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An investigation on topologies of hybrid manifold,impin.ing-jet nozzle and micro-pin.fin heat sinks

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Science China(Technological Sciences) 2024年第4期67卷 1061-1076页

作者： SHI QianLei YAO XiaoLe LIU Qian QIN Le ju Xing XU Chao Key Laboratory of Power Station Energy Transfer Conversion and System of MOE North China Electric Power UniversityBeijing 102206China

The hybrid manifold micro-pin.fin(MMPF)heat sink combined nozzle jets is an option for large-scale integrated circuits(LSI).The demond for uniform and ultra-high heat flux removal by MMPF heat sink has not been adequately *** work aims to solve the problem of fluid *** proposed basic tiling topologies,including square,regular hexagon,30°rhombus,and 60°rhombus topologies,provide different organized fluid flows and heat transfer *** present study focuses on comparing these topologies according to independent porous medium parameters,such as nozzle pore size D_(Z),flow pore size D_(X,Y),and porosityε.The results show that the square topology achieves the smallest total thermal resistance R_(tot)value of0.0975×10^(-4)K m^2/W,while the hexagon topology achieved the highest value of COP/?T,which was 2033.9 K^(-1).According to the sensitivity analysis results,the optimal total thermal resistance can be obtained by balancing the influences of nozzle pore size,flow pore size,and *** optimal pressure drop can be obtained by maximizing the porosity.

关键词： heat sink ultra-high heat flux manifold micro-pin.fin impin.ing-jet topology

Divergence of trafficking and polarization mechanisms for pin.auxin transporters during land plant evolution

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Plant Communications 2024年第1期5卷 116-129页

作者： Han Tang Kuan-ju Lu YuZhou Zhang You-Liang Cheng Shih-Long Tu Jiri Friml Institute of Science and Technology Austria(ISTA) Am Campus 13400 KlosterneuburgAustria Graduate Institute of Biotechnology National Chung Hsing UniversityNo.145Xingda Rd.South Dist.Taichung 40227TaiwanR.O.C College of Life Sciences Northwest A&F UniversityShaanxiYanglingChina Institute of Plant and Microbial Biology Academia Sinica128 Sec.2Academia RdNankangTaipei 11529TaiwanR.O.C Present address:Graduate Institute of Biochemistry National Chung Hsing UniversityNo.145Xingda Rd.South Dist.Taichung 40227TaiwanR.O.C

The phytohormone auxin,and its directional transport through tissues,plays a fundamental role in the development of higher *** polar auxin transport predominantly relies on pin.FORMED(pin.auxin ***,pin.polarization is crucial for development,but its evolution during the rise of morpho-logical complexity in land plants remains ***,we performed a cross-species investigation by observing the trafficking and localization of endogenous and exogenous pin. in two bryophytes,Physco-mitrium patens and Marchantia polymorpha,and in theflowering plant Arabidopsis *** confirmed that the GFP fusion did not compromise the auxin export function of all examined pin. by using a radioac-tive auxin export assay and by observing the phenotypic changes in transgenic *** pin. polarize tofilamentous apices,while exogenous Arabidopsis pin. distribute symmetrically on the membrane in both *** the Arabidopsis root epidermis,bryophytic pin. have no defined *** interference revealed a strong cytoskeletal dependence of bryophytic but not Arabidopsis pin.*** divergence of pin.polarization and trafficking is also observed within the bryophyte clade and between tissues of individual *** results collectively reveal the divergence of pin.traf-ficking and polarity mechanisms throughout land plant evolution and the co-evolution of pin.sequence-based and cell-based polarity mechanisms.

关键词： Arabidopsis evolution Marchantia Physcomitrium pin. polarization protein trafficking

左氏醒神明目针治疗原发性开角型青光眼视神经萎缩的疗效观察

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中国中医眼科杂志 2024年第10期34卷 917-921页

作者：鞠品赵磊左韬辽宁中医药大学沈阳110032 辽宁中医药大学附属第二医院沈阳110034

目的观察左氏醒神明目针法治疗原发性开角型青光眼视神经萎缩的疗效。方法纳入2022年5月—2023年2月辽宁中医药大学附属第二医院眼科诊治的原发性开角型青光眼视神经萎缩患者72例(72只眼),证属肝郁气滞证,均以右眼作为研究对象。随机... 详细信息

目的观察左氏醒神明目针法治疗原发性开角型青光眼视神经萎缩的疗效。方法纳入2022年5月—2023年2月辽宁中医药大学附属第二医院眼科诊治的原发性开角型青光眼视神经萎缩患者72例(72只眼),证属肝郁气滞证,均以右眼作为研究对象。随机分为对照组和试验组,每组36例(36只眼)。对照组予腺苷钴胺片口服,试验组在对照组的基础上联合左氏醒神明目针法治疗。2组均观察4周。分别于治疗前和治疗后检查受试者的最佳矫正视力(BCVA)、视野改变[包括视野指数(VFI)、图形标准差(PSD)、平均缺损(MD)]、视神经纤维层(RNFL)厚度和中医证候积分(TCMS)。结果 (1)BCVA:试验组治疗后BCVA较治疗前改善,差异有统计学意义(t=2.078,P=0.041)。对照组治疗后BCVA与治疗前比较,差异无统计学意义(P>0.05)。治疗后2组间比较,试验组BCVA优于对照组,差异有统计学意义(t=2.146,P=0.035)。(2)视野改变:试验组治疗后VFI较治疗前升高,PSD、MD均较治疗前降低,差异均有统计学意义(t_(VFI)=2.882,P=0.005;t_(PSD)=2.114,P=0.038;t_(MD)=2.601,P=0.011)。对照组治疗后的VFI、PSD、MD与治疗前比较,差异均无统计学意义(P>0.05)。治疗后2组间比较,试验组VFI高于对照组,MD低于对照组,差异均有统计学意义(t_(VFI)=2.102、t_(MD)=2.103,均P=0.039)。(3)RNFL厚度:2组治疗前、后RNFL厚度比较及治疗后2组间比较,差异均无统计学意义(P>0.05)。(4)TCMS:试验组治疗后TCMS较治疗前降低,差异有统计学意义(t=7.869,P=0.000)。对照组治疗后TCMS与治疗前比较,差异无统计学意义(P>0.05)。治疗后2组间比较,试验组TCMS低于对照组,差异有统计学意义(t=6.795,P=0.000)。结论左氏醒神明目针法可有效改善原发性开角型青光眼视神经萎缩肝郁气滞证患者的主要症状体征。

关键词：青光眼视神经萎缩针刺肝郁气滞证

高职院校“一站式”学生社区建设价值、困境与路径

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湖北开放职业学院学报 2024年第13期37卷 68-70页

作者：王韶频杭金菊苏州卫生职业技术学院江苏苏州1215009

“一站式”学生社区作为高校思想政治工作体系内容之一,是提升大学生思想政治教育成效的重要一环,具有重要价值。高校“一站式”学生社区从试点探索到全面推广,取得成效。但是,基于高职院校建设基础,高职院校“一站式”学生社区逻辑空... 详细信息

“一站式”学生社区作为高校思想政治工作体系内容之一,是提升大学生思想政治教育成效的重要一环,具有重要价值。高校“一站式”学生社区从试点探索到全面推广,取得成效。但是,基于高职院校建设基础,高职院校“一站式”学生社区逻辑空间、物理空间、社会空间建设仍存在现实困境。对此,要围绕逻辑、物理、社会空间三个维度,强化理念共识、管理体系、实体建设、网络空间、党建引领、协同联动、自我治理等方面的实践路径,推动社区高质量建设。

关键词：高职院校 “一站式”学生社区思想政治教育

High Refractive Index without Absorption in a Ladder-Type System

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Chinese Physics Letters 2014年第3期31卷 58-61页

作者： ZENG Zhi-Qiang HOU Bang-pin.LIU Fu-Ti SHAO ju-Xiang School of Physics and Electronic Engineering Yibin University Yibin 644000 Computational Physics Key Laboratory of Sichuan Province Yibin University Yibin 644000 School of Physics and Electronic Engineering Sichuan Normal University Chengdu 610066

A three-level ladder-type system with vacuum-induced coherence and incoherent pumpin. is studied to obtain a high refractive index without absorption. It is shown that the enhancement of the refractive index without absorption can be accomplished by choosing the proper values of the incoherent pumpin., the angle between the two dipole moments, the probe detuning and the relative phase of the two coherent fields.

关键词： Refractive index

RV减速器摆线针轮传动机构轮齿承载接触分析

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机械传动 2024年第2期48卷 131-141页

作者：韩炬张伟昌华北理工大学机械工程学院河北唐山063210

RV减速器摆线针轮传动机构的轮齿承载接触分析是进行该机构润滑分析的基础。为明确摆线轮齿与针齿、曲拐轴承滚针与内外圈之间的动态接触特性,基于摆线针轮传动机构啮合原理,分析了6种不同齿廓修形方式下的轮齿间隙及啮合点的运动学特性... 详细信息

RV减速器摆线针轮传动机构的轮齿承载接触分析是进行该机构润滑分析的基础。为明确摆线轮齿与针齿、曲拐轴承滚针与内外圈之间的动态接触特性,基于摆线针轮传动机构啮合原理,分析了6种不同齿廓修形方式下的轮齿间隙及啮合点的运动学特性;结合静力平衡方程及变形协调条件,引入非线性赫兹接触刚度,建立了摆线针轮传动机构的三维动态承载接触分析模型,确定了含有初始间隙的轮齿受载变形,利用迭代法完成模型求解,明确了传动过程中轮齿及曲拐轴承滚针内外圈啮合处的时变受力特性。

关键词：摆线针轮传动承载接触分析齿廓修形轴承受力

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血型分析仪专利技术分析

中国医疗器械信息 2024年第3期30卷 68-72页

作者：赖鹏飞刘兰菊王学琴张洁品深圳市爱康生物科技股份有限公司广东深圳518118

血型检测在临床输血中十分重要,是避免因血型不匹配的血液输入体内而发生免疫排异、产生溶血反应的有效方式。而采用自动化、标准化程度高的血型分析仪可大批量快速检测血型,提高血型检测效率和准确率。文章对全球血型分析仪的专利进行... 详细信息

血型检测在临床输血中十分重要,是避免因血型不匹配的血液输入体内而发生免疫排异、产生溶血反应的有效方式。而采用自动化、标准化程度高的血型分析仪可大批量快速检测血型,提高血型检测效率和准确率。文章对全球血型分析仪的专利进行检索分析,从血型分析仪整机、类型、加样及判读等机械模块和微柱凝胶法、微孔板法等方法学角度进行专利情报分析,阐明血型分析仪的技术分布及核心技术研发方向,以期对我国血型仪器的研发提供技术指引和参考。

关键词：血型血型分析仪专利体外诊断仪器

Combined chemo-endocrine therapy as a potential new option for HR+/HER2−advanced breast cancer:a prospective study of fulvestrant plus oral vinorelbine

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Cancer Biology & Medicine 2023年第4期20卷 287-296页

作者： Xue Wang Jian Yue Yikun Kang Zhong Dai Jie ju Jiayu Wang pin.Zhang Fei Ma Binghe Xu Peng Yuan Department of VIP Medical Services National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Comprehensive Oncology Huanxing Cancer HospitalBeijing 100026China Department of Medical Oncology and Clinical Trial Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective:Endocrine therapy with fulvestrant has shown synergistic antitumor effects with some chemotherapy drugs in *** study evaluated the efficacy and safety of fulvestrant with vinorelbine in patients with hormone receptor positive(HR+)/human epidermal growth factor receptor-2-negative(HER2−)recurrent or metastatic breast ***:Patients were intramuscularly administered fulvestrant 500 mg(day 1 per cycle for 28 days)and oral vinorelbine(60 mg/m2 on days 1,8,and 15 of each cycle).The primary endpoint was progression-free survival(PFS).Secondary endpoints included overall survival,objective response rate,disease control rate,duration of response,and ***:A total of 38 patients with HR+/HER2−advanced breast cancer included in the study were followed up for a median time of 25.1 *** overall median PFS was 9.86 months[95%confidence interval(CI)7.2-23.13],and the median PFS of the first-line and the second-line treatment population was 20.73 months(95%CI 9.82 to NR)and 4.27 months(95%CI 3.68 to NR),*** adverse events reported were of grade 1/2,and none were of grade 4/***:This is the first exploratory study of a fulvestrant and oral vinorelbine regimen in the treatment of HR+/HER2−recurrent and metastatic breast *** combination chemo-endocrine therapy was efficacious,safe,and promising for patients with HR+/HER2−advanced breast cancer.

关键词： HR+/HER2−breast cancer recurrence metastasis fulvestrant oral vinorelbine

PACLITAXEL PLUS CARBOPLATIN FOR WOMEN WITH ADVANCED BREAST CANCER

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Chinese Medical Sciences Journal 2007年第2期22卷 93-97页

作者： ju Liu Qing Li pin.Zhang Jia-yu Wang Long-mei Zhao Bing-he Xu Department of Medical Oncology Cancer Hospital ＆ Institute Chinese Academy of Medical Sciences ＆Peking Union Medical College Beijing 100021

Objective To evaluate the efficacy and safety of combination chemotherapy with paclitaxel and carboplatin for advanced breast cancer (ABC). Methods From January 2001 to March 2006, 45 patients with ABC were treated with combination chemotherapy of paclitaxel and carboplatin. Patients received infusion of paclitaxel 175 mg/m2 on day 1 every 3 weeks or 75 mg/m2 on day 1, 8, 15 every 4 weeks. Carboplatin was administrated on day 2 with a dose of area under the time-concentration curve (AUC) being 5. Results The median number of cycles was 3 (range, 2-6). The overall response rate was 62.2%. Median time to progression was 7.0 months (95%CI:5.1-8.9). Median overall survival was 29.0 months (95%CI: 20.1-37.9). One year survival rate was 73.3%. Response rate for first line and second line treatment were 62.1% and 62.5%, respectively. No significant difference in response existed between visceral metastasis and soft tissue metastasis. The main side effects included nausea/vomiting, neurotoxicity, and hematologic toxicities. Grade Ⅲ to Ⅳ adverse events included nausea/vomiting in 2 cases (4.4%), leukopenia in 17 cases (37.8%), and alopecia in 6 cases (13.3%). Conclusion Combination of paclitaxel and carboplatin is active in treatment of ABC with an acceptable toxicity profile.

关键词： breast neoplasms paclitaxel carboplatin