859页
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学]
主 题：Hepatitis B virus Host genome Integration Hepatitis B virus proteins Epigenetic
摘 要：The principal reason of chronic liver disease,cirrhosis and hepatocellular carcinoma is chronic viral hepatitis all over the *** B virus(HBV)has some mutagenic effects on the host *** may be exhibiting these mutagenic effects through integrating into the host genome,through its viral proteins or through some epigenetic mechanisms related with HBV *** review aims to summarize the molecular mechanisms used by HBV for effecting host genome determined in the last *** focus will be on the effects of integration,HBV proteins,especially HBV X protein and epigenetic mechanisms on the host *** interactions between HBV and the host genome also forms the underlying mechanisms of the evolution of hepatocellular carcinoma.
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