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Noninvasive ventilation in cancer children with acute respiratory failure

Journal of Acute Disease 2017年第1期6卷 23-27页

作者： Sema Yilmaz Riza Dincer Yildizdas Oguz Dursun Bulent Karapinar Tanil Kendirli Demet Demirkol Agop Citak Alphan Kupesiz Hakan Tekguc Muhterem Duyu pinar Yazici Ufuk Yukselmis Caglar Odek Ayhan Yaman Suleyman Bayraktar Guntuluk Fatma Betul Cakir Department of Pediatric Hematology/Oncology Faculty of MedicineYeditepe UniversityIstanbulTurkey Intensive Care Unit Department of PediatricFaculty of MedicineCukurova UniversityAdanaTurkey Intensive Care Unit Department of PediatricFaculty of MedicineAkdeniz UniversityKonyaaltiAntalyaTurkey Intensive Care Unit Department of PediatricFaculty of MedicineEge UniversityBornovaIzmirTurkey Intensive Care Unit Department of PediatricFaculty of MedicineAnkara UniversityAnkaraTurkey Intensive Care Unit Department of PediatricFaculty of MedicineBezmialem UniversityIstanbulTurkey Intensive Care Unit Department of PediatricFaculty of MedicineIstanbul UniversityIstanbulTurkey Department of Pediatric Hematology/Oncology Faculty of MedicineBezmialem UniversityIstanbulTurkey

Objective: To establish the effectiveness of noninvasive ventilation in cancer children with acute respiratory failure. Methods: The data of 33 cancer patients were obtained prospectively from six different pediatric intensive care units in Turkey between the years of 2012 and 2013. Results: The diagnosis was leukemias in 25 (75.8%), lymphomas in 3 (9.1%) and other solid tumors in 5 (15.1%) patients. Pneumonia in 12 (36.3%) and sepsis in 15 (45.4%) patients were seen as the common reasons of respiratory failure. The mean PaO2/FiO2 ratios were (164.22 ± 37.24) and (126.80 ± 42.73) in noninvasive ventilation success and failure group, respectively. Noninvasive ventilation was successful in 18 (54.5%) patients. The failure group consisted of 15 patients required intubation. A total of 14 (42.4%) patients died. The clinical outcome in terms of success and failure was meaningful statistically (P = 0.0 00 1). Conclusions: Our results could encourage the use of noninvasive ventilation in children with cancer who develop acute respiratory failure. It should be considered as a useful therapeutic approach to avoid endotracheal intubation.

关键词： Noninvasive ventilation Respiratory Children Cancer

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Mitoquinone attenuates blood-brain barrier disruption through Nrf2/PHB2/OPA1 pathway after subarachnoid hemorrhage in rats

Mitoquinone attenuates blood-brain barrier disruption throug...

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第十四届中国医师协会神经外科医师年会

作者： Tongyu Zhang Pei Wu Keren Zhou Lingyun Wu Zhiyi Xie Weilin Xu Xu Luo Peng Li Umut Ocak pinar Eser Ocak Zachary D.Travis Jiping Tang Huaizhang Shi John H.Zhang Department of Neurosurgery The First Affiliated Hospital of Harbin Medical University Department of Physiology and Pharmacology Loma Linda University Department of Earth and Biological Sciences Loma Linda University

Background and Purpose— Mitochondrial dysfunction is involved in the mechanism of early brain injury（EBI） following subarachnoid hemorrhage（SAH）. Blood-brain barrier disruption is a devastating outcome in the early stage of SAH. In this study, we aimed to investigate the role of a mitochondria-related drug Mitoquinone（MitoQ） in blood-brain barrier disruption after SAH in rats. Methods— A total of 181 male Sprague–Dawley SAH rats with the endovascular perforation model were utilized. Intraperitoneal MitoQ was given 1 hour（h） post-SAH. Cerebroventricular ML385, an inhibitor of NF-E2-related factor 2（Nrf2） and Small interfering ribonucleic acid（siRNA） for Prohibitin 2（PHB2） were injected respectively 24 h and 48 h before SAH. Neurological function evaluation was performed before sacrifice. SAH grade was measured during the sacrifice of each animal. Brain water content was performed at 24 h. Coimmunoprecipitation was used to demonstrate the relationship of proteins Nrf2 and PHB2. Mitochondrial and cytoplasmic fractions were gathered using mitochondria isolation kits. Pathway related proteins were investigated with Western blot and immunofluorescence staining. Transmission electron microscopy was performed for mitochondrial morphology. Results— Expression of Nrf2 levels peaked at the 3 h time point following SAH and then decreased to normal levels at 24 h, while PHB2 and Optic Atrophy 1（OPA1） decreased at 24 h and 72 h after SAH compared with the Sham group. MitoQ treatment attenuated neurological deficits and brain edema, thereby resulting in a decreased expression of Albumin, while an increase of Nrf2, PHB2, OPA1 and Claudin-5 proteins compared with SAH+vehicle group. With co-immunoprecipitation, Nrf2 and PHB2 were further demonstrated to show their interaction. And MitoQ administration lead to more binding of the two proteins. ML385 abolished the effects of MitoQ on neurobehavior and protein levels post-SAH. Similarly, PHB2 siRNA reversed the neuroprotection of MitoQ

关键词： Mitoquinone NF-E2-related factor 2 Prohibitin 2 Optic Atrophy 1 Blood-brain barrier disruption Subarachnoid hemorrhage

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全科医学科研的范畴、研究需求和适用方法——《欧洲全科医学/家庭医学和基本医疗保健科研纲要》中文摘译

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中国全科医学 2022年第9期25卷 1027-1039页

作者： Eva Hummers-Pradier Martin Beyer Patrick Chevallier Sophia Eilat-Tsanani Christos Lionis Lieve Peremans Davorina Petek Imre Rurik Jean Karl Soler Henri E.J.H.Stoffers pinar Topsever Mehmet Ungan Paul van Royen Hanny Prick 无汉诺威医学院全科医学研究所德国汉诺威法兰克福大学全科医学研究所德国法兰克福圣昆廷大学全科医学系法国凡尔赛法国国家全科医学教师学会法国内盖夫本古里安大学健康科学学院艾梅克医学中心家庭医学系克拉利特卫生服务部阿富拉山谷地区以色列北区克里特大学社会和家庭医学诊所主任和社会医学系希腊克里特岛安特卫普大学全科医学系安特卫普布鲁塞尔自由大学青年健康系比利时布鲁塞尔卢布尔雅那大学医学院家庭医学系斯洛文尼亚德布勒森大学家庭医学系匈牙利地中海基本保健研究所马耳他阿塔尔德马斯特里赫特大学医学中心公共卫生和基本保健学院(CAPHRI)全科医学系荷兰阿希巴德姆大学家庭医学系土耳其伊斯坦布尔中东技术大学医学中心土耳其安卡拉安特卫普大学初级和跨学科保健系比利时 EGPRN协调中心马斯特里赫特大学全科医学系 Family Medicine and Community Health青年编委会科学翻译小组

本文对《欧洲全科医学/家庭医学和基本医疗保健科研纲要》的中文译稿进行了重点摘登。该文件由欧洲全科医学科研网络制订,包括7部分内容:序言、导言、方法、结果、独立章节,讨论和启示。作为在欧洲发展全科医学科研的核心指南,该文件对... 详细信息

本文对《欧洲全科医学/家庭医学和基本医疗保健科研纲要》的中文译稿进行了重点摘登。该文件由欧洲全科医学科研网络制订,包括7部分内容:序言、导言、方法、结果、独立章节,讨论和启示。作为在欧洲发展全科医学科研的核心指南,该文件对欧洲的全科医学学科和科研发展产生了深远的影响。欧洲的全科医学体系和以此为基础而构建的学科理论共识与我国全科医学当前的实际情况可能更为接近。因篇幅所限,本文刊登了其中最重要,对中国研究者也最实用的5部分内容,包括:(1)导言——全科医学的核心能力/特征以及全科医学科研的意义;(2)结果——全科医学的6个核心领域(基本保健管理、"以人为本"的照护、解决具体问题的技能、综合的方法、以社区为导向、整体的方法)的科研范畴,研究需求和适用方法;(3)独立章节——如何发展基本的科研能力和避免常见的科研失误;(4)讨论——未来的全科医学科研重点;(5)启示——科学协会、研究机构、患者参与、科研工作、期刊、科研政策在发展学科方面应注重的问题。因欧洲的全科医学体制和我国较为相似,且存在一定的科研发展代差,该文件在当前阶段也可为我国全科医学研究者所用,基于全科医学学科的视角,从概念、分类学、范围和科研方法等方面,为我国全科医学科研的发展提供参照。

关键词：全科医学家庭医学基本医疗保健科研方法

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Multiple talon cusps, dens in dente and concrescence in a child with hypomelanosis of Ito

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Open Journal of Stomatology 2012年第3期

作者： Feyza Nur Gorken Ikikarakayali Goksen Arzu pinar Erdem Sinem Kuru Elif Sepet

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Prospective application of a bleeding and ischemic risks-adjusted antithrombotic protocol in elderly patients revascularized with everolimus-eluting stents:EPIC05-Sierra75 study

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Journal of Geriatric Cardiology 2022年第5期19卷 354-366页

作者： Jose M de la Torre Hernandez Ramon Lopez Palop Jesus M Jimenez Mazuecos Pilar Carrillo Sáez Alejandro Gutierez-Barrios Eduardo pinar Belen Cid Luis Fernandez Tamara Garcia Camarero Cristóbal Urbano-Carrillo Juan F Oteo Dominguez Victor A Jimenez Diaz Antonio EGomez Menchero Eladio Galindo Fernández Juan GCórdoba Soriano Raymundo Ocaranza Eduardo ArroyoÚcar Koldobika Garcia San Roman Silvio Leal Ginés Martínez Cáceres Jose A Linares Vicente Georgina Fuertes Ferre Xavier Carrillo Juan CRama Merchán Catia Costa Juan Sanchis Renato Fernandes Alberto Rodrigues Jose M Vegas Valle Hélder Pereira Armando Perez de Prado Cardiology Department Hospital Universitario Marqués de ValdecillaIDIVALSantanderSpain Cardiology Department Hospital Universitario San JuanAlicanteSpain Cardiology Department Complejo Hospitalario Universitario de AlbaceteAlbaceteSpain Cardiology Department Hospital Universitario Puerta del MarCadizSpain Cardiology Department Hospital Clínico Universitario Virgen de la ArrixacaMurciaSpain Cardiology Department Hospital Clinico Universitario de SantiagoCIBERCVSantiago de CompostelaSpain Cardiology Department Hospital Universitario de CrucesBilbaoSpain Cardiology Department Hospital Regional Universitario de MálagaMalagaSpain Cardiology Department Hospital Universitario Puerta de HierroMadridSpain Cardiology Department Hospital Alvaro CunqueiroVigoSpain Cardiology Department Hospital Juan Ramon JimenezHuelvaSpain Cardiology Department Hospital Universitario de BadajozBadajozSpain Cardiology Department Hospital Universitario Lucus AugustiLugoSpain Cardiology Department Hospital de Torrevieja/VinalopóRibera SaludTorreviejaSpain Cardiology Department Hospital Santa CruzLisboaPortugal Cardiology Department Hospital Clínico Universitario Lozano BlesaZaragozaSpain Cardiology Department Hospital Universitario Miguel ServetZaragozaSpain Cardiology Department Hospital Germans Trias i PujolBadalonaSpain Cardiology Department Hospital de MeridaMeridaSpain Cardiology Department Hospital São BernardoSetúbalPortugal Cardiology Department Hospital Clinico Universitario de ValenciaUniversidad de ValenciaCIBERCVValenciaSpain Cardiology Department Hospital do Espirito SantoEvoraPortugal Cardiology Department Centro Hospitalar de Vilanova de GaiaVilanova de GaiaPortugal Cardiology Department Hospital de CabueñesGijonSpain Cardiology Department Hospital Garcia de OrtaAlmadaPortugal Cardiology Department Complejo Asistencial Universitario de LeónLeonSpain

OBJECTIVES Elderly patients show a higher incidence of ischemic and bleeding events after percutaneous transluminal coron-ary intervention(PCI).We sought to investigate outcomes in elderly patients treated with antithrombotic strategy guided by bleeding and ischemic risks after revascularization with last generation everolimus-eluting stent(EES).METHODS Prospective multicenter registry including patients over 75 years revascularized with EES and antithrombotic ther-apy guided by clinical presentation,PCI complexity and PRECISE DAPT ***-primary safety endpoints were:(1)composite of cardiac death,myocardial infarction and stent thrombosis and;(2)bleeding(BARC 2-5).Primary efficacy endpoint was target lesion revascularization.A matched group of patients revascularized with current drug-eluting stents and no such tailored antith-rombotic therapy was used as *** Finally,1064 patients were included in SIERRA-75 cohort,80.8±4.2 years,36.6%women,71%acute coronary syn-dromes(ACS)and 53.6%complex ***-primary safety endpoint of major adverse cardiovascular events was met in 6.2%,co-primary safety endpoint of bleeding in 7.8%and primary efficacy endpoint of TKLR in 1.5%.The multivariable adjusted model showed no significant association of the prescribed short/long dual antiplatelet therapy(DAPT)durations with any endpoint suggesting a well tailored *** stent thrombosis reported in the subgroup with 1-3 months DAPT *** compared to control group,bleeding BARC 2-5 was significantly lower in SIERRA-75 group(7.4%vs.10.2%,P=0.04)as well as the net safety-efficacy endpoint(14.3%vs.18.5%,P=0.02).CONCLUSIONS In elderly population,the application of this risks-adjusted antithrombotic protocol after revascularization with last generation EES seems to be associated with an improved prognosis in terms of ischemic and bleeding outcomes.

关键词： patients bleeding antithrombotic

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Is routine pregnancy test necessary in women of reproductive age admitted to the emergency department?

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World Journal of Emergency Medicine 2013年第3期4卷 175-178页

作者： zlem Kksal Fatma zdemir Erol Armagan Nuran ner pinar inar Sert Deniz Sigirli Department of Emergency Medicine Faculty of MedicineUludag UniversityBursaTurkey Department of Biostatistics Faculty of MedicineUludag UniversityBursaTurkey

BACKGROUND:This study aimed to determine the necessity of pregnancy test in women of reproductive age admitted to emergency department(ED) in routine ***:We retrospectively reviewed the records of patients who presented to the ED between January 1,2006 and December 31,2010 and received a pregnancy ***:The median age of 1 586 patients enrolled into the study was 27 *** these patients,19.55%had a positive result of pregnancy *** most common complaint at admission was abdominal pain in 60.15%of the patients,and pregnancy test was prescribed.15.83%of the patients with abdominal pain had a positive result of pregnancy *** the patients,30.64%had nausea-vomiting at admission,and 11.52%had a positive result of pregnancy *** other complaints were considered,the most commonly observed complaints were non-specific symptoms such as dizziness,malaise and respiratory *** the patients,70.93%were not remembering the date of last menstruation,and 9.51%showed a positive result of pregnancy *** tract infection(UTI) was commonly diagnosed with an incidence of 17.65%,which was followed by nonspecific abdominal pain(NSAP)(16.77%) and gastrointestinal disorders such as gastritis and peptic ulcer(6.87%).Of the patients,88.40%were discharged from ED,and 11.60%were ***:Pregnancy test should be given to women of reproductive age as a routine practice in ED in developing countries like Turkey.

关键词： Female Emergency Medical Services Pregnancy Reproduction

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Fanconi anemia manifesting as a squamous cell carcinoma of the mandible: a case report

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Open Journal of Stomatology 2011年第2期

作者： A. pinar Erdem G. Ikikarakayali N. Yalman G. Ak M. A. Erdem M. B. Bilgic E. Sepet

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Services provided at the premarital counseling center and characteristics of the clients, in Kayseri, Turkey

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Health（健康） 2011年第6期 333-337页

作者： Mürüvvet Baser Tülay Özkan pinar Tekinsoy Evrim Albayrak Sultan Tasci

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